• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.2
• /
• pp.595-600
• /
• 2015

Background: Accumulating evidence suggests that metformin possesses anticarcinogenic properties, and its use is associated with favorable outcomes in several cancers. However, it remains unclear whether metformin influences prognosis in prostate cancer (PCa) with concurrent type 2 diabetes (T2D). Materials and Methods: We searched PubMed, EMBASE, and the Cochrane Library from database inception to April 16, 2014 without language restrictions to identify studies investigating the effect of metformin treatment on outcomes of PCa with concurrent T2D. We conducted a meta-analysis to quantify the risk of recurrence, progression, cancer-specific mortality, and all-cause mortality. Summary relative risks (RRs) with corresponding 95% confidence intervals (CIs) were calculated. Publication bias was assessed by Begg's rank correlation test. Results: A total of eight studies fulfilled the eligibility criteria. We found that diabetic PCa patients who did not use metformin were at increased risk of cancer recurrence (RR, 1.20; 95%CI, 1.00-1.44), compared with those who used metformin. A similar trend was observed for other outcomes, but their relationships did not reach statistical significance. Funnel plot asymmetry was not observed among studies reporting recurrence (p=0.086). Conclusions: Our results suggest that metformin may improve outcomes in PCa patients with concurrent T2D. Well-designed large studies and collaborative basic research are warranted.

• Korean Journal of Clinical Pharmacy
• /
• v.27 no.3
• /
• pp.150-160
• /
• 2017

Background: Recently, a fixed combination of grazoprevir and elbasvir (GE) has been introduced to the arsenal of chemotherapeutics to fight against this virus. The study aimed to provide information on the efficacy and safety of GE for the treatment of HCV infection by performing a meta-analysis of literature data. Methods: PubMed and EMBASE database searches were conducted. Among the literature retrieved, pivotal Phase III clinical studies were analyzed. Statistical analysis of the data was performed by RevMan. Results: Four pivotal Phase III clinical studies compared the efficacy and safety of GE. When HCV patients were treated with GE for 12 weeks, the sustained virologic response, defined as the viral RNA level below the lower limit of quantification at 12 weeks after the cessation of therapy (SVR12), was 94.7%. The clinical advantage of GE involves its use by patients with cirrhosis and/or renal failure without dose adjustment. If the genotype (GT) of the causative virus was GT1a with NS5A polymorphism or GT4 with resistance to peginterferon/ribavirin, treatment with GE plus ribavirin for 16 weeks resulted in a better outcome compared to treatment with GE alone for 12 weeks. Adverse events reported during the four clinical studies were 71.09% in the GE arms and it was 76.61% in the non-GE arms, with the most frequent events being mild central nervous system symptoms. Conclusion: GE was generally safe and effective for the treatment of HCV infection. However, since HCV mutates very rapidly and becomes resistant to antiviral agents, long-term monitoring should be mandatory.

• Journal of Korean Medicine Rehabilitation
• /
• v.27 no.3
• /
• pp.47-60
• /
• 2017

Objectives The aim of this research is to assess the effects of bee venom acupuncture for knee osteoarthritis. Methods For a systematic review, we constructed a key question as the effect of bee venom acupuncture for knee osteoarthritis and selected RCTs and nRCTs. We searched the following 15 databases without a language restriction: Pubmed, EMBASE, Cochrane CENTRAL (CENTRAL), CINAHL, AMED, seven Korean medical databases (KoreaMed, Kmbase, KISS, NDSL, KISTI, Koreantk, OASIS) and three Chinese databases including CNKI, Wanfang and VIP database. Results A total of 300 potentially relevant studies were identified; only 13 studies were selected for systematic review. Almost studies showed that bee venom acupuncture has significant effect on knee osteoarthritis. 5 studies comparing bee venom acupuncture with acupuncture were included in the meta-analysis. The effect size of standardized mean difference (SMD) was analyzed as 'small effect' with 0.47 (95% CI: 0.10~0.83, Z=2.49, p=0.01). Conclusions The research showed that bee venom acupuncture can significantly reduce pain, stiffness and improve the quality of life of patients with knee osteoarthritis. However, most of the studies included in the analysis were evaluated as methodologically high risk of bias. This suggests that there is limitation applying this study. In the future, more Randomized Controlled trial should be actively conducted.

• Journal of Periodontal and Implant Science
• /
• v.42 no.1
• /
• pp.3-12
• /
• 2012

Purpose: Anti-rheumatic agents target common molecular pathways of inflammation in rheumatoid arthritis (RA) and periodontitis. The purpose of this study was to determine the relative effect of anti-rheumatic agents on the levels of inflammatory biomarkers and periodontal inflammation in RA patients with periodontitis. Methods: A systematic review and meta-analysis were conducted of studies comparing periodontal parameters of inflammation, such as bleeding on probing, and biomarkers of inflammation in RA patients with periodontitis and healthy adults with and without periodontitis. The search included the electronic databases MEDLINE, Cochrane Database of Systematic Reviews, and Google Scholar, inclusive through October 2011, with no language restrictions. Hand searches were conducted of the bibliographies of related journals and systematic reviews. Observational and interventional studies assessing the effects of antirheumatic therapy qualified for inclusion. Two reviewers performed independent data extraction and risk-of-bias assessment. Of the 187 identified publications, 13 studies fulfilled the inclusion criteria. Results: When compared to healthy adults without periodontitis, RA subjects were found to have significantly higher levels of bleeding on probing and limited evidence of higher levels of interleukin-$1{\beta}$ and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) in gingival crevicular fluid and saliva. No consistent differences were found in periodontal parameters and inflammatory biomarkers between RA subjects and adults with periodontitis. Studies evaluating the effect of anti-TNF-${\alpha}$ therapy in RA subjects with periodontitis have yielded inconsistent results. Conclusions: There are limited data, however, to suggest that anti-TNF-${\alpha}$ agents can reduce local production of inflammatory cytokines and periodontal inflammation in RA patients with periodontitis.

• Journal of KIISE:Databases
• /
• v.33 no.4
• /
• pp.363-371
• /
• 2006

In spite of computer's development, the present state of a lot of electronic documents overflowed it's going to be more difficult to get appropriate information. Therefore it's more important to get meaningful information than to focus on the speed of processing. Semantic web enables and intelligent processing by adding semantic meta data on your web documents. Also as the semantic web grows, the knowledge resource is more important. In this paper, we propose a RDF storage system using relational database model aimed at intelligent processing by adding semantic meta data on your web documents, also a query processor aimed at query processing through the storage system. By using relational model, we could overcome a weakness of object or memory model.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2016.05a
• /
• pp.123-125
• /
• 2016

Big data analysis refers the ability to store, manage and analyze collected data from an existing database management tool. In addition, extract value from large amounts of structured or unstructured data set and means the technology to analyze the results. Meta-analysis refers to a statistical literature synthesis method from the quantitative results of many known empirical studies. We conducted a meta-analysis and review of between success factors based the information systems success model researches. This study focused a total of 14 research papers that established causal relationships between success factors based the information systems success model published in Korea academic journals during 2000 and 2016. Based on these findings, several theoretical and practical implications were suggested and discussed with the difference from previous researches.

• The Transactions of the Korea Information Processing Society
• /
• v.5 no.3
• /
• pp.633-648
• /
• 1998

Rapid computing environment, change of the application structure, and various user demand will increase the demand of the software development. Version control is helpful to improve productivity using delta, and useful to establish component from existing data of source code. This paper presents the design and implementation of the version control system. which is composed of retrieval system and delta management system. In retrieval system, vanous retrieve methods arc proposed. This methods provides the process methodology with filename, content, size and date. Various retrieve methods arc important for the effective delta management. Meta data can be easily composed for the delta management by these methods. Compared with other systems, this implemented version control system has some advantage. First, for delta management, version maintenance for delta management becomes easier by integrating the forward and back-ward methods. Second, delta managent part of a project is to unite the forward and backward method. the effieiency of this system is to increased in management. Also, this system supports a thechnique of using the database and files for project repository and makes the version management more effective.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2017.10a
• /
• pp.140-141
• /
• 2017

Big data analysis, in the large amount of data stored as the data warehouse which it refers the process of discovering meaningful new correlations, patterns, trends and creating new values. Thus, Big data analysis is an effective analysis of various big data that exist all over the world such as social big data, machine to machine (M2M) sensor data, and corporate customer relationship management data. In the big data era, it has become more important to effectively analyze not only structured data that is well organized in the database, but also unstructured big data such as the internet, social network services, and explosively generated web documents, e-mails, and social data in mobile environments. By the way, a meta analysis refers to a statistical literature synthesis method from the quantitative results of many known empirical studies. We reviewed a total of 750 samples among 50 studies published on the topic related as IDT between 2000 and 2017 in Korea.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.11 no.10
• /
• pp.1957-1967
• /
• 2007

User can be offered various information form internet and reserve. However this operation is hard to be satisfied with user's requirement. Because it offer the alternative by self-mediation and the place where offer the information is distributed and a form or stored f[nm of data would be different. These cases occurred in change of enterprise recently. In a process of M&A, outsourcing or cooperation. necessity of new strategy become a pressing issue for ensuring interoperability on application, database of each enterprise and integration information management. Thus, interoperability of distributed data is a base condition for cooperation of legacy system, it will solve a problem such as available or clarity of data, problem of cooperation system. This paper use a XMDR for integration of distributed system and ensuring interoperability. By using XMDR, integrate a traveling information system and it will be solve the problem of interoperability and variety data problem that be occurred in integration of data by suggesting a technique of transaction management.

• Korean Journal of Clinical Pharmacy
• /
• v.28 no.4
• /
• pp.320-332
• /
• 2018

Background: This study was performed to clarify the effect of SLCO1B1 T521C on statin-induced myotoxicity. Methods: The PubMed, Embase, Ovid, and Cochrane Library databases were searched for all published studies between database inception and April 2018. Using Review Manager 5, the pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were determined to assess the effect of SLCO1B1 T521C on statin-induced myotoxicity by using different genetic models. Results: Eleven observational studies and one randomized controlled trial were included in the meta-analysis. The pooled analysis showed that the incidence of statin-induced myotoxicity was significantly associated with the SLCO1B1 521C variant allele. Among patients using statins, the incidence of myotoxicity was higher in those carrying the 521TC or 521CC variant than in those carrying the 521TT variant in the dominant model (TC + CC vs TT, OR: 1.57; 95% CI: 1.20, 2.05; p = 0.001). The 521TC genotype was associated with a higher risk of myotoxicity than the 521TT genotype (OR: 1.42; 95% CI: 1.09, 1.86; p = 0.009). Furthermore, the incidence of myotoxicity was higher in 521CC carriers than in 521TC carriers (OR: 1.40; 95% CI: 1.06, 1.83; p = 0.02) and noticeably higher in 521CC carriers than in 521TT carriers (OR: 2.26; 95% CI: 1.23, 4.17; p = 0.009). Conclusion: The identification of individuals with the SLCO1B1 521C variant allele prior to the initiation of statin therapy might be useful to predict the risk of toxicity development, determine the individual dose, and prevent myotoxicity.