• The Journal of Korean Obstetrics and Gynecology
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• v.23 no.3
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• pp.123-138
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• 2010

Purpose: The purpose of this study is to identify the real condition of urinary incontinence(UI), interstitial cystitis(IC), atrophic viginitis(AV) for elderly women and analyze the cognition of traditional korean medicine(TKM) for them. Methods: We utilized questionnaire from May to June, 2010. Questionnaires were taken from 125 women using senior welfare center and nursing home, aged over 65 up to 92. The data were analyzed by $X^2$-test using SPSS/PC ver 18.0 program. Results: The prevalences of UI, IC and AV symptoms were 50.4%, 40.8%, 56%, respectively. The average I-QoL score for UI was $82.62{\pm}21.16$, and the average ICSI score for IC was $8.16{\pm}2.50$. After adjustment for each of the variables considered in this study, alcohol was associated with UI and age, BMI(body mass index) were associated with IC. Most of respondents have no experience(94.4%) or don't know (79.2%) about TKM for UI, IC and AV. 44 women(37.3%) indicated that they weren't willing to use TKM for UI, IC and AV. Reasons for not taking TKM were because of 'no knowledge of TKM(34.1%)' and 'more accustomed to western treatment(34.1%)'. Conclusion: Although the prevalence of UI, IC, AV for elderly women was high, the actual percentage of treatment for these diseases was low, furthermore, patients were not aware of TKM and had very few experiences of TKM for these diseases. The development and increased promotion about TKM program for elderly women's urogenital diseases is needed.

• Journal of Digital Convergence
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• v.12 no.10
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• pp.467-476
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• 2014

This study aims to determine the effects of mental health on obesity among Korean adolescents. The data in this study were obtained from the 2013 Korean Youth Health Risk Behavior Web-based Survey conducted in 70,354 adolescents aged twelve to eighteen (35,575 males and 34,779 females) from June 1 to 30, 2013. The variables included age, the economic status of household, academic achievement, health status, perceived happiness, perceived stress, satisfaction of sleeping, perceived depression, and suicidal ideation and the data were processed using t-test, chi square test, and logistic regression analysis. The general characteristics affecting obesity for both Korean male and female adolescents included age (p<0.001), the economic status of households (p<0.001), academic achievement (p<0.001), and health status (p<0.001); the variable of mental health affecting obesity was suicidal ideation among females (p<0.05). It is expected that female adolescents' experience of suicidal ideation can be used as information to predict the likelihood of obesity in managing an obesity program for adolescents and it is necessary to provide obesity education suitable for age and to include obesity guidance in consideration of gender and the economic status.

• Genomics & Informatics
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• v.8 no.3
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• pp.108-115
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• 2010

Hypertension is the most prevalent disease worldwide and is itself a risk factor for cerebral, cardiac, and renal diseases. The inconsistency of candidate genes suggested by previous genomewide association studies (GWASs) may be due to not only differences in study design and genetic or environmental background but also the difference in the power of analysis between continuous traits and discrete traits. We analyzed 352,228 single nucleotide polymorphisms (SNPs) in 8842 unrelated Koreans obtained from Ansan and Ansung cohorts. We performed a series of GWA analyses using three different phenotype models; young hypertensive cases (278 subjects) versus elderly normotensive controls (680 subjects); the upper 25% (2211 hypertensive cases) versus the lower 25% of the SBP distribution (2211 hypotensive controls); and finally SBP and DBP as continuous traits (8842 subjects). The numbers of young hypertensive cases and elderly normotensive controls were not large enough to achieve genomewide significance. The model comparing the upper 25% subjects to the lower 25% of subjects showed a power that was approximate to that of QTL analysis. Two neighboring SNPs of the ATP2B1 gene, rs17249754 (SBP, p=$2.53^{-10}$; DBP, p=$1.28{\times}10^{-8}$) and rs7136259 (SBP, p=$1.30{\times}10^{-9}$; DBP, p=$6.41{\times}10^{-8}$), were associated with both SBP and DBP. Interestingly, a SNP of the RPL6 gene, rs11066280, revealed a significant genomewide association with SBP in men only (p=$3.85{\times}10^{-8}$), and four SNPs located near the MAN2A1 gene showed a strong association with DBP only in elderly men aged 60-70 years (e.g., rs6421827, p=$4.86{\times}10^{-8}$). However, we did not observe any gene variant attaining genomewide significance consistently in the three phenotype models except for the ATP2B1 gene variants. In general, the association signal with blood pressure was stronger in women than in men. Genes identified in GWASs are expected to open the way for prevention, early diagnosis, and personalized treatment of hypertension.

• Journal of Hospice and Palliative Care
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• v.7 no.1
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• pp.29-36
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• 2004

Purpose: A quantitative descriptive study aimed to identify the relationships between spiritual well-being and perception attitudes of death in nursing students. Methods: A survey was conducted and 175 data were collected. Collected data were computed and analyzed using SPSS10.0 for Win. 1) Descriptive statistics were used to identify demographic data, and 2) both t-test and ANOVA statistics were used to figure out the relationships between spiritual well-being /or perception attitudes of death and demographic data of the participants. 3) Pearson's correlation coefficient was used to identify the relationships between the two main variables. Results: 1) The mean of spiritual well-being score of the participants was $50.9943{\pm}10.7235$. Significant relationships between religion /or doing economic activity and spiritual well-being were found. 2) The mean of perception attitudes of death was $20.4914{\pm}2.6280$. There were significant relationships between gender /or age and perception attitudes of death among participants. 3) A strong positive relationship between spiritual well-being and perception attitudes of death of participants was also found(r=.261, P=.000). Conclusion: The study results shows that spiritual well-being of nursing students as caregivers of terminal patients is important when the perception of death of terminal patients is considered. Previous studies indicate that caregivers' perception attitudes impact on those of terminal patients. Therefore, it is suggested that not only perception attitudes of death and spiritual well-being in terminal patients, but also those of caregivers are importantly required to consider in educational programs in relation to spiritual care of terminal patients.

• Sleep Medicine and Psychophysiology
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• v.25 no.2
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• pp.82-91
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• 2018

Objectives: Synchronous electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) has been used to explore sleep stage dependent functional brain networks. Despite a growing number of sleep studies using EEG-fMRI, few studies have conducted network analysis on whole night sleep due to difficulty in data acquisition, artifacts, and sleep management within the MRI scanner. Methods: In order to perform network analysis for whole night sleep, we proposed experimental procedures and data processing techniques for EEG-fMRI. We acquired 6-7 hours of EEG-fMRI data per participant and conducted signal processing to reduce artifacts in both EEG and fMRI. We then generated a functional brain atlas with 68 brain regions using independent component analysis of sleep fMRI data. Using this functional atlas, we constructed sleep level dependent functional brain networks. Results: When we evaluated functional connectivity distribution, sleep showed significantly reduced functional connectivity for the whole brain compared to that during wakefulness. REM sleep showed statistically different connectivity patterns compared to non-REM sleep in sleep-related subcortical brain circuits. Conclusion: This study suggests the feasibility of exploring functional brain networks using sleep EEG-fMRI for whole night sleep via appropriate experimental procedures and signal processing techniques for fMRI and EEG.

• Journal of Convergence for Information Technology
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• v.9 no.6
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• pp.44-51
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• 2019

This study was performed to explore the difference in communication anxiety and class satisfaction after taking the traditional lecture and flipped learning lecture. Fifty four nursing students participated in this study. The study design was one group pretest-posttest design. 4 weeks traditional lecture and 4 weeks flipped learning lecture was applied. Flipped learning was ineffective in improving communication anxiety (t=1.85, p=.069) of nursing students. But emotional state variables and activity variables in the emotional domain were significantly higher after taking the flipped learning lecture(t=-3.80, p=.000; t=-3.35, p=.001). In addition, all of the variables were higher in the flipped learning based team, in the control of the class activities (t=-3.07, p=.003), personal ability (t=-2.48, p=.016), and class participation(t=-3.25, p=.002). Flipped learning is therefore considered to be effective in training nursing students. This study suggested to investigate the effectiveness of flipped learning and learners' satisfaction.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.24 no.2
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• pp.173-186
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• 2021

Purpose: Biliary atresia (BA) is a disease that manifests as jaundice after birth and leads to progressive destruction of the ductal system in the liver. The aim of this study was to investigate histopathological changes and immunohistochemically examine the expression of glial cell line-derived neurotrophic factor (GDNF), synaptophysin, and S-100 protein in the gallbladder of BA patients. Methods: The study included a BA group of 29 patients and a control group of 41 children with cholecystectomy. Gallbladder tissue removed during surgery was obtained and examined immunohistochemically and histopathologically. Tissue samples of both groups were immunohistochemically assessed in terms of GDNF, S-100 protein, and synaptophysin expression. Expression was classified as present or absent. Inflammatory activity assessment with hematoxylin and eosin staining and fibrosis assessment with Masson's trichrome staining were performed for tissue sample sections of both groups. Results: Ganglion cells were not present in gallbladder tissue samples of the BA group. Immunohistochemically, GDNF, synaptophysin, and S-100 expression was not detected in the BA group. Histopathological examination revealed more frequent fibrosis and slightly higher inflammatory activity in the BA than in the control group. Conclusion: We speculate that GDNF expression will no longer continue in this region, when the damage caused by inflammation of the extrahepatic bile ducts reaches a critical threshold. The study's findings may represent a missing link in the chain of events forming the etiology of BA and may be helpful in its diagnosis.

• Journal of the Health Care and Life Science
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• v.8 no.2
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• pp.165-172
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• 2020

This study was conducted to identify the subjective happiness and self-esteem of nursing students and how these variables affect clinical practice stress. Participants consisted of 199 nursing students who were in the third and fourth years who had experienced clinical practice at two nursing universities located in Gyeongnam, and agreed to the survey. Data were collected using questionnaires from June 15 to August 29, 2020. Collected data were analyzed using the SPSS 22.0 statistics program with descriptive statistics, an independent t-test, ANOVA, Scheffe's test, and multiple regression. The mean score for subjective happiness was 4.87 (out of 7), the mean for self-esteem was 3.84 (out of 5), and clinical practice stress was 2.77 (out of 5). The significant predictors of the clinical practice stress were gender, major satisfaction and self-esteem, and the explanatory power of variance was 14.1%. Therefore, we need differentiated clinical practice stress reduction programs according to gender and various strategies that can enhance major satisfaction in order to reduce the clinical practice stress of nursing students.

• Journal of the Health Care and Life Science
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• v.9 no.1
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• pp.147-151
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• 2021

This study was conducted to investigate the variables affecting the quality of life according to the degree of obesity of male and female college students. The research data used the data of the 8th year (2019) of the National Health and Nutrition Survey. Among the survey data, 287 students enrolled in college were enrolled. As a result of the study, the body mass index according to sex was 23.71kg/m2 for male students, 21.31kg/m2 for female students, and male students were overweight, and female students showed normal weight. The quality of life score according to gender was 0.97 points for male students and 0.98 points for female students, indicating a high quality of life score for female students. In the results of a regression analysis conducted to investigate the effect of obesity on the quality of life of college students, boys had normal weight (β=0.053, p=0.003), overweight (β=0.041, p=0.030) and obese weight compared to underweight. The quality of life was significantly higher in (β=0.046, p=0.012). However, there was no significant relevance in female students. In the future, it is considered that the education program for obese body type and the education program for underweight should be combined with the university's health-related education program.

• Tuberculosis and Respiratory Diseases
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• v.59 no.2
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• pp.142-150
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• 2005

Background : Continuous growth stimulation by various factors, as well as chronic oxidative stress, may co-exist in many solid tumors, such as lung cancer. A new family of antioxidant proteins, the peroxiredoxins (Prxs), have been implicated in the regulation of many cellular processes, including cell proliferation, differentiation and apoptosis. However, a real pathophysiological significance of Prx proteins, especially in lung disease, has not been sufficiently defined. Therefore, this study was conducted to investigate the distribution and expression of various Prx isoforms in lung cancer and other pulmonary conditions. Method : Patients diagnosed with lung cancer, and who underwent surgery at the Ajou Medical Center, were enrolled. The expressions of Prxs, Thioredoxin (Trx) and Thioredoxin reductase (TR) were analyzed using proteomic techniques and the subcellular localization of Prx proteins was studied using immunohistochemistry on normal mouse lung tissue. Result : Immunohistochemical staining has shown the isoforms of Prx I, II, III and V are predominantly expressed in bronchial and alveolar lining epithelia, as well as in the alveolar macrophages of the normal mouse lung. The isoforms of Prx I and III, and thioredoxin were also found to be over-expressed in the lung cancer tissues compared to their paired normal lung controls. There was also an increased amount of the oxidized form of Prx I, as well as a putative truncated form of Prx III, in the lung cancer samples when analyzed using 2-dimensional electrophoresis. In addition, a 43 kDa intermediate molecular weight protein band, and other high molecular weight bands of over 20 kDa, recognized by the anti-Prx I antibody, were present in the tissue extracts of lung cancer patients on 1-Dimensional electrophoresis, which require further investigation. Conclusion : The over-expressions of Prx I and III, and Trx in human lung cancer tissue, as well as their possible chaperoning function, may represent an attempt by tumor cells to adjust to their microenvironment in a manner advantageous to their survival and proliferation, while maintaining their malignant potential.