• Molecules and Cells
• /
• v.28 no.2
• /
• pp.75-80
• /
• 2009

The cyclic environmental conditions brought about by the 24 h rotation of the earth have allowed the evolution of endogenous circadian clocks that control the temporal alignment of behaviour and physiology, including the uptake and processing of nutrients. Both metabolic and circadian regulatory systems are built upon a complex feedback network connecting centres of the central nervous system and different peripheral tissues. Emerging evidence suggests that circadian clock function is closely linked to metabolic homeostasis and that rhythm disruption can contribute to the development of metabolic disease. At the same time, metabolic processes feed back into the circadian clock, affecting clock gene expression and timing of behaviour. In this review, we summarize the experimental evidence for this bimodal interaction, with a focus on the molecular mechanisms mediating this exchange, and outline the implications for clock-based and metabolic diseases.

• Journal of Institute of Control, Robotics and Systems
• /
• v.20 no.5
• /
• pp.486-494
• /
• 2014

Intelligent homes consist of ubiquitous sensors, home networks, and a context-aware computing system. These homes are expected to offer many services such as intelligent air-conditioning, lighting control, health monitoring, and home security. In order to realize these services, many researchers have worked on various research topics including smart sensors with low power consumption, home network protocols, resident and location detection, context-awareness, and scenario and service control. This paper presents the real-time metabolic rate estimation method that is based on measured heart rate for human adaptive appliance (air-conditioner, lighting etc.). This estimation results can provide valuable information to control smart appliances so that they can adjust themselves according to the status of residents. The heart rate based method has been experimentally compared with the location-based method on a test bed.

• Journal of Institute of Control, Robotics and Systems
• /
• v.18 no.8
• /
• pp.750-757
• /
• 2012

This paper focuses on human adaptive HVAC system that can regulate the thermal comfort of the resident in intelligent buildings. The thermal comfort is represented in this paper by PMV (Predicted Mean Vote) as defined by ISO 7730. This PMV value indicates how hot or cold a resident feels by considering temperature, humidity, resident's metabolic rate, relative air velocity, and clothing insulation. In order to develop such a system, a location detection system based on ZigBee module was used along with temperature sensors, other environment sensors. The human adaptive HVAC system was evaluated experimentally on a test bed emulating a room.

• Journal of Applied Biological Chemistry
• /
• v.56 no.1
• /
• pp.37-42
• /
• 2013

In eukaryotes, most of the genome are transcribed, however only a small proportion of total transcripts encodes for protein, thus resulting in many of noncoding RNAs. In order to recover DNA damage including DNA double-strand breaks (DSBs) eukaryotes have evolved complex mechanisms and these are processed through coordinated mechanisms of protein sensors, transducers, and effectors including RNAs. During recent years, small RNAs have been increasingly studied and gradually considered as key regulators in various aspects of biology. Upon DNA damage, small RNAs including diRNAs (DSB induced RNA) are generated in both plant and human cell lines. Inhibition of their biogenesis has severe influence on DSB repair system.

• Molecules and Cells
• /
• v.42 no.8
• /
• pp.569-578
• /
• 2019

Transient receptor potential (TRP) channels are nonselective cationic channels, conserved among flies to humans. Most TRP channels have well known functions in chemosensation, thermosensation, and mechanosensation. In addition to being sensing environmental changes, many TRP channels are also internal sensors that help maintain homeostasis. Recent improvements to analytical methods for genomics and metabolomics allow us to investigate these channels in both mutant animals and humans. In this review, we discuss three aspects of TRP channels, which are their role in metabolism, their functional characteristics, and their role in metabolic syndrome. First, we introduce each TRP channel superfamily and their particular roles in metabolism. Second, we provide evidence for which metabolites TRP channels affect, such as lipids or glucose. Third, we discuss correlations between TRP channels and obesity, diabetes, and mucolipidosis. The cellular metabolism of TRP channels gives us possible therapeutic approaches for an effective prophylaxis of metabolic syndromes.

• Proceedings of the KSME Conference
• /
• 2008.11a
• /
• pp.1609-1612
• /
• 2008

RQ(Respiratory Quotient) value is obtained from the ratio of the consumed oxygen and the produced carbon dioxide during the patient's respiration. To investigate the efficacy of insulin and diagnosis the metabolic disorder in short time, the RQ value can be used as important parameter. The measurement of oxygen and carbon dioxide amounts is needed large chamber and complex sensors. But If the atmospheric oxygen and carbon dioxide concentrations do not change, the expiratory oxygen and carbon dioxide can be used to obtain RQ value. A convenient RQ measuring device has been developed by using two sensors for O2 and CO2. The estimation of RQ devices confirms that the RQ device can obtain accurate data by eliminating uncertain factor such as delay time and remaining gases.

• IMMUNE NETWORK
• /
• v.21 no.3
• /
• pp.20.1-20.18
• /
• 2021

The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems. It can influence disease processes in the gut as well as extra-intestinal organs, including the brain. The gut closely connects with the central nervous system through dynamic bidirectional communication along the gut-brain axis. The connection between gut environment and brain may affect host mood and behaviors. Disruptions in microbial communities have been implicated in several neurological disorders. A link between the gut microbiota and the brain has long been described, but recent studies have started to reveal the underlying mechanism of the impact of the gut microbiota and gut barrier integrity on the brain and behavior. Here, we summarized the gut barrier environment and the 4 main gut-brain axis pathways. We focused on the important function of gut barrier on neurological diseases such as stress responses and ischemic stroke. Finally, we described the impact of representative environmental sensors generated by gut bacteria on acute neurological disease via the gut-brain axis.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.15 no.10
• /
• pp.870-878
• /
• 2003

The maintenance of thermal equilibrium between the human body and its environment is one of the primary requirements for health, wellbeing and comfort. For the effective control of indoor thermal environment, thermostat or humidistat is used. But, it is not sufficient to control the indoor thermal environment using only one or two parameters as human response for the indoor comfortable environment. So an environmental thermal index is required for the control of indoor thermal environment effectively. In this study, a PMV sensor has been developed which has integrated from various kinds of individual sensors for temperature, humidity, air velocity, radiant temperature. After applying the PMV and PPD equation, it is possible to monitor the indoor thermal environment with the sensor system, which is adopted to the circuit for optimization according to the human response with the metabolic rate and activities. The measurement was carried out to verify the performance of the integrated sensor system in comparison with existing measurement system, the PMV meter. As a result, the possibility of applying the PMV sensor to control the indoor thermal environment simultaneously was examined.

• Journal of Sensor Science and Technology
• /
• v.19 no.6
• /
• pp.435-442
• /
• 2010

Typically, the vital signs that are representing the state of human body, are the body temperature, sphygmus, respiration and blood pressure. The body temperature is the result of metabolic regulation and human steady-state body temperature is maintained from 35.9 to $37.4^{\circ}C$ by heat regulatory center. The body temperature is indicative of infection and especially it should be monitored to requiring intensive care patients or after surgical patients. But, measuring of body temperature to a heavy workload on nursing staff has been recognized. And, the health service of nurse is limited by simple tasks such as the measurement and record of vital sign. In this paper, the body temperature monitoring telemetry system was proposed to prove the recoding and transmission of body temperature patch system according the standard(ISO TS11073-92001). We proposed the transmission protocol to suit the MFER(medical waveform format encoding rules). The telemetry patch system was implemented and it was verified by experiments.

• Journal of Sensor Science and Technology
• /
• v.26 no.5
• /
• pp.314-323
• /
• 2017

Indicators to quantitatively evaluate the body function may help to optimize the effectiveness of rehabilitation therapy for stroke patients. In this study, we analyzed the body composition in the paretic and nonparetic regions of stroke patients with hemiplegia caused by cerebral hemorrhage (7 cases) and cerebral infarction (13 cases) using multifrequency bioelectrical impedance. Specifically, we considered fat mass (FM), fat-free mass (FFM), FFMI index (FFMI), FM/FFM relation, body cell mass (BCM), basal metabolic rate (BMR), and BMR/FFM relation to evaluate the bodily function in the paretic and nonparetic regions. These values showed considerable differences according to grades determined by the stroke causes and the paralysis status. In the paretic regions, the FFM, FFMI, BCM, and BMR were low and the FM was high. In contrast, the nonparetic regions showed a high FFM and low FM. Furthermore, the paretic and nonparetic regions of all patients suitably fit a linear relation (slope: 22.17 kcal/day/kg) between BMR and FFM. Therefore, bio-electrical impedance measurements can be very useful to quantitatively assess paretic and nonparetic regions in hemiplegic stroke patients.