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http://dx.doi.org/10.5483/BMBRep.2014.47.4.060

The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1  

Harikrishna, Reddy R. (Departments of Applied Biochemistry, Konkuk University)
Kim, Hackyoung (Departments of Applied Biochemistry, Konkuk University)
Noh, Kwangmo (Nanotechnology Research Center, Konkuk University)
Kim, Young Jun (Departments of Applied Biochemistry, Konkuk University)
Publication Information
BMB Reports / v.47, no.4, 2014 , pp. 192-196 More about this Journal
Abstract
RNA polymerase II carboxyl-terminal domain (pol II CTD) phosphatases are a newly emerging family of phosphatases that are members of DXDX (T/V). The subfamily includes Small CTD phosphatases, like SCP1, SCP2, SCP3, TIMM50, HSPC129 and UBLCP. Extensive study of SCP1 has elicited the diversified roles of the small C terminal domain phosphatase. The SCP1 plays a vital role in various biological activities, like neuronal gene silencing and preferential Ser5 dephosphorylation, acts as a cardiac hypertrophy inducer with the help of its intronic miRNAs, and has shown a key role in cell cycle regulation. This short review offers an explanation of the mechanism of action of small CTD phosphatases, in different biological activities and metabolic processes.
Keywords
Cardiac hypertrophy; Cell cycle regulation; Neuronal; gene silencing; SCP1; Small CTD phosphatases;
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