• Journal of the Korean Dietetic Association
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• v.17 no.2
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• pp.206-215
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• 2011

Currently, metabolic surgery (Laparoscopic Roux-en-Y gastric bypass, LRYGB) has an important role and should be recommended as an intervention in the management of obese patients with type 2 diabetes mellitus (T2DM). A successful outcome of surgery requires medical nutrition therapy. Therefore, we performed a retrospective study on 25 patients with T2DM who underwent LRYGB at Yeouido St. Mary's Hospital from October 2008 to May 2010. The patients were followed up for an average of 6 months after surgery (range: 2~19 months). Diabetes was resolved in 80% of the patients. Percentage of excess weight loss was (%EWL) was 56.2%. After surgery, fasting blood sugar (FBS) and HbA1c were significantly reduced (123 mg/dl, A1c 6.7%, P<0.001) and triglyceride was also significantly reduced to 107.6 mg/dl (P<0.05). As diets of the patients progressed from liquid to soft to regular diet, energy, carbohydrates, and fat intakes increased significantly (P<0.001). But protein intake did not change significantly. Nutrient intake of the patients after the surgery was significantly lower than the recommended diet for the non-surgery group. Patients experienced side-effects related to the diets after surgery, including hair-loss (76%), smelly gas (52%), vomiting (48%), etc. A significantly positive correlation was observed between vomiting and FBS (P<0.001). There was a significant relationship between side effects and the amount of nutrient intakes. Therefore, guide patients to a diet progression with treatment to minimize side effects, especially vomiting. And monitor their dietary life to be healthy and not to regain weight until remission of T2DM.

• Molecules and Cells
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• v.38 no.12
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• pp.1044-1053
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• 2015

This study first investigated the effects of corn gluten hydrolysate (CGH) (1.5 g/day) administration for 7 days on appetite-responsive genes in lean Sprague-Dawley (SD) rats. In a second set of experiments, the metabolic changes occurring at multiple time points over 8 weeks in response to CGH (35.33% wt/wt) were observed in high-fat (HF, 60% of energy as fat) diet-fed SD rats. In lean rats, the hypothalamus neuropeptide-Y and proopiomelanocortin mRNA levels of the CGH group were significantly changed in response to CGH administration. In the second part of the study, CGH treatment was found to reduce body weight and perirenal and epididymal fat weight. CGH also prevented an increase in food intake at 2 weeks and lowered plasma leptin and insulin levels in comparison with the HF group. This reduction in the plasma and hepatic lipid levels was followed by improved insulin resistance, and the beneficial metabolic effects of CGH were also partly related to increases in plasma adiponectin levels. The Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR), an index of insulin resistance, was markedly improved in the HF-CGH group compared with the HF group at 6 weeks. According to the microarray results, adipose tissue mRNA expression related to G-protein coupled receptor protein signaling pathway and sensory perception was significantly improved after 8 weeks of CGH administration. In conclusion, the present findings suggest that dietary CGH may be effective for improving hyperglycemia, dyslipidemia and insulin resistance in diet-induced obese rats as well as appetite control in lean rats.

• Korean Journal of Poultry Science
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• v.22 no.3
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• pp.133-144
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• 1995

One metabolism trial(Experiment I) and another respiration trial(Experiment II) were conducted to investigate the effects of dietary fiber supplementation(20% wheat bran) on the water balance, blood acid-base balance, body temperature, and metabolic rate of heat-stressed adult roosters. In Experiment I, twenty 20-wk-old SCWL roosters(BW 1.6 kg) were randomly alloted to 4 treatments with 5 birds per treatment and one per replicate. The 4 treatments were consisted of two temperature(21~22˚C vs. 34~35˚C) and two dietary fiber treatment(0% and 20% wheat bran), making Experiment I a 2x2 factorial. After 4 d of preliminary period, birds we subjected to 3-d collection period. Sixteen 20-wk-old SCWL roosters(BW 1.6 kg) were employed Experiment H, with two temperature(21~22˚C vs. 34~35˚C) and two wheat bran levels(0% and 20%). Brids were housed in individual metabolism cages under normal temperature(21~22˚C), at fed one of the experimental diet. After 4 d of preliminary period, a respiration trial with open-circuit gravimetric respiratory apparatus was carried out for each bird for 6 h, one by one, normal(20~21˚C) and hot(34~35˚C) temperatures. The ANOVA test and comparisons among treatment means were done at 5% probability level for both experiments. Results obtained from Experiment I and, II were summarized as follows, 1.The amounts of DM intake and excretion were significantly(P<.05) decreased by heat stress. The DM intake was not affected by the addition of 20% wheat bran, however, the amount of DM excretion was significantly increased by the high fiber diet. Thus, the DM metabolizability decreased significantly by the addition of 20% wheat bran. 2. The heat-stressed roosters increased the water intake and excreta moisture content significantly. Although not significant, the water intake tended to increase in roosters fed the 20% wheat bran diet. 3. The amounts of total water input and evaporative water loss were increased significantly by heat stress, and the addition of 20% wheat bran did not exert any influence on the total water input and evaporative water loss. However, roosters fed the 20% wheat bran diet increased the excreta water output significantly. 4. Neither the heat stress nor the dietary fiber did affect the blood pH, pCO2, and HCO$_3$- significantly. 5. The body temperature increased significantly by the heat stress. However, the high fiber deit failed to decrease the body temperature. 6. The heat-stressed roosters decreased the 02 consumption and C0$_2$ production, and increased the evaporative water loss significantly. However, the high fiber diet did not exert any infulence in this regard. It appears that the beneficial effect, if any, of high fibrous diet during heat stress episode may be due to the increased heat loss through the enhanced excreta water.

• Journal of the East Asian Society of Dietary Life
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• v.22 no.2
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• pp.175-189
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• 2012

The purpose of this study was to investigate the relationship between pack-years of smoking, metabolic biomarkers, and diet quality in male adults. We analyzed data from the combined 2007-2009 Korean National Health and Nutrition Examination Survey (KNHANES). The extent of smoking was quantified in pack-years (py), with 1 py equivalent to 20 cigarettes per day for 1 year. Subjects (n=1,318) were recruited and divided into two groups according to age (30~49 years age group, n=695; ${\geq}50$ years age group, n=623). In ach age group, subjects were divided into three groups according to the extent of smoking, which included non-smokers (30~49 years, n=156; ${\geq}50$ years, n=217), light smoker (30~49 years, n=269; py<16; ${\geq}50$ years, n=189, py<31), and moderate smoker (30~49 years, n=270; $py{\geq}16$; ${\geq}50$ years, n=217, $py{\geq}31$). The Nutrient Adequacy Ratio (NAR) and the number of foods (Dietary Variety Score, DVS) were analyzed by using the data from the 24-recall method. The results showed that moderate smokers were significantly more likely to drink alcohol compared with the other two groups. Triglyceride and cholesterol levels were significantly higher in smoker groups. The non-smoker group consumed significantly higher levels of vitamin C and potassium compared to the smoker groups. In the diet quality, vitamin C NAR of non-smoker group was significantly higher than those of smoker groups. In the ${\geq}50$ age group, the MAR of nonsmoker, light, and moderate smoker groups were 0.81, 0.78, and 0.78 respectively. The smoker group consumed significantly greate sugar and oils compared to the non-smoker group. Py showed a significantly positive relationship with serum triglyceride level, and a negative relationship with MAR after adjusting for potential confounding factors. In conclusion, male moderate smokers take too little vitamin C, partly due to low diet quality. Therefore, a well-planed diet must be used to replace the nutrients lost from excluded food groups in smoker.

• Journal of Korean Medicine for Obesity Research
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• v.3 no.1
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• pp.95-105
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• 2003

The obesity is the matter of the energy balance in essential. The energy balance in human body is energy expenditure subtracted from energy intake. The energy intake is mainly supplied by carbohydrates, proteins and lipids in food, and the energy expenditure is composed of basal metabolic rate or resting energy expenditure, physical activity and thermogenesis including diet-induced thermogenesis. The resting energy expenditure is measured by direct calorimetry and indirect calorimetry. Generally we can simply use predictive equation with the variables of weight, height, age and fat-free mass to yield metabolic rate. But there is discrepancy between the estimate and real metabolic rate because the equations can not reflect individuality and environments. The resting energy expenditure is influenced by many factors but the fundamental factor is fat-free mass. We briefly reviewed the concept and evaluation of the energy balance, intake and expenditure, which are important parts in the study of obesity. Finally, we surveyed the correlation between metabolic rate and obesity and suggested applicable herb medication to increase metabolic rate.

• Biomedical Science Letters
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• v.19 no.3
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• pp.195-205
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• 2013

Obesity may cause metabolic syndrome and adult diseases. This study was undertaken to investigate the ameliorative or useful effects of beanleaves on inflammation and liver damage in obese rat models. Rats were divided into three groups: a control group (normal diet, n=6), a fat diet group (45%-fat diet, n=7), and a bean leaf group (45%-fat+Korean bean leaves diet, n=7). Body weights in the bean leaf group were lower than those of the fat group (P<0.05). Serum tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and prostaglandin $E_2$ ($PGE_2$) concentrations were lower in both the control and bean leaf groups than in the fat group (P<0.001). TNF-${\alpha}$ concentrations in the bean leaf group were slightly higher than in the control group but statistically significant (P<0.05). The bean leaf group histologically exhibited lower fatty degeneration, spotty necrosis, and leukocyte infiltrations in hepatic tissues than those of the fat group. In the homogenized liver tissues, the cyclooxygenase-2 (COX-2) gene was only expressed in the fat group. The gene expression levels of hepatic TNF-${\alpha}$, inducible nitric-oxide synthase, peroxiome proliferator-activated receptor-${\alpha}$ (PPAR-${\alpha}$), poly (ADP-ribose) polymerase (PARP), and transforming growth factor-${\beta}1$ (TGF-${\beta}1$) were weaker in the bean leaf group than in the fat group. These results suggest that adding bean-leaves to the diet may ameliorate obesity-induced systemic inflammation and liver damage and that bean leaves may be a useful food for preventing obesity and thereby metabolic syndrome and adult diseases.

• Journal of the East Asian Society of Dietary Life
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• v.4 no.1
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• pp.105-112
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• 1994

To evaluate the role of dietary earthworm flour in liver injury by CCl4 treatment, the rats were fed 5% earthworm flour supplemented diet for 53 days and control rats were fed standard diet without earthworm supplementation. Liver damage was induced both in earthworm flour supplemented diet and control groups by two intraperitoneal injections of CCl4 at the level of 0.1$m\ell$/100g body weight(50% in olive oil) at intervals of 16 hours the increasing rate of lover weight/body weight(%) and serum levels of alanine aminotransferase activity to the control group were higher in CCl4-treated rats fed earthworm flour supplemented diet than those fed standard diet. The decreasing rate of hepatic microsomal aniline hydroxylase activity was also higher in rats fed earthworm supplemented rats by the CCl4 treatment, Hepatic glutathione S-transferase activity was sinificantly higher in rats fed earthworm supplemented diet than those fed standard diet. It is concluded that a dietary earthworm flour argument the metabolic rate of CCl in rats.

• The Korean Journal of Food And Nutrition
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• v.28 no.6
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• pp.988-994
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• 2015

Menopausal status and hormonal changes are important factors related to the prevalence of metabolic syndrome in women. Nutrient intake is also a risk factor for metabolic syndrome. Although, postmenopausal status and hormonal changes result in a 60% increased risk for metabolic syndrome, there has been no method to elucidate the effects of nutrient intake on metabolic syndrome following menopause. This study was conducted to evaluate the effects of nutrient intake by menopausal women on the prevalence of metabolic syndrome. All data were obtained from the Korean National Health and Nutrition Examination Survey 2007-2009. Menopausal women showed a 1.8-fold increase in the prevalence of metabolic syndrome. Metabolic syndrome group showed significantly lower values in calcium, iron, vitamin A, carotin, retinol and riboflavin intake than those of normal group in premenopausal women. In postmenopausal women, there are significant differences in crude fiber, calcium, iron, potassium, riboflavin and niacin. Indeed, different patterns of nutrient intake were observed by menopausal status and metabolic syndrome. As menopause cannot be controlled, a diet with adequate nutrient intake may be useful to control the rapid increase in the prevalence of metabolic syndrome due to menopause.

• Clinical Nutrition Research
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• v.3 no.2
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• pp.106-114
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• 2014

It is generally accepted that diet modification provides beneficial effects on the management of diabetes. In the present study, we evaluated the effects of diet modification on nutrient intake and quality of life in a large sample of diabetic patients. This study was conducted using data from the Korea National Health and Nutrition Examination Survey IV and V (2007-2010). A total of 2,484 of diabetic patients were included in the analysis. Then, we compared the overall quality of dietary intake between diabetic patients with diet modification and those without dietary modification. The result showed that subjects on diabetic diet (DDG) showed lower levels of total cholesterol, triglyceride, and AST before and after the adjustment for covariates (all p < 0.05). The results of nutrient assessment showed that DDG had lower intakes of total energy, fat, and carbohydrate (all p < 0.05), but higher intakes of energy from protein, vitamin B1, vitamin B2, niacin and vitamin C than NDG. (all p < 0.05). In addition, nutritional adequacy ratio of calcium and vitamin B2 were significantly higher in DDG than those in normal diet group (NDG) (p < 0.05). However, we observed no significant differences in quality of life between two groups. In conclusion, diet modification in diabetic patients seemed to be effective to improve blood lipid profile and the adequacy of nutrient intake without sacrificing the quality of life.

• Journal of Preventive Medicine and Public Health
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• v.42 no.5
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• pp.331-336
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• 2009

Objectives : The objectives of this study were to determine the relationship between lifestyle-implementation and metabolic syndrome in an electronics research and development company, and to provide a foundation for health providers of health management programs for setting priorities. Methods : From July 1 to July 16, 2008 we carried out a descriptive cross-sectional survey. Consecutive workers of one R & D company in Seoul, Korea (N=2,079) were enrolled in study. A checklist for lifestyle (from the National Health Insurance Corporation) consisted of questions regarding diet, drinking, smoking and exercise. After the survey, researchers obtained data from health profiles for metabolic syndrome(waist-circumference, triglycerides, HDL cholesterol, blood pressure and fasting blood sugar level). Lifestyle was recorded as good or not good. Statistical analysis of metabolic syndrome and the lifestyle of subjects was done using multiple logistic regression analysis. Results : The prevalence of metabolic syndrome in our study gropu was 13.3% (N=277). After adjustment for age, the adjusted odds ratios (odds ratio, 95% confidence intervals) for metabolic syndrome increased in proportion to the number of bad habits: two (1.72, 1.23-2.44), three (2.47, 1.73-3.56), and four (3.63, 2.03-6.34). Relative to subjects eating both vegetables and meat', the OR for 'meat' eaters was 1.66 (1.18-2.31). Compared with 'nonsmokers and ever-smoker', the OR for 'current-smoker' was 1.62 (1.25-2.10). Compared with 'Healthy drinker', the OR for 'unhealthy drinker' was 1.38 (1.05-1.83). Conclusions : Poor lifestyle was associated with an increased likelihood of metabolic syndrome. These findings suggest that lifestyle-based occupational health interventions for young employees should include a specific diet, smoking cessation, and healthy-drinking programs.