• Title/Summary/Keyword: miR-192

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Relationship between Savant Skills and Autistic Symptoms in Korean Patients with Autism Spectrum Disorder (한국인 자폐스펙트럼장애에서 Savant Skill과 자폐증상의 연관성)

  • Kim, Yun-Mi;Cho, Soo-Churl;Yoo, Hee-Jeong;Chung, Un-Sun;Park, Tae-Won;Sohn, Jung-Woo;Shin, Min-Sup;Kim, Boong-Nyun;Kim, Jae-Won;Cho, In-Hee
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.22 no.3
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    • pp.192-197
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    • 2011
  • Objectives: This study was conducted to examine the prevalence and characteristics of savant skills and the relationship between the savant skills and autistic symptoms in Korean ASD children. Methods: 141 ASD subjects participated in this study and they were divided in to two groups based on the presence or lack of savant skills. The domain scores and total scores of the K-ADI-R, K-ASDS and SRS were used for evaluating the ASD symptoms between the groups. Results: Memory (N=47) was the most prevalent savant skill in the savant ASD group (N=60). The savant ASD group had a statistically higher mean age and IQ score than did the nonsavant ASD group. Despite their high IQ profile, the savant ASD group showed a higher restricted, repetitive and stereotype behavior score on the K-ADI-R and higher language and cognitive scores on the K-ASDS than did the nonsavant ASD group. Conclusions: These results suggest savant syndrome in ASD might be related to the severity of some subdomain of autistic symptoms even though their IQ scores were higher than nonsavant ASD patients.

Influence of Consciousness of Biomedical Ethics on Nursing Professionalism of Nursing Students (간호대학생의 생명의료윤리의식이 간호전문직관에 미치는 영향에 관한 연구)

  • Yun, Mi Jin
    • The Journal of the Convergence on Culture Technology
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    • v.7 no.4
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    • pp.105-112
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    • 2021
  • The purpose of this study was to investigate the influence of Consciousness of biomedical ethics on nursing professionalism among nursing students. Data were collected among 192 nursing students in G city, from May 20 to 27, 2021. The collected data was analyzed a using t-test, One way ANOVA, Pearson's correation coeffcient and Stepwise multiple regression using SPSS 20.0 WIN program. The average score for Consciousness of biomedical ethics was 3.28±0.41 and nursing professionalism was 3.32±0.85. nursing professionalism showed a positve correlation(r=.55, p=.000) with Consciousness of biomedical ethics, Models including the variables, Organ transplant, Euthanasia, explained 37%, 16.5% of the variance in the nursing professionalism. Based on the outcome of this study, steps should be taken to design intervention program that emphasize a improve nursing professionalism for nursing students.

Programming Interface for DAG-based Co-scheduling of GirdRPC (GridRPC의 DAG 기반 Co-scheduling을 위한 프로그래밍 인터페이스)

  • Choi, Ji-Hyun;Lee, Dong-Woo;Kim, Mi-Ok;Ramakrishna, R.S.
    • Proceedings of the Korea Information Processing Society Conference
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    • 2003.11a
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    • pp.189-192
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    • 2003
  • 이 논문에서는 그리드환경에서 Remote Procedure Call(RPC) 프로그래밍 인터페이스를 위한 메커니즘인 GridRPC 의 성능향상을 위해 DAG 기반의 Co-scheduling API 를 제안한다. 네트워크 상의 통신횟수를 줄임으로써 GridRPC call 의 최적화를 도모하기 위한 프로그래밍 인터페이스와 이를 가능하게 하는 서버구조를 제안한다. DAG 기반의 co-scheduling 은 서버-클라이언트간의 연산에 사용되는 입력값과 출력값들의 흐름을 분석하여 사용자로 하여금 DAG(Directed Acyclic Graph)로 GridRPC call 들을 구성하고 이를 기반으로 GridRPC call 들을 최적화하는 방법이다. 또한, GridRPC가 Client Interface 이기 때문에 생기는 문제점인 서버간의 지원의 문제점을 SOAP 서버의 Wrapping 을 통해 해결한다.

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The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1

  • Harikrishna, Reddy R.;Kim, Hackyoung;Noh, Kwangmo;Kim, Young Jun
    • BMB Reports
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    • v.47 no.4
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    • pp.192-196
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    • 2014
  • RNA polymerase II carboxyl-terminal domain (pol II CTD) phosphatases are a newly emerging family of phosphatases that are members of DXDX (T/V). The subfamily includes Small CTD phosphatases, like SCP1, SCP2, SCP3, TIMM50, HSPC129 and UBLCP. Extensive study of SCP1 has elicited the diversified roles of the small C terminal domain phosphatase. The SCP1 plays a vital role in various biological activities, like neuronal gene silencing and preferential Ser5 dephosphorylation, acts as a cardiac hypertrophy inducer with the help of its intronic miRNAs, and has shown a key role in cell cycle regulation. This short review offers an explanation of the mechanism of action of small CTD phosphatases, in different biological activities and metabolic processes.

A report of nine unrecorded bacterial species in the phylum Bacteroidetes collected from freshwater environments in Korea

  • Park, Sanghwa;Beak, Kiwoon;Han, Ji-Hye;Nam, Yoon-Jong;Lee, Mi-Hwa
    • Journal of Species Research
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    • v.7 no.3
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    • pp.187-192
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    • 2018
  • During a comprehensive study of indigenous prokaryotic species in South Korea, nine bacterial species in the phylum Bacteroidetes were isolated from freshwater environmental samples that were collected from three major rivers in the Republic of Korea. High 16S rRNA gene sequence similarity (${\geq}98.7%$) and robust phylogenetic clades with the closely related species suggest that each strain was correctly assigned to an independent and predefined bacterial species. There were no previous reports of these nine species in Korea. Within the phylum Bacteroidetes, four species were assigned to the genus Flavobacterium, order Flavobacteriales, and five species to three genera of two families in the order Cytophagales. Gram reaction, colony and cell morphology, basic biochemical characteristics, isolation source, and strain IDs are described in the species description section.

The Effects of General Characteristics, Lifestyle and Nutrients on Obesity, Serum Lipids and C-Reactive Protein for Adults (일반적 특성, 생활습관과 영양소 섭취가 성인의 비만, 혈청지질 및 C-반응성 단백에 미치는 영향)

  • Park, Hyo-Mi;Ha, Na-Sun
    • The Korean Journal of Rehabilitation Nursing
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    • v.11 no.2
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    • pp.99-106
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    • 2008
  • Purpose: The purpose of this study was to identify predictors of obesity, serum lipids and CRP in Korean adults. The predictors of obesity and serum lipids were the subject's general characteristics, life style, eating habit and nutrients. The predictors of CRP were the subject's general characteristics, life style, eating habit, nutrients, obesity and serum lipids. Method: 115 subjects who had visited the health examination center at a hospital participated in the study. The data analysed with descriptive analysis, ANOVA, Chi-square test, Pearson correlation coefficient and multiple regression. Result: Sex, married, eating out ($4{\leq}$/w), eating out (2-3/w) and age ($61{\leq}$) were anticipated variable on BMI ($R^2$=0.488). Sex and overeating (2-3/w) were anticipated variable on body fat($R^2$=0.218). Drink (4-6/w), age (51-60), sex, vegetable fat and Systolic BP were anticipated variable on total cholesterol ($R^2$=0.217). Age (51-60), vegetable fat and unmarried were anticipated variable on LDL ($R^2$=0.180). Sex was anticipated variable on HDL and Triglyceride ($R^2$=0.054, 0.192). Breakfast (1-3/w) and meal (2/d) were anticipated variable on CRP ($R^2$=0.1268). Conclusion: It is thought that decreasing eating out and overeating might be important to prevent obesity. It is thought that decreasing drinking and fat eating might be important to improve serum lipids. It is thought that eating breakfast might be important to decrease CRP.

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Efficient approach for determining four-dimensional computed tomography-based internal target volume in stereotactic radiotherapy of lung cancer

  • Yeo, Seung-Gu;Kim, Eun Seog
    • Radiation Oncology Journal
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    • v.31 no.4
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    • pp.247-251
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    • 2013
  • Purpose: This study aimed to investigate efficient approaches for determining internal target volume (ITV) from four-dimensional computed tomography (4D CT) images used in stereotactic body radiotherapy (SBRT) for patients with early-stage non-small cell lung cancer (NSCLC). Materials and Methods: 4D CT images were analyzed for 15 patients who received SBRT for stage I NSCLC. Three different ITVs were determined as follows: combining clinical target volume (CTV) from all 10 respiratory phases ($ITV_{10Phases}$); combining CTV from four respiratory phases, including two extreme phases (0% and 50%) plus two intermediate phases (20% and 70%) ($ITV_{4Phases}$); and combining CTV from two extreme phases ($ITV_{2Phases}$). The matching index (MI) of $ITV_{4Phases}$ and $ITV_{2Phases}$ was defined as the ratio of $ITV_{4Phases}$ and $ITV_{2Phases}$, respectively, to the $ITV_{10Phases}$. The tumor motion index (TMI) was defined as the ratio of $ITV_{10Phases}$ to $CTV_{mean}$, which was the mean of 10 CTVs delineated on 10 respiratory phases. Results: The ITVs were significantly different in the order of $ITV_{10Phases}$, $ITV_{4Phases}$, and $ITV_{2Phases}$ (all p < 0.05). The MI of $ITV_{4Phases}$ was significantly higher than that of $ITV_{2Phases}$ (p < 0.001). The MI of $ITV_{4Phases}$ was inversely related to TMI (r = -0.569, p = 0.034). In a subgroup with low TMI (n = 7), $ITV_{4Phases}$ was not statistically different from $ITV_{10Phases}$ (p = 0.192) and its MI was significantly higher than that of $ITV_{2Phases}$ (p = 0.016). Conclusion: The $ITV_{4Phases}$ may be an efficient approach alternative to optimal $ITV_{10Phases}$ in SBRT for early-stage NSCLC with less tumor motion.

Natural Tooth Color Evaluation in the Korean Elderly Population

  • Bye-Ri Han;Mi-Yeon Kim;Sun-Ho Kim;Jeong-Hee Kim;Ran-Ah Kim
    • Journal of Korean Dental Science
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    • v.16 no.2
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    • pp.192-203
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    • 2023
  • Purpose: This study is to investigate the distribution of natural tooth shades in the Korean elderly population to quantify the correlation and changes of tooth color with age and gender. In addition, the possible effects of habits on tooth color were assessed. Materials and Methods: The tooth color of one of the maxillary central incisors of 200 Korean individuals aged 50 to 89 years, males and female, was measured using the portable intraoral spectrophotometer (VITA Easyshade V). CIELab and CIELCh color coordinates were recorded. We conducted the survey about the tobacco smoking, chronic disease, medication, eating habits, oral health behaviors and satisfaction with tooth color. Experimental data were statistically analyzed by using the t-test (P<0.05), two-way analysis of variance and Pearson's correlation test. Result: The most frequent color in the Korean elderly population was 3M3 & A3.5 shade. L* and h* values decreased, whereas C*, a* and b* values increased progressively with age. There was a significant interaction between age and color coordinates for b* values (r=0.245, P<0.05). Males generally have significantly higher C*, a*, b* values and lower L*, h* value compared to females. Individuals who consumed alcohol had a higher L* value (P<0.05). Conclusion: Within the limitation of this study, the central incisors were getting darker, more reddish, and yellowish with age. Information on the chromatic range of natural teeth by age and gender could help to select colors for esthetic dental restorations.

PCR-RFLP and Sequence Analysis of the rDNA ITS Region in the Fusarium spp.

  • Min, Byung-Re;Lee, Young-Mi;Choi, Yong-Keel
    • Journal of Microbiology
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    • v.38 no.2
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    • pp.66-73
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    • 2000
  • To investigate the genetic relationship among 12 species belonging to the Fusarium section Martiella, Dlaminia, Gibbosum, Arthrosporiella, Liseola and Elegans, the internal transcribed spacer(ITS) regions of ribosomal DNA (rDNA) were amplified with primer pITS1 and pITS4 using the polymerase chain reaction(PCR). After the amplified products were digested with 7 restriction enzymes, restriction fragment length polymorphism (RFLP) patterns were analyzed. The partial nucleotide sequences of the ITS region were determined and compared. Little variation was observed in the size of the amplified product having sizes of 550bp or 570bp. Based on the RFLP analysis, the 12 species studied were divided into 5 RFLP types. In particular, strains belonging to the section Martiella were separated into three RFLP types. Interestingly, the RFLP type of F. solani f. sp. piperis was identical with that of isolates belonging to the section Elegans. In the dendrogram derived from RFLP analysis of the ITS region, the Fusarium spp. examined were divided into two major groups. In general, section Martiella excluding F. solani f. sp. piperis showed relatively low similarity with the other section. The dendrogram based on the sequencing analysis of the ITS2 region also gave the same results as that of the RFLP analysis. As expected, 5.8S, a coding region, was highly conserved, whereas the ITS2 region was more variable and informative. The difference in the ITS2 region between the length of F. solani and its formae speciales excluding F. solani f. sp. piperis and that of other species was caused by the insertion/deletion of nucleotides in positions 143-148 and 179-192.

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Effects of Dietary Cu Levels and Kinds of Dietary Lipid on the Lipid Metabolism in Rats (식이내 Cu의 수준과 지방의 종류를 달리 하였을때 흰쥐의 체내 지방대사에 미치는 영향)

  • Kim, Kap-Soon;Kim, Mi-Kyung
    • Journal of Nutrition and Health
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    • v.17 no.3
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    • pp.185-192
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    • 1984
  • This study was performed to investigate the effects of different levels of Cu(0,6,60 ppm ) and kinds of lipid(corn oil, sesame oil or butter) in the diet upon lipids metabolism and Cu & Fe contents in weanling rats. The results obtained were summarized as following : 1) Food consumptions, total body weight gains and F.E.R.s showed no significant differences among groups with different dietary Cu levels and the kinds of lipid. 2) Weights of liver, hind limb muscle, kidney, spleen and epididymal fat pad showed no significant differences among groups. 3) The contents of total lipids and total cholesterols in serum, hind limb muscle were significantly higher in low Cu groups than in control and high Cu groups. But the contents of total lipid in liver were significantly lower in low Cu groups than in other groups. 4) The contents of total lipid and total cholesterol in serum, liver and total lipid in muscle were significantly higher in butter groups, but the contents of total cholesterol in muscle were significantly lower in butter groups. 5) The Cu concentrations in serum, liver, muscle and feces were significantly higher in high Cu groups than in control and low Cu groups. The Fe concentrations in serum tended to be lower and those in muscle were significantly higher in low Cu groups.

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