• Journal of the Korean Data and Information Science Society
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• 제22권3호
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• pp.413-421
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• 2011

평균차를 이용한 메타분석을 실시하여 마늘을 투여한 고지혈증 유발 쥐들의 체중과 각 기관의 무게, 혈액 내 혈당량, 총 콜레스테롤, 중성지방, 고농도지단백 콜레스테롤, 저농도지단백 콜레스테롤, 간의 콜레스테롤, 간의 중성지방의 평균비교를 통해 마늘의 효과에 대해 알아보고자 한다. 고정효과 모형에서는 체중과 간, 신장, 심장의 무게에서 유의한 감소를 보였다. 또한 혈액 내 혈당량과 총 콜레스테롤, 중성지방, 저농도지단백 콜레스테롤, 간의 콜레스테롤, 간의 중성지방에서 통계적으로 유의한 감소를 보였고, 고농도지단백 콜레스테롤에서 유의한 증가를 보였다. 동질성 검정을 통해 연구 간의 이질성을 보인 모든 변수에 대해 랜덤효과모형을 적용시킨 결과 간의 무게와 혈액 내 혈당량, 총 콜레스테롤, 중성지방, 저농도지단백 콜레스테롤, 간의 콜레스테롤, 간의 중성지방의 감소에 유의한 효과를 보였고, 고농도지단백 콜레스테롤의 증가에 유의한 효과를 보였다. 또한 마늘의 투여기간이 변수에 영향을 미치는지 알아보기 위해 메타회귀분석을 실시한 결과 신장의 무게와 고환의 무게, 총 콜레스테롤, 중성지방, 고농도지단백 콜레스테롤, 저농도지단백 콜레스테롤, 간의 콜레스테롤, 간의 중성지방에 대해 마늘의 투여기간이 유의한 변수로 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5625-5633
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• 2015

Background: ${\beta}$-catenin plays a crucial role in the progression of breast cancer (BC) and a prognostic role of in BC patients has been widely reported. However, controversy still remains. Materials and Methods: Identical search strategies were used to search relevant literature in electronic databases updated to July 1, 2014. Individual hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted and pooled HRs with 95%CIs were used to evaluate the strength of association between positive ${\beta}$-catenin expression in different subcellular locations and survival results of BC patients. Subgroup and meta-regression analyses were performed to explore heterogeneity. Funnel plots of Begg's and Egger's linear regression test were used to investigate publication bias. Heterogeneity and sensitivity were also assessed. All the work was completed using STATA. Results: A total of 2,204 patients from 12 evaluative studies were finally included. Pooled HRs and 95%CIs suggested that ${\beta}$-catenin expression in cytoplasm/nucleus had an unfavorable impact on both overall survival (OS) (HR: 1.93, 95%CI: 1.40-2.65) and disease free survival (DFS)/ recurrent free survival (RFS) (HR: 1.60, 95%CI: 1.20-2.13) in BC patients. However, here was no significant association between ${\beta}$-catenin expression in the membranes with OS (HR: 0.65, 95%CI: 0.42-1.02) or DFS/RFS (HR: 0.66, 95%CI: 0.38-1.13). Publication bias was absent in all of the four outcomes. Sensitivity analysis revealed that the results of this meta-analysis were robust. Conclusions: Positive ${\beta}$-catenin expression in cytoplasm/nucleus rather than in membrane is a significant prognostic factor in patients with BC who have been surgically treated.

• 대한통합의학회지
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• 제8권4호
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• pp.1-11
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• 2020

Purpose : The purpose of this meta-analysis was to examine the effects of microcurrent on inflammatory musculoskeletal diseases. Methods : Domestic databases (RISS, NDSL, KISS, DBpia, and Kmbase) were searched for studies that conducted clinical trials associated with microcurrent and its impact on inflammatory musculoskeletal diseases. A total of 606 studies published between 2002 and 2019 were identified, with 8 studies satisfying the inclusion data. The studies were classified according to patient, intervention, comparison, and outcome (PICO). The search outcomes were items associated with blood component, pain, and function. The 8 studies that were included in the study were evaluated using R meta-analysis (version 4.0). The quality of 7 randomized control trials was evaluated using Cochrane risk of bias (ROB). The quality of 1 non-randomized control trial was evaluated using risk of bias assessment tool for non-randomized studies (RoBANS). Effect sizes were computed as the corrected standard mean difference (SMD). A random-effect model was used to analyze the effect size because of the high heterogeneity among the studies. Egger's regression test was carried out to analyze the publishing bias. Results : The following factors had a large effect size involving microcurrent on inflammatory musculoskeletal diseases: blood component (Hedges's g=-2.46, 95 % CI=-4.20~-0.73), pain (Hedges's g=3.51, 95 % CI=2.44~4.77), and function (Hedges's g=3.06, 95 % CI: 1.53~4.58). Except for function (t=1.572, p=.191), Egger's regression test showed that the publishing bias had statistically significant differences. Conclusion : This study provides evidence for the effectiveness of microcurrent on inflammatory musculoskeletal diseases in terms of blood component, pain, and function. However, due to the small sample sizes used in the included studies, the results of our study should be interpreted cautiously, especially considering the publishing bias.

• 대한치과교정학회지
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• 제53권6호
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• pp.374-392
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• 2023

Objective: Assess and evaluate the different indicators of oral health-related quality of life (OHRQoL) among patients treated with clear aligners (CAs) versus those treated with conventional fixed orthodontics (FAs). Methods: An electronic search was performed on the database is Web of Science, Scopus, and Embase databases. Randomized and non-randomized control trials, cross-sectional, prospective cohort and retrospective trials were included. Quality was assessed with risk of bias tool and risk of bias in non-randomised studies. Meta-analyses were performed with random effects models, estimating the standardized and non-standardized mean differences, odds ratio and risk ratio as the measure of effect. The effect on time was determined using a meta-regression model. Results: Thirty one articles were included in the qualitative synthesis and 17 in the meta-analysis. CAs had a significantly lower negative impact on QoL, with an "important" effect size, while the influence of time was not significant. Periodontal indicators plaque index (PI), gingival index (GI), probing depth (PD), and bleeding on probing show significantly better values in patients treated with CAs, with moderate to large effect sizes. PI and GI have a significant tendency to improve over time. In microbiological indicators, CAs present a lower biofilm mass without differences in the percentage of patients with high counts of Streptococcus mutans and Lactobacilli bacteria. The risk of white spot lesion onset is ten times lower in carriers of CAs. Conclusions: Patients wearing CAs show better periodontal indicators, less risk of white spot development, less biofilm mass and a better QoL than patients with FAs.

• Asian Pacific Journal of Cancer Prevention
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• 제15권9호
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• pp.4071-4077
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• 2014

Background: The effects of CYP1A1 gene polymorphisms on the risk of bladder cancer (BC) remain controversial. We carried out a meta-analysis to clarify the role of CYP1A1 gene polymorphisms in BC. Material and Methods: A comprehensive literature search was conducted up to November 20, 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the association. Meta-regression, subgroup analysis, sensitivity analysis and publication bias were also performed. Results: Eight studies involving 1,059 BC cases and 1,061 controls were included. The meta-analysis showed that there was no significant association between the two common mutations of CYP1A1 and BC risk. For the I1e462Val A/G polymorphism with GG vs. AA the OR was 1.47 (95 % CI= 0.70-3.07, P =0.308). For the MspI T/C polymorphism, though a slight trend was found this was not statistically nonsignificant (CC vs.TT, OR = 1.24, 95 % CI= 0.98-1.58, P =0.078). Subgroup analyses by ethnicity also found no obvious association between CYP1A1 and BC risk. Conclusion: The present meta-analysis suggests that CYP1A1 polymorphism is not associated with bladder cancer risk.

• Asian Pacific Journal of Cancer Prevention
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• 제15권21호
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• pp.9085-9091
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• 2014

Background: Epidemiology studies have shown an inconclusive relationship between phytoestrogen intake and ovarian cancer risk and there have been no relevant meta-analyses directly regarding this topic. The purpose of the present meta-analysis was therefore to investigate any association between phytoestrogen intake and ovarian cancer in detail. Materials and Methods: We conducted a search of PubMed, EMBASE, EBSCO, the Cochrane Library, CNKI and Chinese Biomedical Database (up to April 2014) using common keywords for studies that focused on phytoestrogen and ovarian cancer risk. Study-specific risk estimates (RRs) were pooled using fixed effect or random-effect models. Results: Ten epidemiologic studies were finally included in the meta-analysis. The total results indicated higher phytoestrogen intake was associated with a reduced ovarian cancer risk (RR, 0.70; 95%CI: 0.56-0.87). The association was similar in sensitivity analysis. Meta regression analysis demonstrated sources and possibly types and regions as heterogeneous factors. Subgroup analysis of types, sources and regions showed that isoflavones (RR: 0.63; 95%CI: 0.46, 0.86), soy foods (RR: 0.51; 95%CI: 0.39, 0.68) and an Asian diet (RR: 0.48; 95%CI: 0.37, 0.63) intake could reduce the incidence of ovarian cancer. Conclusions: Our findings show possible protection by phytoestrogens against ovarian cancer. We emphasize specific phytoestrogens from soy foods, but not all could reduce the risk. The habit of plentiful phytoestrogen intake by Asians is worthy to recommendation. However, we still need additional larger well designed observational studies to fully characterize underlying associations.

• 한국의류학회지
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• 제40권6호
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• pp.1150-1163
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• 2016

This study makes use of meta-analysis to statistically integrate the quantitative results of individual research on the influence of fashion product attributes on purchase; in addition, this study utilizes the effect sizes of correlation coefficients. This study was based on 24 individual studies from January 2000 to March 2015. The meta-analysis analyzed 91 effect sizes and 24 studies and calculated the correlation coefficient effect sizes. A random effect model was employed for meta-analysis because the results for the homogeneity test indicated that the effect sizes of each research were heterogeneous. The analysis results are as follows. First, when the total effect sizes of the fashion product attributes that influence clothing purchase decisions were calculated as .256; this indicated that the effect size is slightly below the mid-sized level. Second, upon examining the effect sizes of the categorized fashion product attributes, the intrinsic attributes yielded .222, extrinsic factors yielded .235, and the compiled attributes yielded .420; this demonstrated that the compiled attributes have a larger effect size than individual attributes. Third, when they were measured by the characteristics of study targets, they were larger for a mixed-gender group than women as well as for ordinary citizens than university students. When the effect sizes were measured based on the characteristics of fashion products as suggested in the study, there were significant differences with respect to sportswear, followed by SPA brand clothing, general clothing, fashion accessories, and designer clothing. The cases where the clothing were purchased in non-retail stores were found to have a slightly larger effect size than those of offline retail stores when the effect sizes were measured based on purchase routes; however, the difference was not statistically significant. Next, an investigation of the trend of effect sizes based on published year via the meta regression analysis indicated slightly larger effect sizes as shown in more recent publications, but this was not statistically significant.

• 한국산학기술학회논문지
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• 제17권12호
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• pp.242-252
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• 2016

본 연구는 유치원교사의 직무만족과 관련하여 지난 20여년 간 국내에서 이루어진 석 박사 학위논문과 학술지 논문을 중심으로 직무만족 관련변인에 대한 효과크기를 메타분석을 통해 검증하였고, 출판연도에 따른 변화추이를 살피기 위해 메타회귀분석을 활용하였다. 메타분석과 메타회귀 분석 결과 다음의 결과를 얻을 수 있었다. 첫째, 유치원교사의 직무만족관련 변인들의 전체효과크기는 유의미한 큰효과크기를 보인 것으로 나타났다. 둘째, 유치원교사의 직무만족관련 변인군 간의 효과크기는 유의미한 효과를 보이지 않은 개인특성변인군을 제외한, 직무특성변인군, 조직내면적변인군, 조직외면적변인군 모두 비슷한 수준에서 유의미한 큰효과크기를 보인 것으로 나타났다. 셋째, 각 변인군 별 주목할 만한 결과는, 개인특성변인군에서 큰효과크기 가진 것으로 나타난 직위변인을 제외 한 근무경력, 연령, 교육 정도 등의 연인들이 유의미하지 않은 것으로 나타났으며, 조직내면적변인군에 있어 조직 내 대인관계요인이 조직 내 풍토요인보다 상대적으로 높은 효과크기를 보인 것으로 나타났다는 점이다. 마지막으로, 출판연도에 따른 효과크기 변화추이를 검정 결과, 개인특성변인군을 제외한 직무특성변인군, 조직내면적변인군, 조직외면적변인군은 최근 출판물에 가까울수록 직무만족도가 높아지는 것으로 나타났다. 본 연구 결과 주목할 만한 시사점은, 조직내외부적 환경 개선을 위한 노력이 가장 시급하다는 점이며, 특허 직무상 받게 되는 스트레스와 행정적 업무 부담 동을 줄이기 위한 방안 그리고 교사효능감과 교직에 대해 헌신할 수 있는 분위기 조성이 무엇보다 필요하다는 점이다.

• 한국보육지원학회지
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• 제8권1호
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• pp.25-44
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• 2012

본 연구는 지난 10년간의 보육교사 이직의도와 관련된 선행연구를 바탕으로 이직의도를 억제하는 변인들의 효과크기를 메타분석을 통해 검증하였고 메타회귀분석을 통해 조사시기와 조사지역에 따른 변화추이를 검증하였다. 연구대상으로는 분석을 위해 효과크기 변환이 가능한 논문 33편을 선정하였다. 연구결과 이직의도와 관련된 억제변인군의 효과크기는 조직외면적, 직무, 조직내면적변인군 순으로 나타났고, 세변인군 모두 중간효과크기를 가지고 있는 것으로 나타났다. 조직외면적변인군의 하위변인은 근로시간의 효과크기가 가장 큰 것으로 나타났으며, 직무변인군의 하위변인은 교사효능감과 직무만족이 큰 효과크기를 가진 것으로 나타났다. 또한 조직내면적변인군의 하위변인은 대인관계와 원장과의 관계의 관계가 큰 효과크기를 가진 것으로 나타났다. 조사대상, 조사년도에 따른 이직의도 억제와 관련된 변인의 메타회귀분석 결과 모든 연구 개념들이 통계적으로 유의미한 차이가 없는 것으로 나타났다. 그러나 변인들에 대한 상관분석 결과, 복지후생은 수도권외지역보다 수도권지역일 수록 효과크기가 큰 것으로 나타났다.

• 성인간호학회지
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• 제29권2호
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• pp.177-189
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• 2017

Purpose: A meta-analysis was conducted to identify the effect of cognitive improvement programs for the elderly with mild cognitive impairment (MCI) in Korea. Methods: Five databases, as well as relevant reference lists, of studies published from 2000 to 2016, were searched. Fourteen studies were identified. Quality assessments of included studies were conducted using the Scottish Intercollegiate Guidelines Network checklist. An R program was used to analyze effect sizes and to identify possible sources of heterogeneity among studies. The potential for publication bias was investigated using a funnel plot, Egger's regression test and sensitivity analysis. Results: The total effect size was large (Standardized Mean Difference [SMD]=1.44, 95% CI: 1.11~1.77), with cognition based intervention (SMD= 1.77, 95% CI: 1.26~2.29) and exercise intervention (SMD=1.13, 95% CI: 0.82~1.44). Statistically significant moderators were identified intervention type by meta-ANOVA analyses. Finally, no significant evidence of publication bias was found. Conclusion: There is clear evidence that cognitive improvement programs can greatly enhance cognition in elderly with MCI. Future research should examine the effects of non-pharmacological interventions targeting elderly populations with mild-to-severe cognitive impairment in order to develop and enhance the effectiveness of cognitive improvement programs in Korea.