• Korean Journal of Clinical Pharmacy
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• v.10 no.3
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• pp.101-106
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• 2000

Menopausal women experience urogenitory and vasomotor symptoms with increased risk of osteoporosis and cardiovascular diseases, which can be reduced by hormone replacement therapy. However unopposed estrogen therapy has been associated with an increased risk of endometrial hypeiplasia or cancer. The objectives of this study were to compare effects of continuous vs. sequential hormone replacement therapy (HRT) on lipid profile, bone mineral density and menopausal symptoms of postmenopausal women and to assess how they perceive the menopause and HRT culturally. In this retrospective study, women in menopause longer than 6 months, normal in the mam-mogram and Papanicolaou smear, cholesterol level lower than 190 mg/dL or triglyceride level lower 4han 500 mg/dL were treated with Srogen (conjugated equine estrogen 0.625 mg tablet) and Provera (medroxyprogesterone acetate 2.5 mg tablet) for continuous treatment(CT) or Cycloprogynova (Estradiol valerate 2 mg and Norgestrel 0.5 mg complex tablet) for sequential treatment(ST). They were evaluated for lipid profile, bone mineral density, menopausal symptoms, side effects and their perception of menopause and HRT. As results, total sixty-seven patients out of ninety-four enrollees were included in final analysis (33 in continuous therapy, 34 in sequential therapy). There were significant decrease in total cholesterol ($15.04\pm3.17$, p=0.0001), LDL ($19.72\pm3.27$, p=0.0001), and increase in HDL ($5.89\pm1.63$, p=0.0001). Bone minora) density increased significantly with HRT ($0.02\pm0.11$, p=0.0001). But, there were no significant differences in change of lipid profile between continuous and sequential therapy: Total cholesterol, $13.12\pm4.7\;vs.\;16.91\pm4.3;\;LDL\;20.53\pm4.1\;vs.\;18.93\pm5.12:HDL\;7.15\pm2.3\;vs.\;4.67\pm2.2,\;p>0.05$. Incidences of flush reduced from $75\%\;(CT)\;to\;3.13\%\;and\;71.88\%\;(ST)\;to\;9.35\%$. The change of endometrium and breast were found 3 (CT) and 5 (ST) women, respectively. Most of women recognized that HRT is necessary $(70\%)$ for postmenopausal period but did not understand well the cardiovascular protective effect. In conclusion, hormone replacement therapy was effective in improving lipid profile, bone mineral density and menopausal symptoms in both continuous and sequential treatments with similar efficacy.

• Journal of Preventive Medicine and Public Health
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• v.48 no.4
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• pp.216-224
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• 2015

Objectives: Decreased fertility and impaired health owing to early menopause are significant health issues. Smoking is a modifiable health-related behavior that influences menopausal age. We investigated the effects of smoking-associated characteristics on menopausal age in Korean women. Methods: This study used data from the Korea National Health and Nutrition Examination Survey from 2007 to 2012. Menopausal age in relation to smoking was analyzed as a Kaplan-Meier survival curve for 11 510 women (aged 30 to 65 years). The risk of entering menopause and experiencing early menopause (before age 48) related to smoking were assessed using a Cox proportional hazards model. Results: The menopausal age among smokers was 0.75 years lower than that among non-smokers (p<0.001). The results of the Cox proportional hazards model showed pre-correction and post-correction risk ratios for entering menopause related to smoking of 1.26 (95% confidence interval [CI], 1.09 to 1.46) and 1.27 (95% CI, 1.10 to 1.47), respectively, and pre-correction and post-correction risk ratios for experiencing early menopause related to smoking of 1.36 (95% CI, 1.03 to 1.80) and 1.40 (95% CI, 1.05 to 1.85), respectively. Conclusions: Smokers reached menopause earlier than non-smokers, and their risk for experiencing early menopause was higher.

• Biomedical Science Letters
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• v.16 no.1
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• pp.53-64
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• 2010

A randomized, double blind, placebo-controlled human intervention study involving 58 menopause women was performed to investigate the effect of pomegranate extracts on menopausal symptoms. The volunteers were randomly distributed into two groups, one taking pomegranate extracts (1.5 g/day) and the other being a placebo by taking oral administration for 8 weeks. The results from this study showed that duration of hot flush and sweating were significantly decreased by taking pomegranate extracts. In addition, menopausal rating scales and the Kuppermann index were significantly decreased in pomegranate extract taking group. This result suggests a possibility that pomegranate extracts can be helpful for menopause women.

• Women's Health Nursing
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• v.1 no.2
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• pp.275-286
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• 1995

The purpose of this study was to investigate health promoting life-style(HPLS) and its predictors by menstrual status among middle-aged women. The HPLS was conceptualized to have six domains such as self-actualization, responsibility for health, nutrition, exercise, interpersonal relationships, and stress control. Those predictors included three sociodemographic factors and five cognitive factors. Menstrual status was classified into three stages : regular menstrual(premenopausal), menopausal, and postmenopausal stages. Data were collected from 240 women between 30 and 59 years through self-reported questionnaires. Chi-square test, ANOVA, and stepwise multiple regression techniques were used to analyze the data. The results are summarized as follows : 1. The HPLS activities, when aggregated, were not statistically different across the three groups. The activities of the domains of interpersonal relationships and self-actualization were higher then those of other domains. On the other hand, the activities of the domains of exercise and responsibility for health were lower than those of the other domains. 2. The predictors explained 27.2%, 43.8%, and 41.6% of the variance of HPLS in the regular menstrual, the menopausal, and the postmenopausal groups, respectively. 3. In the regular menstrual group, total HPLS was significantly predicted by monthly income, family support, number of family members and education level at the .05 level in the HPLS. 4. In the menopausal group was significantly predicted by self efficacy. 5. The HPLS activities of the postmenopausal group were significantly predicted by family support, self efficacy, and monthly income at the .05 level in the HPLS.

• Korean Journal of Community Nutrition
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• v.16 no.2
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• pp.239-252
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• 2011

The aim of the study was to explore the current status as well as personal views, attitudes, and beliefs regarding daily meal consumption (DM) and food supplement use (FS) in conjunction with the improvement of health condition of the women. Eight focus group interviews were performed and the interview material was condensed systematically with the aim to extract core meanings related to DM, FS, and menopause-associated health. Participants were 40 in number and showed ages ranging from 45 and 60 years with various menopausal status. Current status and beliefs about DM, resources of purchase motivation of FS, types of FS that are currently used, and perceived effects and personal beliefs about FS are discussed. Theme content analysis revealed 3 themes for beliefs about DM, 5 themes for beliefs pertaining FS, and 4 themes for the association between DM and FS. Non-dietary factors such as positive mental attitude and exercise appeared to be also important to maintain good health. The bottom line message from this study may be that proper nutrition through daily meals is essential for good health, while food supplement are used merely to supplement the diet. Findings from this study may deepen our understanding of how women who translate their lifespan through "menopause" perceive the roles and meaning of DM and FS, suggesting health professionals need to monitor and evaluate DM and implement strategies targeting the improvement of daily meal quality of middle and older aged women.

• The Journal of the Korea Contents Association
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• v.17 no.11
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• pp.110-122
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• 2017

This study is to examine moderating effects of income and mediating effects of health related quality of life in the relationship between depression experience and suicidal behavior among menopausal middle-aged women in Korea. This study employed 1,182 middle-aged women aged 40 to 60 of the third year (2015) data from the 6th Korean National Health and Nutrition Examination Survey(KNHANES VI). The results are that first, depression experience were significantly associated with suicidal behavior. Secondly, health related quality of life appeared to mediate the relationship between depression experience and suicidal behavior. Thirdly, income was significantly moderated the relationship between depression experience and suicidal behavior in relatively low income group below average income after controlling for mediating effects of health related quality of life. These results showed that there is a need to enhance health policy for mental health care in middle-aged women and to expand intervention program for improvement of health related quality of life, and especially, intervention for improving mental health of low-income group.

• Women's Health Nursing
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• v.8 no.2
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• pp.151-164
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• 2002

PURPOSE: Estrogen replacement therapy is indicated for the relief of hot flushes and urogenital atrophy, the prevention of osteoporosis and the reduction in risk of cardiovascular disease. The present study assessed by blood pressure, heart rate variability, and climacteric symptoms in menopausal women before treatment and at 1 month during estrogen replacement therapy. METHODS: The study sample consisted of 16 healthy menopausal women (range 49 to 59 years, mean : 53.4 years) attending menopausal clinics for the complaint of climateric symptoms at S. hospital in Chunchoen. They were all non-smokers and no patient had symptoms or evidence of cardiovascular disease. They took estrogen replacement therapy (conjugated estrogen 0.625 mg with or without medroxy progesteron 2.5mg) for 1 month. Blood pressure, heart rate variability(heart period and vagal tone) through ECG, and climacteric symptom were measured in all subjects before treatment and at 1 month during treatment. Climacteric symptom questionnaire which was developed by Neugarten et al.(1963) was modified with 20 items of question(Cronbach's alpha = 88 -.89). The data was collected from Sept. 1. 2000 to July. 30. 2001. RESULTS: There was no significant difference in mean systolic and diastolic pressure between the baseline and at 1 month during treatment. The mean heart period and vagal tone were slightly increased, but difference of mean heart period and vagal tone were not statistically significant between the baseline and at 1 month during treatment. The score of climacteric symptoms decreased significantly from the baseline after treatment. CONCLUSIONS: Even though, this study did not show that estrogen replacement therapy led decrease of blood pressure and increase heart rate variability, climacteric symptoms reduced much in all subjects after taking drugs. These results suggest that there is need to repeat study with long term period.

• Safety and Health at Work
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• v.5 no.4
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• pp.186-190
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• 2014

Background: Physical exercise during leisure time is known to increase physical capacity; however, the long-term effects on work ability and work strain are inconclusive. The aim of this study was to investigate the effects of a 6-month physical exercise program on work ability and work strain after 6 months and 30 months, among women with menopausal symptoms at baseline. Methods: A questionnaire including questions on work ability and work strain was mailed in the beginning, at 6 months and after 30 months after the intervention to occupationally active women participating in a randomized controlled study on physical exercise and quality of life. The intervention included aerobic exercise training 4 times per week, 50 minutes per session. Work ability was measured with the Work Ability Index (WAI) and with questions about physical and mental work strain. Results: Women aged 47-62 years (N=89) who were occupationally active at baseline were included in the analyses. The increase in WAI from baseline to the end of the exercise intervention (6 months) was statistically significantly greater among the intervention group than among the control group (regression coefficient 2.08; 95% confidence interval 0.71-3.46). The difference between the groups persisted for 30 months. No significant short- or long-term effects on physical and mental work strain were found. Conclusion: A 6-month physical exercise intervention among symptomatic menopausal women had positive short-term as well as long-term effects on work ability.

• Journal of the Korea Convergence Society
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• v.10 no.4
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• pp.257-264
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• 2019

The purpose of this study was to investigate the main results of the nursing intervention program for reducing depression in menopausal women in Korea and to investigate the effects of systematic review of literature. Research methods were searched for RISS, KMbase, KoreaMed and KISS as domestic databases and limited to domestic papers published in last 10 years from 2006 to 2015. The analysis of 14 articles showed that exercised therapy among the various nursing intervention programs provided significant effects on reducing depression. The intervention methods provided oral education, demonstration training, and practical training, 6 sessions, 60 sessions per session, 5~10 weeks for intervention, and 6~12 weeks for intervention. Depression in menopausal women is not a temporary or short-term emotional state. So it is necessary to provide appropriate exercises that can be applied for their own, regardless of daily life.

• Journal of radiological science and technology
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• v.34 no.3
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• pp.195-201
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• 2011

We studied the relationship between prediction parameters and bone mineral density for pre-and-post menopausal women. We measured BMI%Fat by BIA, blood pressure and lipid profiles for 483 adult women who are in NPO state. SBP, TC, TG, LDL have significant statistical value in the postmenopause women group and postmenopause woman. The value of postmenopause women of these parameters are lower than premenopause woman. BMD has the most strongest relationship with LBM. The BMD and LDL level of postmenopause women have statistically negative relationship. The results show that for the premenopause cases, weight, BF, and HDL level were the major factors which affect the BMD. For postmenopause cases, however, weight, age, and LDL level turned out to be the most significant factors.