• The Korean Journal of Physiology and Pharmacology
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• 제26권6호
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• pp.415-425
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• 2022

Memory formation in the hippocampus is formed and maintained by circadian clock genes during sleep. Sleep deprivation (SD) can lead to memory impairment and neuroinflammation, and there remains no effective pharmacological treatment for these effects. Myricetin (MYR) is a common natural flavonoid that has various pharmacological activities. In this study, we investigated the effects of MYR on memory impairment, neuroinflammation, and neurotrophic factors in sleep-deprived rats. We analyzed SD-induced cognitive and spatial memory, as well as pro-inflammatory cytokine levels during SD. SD model rats were intraperitoneally injected with 10 and 20 mg/kg/day MYR for 14 days. MYR administration significantly ameliorated SD-induced cognitive and spatial memory deficits; it also attenuated the SD-induced inflammatory response associated with nuclear factor kappa B activation in the hippocampus. In addition, MYR enhanced the mRNA expression of brain-derived neurotropic factor (BDNF) in the hippocampus. Our results showed that MYR improved memory impairment by means of anti-inflammatory activity and appropriate regulation of BDNF expression. Our findings suggest that MYR is a potential functional ingredient that protects cognitive function from SD.

• 한국엔터테인먼트산업학회논문지
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• 제13권5호
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• pp.247-262
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• 2019

본 연구는 가정방문 인지자극 활동이 치매특별등급(5등급) 노인의 인지기능 및 기억 자기효능감에 미치는 효과를 알아보고자 하였다. 연구기간 및 대상은 2019년 2월 11일부터 4월 26일까지 G광역시에 거주하는 65세 여성 1명으로, 개별대상연구의 A-B-A' 설계를 사용하였다. 초기 진단을 받은 치매특별등급(5등급)의 경증치매 노인에게 비교적 접근성이 쉽고, 스스로 생각하고 풀어갈 수 있는 수준의 신체·인지자극 활동을 병행함으로써 지적능력을 반복적으로 자극하여 저하된 인지기능을 완화시켰고, 일상생활에서 친숙한 글자, 숫자, 신체 움직임 등을 이용한 단기기억 및 회상 활동을 지속적으로 훈련함으로써 저하된 기억력과 집중력의 인지기능에 긍정적 영향을 미쳤다. 이는 인지자극 활동이 초기 경증치매 노인들에게 센터, 복지관 등의 특정장소를 벗어나 가정에서 손쉽게 접근 가능한 치매예방프로그램임을 확인하였다. 따라서 본 연구의 인지자극 활동은 치매특별등급(5등급) 노인의 인지기능 및 두드러지는 기억저하에 긍정적 영향을 미칠 수 있는 효과적 중재로의 가능성을 확인하였기에, 적극적인 실용 방안을 제안하는 바이다.

• 한국융합학회논문지
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• 제10권5호
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• pp.95-102
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• 2019

본 연구는 정상 성인을 무작위로 급속안구움직임(saccadic eye movement, SEM)군과 의식적손가락움직임(intentional finger movement, IFM) 군으로 구분하여 2주 동안 중재를 실시한 후 숫자외우기 검사와 n-back 검사를 사용하여 인지기능의 변화를 알아보았다. 그 결과 IFM군의 단기기억은 시간이 지날수록 유의하게 상승하였으며, 추적 검사에서는 군간 차이를 나타내었다. IFM군의 n-back은 수행시간, 오류횟수, 정확률에서 시간이 지날수록 유의한 효과를 나타내었다. SEM군의 n-back은 수행시간과 정확률에서 시간이 지날수록 유의한 효과를 나타내었다. 결론적으로 인지기능 향상에는 단일 자극인 SEM보다 대뇌겉질을 광범위하게 활성화 시킬 수 있는 다중 자극인 IFM 방법이 인지기능 향상의 중재 방법으로 더 유용할 것으로 생각된다.

• 인지과학
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• 제33권1호
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• pp.23-50
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• 2022

출처기억은 사물에 대한 일화기억 경험의 맥락을 표상하는 중요 인지기제이다. 출처기억에 대한 그 동안의 연구는 일상의 일화기억과 밀접한 뇌신경, 행동학적 중요 연구들의 기초가 되어 왔고, 특히 집행기능이나 연합기제와 같은 인지기제를 강조하여 왔다. 본 연구에서는 계량서지학적 방법론을 통해 1989년에서 2020년 사이 출간된 출처기억 연구논문들을 분석하였고 핵심어 공동출현 연결네트워크와 저자 인용 연결망을 기반으로 출처기억 연구의 발전 흐름에 대한 깊이 있는 개관을 제시한다. 계량서지학적 분석을 통해 출처기억 연구의 추세를 확인한 결과, 2010년을 기준으로 이전 연구들에서는 출처기억의 인지적 기제와 관련한 개별 특성을 살핀 반면, 최근의 연구들은 뇌신경영역 간 연결성 특징 분석을 통한 임상적 특징연구를 비롯해 사회신경과학적 주제에 이르는 영향을 탐색하였다. 핵심어 연결성 분석을 통해 노화, 집행기능이 주요 핵심 주제어로서 연구되었음을 확인하였고, 최근 아동발달심리학과 메타기억 등의 관점에서 연구되는 추세로 나아가고 있음을 보았다. 관련된 출처기억의 이론과 연구모델을 기반으로 심리과학분야 내외에서 인지적 향상의 발달과 관련된 연구가 지속될 가능성을 제안하였다.

• 중환자간호학회지
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• 제14권1호
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• pp.50-62
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• 2021

Purpose : This study examined the effects of an integrated management program on physical function, cognitive function, and depression in patients with subacute stroke. Methods : A nonequivalent control group design was adopted. The participants were assigned to either the experimental group (n=20) or control group (n=23). The experimental group received an 8-week integrated management program and standard rehabilitation service (i.e., physical therapy and occupational therapy), while the control group received the standard rehabilitation service only. Physical function was measured as gait speed and balance ability using the Berg Balance Scale (BBS). Cognitive function was measured with neuro-behavioral cognitive status examination (NCSE), and depression was measured using the Beck Depression Inventory-II (BDI-II). Repeated measure ANOVA was used to determine changes in physical function, cognitive function, and depression over 8-weeks. Results : The interaction between group and time was significant, indicating that the experimental group showed improvement in gait speed, balance ability, cognitive function (linguistic ability, linguistic memory, reasoning), and a decrease in depression compared to the control group. Conclusion : These results indicate that the integrated management program developed herein was beneficial in restoring physical function, cognitive function, and depression in subacute stroke patients.

• 한국산학기술학회논문지
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• 제21권5호
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• pp.150-166
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• 2020

본 연구는 인지예비능 이론에 입각하여 인지기능감퇴를 호소하는 갱년기 여성들을 위해 인지기능훈련 프로그램을 개발하고자 하였다. Jung의 웹기반 교수-학습 체제 설계의 절차적 모형에 근거하여 분석, 설계 및 개발 단계를 거쳐 개발하였다. 인지기능훈련 프로그램은 8주간의 프로그램으로 모바일 애플리케이션을 활용한 인지훈련과 동영상 교육이며 총 24회기로 매 회기는 20~30분이 소요되며 3회/주 하도록 구성되었다. 인지기능훈련은 갱년기 여성들에 있어서 가장 취약한 인지영역으로 확인된 기억력, 주의집중력, 언어기능과 통합적 집행기능을 위한 시나리오기반 문제해결 등으로 내용을 구성하였다. 각 주차별 교육내용은 갱년기의 정의, 원인 및 증상, 갱년기와 뇌기능 등 총 8가지 주제로 개발되었다. 프로그램 시범운영을 위해 인지기능감퇴를 호소하는 10명의 갱년기 여성을 대상으로 인지기능훈련 프로그램을 적용하여 훈련 전과 훈련 8주후 인지기능의 효과를 측정한 결과 전반적 인지기능이 증가되었고 통계적으로 유의하였다(t=-3.04, p=.014). 모바일 앱 기반 인지기능훈련 프로그램은 기억력 향상뿐만 아니라 잠재적 치매 유병율을 감소시키는 효과도 기대할 수 있을 것이라 기대된다.

• 한국임상보건과학회지
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• 제8권2호
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• pp.1426-1435
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• 2020

Objective: This study aims to develop CFT, a screening test for dementia that can be conducted on patients with mild cognitive impairment or early dementia. Methods: This study was conducted on therapists working at occupational therapy hospital in Gyeongsangnam-do. The data collection period is two months from July to September 2020, and the research participants were briefed on the purpose, significance, and anonymity of the research in consideration of ethical issues. A total of 33 copies of the data were finally analyzed, excluding those containing insufficient answers and errors, by distributing 40 copies of the data. SPSS Data Access pack 8.0 was used for data analysis, Cronbach's α value was evaluated for internal consistency reliability of each item, and Pearson Correlation coeffient between the lower scales of the assessment tool was measured. Results: The Cronbach's α value of the CFT was shown as .892 and the reliability of the assessment paper was shown to be quite high. The Cronbach's α value for each item in the cognitive assessment tool was the highest at .899 in the subtraction item, with exercise control (mook Chi Pa) at 888, visual memory, plus .887. The correlation of each item of cognitive assessment tools was found to be most correlated with the number of sustained concentrates and word2 to .934; in the stop word-numeric item and visual memory to be .85; and in the addition to the auditory memory item .739. Conclusion: Therefore, this study developed cognitive evaluation tools that can distinguish the diversity and cognitive level of screening tests and clarify standards, which are different from the existing dementia screening tools in Korea. Furthermore, the cognitive assessment tools of this study can be verified by applying them to patients with mild cognitive impairment and early dementia, and the criteria for generalization can be established.

• 한국임상보건과학회지
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• 제10권2호
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• pp.1600-1606
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• 2022

Objective: This study was to compares and analyzes programs applied to improve cognitive function in patients with mild cognitive impairment and early dementia in the community to find out their effectiveness. Methods: In this study, 12 papers were finalized by searching for "elderly", "cognitive", "community", and "program" using the database of the Research Information System (RISS), National Assembly Library, and Korean Studies Information (KISS). Results: Programs for cognitive function were in the order of cognitive stimulation program, arts and crafts, and exercise program. In the program, rather than applying the cognitive stimulation program alone, the program was operated by combining leisure or exercise, music, art, and handicraft. The time was shown to be 30 minutes. The most frequently used evaluation tool was MMSE, followed by GDS and BBS. By cognitive domain, cognitive stimulation program and memory, satisfaction in psychology, and balance ability in exercise were evaluated the most. In the cognitive area, various cognitive stimulation areas were included, and in the exercise area, basic exercise, muscle strength exercise, joint exercise, and balance exercise were applied. Conclusion: Therefore, developing a program to improve cognitive function for mild cognitive impairment, it will be possible to prepare guidelines to establish and development.

• 음성과학
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• 제8권4호
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• pp.119-129
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• 2001

Language is one aspect of cognition, along with attention and concentration, learning and memory, visuospatial abilities, and executive function. The purpose of this study was to determine the effect of language intervention by cognitive approach on language expressive performance in a patient with conduction aphasia. This study used several tasks such as Attention and concentration task, visual memory tasks, memory tasks, categorization, divergent thinking, self-monitoring and evaluate thinking. The effects of treatment were evaluated by periodic probing of both trained and untrained familiar words in three tasks; picture naming, answering to questions and telling stories. The results showed improvements both in trained and untrained words. Therefore, we concluded that expressive language performance of this aphasic patient is amenable to this intervention, and that cognitive therapy approach can be useful.

• 말소리와 음성과학
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• 제9권3호
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• pp.57-65
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• 2017

The current study explored how Korean-speaking children processed the multiple acoustic cues (VOT and f0) for the stop laryngeal contrast (/t'/, /t/, and /$t^h$/) and examined whether individual perceptual strategies could be related to a general cognitive ability performing executive functions (EF). 15 children (aged from 7 to 8) participated in the speech perception task identifying the three Korean laryngeal stops (3AFC) on listening to the auditory stimuli of C-/a/ with synthetically varying VOT and f0. They completed a series of EF tasks to measure working memory, inhibition, and cognitive shifting ability. The findings showed that children used the two cues in a highly correlated manner. While children utilized VOT consistently for the three laryngeal categories, their use of f0 was either reduced or enhanced depending on the phonetic categories. Importantly, the children's processing strategies of a f0 suppression for a tense-aspirated contrast were meaningfully associated with children's better cognitive abilities such as working memory, inhibition, and attentional shifting. As a preliminary experimental investigation, the current research demonstrated that listeners with inefficient processing strategies were poor at the EF skills, suggesting that cognitive skills might be responsible for developmental variations of processing sub-phonemic information for the linguistic contrast.