• Tuberculosis and Respiratory Diseases
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• 제51권1호
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• pp.65-69
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• 2001

폐암의 치은에의 전이는 매우 드물게 발생되는 질환으로 아직 국내보고는 없었다. 흉부 전산화단층촬영 및 조직검사를 통하여 치은으로 전이된 소세포 폐암으로 진단되어 항암화학요법과 방사선 치료를 받았으나 1년 후 사망한 증례를 경험하였기에 보고하는 바이다.

• 대한골관절종양학회지
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• 제9권2호
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• pp.169-177
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• 2003

목적: 골육종 환자에서 p21, p27 단백질의 발현과 국소 재발, 원격 전이 및 생존율과의 상관 관계에 대해 알아보고자 하였다. 대상 및 방법: 골육종 환자 40명의 종양학적 결과를 후향적으로 조사하였으며, 이들의 파라핀에 포매된 조직을 실험 재료로 사용하였다. 단백질 발현은 조직 배열법을 이용한 면역염색 화학법으로 측정하였다. 결과: 40례의 골육종에서 p21은 38례에서 발현되었고 p27은 14례에서 발현되었다. p21은 많이 발현될수록 화학요법에 대한 조직의 반응도가 나빴고(p=0.002), 원격 전이가 유의하게 많았다(p=0.024). p27 양성군에서는 음성군에 비해 원격 전이의 발생이 유의하게 적어(p=0.028), p27의 발현이 안될수록 예후가 좋지 않았다. 결론: p21, p27은 서로 상반된 결과를 보였으며, 환자의 예후와 밀접한 관계를 가짐을 알수 있었다. 하지만, 두 인자의 작용 기전은 명확하지 않아 지속적인 연구가 필요할 것으로 사료되었다.

• Tuberculosis and Respiratory Diseases
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• 제64권5호
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• pp.374-378
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• 2008

혈관육종은 매우 드문 악성종양으로 고령 남자의 두피나 얼굴에 주로 발생하며, 폐로 전이되는 경우가 있다. 폐전이의 경우 객혈, 기흉 등의 호흡기계 증상을 일으킬 수 있다. 저자들은 혈관육종의 폐전이가 낭성변화를 일으켜 기흉 및 혈흉을 초래한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Journal of Gastric Cancer
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• 제9권3호
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• pp.104-109
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• 2009

목적: 조기위암 및 림프절 전이에 대한 수술 중 외과적 병기판정의 정확도에 대하여 분석하고, 외과적 병기에 근거한 수술 범위 판단의 유용성에 대하여 조사하고자 하였다. 대상 및 방법: 2006년에서 2007년까지 위암으로 위 절제술을 시행 받은 369명을 대상으로 조기위암 및 림프절 전이에 대한 수술 전 검사 및 외과적 병기판정의 민감도, 특이도 및 정확도를 비교 분석하였다. 결과: 조기위암에 대한 외과적 병기판정의 민감도, 특이도, 정확도는 각각 74.5%, 95.7%, 83.7%였으며 양성 예측도는 95.7%였다. 이는 수술 전 검사에 의한 조기위암의 진단에 비하여 높은 특이도와 양성 예측도를 보였다. 림프절 전이에 대한 외과적 병기판정의 민감도, 특이도 및 정확도는 73.2%, 78.1%. 76.4%였다. 127명의 림프절 전이 환자 중 수술 전 진단에서 59명(46.5%)이, 외과적 병기판정에 의해서는 34명(26.8%)만이 림프절 전이 없음으로 저 평가되었다. 조기위암의 진단에서 술 전 진단과 외과적 병기 사이에 불일치를 보인 70예 가운데, 63예(90%)는 외과적 병기판정이, 7예(10%)는 수술 전 진단이 정확하였다. 결론: 수술 중 외과의사에 의한 외과적 병기판정은 조기 위암 및 림프절 전이에 대하여 수술 전 검사에 비하여 높은 정확도를 보이고 진행위암의 조기위암으로의 저 평가를 현저히 줄인다. 따라서 위암의 수술 시 외과적 병기는 수술 범위를 결정하는데 있어서 중요한 인자로 고려되어야 한다.

• 대한두경부종양학회지
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• 제17권2호
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• pp.185-189
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• 2001

Background: Cervical metastasis of unknown origin is defined as histologic evidence of malignancy in the cervical lymph nodes with no apparent primary site of origin for the metastatic tumor. Patients and Methods: A retrospective review of 20 cervical metastasis of unknown origin diagnosed and managed between january 1989 and December 1999 at the Korea University was undertaken to determine outcome. Patient age ranged 46 to 78 years (mean 60). There were 17 men and 3 women. The aim of this study is to ananlyze the diagnostic approach and the result of treatment of the cervical metastasis of unknown origin. Result: Histopathologically, squamous cell carcinoma (15 case, 75%) were the most common, followed by adenocarcinoma (4 case, 20%), undifferentiated carcinoma (1 case, 5%) According to the criteria of the AJCC on staging, N1 was 2 cases, N2a 2 cases, N2b 5 cases, N2c 1 cases, N3 10 cases. Overall survival rate for all patients at 2 years was 45% and 5 years 25%, and in the combination therapy(surgery and radiotherapy group (12 cases)) it was 67% and 34% respectively, high compared with other treatment modality such as surgery or radiotherapy alone. In extracapsular spread positive group, 5 year survival rate was 12%, but was 33% in the extracapsular spread negative group. Conclusion: With no stastatical significance, extracapsular spread group was poor outcome in our study. Combination of radiotherapy and surgery was more effective treatment result than surgery alone or radiotherapy alone in our study. But, overall prognosis of cervical metastasis of unknown origin was very poor despite aggressive treatment (5 year survival rate: 25%).

• Maxillofacial Plastic and Reconstructive Surgery
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• 제32권2호
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• pp.183-188
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• 2010

Leiomyosarcoma is a malignant neoplasm of smooth muscle origin and mostly originate from the wall of uterus and gastrointestinal tract, but primary leiomyosarcoma of the oral cavity is extremely rare. This tumor has a very poor prognosis due to high recurrence and metastasis rate, with 5 year survival rate of 32%. And regional lymph node metastasis is uncommon event. Complete wide surgical excision is the treatment of choice. A 64-year old man who had a painful ulcerative lesion on the labial & palatal gingiva of #11, 21 visited our department, and was diagnosed as leiomyosarcoma through a biopsy. Partial maxillectomy was carried out, with no following radiotherapy or chemotherapy. After months follow-up, there has been no evidence of recurrence or metastasis. But after months, we clinically find out two enlarged immobile palpable lymph node in right submandibular area of patient. So a biopsy was performed via an extraoral incision under local anesthesia. Histopathologic diagnosis diagnosis of the biopsy was lymph node metastasis of prior existed leiomyosarcoma. We report a case of a primary leiomyosarcoma occurred in a 64 year-old male patient involving the anterior maxillary region with regional lymph node metastasis with a review of literature.

• Nuclear Medicine and Molecular Imaging
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• 제41권3호
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• pp.263-264
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• 2007

Splenic metastasis from colon carcinoma are rare and usually occur in the presence of disseminated visceral metastasis. The liver is the most common site of metastatic spread from colon cancer. Several hypotheses have attempted to explain the low incidence of splenic metastasis. It should be difficult for colorectal cancer cells to reach the spleen through the portal venous system, in which the blood flow is usually from the spleen to the liver. Reticuloendothelial system or rhythmic contraction of the spleen may squeeze out the tumor in the spleen. The absence of afferent lymphatic to the spleen, phagocytic activity and humoral anticancer substances are considered to be other reason for low incidence of splenic metastasis. We report the case of $^{18}F-FDG$ PET/CT finding in a 70-year-old woman who develop isolated splenic metastasis of sigmoid colon cancer.

• Journal of Korean Neurosurgical Society
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• 제30권1호
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• pp.89-94
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• 2001

Skull or brain metastasis from thyroid carcinoma is rare. Between Jan. 1993. and Jan. 2000. the authors experienced 7 cases of skull(4 cases) or brain(3 cases) metastasis from thyroid carcinoma. Clinical characteristics, radiologic findings and pathologic features were analyzed retrospectively. Among 4 cases of skull metastasis, 3 cases were follicular carcinoma and one was papillary carcinoma with follicular variant. All cases of brain metastasis were papillary carcinoma. We treated the patients by combination with surgical resection, radioactive iodine therapy and radiation therapy. Characteristics of skull or brain metastasis from thyroid carcinoma is reviewed with a pertinent literature.

• Journal of Yeungnam Medical Science
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• 제30권2호
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• pp.152-155
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• 2013

Orbital metastasis from hepatocellular carcinoma is very rare, with only 14 biopsy-proven cases from hepa tocellular carcinoma cases reported in English literature and three cases reported in Korea. Common symptoms of orbital metastasis are proptosis, visual loss, ocular pain and oculomotor dysfunction. For its precise diagnosis, we can perform fine needle aspiration biopsy, orbit CT or MRI, and ultrasonography. Radiotherapy is the mainstay in the treatment of orbital metastasis. In addition, chemotherapy, hormonal therapy and surgical intervention can play a role in the treatment of orbital metastasis according to the primary cancer and symptoms. However, the prognosis of orbital metastasis is poor. We report herein a rare case of a patient with orbital metastasis from hepatocellular carcinoma, which was treated with various modalities that included resection, and who had good clinical and radiological responses to radiation therapy and sorafenib (Nexavar, Bayer HealthCare).

• 대한암한의학회지
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• 제14권1호
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• pp.45-52
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• 2009

Lung cancer is the most common primary tumor of brain metastasis. Metastasis to the brain is a frequent complication of non-small cell lung cancer (NSCLC) occuring in 12 ~ 18% of patient. The incidence of brain metastasis is rising because of longer survival of cancer patients as a result of the increase in early diagnosis of primary tumors and aggressive management, and improvements in imaging quality and accessibility such as widespread use of MRI. The most common symptoms are gradual onset of headache, focal weakness, and mental changes. Surgery, chemotherapy, radiotherapy and steroid therapy are treatment of NSCLC with brain metastasis. We report a patient with NSCLC metastasis to the brain. This patient underwent chemotherapy, radiotherapy and steroidtherapy. However, the patient requested oriental medical treatment for the patient's continuous headache and disease. We administered Banhabaekchulchoenma-tang gagambang with Allergen-removed Rhus Verniciflua Stokes(aRVS). The patient showed remarkable improvement in terms of frequency and severity of headache. Further study will be needed in order to determine the long-term effectiveness of oriental medical treatment on cancer patient with headache.