• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.5
• /
• pp.2753-2758
• /
• 2013

Various studies examining the relationship between Ezrin overexpression and response to chemotherapy and clinical outcome in patients with osteosarcoma have yielded inconclusive results. We accordingly conducted a meta-analysis of 7 studies (n = 318 patients) that evaluated the correlation between Ezrin and histologic response to chemotherapy and clinical prognosis (death). Data were synthesized in receiver operating characteristic curves and with fixed-effects and random-effects likelihood ratios and risk ratios. Quantitative synthesis showed that Ezrin is not a prognostic factor for the response to chemotherapy. The positive likelihood ratio was 0.538 (95% confidence interval [95% CI], 0.296- 0.979; random-effects calculation), and the negative likelihood ratio was 2.151 (95% CI, 0.905- 5.114; random-effects calculations). There was some between-study heterogeneity, but no study showed strong discriminating ability. Conversely, Ezrin positive status tended to be associated with a lower 2-year survival (risk ratio, 2.45; 95% CI, 1.26-4.76; random-effects calculation) with some between-study heterogeneity that disappeared when only studies that employed immunohistochemistry were considered (risk ratio, 2.97; 95% CI, 2.01- 4.40; fixed-effects calculation). To conclude, Ezrin is not associated with the histologic response to chemotherapy in patients with osteosarcoma, whereas Ezrin positivity was associated with a lower 2-year survival rate regarding risk of death at 2 years. Expression change of Ezrin is an independent prognostic factor in patients with osteosarcoma.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.34 no.3
• /
• pp.117-125
• /
• 2020

The purpose of this review is to confirm whether Soyo-san (Xiaoyao-san) and its modifications is effective on alleviating clinical symptoms in chronic fatigue syndrome (CFS) patients. We collected clinical trials (randomized controlled trial, quasi-randomized controlled trial, controlled clinical trial) to investigate the effects of Soyo-san and its modifications on general symptoms, fatigue, depression and anxiety in CFS patients. The databases used for data retrieval were Pubmed, Central Cochrane, Embase, CNKI, CQVIP, Wanfang, CiNii, OASIS, RISS, and Koreamed. We performed selection/exclusion process from the found studies to conform with prespecified criteria, and assessed the final included trials according to the Cochrane risk of bias tool. The included studies were classified based on the interventions in experimental and control group. Eight randomized controlled trials and one controlled clinical trial (total 921 participants) were eligible and their results were synthesized in the meta analysis. The synthesis showed a considerable effect of Soyo-san and its modifications on improvement of general symptoms (relative risk 0.27 [95% CI 0.19 to 0.39], Z=7.03, P<0.00001; I2=0%) and fatigue severity (SMD -1.20 [95% CI -1.46 to -0.93], Z=8.78, P<0.00001; I2=52%) in CFS patients, while Effect on depression and anxiety were inconclusive. We found that Soyo-san and its modifications were effective for improvement of general symptoms and fatigue severity in CFS post-treatment.

• Korean Circulation Journal
• /
• v.54 no.3
• /
• pp.126-137
• /
• 2024

Background and Objectives: The impact of off-hours admission (such as weekends, nighttime, and non-working hours) vs. regular hours (weekdays and daytime working hours) on the mortality risk of patients undergoing surgery for type A aortic dissection (TAAD) repair is still uncertain. To address this uncertainty, we undertook a comprehensive systematic review and meta-analysis. We aimed to assess the potential link between off-hours admission and the risk of mortality in patients undergoing TAAD repair surgery. Methods: We conducted a thorough search of the PubMed, Embase, and Cochrane Library databases, covering the period from their inception to May 20, 2023. Our inclusion criteria encompassed all studies that examined the potential relationship between off-hour admission and mortality in individuals who had undergone surgery for TAAD repair. The odds ratios (ORs) were extracted and combined utilizing a random effects model for our synthesis. Results: Nine studies with 16,501 patients undergoing TAAD repair surgery were included in the meta-analysis. Overall, patients who underwent surgery during the weekend had higher in-hospital mortality (pooled OR, 1.41; 95% confidence interval [CI], 1.14-1.75; p=0.002) than those treated on weekdays. However, the mortality risks among patients who underwent TAAD surgery during nighttime and non-working hours were not significantly elevated compared to daytime and working hours admission. Conclusions: Weekend surgery for TAAD was associated with a higher in-hospital mortality risk than weekday surgery. However, further studies are warranted to identify and develop strategies to improve the quality of round-the-clock care for patients with TAAD.

• Animal Bioscience
• /
• v.36 no.11
• /
• pp.1666-1684
• /
• 2023

Objective: Our objective was to examine the relationships of supplemental rumen-protected lysine (RPL) or lysine + methionine (RPLM) on lactational performance, plasma amino acids (AA) concentration, and nitrogen use efficiency of lactating dairy cows by using a meta-analysis approach. Methods: A total of 56 articles comprising 77 experiments with either RPL or RPLM supplementation were selected and analyzed using a mixed model methodology by considering the treatments and other potential covariates as fixed effects and different experiments as random effects. Results: In early lactating cows, milk yield was linearly increased by RPL (β₁ = 0.013; p<0.001) and RPLM (β₁ = 0.014; p<0.028) but 3.5% fat-corrected milk (FCM) and energy-corrected milk (ECM) (kg/d) was increased by only RPL. RPL and RPLM did not affect dry matter intake (DMI) but positively increased (p<0.05) dairy efficiency (Milk yield/DMI and ECM/DMI). As a percentage, milk fat, protein, and lactose were unchanged by RPL or RPLM but the yield of all components was increased (p<0.05) by feeding RPL while only milk protein was increased by feeding RPLM. Plasma Lys concentration was linearly increased (p<0.05) with increasing supplemental RPL while plasma Met increased (p<0.05) by RPLM supplementation. The increase in plasma Lys had a strong linear relationship (R² = 0.693 in the RPL dataset and R² = 0.769 in the RPLM dataset) on milk protein synthesis (g/d) during early lactation. Nitrogen metabolism parameters were not affected by feeding RPL or RPLM, either top-dress or when supplemented to deficient diets. Lactation performance did not differ between AA-deficient or AA-adequate diets in response to RPL or RPLM supplementation. Conclusion: RPL or RPLM showed a positive linear relationship on the lactational performance of dairy cows whereas greater improvement effects were observed during early lactation. Supplementing RPL or RPLM is recommended on deficient-AA diet but not on adequate-AA diet.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.8 no.4
• /
• pp.67-79
• /
• 2013

A meta-analysis is a statistical literature synthesis method that provides the opportunity to view the research context by combining and analyzing the quantitative results of many empirical studies. The technology acceptance model (TAM) has been the subjects of a great deal of MIS research in the last two decades and now also has been continuously studied. Recently, the convergence of knowledge information society and information telecommunication technologies has a rapid impact on politics, economics and various fields. The biggest issue in the information communication and information systems fields is smart. Therefore, we conducted a meta-analysis research on the behavioral intention of smart phone users based on technology acceptance model. Also, this study was targeted a total of 50 research papers that are setting up the causal relationship in TAM among the research papers published in domestic academic journals since 2005. The result of the meta analysis, showed that the effect size was 0.48 in the path from perceived usefulness to behavioral intention, it showed that the effect size was 0.46 in the path from perceived ease of use to behavioral intention. And, it showed that the effect size was 0.46 in the path from perceived ease of use to perceived usefulness. Also, it showed that the effect size was 0.61 in the path from attitude to behavioral intention. Based on the results, it was discussed the difference through comparative analysis with previous research.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.17 no.11
• /
• pp.2581-2587
• /
• 2013

A Meta-analysis is a statistical literature synthesis method that provides the opportunity to view the research context by combining and analyzing the quantitative results of many empirical studies. We conducted a Meta-analysis research on the behavioral intention of information technology based on the theory of planned behavior. This study was targeted a total of 36 research papers that are setting up the causal relationship in the theory of planned behavior among the research papers published in domestic academic journals before 2013. The result of the Meta-analysis, showed that the effect size was 0.571 in the path from attitude toward behavior to behavioral intention, it showed that the effect size was 0.381 in the path from subjective norm to behavioral intention. And, it showed that the effect size was 0.481 in the path from perceived behavioral control to behavioral Intention. Also, it showed that the effect size was 0.421 in the path from behavioral Intention to behavior.

• Membrane and Water Treatment
• /
• v.8 no.4
• /
• pp.323-336
• /
• 2017

The main challenge in many applications of acetic acid is acid dehydration and its recovery from wastewater streams. Therefore, the performance of polyamide thin film composite is evaluated to separate acetic acid from water. To reach this goal, the formation of polyamide layer on polysulfone support membrane was investigated via interfacial polymerization (IP) of meta-phenylenediamine (MPD) in water with trimesoyl chloride (TMC) in hexane. Also, the effect of synthesis conditions, such as concentration of monomers and curing temperature on separation of acetic acid from water were investigated by reverse osmosis process. Moreover, the separation mechanism was discussed. The solute permeation was carried out under applied pressure of 5 bar at $25^{\circ}C$. Surface properties of TFC membrane were characterized by ATR-FTIR, SEM and AFM. The performance test indicated that 3.5 wt% of MPD, 0.35 wt% of TMC and curing temperature of $75^{\circ}C$ are the optimum conditions. Moreover, the permeate flux was $4.3{\frac{L}{m^2\;h}}$ and acetic acid rejection was about 43% at these conditions.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2013.10a
• /
• pp.233-236
• /
• 2013

A Meta-analysis is a statistical literature synthesis method that provides the opportunity to view the research context by combining and analyzing the quantitative results of many empirical studies. The theory of planned behavior (TPB) has been the subjects of a great deal fields and now also has been continuously studied. Recently, the information communication and information systems fields are the biggest issue. At this point, we conducted a Meta-analysis research on the behavioral intention of information technology based on The theory of planned behavior. This study was targeted a total of 36 research papers that are setting up the causal relationship in The theory of planned behavior among the research papers published in domestic academic journals before 2013. The result of the Meta-analysis, showed that the effect size was 0.571 in the path from attitude toward behavior to behavioral Intention, it showed that the effect size was 0.381 in the path from subjective norm to behavioral Intention. And, it showed that the effect size was 0.481 in the path from perceived behavioral control to behavioral Intention. Also, it showed that the effect size was 0.421 in the path from behavioral Intention to behavior. Based on the results, it was discussed the difference through comparative analysis with previous research.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2013.10a
• /
• pp.254-257
• /
• 2013

A Meta-analysis is a statistical literature synthesis method that provides the opportunity to view the research context by combining and analyzing the quantitative results of many empirical studies. The Technology Acceptance Model (TAM) has been the subjects of a great deal fields and now also has been continuously studied. Recently, the issue of the biggest the information communication and information systems fields is smart. At this point, we conducted a Meta-analysis and review of external constructs based on the technology acceptance model. This study was targeted a total of 106 research papers that are setting up the causal relationship in the technology acceptance model among the research papers published in domestic academic journals before 2013. The result of the Meta-analysis, the biggest effect size the path from external Variables to perceived usefulness was showed playfulness. The effect size was 0.536 in the path from perceived usefulness to playfulness. And, the biggest effect size the path from external Variables to perceived ease of use was showed self efficacy. The effect size was 0.536 in the path from perceived ease of use to self efficacy. Based on the results, it was discussed the difference through comparative analysis with previous research.

• Asia pacific journal of information systems
• /
• v.25 no.2
• /
• pp.356-369
• /
• 2015

Public sectors around the world utilize social media tools and technologies in their daily activities for a variety of purposes, including disseminating useful information, fostering mass collaboration, and enforcing laws and regulations. A number of social media-based government stage models have emerged to document this use. In this chapter, we conducted a qualitative meta-synthesis of four social media-based government models. These models include 1) the open government maturity model, 2) the social media utilization model, 3) the adoption process for social media, and 4) the social media-based engagement model. The concepts, metaphors, and themes contained in these developmental models are extracted through a series of in-depth semantic analyses of descriptions, resulting in a common frame of reference.