• 대한한의정보학회지
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• 제11권2호
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• pp.32-39
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• 2005

Objectives To observe relationship between BMD(BMD; bone mineral density) and lipid metabolic indicator which consists of cholesterol, HDL(HDL; high density lipoprotein), Trigliceride which influenced by BMI(BMI; body mass index), BFR(body fat rate) indirectly and directly in both ways. Methods Among 120 old patients aging above 65 who admitted to Dep. of Oriental Rehabilitation, Jeon-Ju Oriental Medical Hospital, Won Kwang University in order to prevent demetia and CVA from Mar. 2004 to May 2005 correlationship between BMI, BFR, BMD etc. and lipid metabolic indicator was statistically analysed. Results BMD of male patient was higher than that of female patients and body weight, height, BFR, BMI was significantly related to BMD as well. Relationship between Total Cholesterol, HDL, Triglyceride and BMD was not significant. Conclusions From the above results, Relationship between Total Cholesterol, HDL, Triglyceride and BMD was not significant.

• 대한임상검사과학회지
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• 제51권1호
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• pp.42-49
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• 2019

이 연구는 대사증후군 위험 예측인자로서 요산과 비교하여 혈청 요산/크레아티닌 비율의 유용성을 확인하고자 하였다. 2016년 11월부터 2018년 10월까지 수도권 소재의 일개 종합병원에서 종합건강검진을 받은 20세 이상 80세 미만의 성인 남성 14,190명을 대상으로 하였다. 대사증후군 진단기준은 American Heart Association/National Heart Lung and Blood Institute (AHA/NHLBI)의 기준에 따라 5가지 대사증후군 구성요소 중 3가지 이상 해당되는 경우 대사증후군을 평가하였으며, 이 중 복부비만은 WHO 서태평양지역의 기준에 따랐다. 이 연구결과 혈청 요산/크레아티닌 비율은 1사분위수보다 4사분위수의 대사증후군 및 대사증후군 구성요소의 높은 발생빈도를 보였다. 그러나 ROC 분석 결과 혈청 요산/크레아티닌 비율은 대사증후군 위험 예측에 있어 혈청 요산치보다 더 유용한 지표는 아니었으며(AUC, 0.554 vs 0.566), 요산치보다 낮은 민감도와 높은 특이도를 보였다. 결론적으로 혈청 요산/크레아티닌 비율의 유용성을 확인한 결과 대사증후군 위험을 예측하는 독립적인 지표로 사용하는데 제한이 있으며, 보조적인 표지자로 사용하는 것이 바람직하겠다.

• 대한의생명과학회지
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• 제15권1호
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• pp.9-15
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• 2009

Early age at menarche, which is indicator of early biological maturity, has been shown to be associated with increased adult body mass index. Early menarche has also been associated with many cardiovascular disease risk factors and metabolic syndrome. To evaluate the impact of menarche to cardiovascular risk factor, we assessed by age at menarche, brachial-ankle pulse wave velocity (baPWV), which represents arterial stiffness, in women with or without metabolic syndrome. The subjects recruited for this study were three hundred one women. Relatively early menarche and relatively late menarche were classified according to less than $50^{th}$ percentile for relatively early menarche, and great than the $50^{th}$ percentile for relatively late menarche. Subject were divided four group, 1) women who had not adulthood metabolic syndrome and relatively early menarche, 2) women who had not adulthood metabolic syndrome and relatively late menarche, 3) women who had adulthood metabolic syndrome and relatively early menarche, 4) women who had adulthood metabolic syndrome and relatively late menarche. Women who had a relatively early menarche with adulthood metabolic syndrome had significantly high levels of blood pressure, triglyceride, fasting insulin and homeostatic model assessment of insulin resistance (HOMA-IR) levels than women with late menarche with adulthood metabolic syndrome, and had significantly lower HDL-cholesterol levels. And also, women who underwent a relatively early menarche with metabolic syndrome had highest level of baPWV in adult. In this study we found effect of age at menarche on adulthood metabolic risk factors for cardiovascular disease (e.g., baPWV, insulin resistance, hyperlipidemia) in Korean women.

• Food Science and Biotechnology
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• 제14권5호
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• pp.639-644
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• 2005

The aim of this study was to investigate the effect of the myosin light chain (MLC) isoforms on the muscle fiber characteristics and meat quality traits in porcine longissimus muscle. Pale, soft, exudative (PSE) samples had a lower content of essential light chain (ELC) 1S isoforms and a higher proportion of the fiber type IIB than the reddish-pink, firm, non-exudative (RFN) samples. These compositions suggest that the PSE pork has a higher glycolytic and a lower oxidative capacity than the RFN pork. Therefore, these characteristics of PSE pork might affect the metabolic rate and meat quality traits, including protein solubility. In addition, the indicator traits of the postmortem metabolic rate were related to the ELC 1F/3F ratio ($pH_{45\;min}$: r = -0.43, P < 0.001; R-value: r = 0.53, P < 0.001). These results suggest that the MLC isoform composition can affect the postmortem metabolic rate and meat quality traits.

• 대한의생명과학회지
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• 제24권3호
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• pp.245-252
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• 2018

Heart rate recovery (HRR) is simply an indicator of autonomic balance and is a useful physiological indicator to predict cardiovascular morbidity and mortality. The purpose of this study was to compare the differences in HRR between metabolically healthy obesity group and metabolically unhealthy obesity and to ascertain whether heart rate recovery is a predictor of metabolic syndrome. Metabolic syndrome was defined according to the standards of the National Cholesterol Education Program Adult Care Panel III. Obesity was assessed according to WHO Asian criteria. It was classified into three groups of metabolically healthy non-obesity group (MHNO, n=113), metabolically healthy obesity group (MHO, n=66), metabolically unhealthy obesity (MUO, n=18). Exercise test was performed with Bruce protocol using a treadmill instrument. There was no difference in HRR between MHO and MUO ($32.71{\pm}12.25$ vs $25.53{\pm}8.13$), but there was late HRR in MUO than MHNO ($25.53{\pm}8.13$ vs $34.51{\pm}11.80$). HRR in obese was significantly correlated with BMI (r=-0.342, P=0.004), waist circumference (r=-0.246, P=0.043), triglyceride (r=-0.350, P=0.003), HbA1c (r=-0.315, P=0.009), insulin (r=-0.290, P=0.017) and uric acid (r=-0.303, P=0.012). HRR showed a lower prevalence of abdominal obesity, hypertriglyceridemia, and low HDL-cholesterol in the third tertile than in the first tertile. In conclusion, MHO had no difference in vagal activity compared with MHNO, but MUO had low vagal activity. HRR is associated with metabolic parameters and is a useful predictor of abdominal obesity, hypertriglyceridemia, and low HDL-cholesterolemia.

• 한국치위생학회지
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• 제12권3호
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• pp.597-609
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• 2012

Objectives : The purpose of this study was to determine the influence of workers health behaviorals, oral health behaviorals and metabolic syndrome risk factors on oral health and to identify the relationship between these. and then, a basis data propose for integrative health promotion programs development and effective Management measures. Methods : The subjects were 4,600 workers working at a industrial place in North Gyeongsang Province, data were collected from July 13, 2010 to September 12, 2010. using the results of the subjects medical check-ups and Oral examinations, this study was performed. collected data included workers general characteristics, job characteristics, and smoking, drinking, exercise behavior as lifestyle factors, and waist measurement, fasting blood sugar level, systolic blood pressure, diastolic blood pressure, the level of Triglyceride and HDL-cholesterol as metabolic syndrome risk factor indicator. Data were analyzed by descriptive statistics, chi-square test, correlation analysis, logistic regression using SPSS 18.0. Results : In results of the subjects medical check-ups, 14.1% were above the criterion value of waist measurement, 2.5% fasting blood sugar level, 8.5% hypertension, 16.8% Triglyceride level and 4.0% HDL-cholesterol respectively. according to oral examination results, showing that 43.3% inflammation of the gums. The inflammation of the gums was correlated with gender, age, dental clinic visit, scaling management, smoking, exercise behavior and high triglyceride level and hypertension of metabolic syndrome risk factor indicators. In addition, this result was statistically significant. Conclusions : Based on this study, the workers health should be managed actively and effectively by using periodical workers health check-ups. At a corporate level, the institutional supports were achieved and arranged for activation of regular oral health education programs, and the prevention plan of metabolic syndrome were needed for changing exercise behavior by conducting suitable exercise programs.

• 비만대사연구학술지
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• 제1권1호
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• pp.33-38
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• 2022

Although it has been confirmed that excessive body fat increases health risks and all-cause mortality, several epidemiological studies have reported that overweight or obesity in patients with chronic diseases and in older adults is advantageous with respect to mortality. Several mechanisms have been proposed to explain the biological basis of this obesity paradox. The marked heterogeneity of findings observed across studies and the possibility of systematic errors in these studies have cast doubt on the actual existence of the obesity paradox. However, the obesity paradox questioned the validity of body mass index as the best indicator for obesity in terms of predicting its comorbidities and urges clinicians to focus more on changes in body composition and related metabolic derangements, rather than body weight per se.

• Journal of Community Nutrition
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• 제8권1호
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• pp.38-43
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• 2006

There were numerous evidences that subjective health evaluation was a powerful indicator for morbidity and mortality in many countries. Since self-rated health (SRH) was a reasonable health measure, identifying predictors for SRH would be beneficial for assessment of overall health, monitoring health status, and development of health promotion programs. Health risks, health behavior, socioeconomic characteristics and social capital were potential indicators for SRH. We examined association. between SRH and indicators such as health risk factors, subjective living condition, income, education level and dietary variety score. Total 4,262 subjects, aged between 20 and 69 years old, were selected from KNHANES 2001; those who completed health examination, nutrition survey, and provided their socioeconomic information. Results of logistic regression showed that it was likely to have better SRH for those who were younger, male and have higher education, higher income, better living condition, no metabolic syndrome and higher dietary variety.

• 한국식품영양과학회지
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• 제24권2호
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• pp.346-353
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• 1995

The dietary requirement for zinc to maintain optimally the various metabolic and physiological funcitons is still under study. Human beings adapt to reductions in zinc intake by reducing the rate of growth or zinc excretion. Reductions in dietary zinc beyond the capacity to maintain homeostasis lead to utilization of zinc from an exchangeable pool. Loss of a small, critical amount of zinc from this pool leads to both biochemical and clinical signs of zinc deficiency. Zinc requirements have been assessed by balance studies and factorial method. As tissue zinc status influences endogenous losses and the dietary needs, individuls in good status may require higher amounts of zinc than those in poor status. While plasma zinc is insensitive to reducitons in dietary zinc, it is regarded as a valid, useful indicator of the exchangeable pool of zinc. Plasma metallothionein concentrations may prove useful for identifying poor zinc status. It has been suggested that functional end point measurement is the new direciton for zinc requirement. However, determination of the functional response to a marginal zinc intake is difficult because of the lack of a specific, sensitive indicator of zinc status. Presently, no good method for assessment of human zinc requirements exists.

• Genomics & Informatics
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• 제11권3호
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• pp.149-154
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• 2013

Liver enzyme elevations, as an indicator of liver function, are widely associated with metabolic diseases. Genome-wide population-based association studies have identified a genetic susceptibility to liver enzyme elevations and their related traits; however, the genetic architecture in childhood remains largely unknown. We performed a genome-wide association study to identify new genetic loci for liver enzyme levels in a Korean childhood cohort (n = 484). We observed three novel loci (rs4949718, rs80311637, and rs596406) that were multiply associated with elevated levels of alanine transaminase and aspartate transaminase. Although there are some limitations, including genetic power, additional replication and functional characterization will support the clarity on the genetic contribution that the ST6GALNAC3, ADAMTS9, and CELF2 genes have in childhood liver function.