• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 추계학술대회
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• pp.129-129
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• 2003

Methylmercury is known to have devastating effects on the mammalian nervous system. When human neuroblastoma SH-SY5Y cells were treated with MeHg at sublethal concentrations (6.25 uM), up-regulated genes (39) ＆ Down-regulated genes (19) were identified by microarray.(omitted)

• Toxicological Research
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• 제35권1호
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• pp.25-35
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• 2019

The extracts of Plathymenia reticulata and Connarus favosus are widely used in the folk medicine. The potential protective effects of these extracts have been evaluated against cadmium in the yeast Saccharomyces cerevisiae, and against mercurial contamination in zebrafish Danio rerio. In yeast, both extracts efficiently protected the ${\Delta}ycf1$ mutant strain exposed to cadmium chloride restoring the growth, the expression of stress-response genes and decreasing the level of oxidative stress. In zebrafish, the supplementation of methylmercury-contaminated diet with both plant extracts similarly protected fish through the suppression of the methylmercury-induced lipid peroxidation, decrease of acetylcholinesterase activity, and restoring the expression levels of stress-response genes. This study particularly demonstrates the protective potential of both aqueous extracts against methylmercury, and could represent an interesting alternative for the Amazonian fish-eating communities to cope with the impact of chronic exposure to contaminated diets.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2000년도 추계심포지움 및 학술발표회:바이오모니터링 기법을 이용한 환경위해성 평가
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• pp.85-85
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• 2000

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2003년도 추계학술대회
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• pp.130-130
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• 2003

• 한국환경보건학회지
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• 제17권2호
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• pp.127-139
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• 1991

Four group(Control I II, Treatment I II ) of Rats, each consisting of 10 rats, were studied Methylmercury Chloride MMc was orally given to Sprague-Dawley male at does of 10mg/kg (5 mg/kg $\cdot$ day), 10mg/kg after two weeks. This study was designed to investigate the distribution, the difference and the ratio of organic mercury, total mercury, zinc and copper in tissue, in each others group. The result were as follows: 1. There was no significantly difference in the body weight between two groups( p > 0.05). 2. There was significantly difference in the distribution of zinc concentration in liver, kidndey, blood, spleen between control I and treatment I, and in blood, spleen between control II and treatment II (P < 0.05). 3. There was significantly difference in the distribution of copper concentration in kidney, blood between control I and treatment I, and in spleen brain between control II and treatment II. 4. The ratio of zinc concentration in treatment/control was high at spleen. 5. The ratio of methylmercury/totalmercury was high at spleen.

• Journal of Preventive Medicine and Public Health
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• 제17권1호
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• pp.245-250
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• 1984

Reciprocal exchanges of DNA in sister chromatids (SCEs) are induced by various carcinogens and mutagens, although the quantitative relationship between the number of mutations and SCEs induced varies among chemicals. Nevertheless, the analysis of SCEs production by various agents often proposed as a sensitive and quantitative assay for mutagenicity and cytotoxicity. Mercury, even if which has no evidences for mutagenicity and carcinogenicity, is reported to exert some cytotoxic effects, such as chromosomal aberrations or bad influences to ovulation and reproduction in experimental animals, etc.. In this study, tests for sister chromatid exchanges have been carried out on normal human lymphocytes in whole blood culture to add mercury chloride ($HgCl_2$) or methylmercury chloride ($CH_3\;HgCl$) for 72 hr. The results indicate the dose-dependent relationship between the frequencies of SCEs and the concentrations of $HgCl_2,\;CH_{3}HgCl$ and 5-bromo-2'-deoxyuridine (BrdU). Lymphocyte proliferation has depressed in the higher concentration of mercury.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 추계학술대회
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• pp.130-130
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• 2003

Methylmercury (MeHg) is a well-known neurotoxicant that causes severe damage to the central nervous system in humans. Many reports have shown that MeHg is poisonous to human body through contaminated foods and has released into the environment. Despite many studies on the pathogenesis of MeHg-induced central neuropathy, no useful mechanism of toxicity has been established so far.(omitted)

• 한국식품위생안전성학회지
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• 제32권1호
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• pp.42-49
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• 2017

본 연구의 목적은 경기도 내 유통되고 있는 수산물(심해성 어류, 다랑어류 및 새치류) 및 어류가공품의 총수은 및 메틸수은 오염도를 알아보기 위해 실시하였다. 수산물 101건과 어류가공품 44건을 수거하여 수은분석기 및 가스크로마토그래피 전자포획검출기를 사용하여 분석하였다. 수산물은 모두에서 총수은이 검출되었고 메틸수은은 92건에서 검출되어 91.1%의 검출률을 나타내었다. 총수은과 메틸수은의 함량은 각각 새치류 $1.968{\pm}0.505$, $0.496{\pm}0.057mg/kg$, 심해성어류 $0.665{\pm}0.091$, $0.252{\pm}0.033mg/kg$, 다랑어류 $0.577{\pm}0.085$, $0.218{\pm}0.025mg/kg$순으로 높게 나타났으며, 황새치의 평균값이 총수은은 1.968 mg/kg, 메틸수은은 0.496 mg/kg으로 가장 높았다. 총수은 대비 메틸수은 함량은 심해성 어류인 쏨뱅이류가 66.5%로 가장 높았다. 어류가공품의 총수은 메틸수은함량은 원육함량 100%인 냉동식품이 가장 높았으며 원재료 함량과 비례하여 나타났다. 심해성 어류, 다랑어류 및 새치류를 통한 총수은 및 메틸수은의 주간섭취량은 JECFA에서 설정한 PTWI의 4.72, 5.24%로 조사된 어류를 통한 우리나라 국민들의 노출량은 안전한 것으로 나타났다.

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2003년도 추계학술대회
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• pp.129-129
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• 2003

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.189.2-190
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• 2003

Methylmercury (MeHg), one of the heavy metal compounds. can cause severe damage to the central nervous system in humans. Many reports have shown that MeHg is poisonous to human body through contaminated foods and has released into the environment. Despite many studies on the pathogenesis of MeHg-induced central neuropathy, no useful mechanism of toxicity has been established so far. (omitted)