• The Korean Journal of Pain
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• 제36권4호
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• pp.425-440
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• 2023

Background: Muscimol's quick onset and GABAergic properties make it a promising candidate for the treatment of pain. This systematic review and meta-analysis of preclinical studies aimed at summarizing the evidence regarding the efficacy of muscimol administration in the amelioration of nerve injury-related neuropathic pain. Methods: Two independent researchers performed the screening process in Medline, Embase, Scopus and Web of Science extracting data were extracted into a checklist designed according to the PRISMA guideline. A standardized mean difference (SMD [95% confidence interval]) was calculated for each. To assess the heterogeneity between studies, ² and chi-square tests were utilized. In the case of heterogeneity, meta-regression and subgroup analyses were performed to identify the potential source. Results: Twenty-two articles met the inclusion criteria. Pooled data analysis showed that the administration of muscimol during the peak effect causes a significant reduction in mechanical allodynia (SMD = 1.78 [1.45-2.11]; P < 0.0001; I² = 72.70%), mechanical hyperalgesia (SMD = 1.62 [1.28-1.96]; P < 0.0001; I² = 40.66%), and thermal hyperalgesia (SMD = 2.59 [1.79-3.39]; P < 0.0001; I² = 80.33%). This significant amendment of pain was observed at a declining rate from 15 minutes to at least 180 minutes post-treatment in mechanical allodynia and mechanical hyperalgesia, and up to 30 minutes in thermal hyperalgesia (P < 0 .0001). Conclusions: Muscimol is effective in the amelioration of mechanical allodynia, mechanical hyperalgesia, and thermal hyperalgesia, exerting its analgesic effects 15 minutes after administration for up to at least 3 hours.

• 한국산학기술학회논문지
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• 제20권5호
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• pp.109-117
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• 2019

본 연구는 골관절염 환자의 통증 감소를 위한 심리적 중재의 효과를 메타 분석한 연구로 심리적 중재 개발을 위한 기초자료를 제공하기 위해 수행되었다. 연구방법으로는 PubMed, EMBASE, Ovid-MEDLINE, CINAHL, Korean database에서 2018년 12월 30일까지 발표된 국내 외 문헌을 검색하였고, 심리적 중재의 효과 크기를 파악하기 위해 R version 3.5.1 프로그램을 이용하였다. 그 결과 총 1,822편의 문헌에서 총 1,847명의 참가자를 가진 12편의 연구가 최종 분석되었다. 분석결과로는 골관절염 환자에게 통증 감소를 위한 심리적 중재의 전체 효과크기는 -0.31(95% CI:-0.50, -0.11)로 작은 정도의 유효한 효과를 보였다(p<.001). 조절효과 분석에서는 중재 종류, 중재 기간, 중재 제공자에 따른 효과크기가 유효한 차이를 나타냈다. funnel plot 분석으로 출판오류를 분석하였고, 시각적으로 비대칭이었으나 egger's regression test 후 비대칭이 아님을 확인하였다(bias= -3.24, p=.077). 본 연구의 결과는 메타분석에 포함된 연구의 수가 적기는 하나 골관절염 환자의 주요 증상인 통증 문제를 개선하기 위한 심리적 중재의 표준을 제시하였고 중재 종류, 중재 기간, 중재 제공자에 대한 임상적 근거를 마련하였다.

• Korean Journal of Radiology
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• 제19권6호
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• pp.1110-1118
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• 2018

Objective: To perform a meta-analysis to quantitatively assess functional magnetic resonance imaging (MRI) in the diagnosis of locally recurrent prostate cancer. Materials and Methods: A comprehensive search of the PubMed, Embase, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews was conducted from January 1, 1995 to December 31, 2016. Diagnostic accuracy was quantitatively pooled for all studies by using hierarchical logistic regression modeling, including bivariate modeling and hierarchical summary receiver operating characteristic (HSROC) curves (AUCs). The Z test was used to determine whether adding functional MRI to T2-weighted imaging (T2WI) results in significantly increased diagnostic sensitivity and specificity. Results: Meta-analysis of 13 studies involving 826 patients who underwent radical prostatectomy showed a pooled sensitivity and specificity of 91%, and the AUC was 0.96. Meta-analysis of 7 studies involving 329 patients who underwent radiotherapy showed a pooled sensitivity of 80% and specificity of 81%, and the AUC was 0.88. Meta-analysis of 11 studies reporting 1669 sextant biopsies from patients who underwent radiotherapy showed a pooled sensitivity of 54% and specificity of 91%, and the AUC was 0.85. Sensitivity after radiotherapy was significantly higher when diffusion-weighted MRI data were combined with T2WI than when only T2WI results were used. This was true when meta-analysis was performed on a per-patient basis (p = 0.027) or per sextant biopsy (p = 0.046). A similar result was found when $^1H$-magnetic resonance spectroscopy ($^1H$-MRS) data were combined with T2WI and sextant biopsy was the unit of analysis (p = 0.036). Conclusion: Functional MRI data may not strengthen the ability of T2WI to detect locally recurrent prostate cancer in patients who have undergone radical prostatectomy. By contrast, diffusion-weight MRI and $^1H$-MRS data may improve the sensitivity of T2WI for patients who have undergone radiotherapy.

• Journal of Nutrition and Health
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• 제54권5호
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• pp.459-473
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• 2021

마늘건조분말을 준건강인이 섭취하였을 때 혈압 개선 효과가 있는지를 평가하기 위하여 메타 분석 기법으로 평가를 수행하였다. 2020년 7월까지 총 3,203건의 자료를 검색하여, 미리 계획한 선정 기준 및 제외 기준에 따라 선별한 결과 총 9건의 연구가 분석에 포함되었다. 편향 위험이 중등도 이상인 2건을 제외하고 총 7건의 연구를 포함하여 분석 결과, 마늘건조분말의 섭취는 수축기혈압 및 이완기혈압을 각각 -6.0 mmHg, -2.7 mmHg 수준으로 대조군 대비 유의하게 개선시키는 것으로 분석되었다.

• 한국노년학
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• 제37권2호
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• pp.431-444
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• 2017

본 연구는 국내 노인의 인지기능 향상 프로그램의 효과를 확인하기 위해 수행되었다. 2000년부터 2016년까지 4개의 데이터베이스에서 9,624개의 논문을 검색하였고, 최종 14개의 논문이 메타분석을 위해서 선정되었다. 선정된 연구의 질 검증을 위해서 Scottish Intercollegiate Guidelines Network의 controlled trial checklist를 사용하였다. R 프로그램 version 3.3.2(2016-10-31)를 사용하여 효과크기와 이질성 검증, 출간오류를 분석하였다. 인지기능 향상 프로그램의 전체 효과크기는 중간 효과크기를 나타냈고 이질성은 중간 정도의 이질성을 나타냈다(SMD=0.759, 95% CI: 0.506~1.013, $I^2=34%$). 전체 논문의 이질성 검증을 위한 조절효과분석을 실시한 결과 중재종류에 따라 통계적으로 유의한 차이를 보였으며 복합운동중재가 가장 큰 효과크기를 나타냈다(SMD=1.231, 95% CI: 0.658~1.804, $I^2=40.8%$). 출간오류는 Funnel plot과 Egger's regression test를 통해서 통계적으로 유의한 오류가 발견되었지만 오류의 심각정도를 확인하기 위해 Trim-and-Fill 분석을 실시한 결과 전체연구 결과를 번복할 정도의 심각한 오류는 확인되지 않았다. 따라서 노인을 대상으로 한 인지기능 향상 프로그램 중 복합운동중재는 노인의 인지기능 향상에 도움이 될 것으로 사료된다.

• 한국시뮬레이션학회논문지
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• 제14권3호
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• pp.43-54
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• 2005

For the effective design of automated distribution center composed of Automated Storage/Retrieval System, Automated Guided Vehicle System, and Conveyor System, we proposed an analysis method to determining. design and control parameters with multiple performance objectives using Compromise Programming, which can resolve the dilemma of conflicting objectives. The Evolution Strategy generates the optimal solutions for each objectives. The Analytic Hierarchy Process selects the best solution among the alternatives generated from Evolution Strategy. The Regression Analysis formulates the objective functions for each objectives. By reducing deviations between goal values and target values generated from Analytic Hierarchy Process, Compromise Programming determines design and control parameters by compromising the multiple objectives formulated using Regression Analysis. When the parameters of system are changed, this proposed analysis method has a benefit of reducing costs and time without repeating whole simulation run.

• 한국콘텐츠학회논문지
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• 제17권4호
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• pp.424-433
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• 2017

본 연구의 목적은 노인 주관적 건강상태 관련 사회경제적 지위, 심리사회적 요인의 효과크기를 메타분석 방법으로 비교하고, 이러한 효과크기들이 조절변수인 성별에 따라 달라지는지 메타 회귀분석으로 살펴보는 것이다. 분석대상은 2014년까지 국내 학술지 논문 80편에서 추출된 총 487개의 효과크기이다. 분석결과 첫째, 노인의 주관적 건강상태에 배우자지지의 효과크기가 가장 크고, 다음으로 소득, 교육수준, 직업, 자녀지지, 자산, 가족외 지지, 가족지지, 사회활동 순이었다. 둘째, 여성노인일수록 소득이 주관적 건강상태에 긍정적으로 미치던 영향력이 감소하고, 가족외지지의 영향력은 증가하는 것으로 나타났다. 이러한 결과에 따른 제언은 노년기 건강에 있어서 배우자지지의 중요성을 인식하고 배우자 사별을 경험한 노인의 건강지원을 우선시해야 한다는 점과, 여성노인을 위한 소득보장정책과 가족외지지가 강화되어야 한다는 점이다.

• Clinical and Experimental Pediatrics
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• 제63권2호
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• pp.34-43
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• 2020

Phenylketonuria is a disease caused by congenital defects in phenylalanine metabolism that leads to irreversible nerve cell damage. However, its detection in the early days of life can reduce its severity. Thus, many countries have started disease screening programs for neonates. The present study aimed to determine the worldwide prevalence of classic phenylketonuria using the data of neonatal screening studies.The PubMed, Web of Sciences, Sciences Direct, ProQuest, and Scopus databases were searched for related articles. Article quality was evaluated using the Joanna Briggs Institute Critical Appraisal Evaluation Checklist. A random effect was used to calculate the pooled prevalence, and a phenylketonuria prevalence per 100,000 neonates was reported. A total of 53 studies with 119,152,905 participants conducted in 1964-2017 were included in this systematic review. The highest prevalence (38.13) was reported in Turkey, while the lowest (0.3) in Thailand. A total of 46 studies were entered into the meta-analysis for pooled prevalence estimation. The overall worldwide prevalence of the disease is 6.002 per 100,000 neonates (95% confidence interval, 5.07-6.93). The meta-regression test showed high heterogeneity in the worldwide disease prevalence (I²=99%). Heterogeneity in the worldwide prevalence of phenylketonuria is high, possibly due to differences in factors affecting the disease, such as consanguineous marriages and genetic reserves in different countries, study performance, diagnostic tests, cutoff points, and sample size.

• Journal of Preventive Medicine and Public Health
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• 제33권3호
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• pp.343-348
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• 2000

Objectives : This study was conducted to integrate the results of studies assessing the association between chronic noise exposure and blood pressure. Methods : Using a MEDLINE search with noise exposure, blood pressure and hypertension as key words, we retrieved articles from the literature that were published from 1980 to December 1999. The criteria for quality evaluation were as follows: 1) the study subjects must have been workers employed at a high noise level area 2) The paper should use average and cumulative noise exposure as method for exposure evaluation. 3) Blood pressure in each article should be reported in a continuous scale Among the 77 retrieved articles, six studies were selected for quantitative meta-analysis. Before the integration of the regression coefficients for the association between blood pressure and noise level, homogeneity tests were conducted. Results : All studies were a cross-sectional design and the study subjects were industrial workers. Five papers used a time-weighted average for noise exposure and only one paper calculated the cumulative noise exposure level. The measurement of blood pressure in the majority of studios were accomplished in a resting stale, and used an average of two or more readings. The homogeneity of studies was rejected in a fixed effect model, so we used the results in a random effect model. The results of the quantitative meta-analysis, the weighted regression coefficient of noise associated with systolic blood pressure and diastolic blood pressure were 0.05 (95% confidence interval [CI]: -0.03, 0.13) and 0.06 (95% CI: -0.01, 0.13), respectively. Conclusions : Our results suggested that chronic exposure to industrial noise does not cause elevated blood pressure.

• Journal of Preventive Medicine and Public Health
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• 제49권4호
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• pp.205-219
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• 2016

Objectives: No children-specified review and meta-analysis paper about the short-term effect of fine particulate matter ($PM_{2.5}$) on hospital admissions and emergency department visits for asthma has been published. We calculated more precise pooled effect estimates on this topic and evaluated the variation in effect size according to the differences in study characteristics not considered in previous studies. Methods: Two authors each independently searched PubMed and EMBASE for relevant studies in March, 2016. We conducted random effect meta-analyses and mixed-effect meta-regression analyses using retrieved summary effect estimates and 95% confidence intervals (CIs) and some characteristics of selected studies. The Egger's test and funnel plot were used to check publication bias. All analyses were done using R version 3.1.3. Results: We ultimately retrieved 26 time-series and case-crossover design studies about the short-term effect of $PM_{2.5}$ on children's hospital admissions and emergency department visits for asthma. In the primary meta-analysis, children's hospital admissions and emergency department visits for asthma were positively associated with a short-term $10{\mu}g/m^3$ increase in $PM_{2.5}$ (relative risk, 1.048; 95% CI, 1.028 to 1.067; $I^2=95.7%$). We also found different effect coefficients by region; the value in Asia was estimated to be lower than in North America or Europe. Conclusions: We strengthened the evidence on the short-term effect of $PM_{2.5}$ on children's hospital admissions and emergency department visits for asthma. Further studies from other regions outside North America and Europe regions are needed for more generalizable evidence.