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http://dx.doi.org/10.18325/jkmr.2017.27.3.47

A Systematic Review of Bee Venom Acupuncture for Knee Osteoarthritis  

Gu, Ji-Hyang (Department of Korean Rehabilitation Medicine, College of Korean Medicine, Dae-Jeon University)
Kim, Eunseok (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Dae-Jeon University)
Park, Yang-Chun (Department of Internal Medicine, College of Korean Medicine, Dae-Jeon University)
Jung, In Chul (Department of Neuropsychiatry, College of Korean Medicine, Dae-Jeon University)
Lee, Eun-Jung (Department of Korean Rehabilitation Medicine, College of Korean Medicine, Dae-Jeon University)
Publication Information
Journal of Korean Medicine Rehabilitation / v.27, no.3, 2017 , pp. 47-60 More about this Journal
Abstract
Objectives The aim of this research is to assess the effects of bee venom acupuncture for knee osteoarthritis. Methods For a systematic review, we constructed a key question as the effect of bee venom acupuncture for knee osteoarthritis and selected RCTs and nRCTs. We searched the following 15 databases without a language restriction: Pubmed, EMBASE, Cochrane CENTRAL (CENTRAL), CINAHL, AMED, seven Korean medical databases (KoreaMed, Kmbase, KISS, NDSL, KISTI, Koreantk, OASIS) and three Chinese databases including CNKI, Wanfang and VIP database. Results A total of 300 potentially relevant studies were identified; only 13 studies were selected for systematic review. Almost studies showed that bee venom acupuncture has significant effect on knee osteoarthritis. 5 studies comparing bee venom acupuncture with acupuncture were included in the meta-analysis. The effect size of standardized mean difference (SMD) was analyzed as 'small effect' with 0.47 (95% CI: 0.10~0.83, Z=2.49, p=0.01). Conclusions The research showed that bee venom acupuncture can significantly reduce pain, stiffness and improve the quality of life of patients with knee osteoarthritis. However, most of the studies included in the analysis were evaluated as methodologically high risk of bias. This suggests that there is limitation applying this study. In the future, more Randomized Controlled trial should be actively conducted.
Keywords
Knee Osteoarthritis; Bee Venom; Systematic review; Meta-analysis;
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Times Cited By KSCI : 12  (Citation Analysis)
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1 Li Shu Qian. Clinical study of treating knee osteoarthritis by Apithera. master's thesis. Guangzhou university of Chinese medicine. 2014.
2 Ryu SM, Lee JS, Kim SS, Jung SH. The Effect of Intra-articular Bee Venom Injection on Osteoarthritis of the Knee. J Oriental Rehab Med. 2004;14(1):35-52.
3 Yang KR, Song HS. A Comparative study of Warm needling and Bee Venom Pharmacopuncture on Osteoarthritis of the Knee. Journal of korean pharmacopuncture. 2008;11(2):21-31.
4 Yang Tian Jing. Clinical study of treatment of knee osteoarthritis by bee needle therapy. master's thesis. Guangzhou university of Chinese medicine. 2013.
5 Su Jie Bin. Treating 50 cases of osteoarthritis of the knee by Fengzhen plus Wenzhen therapy. CJCM. 2011; 03(7):61-3.
6 王小寅. 蜂针疗法治疗双膝骨性关节炎50例临床观察. 中国中医药咨讯. 2012;04(2):128-9.
7 张金禄, 叶丽红, 刘喜德, 张平. 蜂针疗法治疗膝骨性关节炎86例疗效观察. 中国中医药科技. 2011;18(2):144-5.
8 刘雪婷. 蜂针疗法治疗双膝骨性关节炎40例. 中国中医药现代远程教育. 2014;12(8):85-6.
9 黄海振, 陈希, 张还添, 何铭涛. 蜂针配合中药内服治疗膝骨性关节炎. 2008;23(9):1273-4.
10 Kim JH, Han TR. Rehabilitation medicine. Seoul:Koonja publishing. 2006: 501-24.
11 Koh HK, Kwon GL, Yin CS. Bee Venom Acupuncture Therapy, Seoul:Kyung Hee University Press. 2003: 48-9, 115-20, 142-4.
12 Lim JA, Kim SN, Lee SY, Moon HC, Kim SC, Shin MS, Kim HJ, Koo ST, Choi SM. The Clinical Study on Bee Venom Acupuncture Treatment on Osteoarthritis of Knee Joint. Journal of Pharmacopuncture. 2005;8(2):29-37.   DOI
13 Park DH, Baik SK. Design and Conduct of Randomized Controlled Trials(RCTs). Clinical and Molecular Hepatology. 2006;12(3):309-14.
14 Kwon SH, Lee JH, Kim KK. Accuracy of Lower Extremity Alignment in Total Knee Arthroplasty Using Navigation System. Journal of the Korean Orthopaedic Association. 2009;44(6):599-603.   DOI
15 Rehabilitation medicine of Korean Medicine. Oriental Rehabilitation Medicine. 3rd edition. Seoul:Koonja publishing. 2011: 97.
16 The Korean Orthopaedic Association. Orthopaedics. 7th edition. Seoul:Choisin Medical Publishing. 2013: 290, 317-319, 1012-3.
17 Kim HA. Clinical Investigation of Osteoarthritis. Journal of Rheumatic Diseases. 2000;7(3):205-11.
18 Park KH, Park O, Yu CW, Shin SH, Kim YB, Cheong HJ, Kim WJ, Kim MJ, Park SC. Clinical Presentation and Risk Factors for Prosthetic Joint Related Infections. J Korean Soc Chemother. 1999;17(3):211-20.
19 Motsis EK, Paschos N, Pakos EE, Georgoulis AD. Review article: Patellar instability after total knee arthroplasty. Journal of orthopaedic surgery. 2009;17(3):351-7.   DOI
20 Kim SC, Lim JA, Lee JD, Lee SK, Lee SY, Moon HC, Choi SM, Chung YH. A Pilot Study of Acupuncture Treatment for the Osteoarthritis of the Knee Joint on the EBM. The Journal of Korean Acupuncture & Moxibustion Society. 2006;23(1):187-215.
21 Jung HC, Jeong SH. A Clinical Study of Knee Joint Osteoarthritis Patients on the Effect of Korean Traditional Medicine Treatment with Acupuncture, Cupping, Physical Therapy and Ganghwalijetong-yeum; Case Series. The Journal of the Society of Korean Medicine Diagnostics. 2015;19(2):125-32.
22 Korean Pharmacopuncture institute. Pharmacopuncturology. 2nd edition. Seolu:Elsevier Health Sciences KR. 2011: 181-215.
23 Jang JY, Kwon OS, Kim YS, Kim JH, Kim YR, Ahn SH, Sohn IC. Effects of Warm Needling on the Acute Knee Arthritis Induced by Carrageenan in Rats. Journal of Meridian & Acupoint. 2009;26(2):75-89.
24 Lee JH, Yang TJ, Lee DG, Lee OJ, Wei TS. The Effect of Needle-embedding Therapy on Osteoarthritis of Knee Combined with Korean Medical Treatment. The Acupunture. 2014;31(4):195-204.   DOI
25 Yoh SB, Sul JU, Shin MS. Research Trends on the Treatment of Knee Osteoarthritis in Korean Medicine. Korean Jounal of Acupuncture. 2011;28(1):139-55.
26 Han SW, Park KH, Jung TY, Seo JC. The Effect of Bee Venom & Melittin Solution on Cell Death in Synovial Cell Line. The Acupunctre. 2002;19(4):74-88.
27 Park DS, Jeong SH, Kim SJ, Seo IB. Effects of Bee-venom Treatment on the Expression of NOS, C-fos, Serotonin and Substance P in Central Nerve System of Monosodium Iodoacetate-induced Osteoarthritic Pain Model. Journal Korean Medicine Rehabilitation. 2007; 17(3):1-18.
28 Kim YM, Kim SJ, Seo IB. Effects of Bee-venom Treatment on the Monosodium iodoacetate-induced Osteoarthritis in Rats. Journal of Physiology & Pathology in Korean Medicine. 2007;21(5):1154-62.
29 Zhao MA, Hahm DH, Lee SK, Choi SM, Kim GH, Shim IS, Kang SK, Lee HJ. Effect of Bee Venom Herb-acupuncture on the Repair of Articular Full-thickness Defect in Rat. Journal of Physiology & Pathology in Korean Medicine. 2005;19(3):518-622.
30 Wang WH, Ahn KB, Lim JK, Jang HS. Clinical Investigation Compared with the Effects of the Bee-venom Acupuncture on Knee Joint with Osteoarthritis. Journal of Pharmacopuncture. 2001;4(3):101-3.   DOI
31 Lee JD, Park HJ, Chae YB, Lum SB. An Overview of Bee Venom Acupuncture in the Treatment of Arthritis. Evidence-based complementary and alternative medicine. 2005;2(1):79-84.   DOI
32 Kim SY, Park JE, Seo HJ, Lee YJ, Jang BH, Son HJ, Suh HS, Shin CM. NECA's guidance for undertaking systematic reviews and meta-analysis for intervention. National Evidence-based Healthcare Collaborating Agency. 2011.
33 An BJ, Kim KT, Kang MS, Song HS. Effect of Bee Venom-acupuncture on Patients with Osteoarthritis of Knee Joint. The Journal Of Korean Acupuncture & Moxibustion Medicine Society. 2006;23(24):15-20.
34 Kim JH, Lee JD. Clinical research of Bee-venom Acupuncture analgesic effect on Osteoarthritis. The Journal Of Korean Acupuncture & Moxibustion Medicine Society. 1999;16(3):25-38.
35 Lee SN, Hong SY, Jo HS, Byeon IJ, Song HS, Kim KH. The Clinical Study on Bee Venom Acupuncture Treatment on Osteoarthritis of Knee Joint. Journal of Pharmacopuncture. 2005;8(2):29-37.   DOI
36 Kwon YB, Kim JH, Yoon JH, Lee JD, Han HJ, Mar WC, Beitz AJ, Lee JH. The analgesic efficacy of bee venom acupuncture for knee osteoarthritis: a comparative study with needle acupuncture. The American journal of Chinese medicine. 2001;29(2):187-99.   DOI