• Natural Product Sciences
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• 제28권2호
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• pp.89-92
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• 2022

In Asia, the roots of Paeonia lactiflora and Astragalus membranaceus have been used as therapeutic agents for thousands of years. Once the medicinal plants are harvested, they are dried and their ingredients are extracted by heat-mediated reflux extraction. However, the condensed structure of organic products (especially roots) limits the extraction of bioactive components. In this study, we assessed the effect of the puffing method (using high temperature and pressure) before the extraction process in relation to the profile and antioxidant capacity of active ingredients. We demonstrated that the additional puffing process before extraction methods improves the yield of polyphenol concentrations and antioxidant activities from the roots of P. lactiflora and A. membranaceus.

• 한국약용작물학회지
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• 제25권4호
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• pp.224-230
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• 2017

Background: The current regulations regarding the storage of medicinal herbs do not define the storage temperature; instead, but the only requirement is that the plastic bags used for storing the medicinal herbs should be tightly sealed during storage. The practice of storing medicinal herbs at room temperature ($28^{\circ}C$), causes many problems, including growth of insect pests on the stored medicinal herbs. Thus, it is necessary to understand the effect of insect pests on the quality of medicinal herbs stored at room temperature ($28^{\circ}C$) for the improving the relevant regulations. Methods and Results: Cnidium rhizome and Angelica radix were infested with Lasioderma serricorne F. adults and incubated at $28^{\circ}C$ for 2.5 and 5 months. The population of L. serricorne was established rapidly, and left many holes, cadavers, and feces on the stored medicinal herbs, thereby greatly damaging the product appearance and hygiene. In addition, active ingredients of the medicinal herbs were significantly decreased, probably reducing their medicinal quality as well. Conclusions: These results indicate that the current regulations are not sufficient to prevent the establishment of storage insect pests and guarantee the quality and hygiene of stored medicinal herbs. Therefore, it is necessary to devise proper storage protocols and upgrade the current relevant regulations to maintain the quality of medicinal herbs during storage.

• 한국의사학회지
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• 제26권2호
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• pp.135-148
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• 2013

This study analyzed surface-chemical transitions in manufacturing process of traditional acupuncture as proposed method by Dongeuibogam. The manufacturing process of traditional acupuncture from a used iron for a long time was divided by primary medicinal herbs treatment, secondary medicinal herbs treatment and tertiary treatment using by dog meat. The traditional acupuncture research process was measured according to the characteristics and changes of the specimens at each processing step of the manufacturing process. The following devices were used to Surface analysis. Scanning electron microscopy (SEM), Energy Dispersive Spectrometer (EDS), X-ray diffraction analyzer (XRD). As a result, medicinal herbs removed impurities on the surface and raised the antibacterial effect in the manufacturing process of traditional acupuncture. Furthermore, the ingredients of medicinal herbs were coated on the surface of the iron. Dog meat influenced to prevent surface corrosion, reduce friction when the acupuncture was inserted. Although the process empirically obtained, a glimpse of the wisdom of our ancestors was revealed. These ancestral wisdom can be expected to apply today, when used in manufacturing process of a modern stainless steel acupuncture to compensate for the defective part.

• 대한한의학원전학회지
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• 제34권2호
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• pp.169-206
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• 2021

Objectives : Records on medicinal liquor in medical texts and major culinary texts of the Joseon period were examined and compared to identify their relevance. Methods : Liquors that include medicinal ingredients in the Donguibogam, Sangayorok, Suunjapbang, Eumsikdimibang, and the Gyuhapchongseo and Juchan were collected. Similarities and differences of each entry were compared following thorough examination. Results : Direct citing of medical texts or specialized medical descriptions in the culinary texts or descriptions of medical liquor composed of various medicinals close to formula compositions are evidences that medical knowledge influenced culinary texts. Conclusions : Descriptions on medicinal liquor in medical texts and culinary texts could be said to have influenced each other.

• 대한한의학원전학회지
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• 제29권2호
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• pp.79-90
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• 2016

Objectives : Treatment using foods has already been recorded since the time of Zhou Dynasty of China. Modifications in the cooking process of medicinal food or manufactural process of herbal medicines are accompanied by the alterations in the ingredients that affect the actual efficacies of medicinal food or herbal medicine, and may have marked effects on the patients including the difficulties that may be experienced in consuming the food or taking the medicine. Therefore, systemic management is essential in such processes. Accordingly, management of such knowledge system must be standardized and conveniently administered by grafting IT technology. This study aims to overcome the problem of the failure of the knowledge system on the material-oriented medicinal herbs to apply the knowledge on the cooking process that impart marked influence on the actual efficacies of the medicinal herbs. Methods : Therefore, analysis of the cooking process or manufacturing processes of prescriptions was executed by using the morphological analysis method in natural language. In this study, we aimed to make data structure of the terminologies that represent manufacture process of prescription and medicinal food. The data structure is combinations of smallest unit in natural language. We made the database by analyzing morpheme of the natural language to express the manufacture process of prescription and medicinal food. Results & Conclusions : As the results, we can express making process of Cheonjin-won, Guseon-wangdogo and Sanyagbaegboglyeongtalagjuk in DB. It was concluded that the development of DB through the extraction of a total of 15 types of concepts including 'order', 'action' and 'continuous action', etc. was helpful in systematization of the knowledge on medicinal herbs including the manufacturing process.

• 대한예방한의학회지
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• 제20권1호
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• pp.111-124
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• 2016

Objectives : Treatment method using drugs has already been used in Korean medicine for a long time. Moreover, database has been developed and utilized for more efficient management of the treatments that use drugs. Most of such database related to knowledge on drugs is composed of origin, efficacy, temperament, ingredients and examples of application of the standardized drugs. Communication with knowledge information in other specialized areas is also accomplished by using the efficacies and ingredients with the drugs. In this study, we aimed to make data structure of the terminologies that represent the manufacturing process of herbs. However, in spite of the fact that the manufacturing process of the drugs imparts effect on their efficacies and ingredients, details of the manufacturing processes are quite limited to simple text sentences, thereby resulting in substantially lower level of utilization and difficulties in systematic researches on various factors included in the manufacturing processes in comparison to other knowledge on drugs. Methods : This Study extracted the factors necessary in the development of database by executing morphological analysis of the manufacturing process of herbs. Results : The factors are 'Order', 'Act', 'Raw material', 'Tools', 'Supporting materials', 'Intensity', 'Duration Time', 'Interval', 'Focus', 'Repetition Number', 'Untill'. We were able to tell the difference of the manufacturing process with a simple structured query language and the factors. Conclusions : Morphological analysis of medicinal herbs manufacturing Process contributes to standardization with information of the manufacturing process. And it helps to creates a quality management system through the Database.

• 대한한의학원전학회지
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• 제32권2호
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• pp.71-92
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• 2019

Objectives : To examine various ways non-glutinous rice has been applied in different formulas of "Shanghanlun" and the relationship between non-glutinous rice and the formulas' effects. Methods : First, texts that included non-glutinous rice were selected from the "Shanghanlun". Then, they were categorized according to the application of non-glutinous rice, followed by analysis of its relationship with each formula. Results : Most formulas that used non-glutinous rice in raw form when decocting with other ingredients included Shigao. Non-glutinous rice alleviates coldness of Shigao as in the case with Taohuatang where it stops diarrhea. Non-glutinous rice used in Wumeiwan warms the center and boosts Qi and helps the medicinal ingredients to bind when made into pellets. In Guizhitang and Lizhongwan, non-glutinous rice assists Stomach Qi. In Shizaotang, porridge is taken after diarrhea to help quick recovery. To prevent damage of Zheng Qi, Baisan can be mixed with rice water for administration. The level of cathartic effect can be managed through giving cold or hot porridge to the patient according to his/her response to the medicine. Mazirenwan, Mulizexiesan, Banxiasan, Sinisan, Wulingsan are mixed in rice water for administration. It makes it easier to swallow than when mixed with plain water. The application of rice flour is either internal or external. In Zhufutang, where rice flour is parched, it harmonizes the center and stops diarrhea. In Daqinglongtang when there is too much perspiration, warm powder is sprinkled on the skin to stop sweating. Clear porridge in Jiuziyisifang and rice flour in Shechuangzisan were exclusive to "Jinguiyaolue", while Baisan and rice water mixture could only be found in "Shanghanlun". Conclusions : The excavation and research on various ways non-glutinous rice was applied in treatment holds certain meaning in contemporary practice of Korean Medicine where treatment leans heavily on medicinal treatment rather than food, and all ingredients are boiled together in large quantities for most decoctions.

• 한국약용작물학회지
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• 제26권3호
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• pp.220-226
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• 2018

Background: Atractylodes japonica Koidz. and Atractylodes macrocephala Koidz. belong to the family (Asteraceae). Their rhizomes, called white Atractylodes rhizomes, are used in traditional medicine. To address some issues with their cultivation, we recently developed eight hybrid cultivars by interspecific hybridization of A. japonica and A. macrocephala. This study was conducted to screen the hybrid cultivars that have high amounts of active ingredients and yield ability. Methods and Results: Experiments were conducted using the eight hybrid cultivars and A. macrocephala (control cultivar) in the experimental field of the department of Herbal Crop Research located in Eumseong, South Korea. We investigated the growth characteristics of the aerial and underground parts. Among the cultivars, 'Sanwon' had the highest rhizome dry weight (53.8 g/plant), followed by 'Dachul' (50.0 g/plant). In addition, the content of atractylenolide I, II, III and total active ingredients were investigated using high-performance liquid chromatography. Compared with A. macrocephala, most of the inter-specific hybrid cultivars had a higher content of active ingredients and yield ability. Conclusions: Through study, we established the superior quality of Atractylodes inter-specific hybrid cultivars. In particularly, it was found that 'Dachul' may be grown as a superior cultivar, with high amount of active ingredients as well as yield ability.

• Journal of Ginseng Research
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• 제47권4호
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• pp.493-505
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• 2023

In recent years, an increasing number of reports have explored the wound healing mechanism of these two traditional Chinese herbal medicines- Panax ginseng and Panax notoginseng, but there is no systematic research on the related core functions and different mechanisms in the treatment of wound healing up to now. Based on network pharmacology and meta-analysis, the present work aimed to comprehensively review the commonality and diversity of P. ginseng and P. notoginseng in wound healing. In this study, a wound healing-related "ingredients-targets" network of two herbs was constructed. Thereafter, meta-analysis of the multiple target lists by Metascape showed that these two medicines significantly regulated blood vessel development, responses to cytokines and growth factors and oxygen levels, cell death, cell proliferation and differentiation, and cell adhesion. To better understand the discrepancy between these two herbs, it was found that common signaling pathways including Rap1, PI3K/AKT, MAPK, HIF-1 and Focal adhesion regulated the functions listed above. In parallel, the different pathways including renin-angiotensin system, RNA transport and circadian rhythm, autophagy, and the different metabolic pathways may also explained the discrepancies in the regulation of the above-mentioned functions, consistent with the Traditional Chinese Medicine theory about the effects of P. ginseng and P. notoginseng.

• 한국식생활문화학회지
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• 제25권6호
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• pp.734-745
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• 2010

"Sikui-simgam ("食醫心鑑", Book for Alimentotherapist)" written by Jameun, a doctor of Tang (唐) in the 9th century, propagated alimentotherapy in Korea, China, and Japan for a long time. In this study, Sikui-simgam medical theories were studied and the medicinal ingredients and types of food therapy were analyzed to understand alimentotherapy characteristics. "Sikui-simgam" is the first food therapy formulary diverged from herbal therapy forms. Various ingredients from "Sikui-simgam" show the food culture of the Tang age and report much about cooking and cultural history. Many prescriptions in the books are the origins of present-day food culture; thus, they are important clues to understand the present food culture. This book also describes actual prescriptions in detail. Various types of prescriptions with different ingredients are unique characteristics of food therapy and show the various possibilities for food therapy prescriptions. The food therapy prescriptions of "Sikui-simgam" were designed for medical specialists, as the book contains doses and incompatibilities for food therapy. Such food therapy prescriptions were used to treat diseases, so they were used with strict standards.