• Korean Journal of Medicinal Crop Science
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• v.24 no.5
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• pp.375-385
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• 2016

Background: The study was conducted to elucidate the extraction conditions under which white ginseng has cognition-improving efficacy. Methods and Results: Extracts from white ginseng under different solvent and temperature conditions were analyzed for ginsenoside content and inhibitory effect on N-methyl-D-aspartate (NMDA) receptor and acetylcholinesterase. The total ginsenoside contents and amounts of ginsenoside Rb1 plus ginsenoside Rg1 from the 1st extracts (prepared with EtOH/$H_2O$ as solvent) were higher than those from the 2nd extracts (extracted with $H_2O$ after the 1st EtOH/$H_2O$ extraction). The contents in the 1st and 2nd extracts produced at $80^{\circ}C$ were also higher than those obtained at $50^{\circ}C$. Samples from the 1st extraction at $80^{\circ}C$ indicated higher inhibitory activities on NMDA receptors-whose excessive activation is thought to mediate the calcium-dependent neurotoxicity associated with several neurodegenerative diseases-than those from the 2nd extraction. Among the samples prepared at varying temperatures, the extract prepared at $50^{\circ}C$ showed the highest suppression activity on NMDA receptors. Note, however, that the extracts from the 2nd extraction at $50^{\circ}C$ inhibited acetylcholinesterase-whose inhibition could be a therapeutic strategy for neurodegenerative diseases with cognitive deficits and memory malfunction-more effectively than those from the 1st extraction. Conclusions: To enhance the cognition-improving activity of white ginseng extract, it is suggested that the extracts be utilized after being combined the 1st extracts (made with EtOH/$H_2O$ solvent) and the 2nd extracts (prepared with $H_2O$) at low temperature.

• Journal of KIISE
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• v.44 no.1
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• pp.51-56
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• 2017

The research area for solving question answering (QA) problems using artificial intelligence models is in a methodological transition period, and one such architecture, the dynamic memory network (DMN), is drawing attention for two key attributes: its attention mechanism defined by neural network operations and its modular architecture imitating cognition processes during QA of human. In this paper, we increased accuracy of the inferred answers, by adapting an automatic data augmentation method for lacking amount of training data, and by improving the ability of time perception. The experimental results showed that in the 1K-bAbI tasks, the modified DMN achieves 89.21% accuracy and passes twelve tasks which is 13.58% higher with passing four more tasks, as compared with one implementation of DMN. Additionally, DMN's word embedding vectors form strong clusters after training. Moreover, the number of episodic passes and that of supporting facts shows direct correlation, which affects the performance significantly.

• Journal of Korean Biological Nursing Science
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• v.19 no.4
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• pp.276-283
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• 2017

Purpose: The aim of this study was to identify the effects of environmental factors on depressive-like behavior and memory function during adolescence. We performed behavior tests in adolescent rats exposed to environmental enrichment, handling, and social deprivation for eight weeks. Methods: Wistar rats were randomly assigned to control, environmental enrichment, handling, and social deprivation groups at the age of four weeks. Results: In the forced swim test, the immobility time in the environmental enrichment group was decreased than that in the control group (p=.038), while the immobility time in the social deprivation group was increased than that in the control group (p=.035), the environmental enrichment group (p<.001), and the handling group (p=.001). In the Morris water maze test, the social deprivation group had an increased latency time than the control group (p=.013) and the environmental enrichment group (p=.001). In the passive avoidance test, the environmental enrichment group had an increased latency time than the control group (p=.005). However, the social deprivation group had reduced latency time than the socially housed groups (control: p=.030; environmental enrichment: p<.001; handling: p<.001). Conclusion: These findings suggest that environmental factors play an important role in emotion and memory function during adolescence.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.2
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• pp.228-235
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• 2010

This study was performed to investigate the memory enhancing effect of Poria cocos Wolf (Hoelen cum radix) against scopolamine-induced amnesia in Sprague-Dawley (SD) rats. To induce amnesia, scopolamine (0.75 mg/kg) was intraperitonically injected into SD rats 30 min before starting behavior tests. We have conducted Morris water-maze and Y-maze tests to monitor learning and memory functions. Poria cocos effectively reversed scopolamine-induced memory impairment in SD rats which was represented by an improvement of mean escape latency in water-maze test and spontaneous alterations in Y-maze test. To elucidate possible molecule mechanism, we have measured mRNA as well as protein expression of acetylcholine esterase (AchE), choline acetyltransferase (ChAT), muscarinic acetylcholine receptor (mAchR), and brain-derived neurotrophic factor (BDNF) using RT-PCR and Western blot analysis, respectively. Poria cocos increased mRNA levels of ChAT and mAchR in rat hippocampus compared with those in the scopolamine-injected amnesic group. In addition, protein expression of ChAT and BDNF was also elevated by Poria cocos intake. Furthermore, as an upstrem regulator, the activation of cAMP response element-binding protein (CREB) was assessed by immunohistochemistry. In this immunohistochemical analysis, the phosphorylation of CREB (p-CREB) was reduced by scopolamine injection, which was restored back to control levels by administration of Poria cocos. These results suggest that Poria cocos may improve memory and cognitive deficit in amnesia and have therapeutic potentials through up-regulation of ChAT, mAchR, and BDNF, which seemed to be mediated by activation of CREB.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.1
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• pp.475-481
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• 2014

Recently, it is used to apply various improved methods to determine the cause of traffic accidents. However, most of vehicle black box usually start to store the video information by an event trigger in case that the impact value at that time exceeds the threshold impact value as compared the threshold impact value saved in advance with the current impact value. there are problems with above method that a lot video information should be saved in the memory card of the vehicle black box, and the user should delete the unwanted video information every time because of unclassified video store. In this paper, we propose the ontology-based context aware algorithm that the vehicle black box recognize the situation, and then remove the video data with a low weighting factor by itself for efficient memory management.

• Journal of Korean Public Health Nursing
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• v.32 no.1
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• pp.81-95
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• 2018

Purpose: This study was conducted to identify the effects of a group cognitive improvement program on cognitive function, depression and self-esteem in elderly individuals with mild cognitive impairment. Methods: This was an experimental study that employed a pre-post design of a non-equivalence control group. The subjects were 52 elderly people with mild cognitive impairment, 25 of whom were assigned to the experimental group and 27 to the control group. The program was conducted for a total of 12 sessions for 60 minutes each. Data were analyzed using the ${\chi}2-test$, Fisher's exact test, and Independent t-test with the SPSS 20.0 program. Results: After the intervention, the group who participated showed improvement in all areas of cognitive function based on MMSE-KC (F=26.37, p.<0.001), the Rey Complex Figure Test: copy (F=20.66, p.<0.001), Immediate memory of Seoul Verbal Learning Test-Elderly's version (F=29.68, p.<0.001), delayed memory (F=45.79 p.<0.001), memory recall (F=28.97, p.<0.001), Forward of Digit Span Test (F=9.25, p=.004), backward (F=8.33, p.=0.006), language comprehension (F=13.42, p.<0.001), and digit symbol coding (F=17.74, p.<0.001) relative to the control group. Moreover depression (F=24.09, p.<0.001) was decreased in program participants, whereas self-esteem (F=40.24, p.<0.001) was increased. Conclusion: The program could be a useful intervention because the results show that the group cognitive improvement program has a significant effect on cognitive function, depression and self-esteem in elderly with mild cognitive impairment.

• The Korean Journal of Archival Studies
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• no.43
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• pp.43-70
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• 2015

The value and validity of elite oral materials have been questioned because of their gaps with 'fact'. The purpose of this article is to analyze these gaps and to propose some solutions that can reduce the gaps. According to the analysis of this article, there are three types of the gaps that qualitatively differ from each other. The first type of the gaps is produced in the process of generation of memory. This type is made because informants cognize and memorize the facts that exist outside themselves. Selective cognition, selective memory and individual experience come under this category. The second type is produced in the process of preserving the memory. Forgetting and memory transformation are main examples of this type. The third type is produced in the process of the interviews with the informants. False statements or lies fall into this category. The main conclusions are as follows. 1) all gaps in oral materials are not necessarily negative. It is because Some of these gaps- the first and the second type- are not only parts of the real world but also very useful for interpreting the world. 2) The third type of the gaps are very harmful and it is need to be eradicated or reduced. For this, this article proposes some solutions.

• Journal of Life Science
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• v.29 no.5
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• pp.564-569
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• 2019

Heavy drinking disrupts the nervous system by activation of GABA receptors and inhibition of glutamate receptors, thereby preventing short-term memory formation. Degradation of cognition by alcohol induces blackouts, and it can lead to alcoholic dementia if repeated. Therefore, drugs need to be developed to prevent alcohol-induced blackout. In this study, we confirmed the effect of an ethanol extract of Cassia obtusifolia seeds (COE) on alcohol-induced memory impairment. The effects of COE and ethanol on cognitive functions mice were examined using the passive avoidance and Y-maze tests. The manner in which alcohol affects long-term potentiation (LTP) in relation to the learning and memory was confirmed by electrophysiology performed on mouse hippocampal slices. We also measured N-methyl-D-aspartate (NMDA) receptor-mediated field excitatory synapses (fEPSPs), which have a known association with cognitive impairment caused by ethanol. Ethanol caused memory impairments in passive avoidance and Y-maze tests. COE prevented these ethanol-induced memory impairments in these tests. Ethanol also blocked LTP induction in the mouse hippocampus, and COE prevented this ethanol-induced LTP deficit. Ethanol decreased NMDA receptor-mediated fEPSPs in the mouse hippocampus, and this decrease was prevented by COE. These results suggest that COE might be useful in preventing alcohol-induced neurological dysfunctions, including blackouts.

• International Journal of Knowledge Content Development & Technology
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• v.5 no.2
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• pp.65-74
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• 2015

The paper lists problems in defining information and knowledge and also in differentiating between the two. It separately describes physical, economic and cognitive properties of information and knowledge. A long drawn comparative chart of the nature, characteristics and properties of knowledge and information is given. In addition it explains their relation with wisdom. The paper emphasizes that knowledge is only a human preserve. Also it finds common grounds and mutual dependence between information, knowledge and wisdom. The purpose is to clear confusion between knowledge and information, and find their relation with wisdom and tradition by placing these in value added and evolutionary chain: Signals--data-- Information--Knowledge--Wisdom--Tradition.

• International Journal of Advanced Culture Technology
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• v.9 no.1
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• pp.196-202
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• 2021

Currently, as Korea enters into a fast aging society, the problem of dementia population is increasing. In this paper, we intend to contribute to the improvement of welfare for the elderly by developing virtual reality technology and related interface technology to effectively perform hand movements known as effective methods for preventing and treating dementia. As the content of the research and development of this paper, it is designed to be easy for the elderly to use and stimulate brain function by applying VR technology using sensors, and to activate mental and physical activities for the elderly who are marginalized in terms of cultural welfare. We intend to develop by classifying the types of games and contents that can induce them. As a result of this thesis, we developed contents using virtual reality to improve cognitive abilities for elderly people with poor cognitive ability to activate the brains of users' cognition, memory, and attention to prevent and treat dementia I want to contribute.