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http://dx.doi.org/10.7586/jkbns.2017.19.4.276

Effect of Environmental Factors on Depressive-like Behavior and Memory Function in Adolescent Rats  

Song, Min Kyung (Department of Nursing, Graduate School, Kyung Hee University)
Lee, Jae-Min (Department of Physiology, College of Medicine, Kyung Hee University)
Kim, Yoon Ju (Department of Nursing, Graduate School, Kyung Hee University)
Lee, Joo Hee (Department of Nursing, Graduate School, Kyung Hee University)
Kim, Youn-Jung (College of Nursing Science, Kyung Hee University.East-West Nursing Research Institute)
Publication Information
Journal of Korean Biological Nursing Science / v.19, no.4, 2017 , pp. 276-283 More about this Journal
Abstract
Purpose: The aim of this study was to identify the effects of environmental factors on depressive-like behavior and memory function during adolescence. We performed behavior tests in adolescent rats exposed to environmental enrichment, handling, and social deprivation for eight weeks. Methods: Wistar rats were randomly assigned to control, environmental enrichment, handling, and social deprivation groups at the age of four weeks. Results: In the forced swim test, the immobility time in the environmental enrichment group was decreased than that in the control group (p=.038), while the immobility time in the social deprivation group was increased than that in the control group (p=.035), the environmental enrichment group (p<.001), and the handling group (p=.001). In the Morris water maze test, the social deprivation group had an increased latency time than the control group (p=.013) and the environmental enrichment group (p=.001). In the passive avoidance test, the environmental enrichment group had an increased latency time than the control group (p=.005). However, the social deprivation group had reduced latency time than the socially housed groups (control: p=.030; environmental enrichment: p<.001; handling: p<.001). Conclusion: These findings suggest that environmental factors play an important role in emotion and memory function during adolescence.
Keywords
Adolescent; Social environment; Depression; Cognition;
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