• Journal of Pharmaceutical Investigation
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• v.40 no.spc
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• pp.33-43
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• 2010

Hyaluronic acid (HA) is a biodegradable, biocompatible, non-toxic, non-immunogenic and non-inflammatory linear polysaccharide, which has been used for various medical applications including arthritis treatment, wound healing, ocular surgery, and tissue augmentation. Because of its mucoadhesive property and safety, HA has received much attention as a tool for drug delivery system development. It has been used as a drug delivery carrier in both nonparenteral and parenteral routes. The nonparenteral application includes the ocular and nasal delivery systems. On the other hand, its use in parenteral systems has been considered important as in the case of sustained release formulation of protein drugs through subcutaneous injection. Particles and hydrogels by various methods using HA and HA derivatives as well as by conjugation with other polymer have been the focus of many studies. Furthermore, the affinity of HA to the CD44 receptor which is overexpressed in various tumor cells makes HA an important means of cancer targeted drug delivery. Current trends and development of HA as a tool for drug delivery will be outlined in this review.

• Journal of The Korea Institute of Healthcare Architecture
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• v.21 no.3
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• pp.47-55
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• 2015

Purpose: While medical standard is rapidly improved, welfare of users and employees in hospitals is not treated correspondingly. Intercommunication of hospital users is thought to be very important for their welfare, and provision of conversation spaces within hospital environment needs to be expanded by architectural design. Space organization methods for the design of conversation space is to be embellished. Methods: Literature and hospital designs are analysed in order to develop the basis of argumentation for the hospital conversation space. 15 hospitals are reviewed and designed spaces for the intercommunication of the users are examined, Space organization efforts and design experiments are identified, and 6 organizational methods are proposed such as: 1) reducing territoriality 2) flowing space 3) categorizing and separating spaces 4) height variation 5) contact with outside and 6) Sun-lighted space. Results: 6 organization methods are confirmed in precedent hospital cases, and these proposed methods are applied in a new hospital design project to verify their usefulness. Implications: A hospital design project is presented based on these proposed methods of organization for the conversation space. Outcomes of this study can be applied for the formulation of human intercommunication spaces in other facilities.

• Journal of Pharmaceutical Investigation
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• v.39 no.1
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• pp.43-49
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• 2009

Aspirin or acetylsalicylic acid, a member of the salicylate family, is frequently used as an analgesic, antipyretic, anti-inflammatory and antiplatelet drug. Because aspirin is chemically unstable in water and heat for tablet formulation, additives including lubricants are used in preparing aspirin tablets, using a dry-granulation process. Aspirin tablets are produced by a number of manufacturers which usually use their own unique combination of additives during the manufacturing process. In this study, we employed an NMR based metabolomics technique to identify the manufacturers of various aspirin tablets. Aspirin tablets from six different companies were analyzed by 1H 400 MHz NMR. The acquired data was then integrated and processed by principal component analysis (PCA). Based on the NMR data, we were able to identify peaks corresponding to acetylsalicylic acid in all of the six samples, whereas different NMR patterns were found in the aromatic and aliphatic regions depending on the unique additive used. These observations led to the conclusion that the differences in the NMR patterns among the different aspirin tablets were due to the presence of additives.

• The Journal of Pediatrics of Korean Medicine
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• v.21 no.2
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• pp.121-132
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• 2007

Objectives The purpose of this study is to determine oriental medical concept of emotional intelligence, and to develop the ways of treatment. Methods We investigated the literature of the oriental and western medicine about an emotional intelligence. Results Regarding an emotional intelligence from the oriental medicine, it will follow in attributes of five elements(五行), five emotions(五志), seven passions(七情). Due to the five emotions and seven passions will take to control themselves with following the principle of poles at interinhibition, and intergeneration among the five phases. There is a possibility of trying to apply in reflection control of emotion(partIV). Five emotions(五志), depression theories(鬱症), and a control of theories of seven passions(七情調節) will be applied an emotional stability and an emotional control. Conclusions This study showed that oriental medicine has more merits better than western medicine about emotional intelligence, because oriental medicine consider that the body and mental is an inseparable relation. The further study is necessary with the concept formulation and for a historical investigation about an emotional intelligence.

• Women's Health Nursing
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• v.19 no.3
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• pp.188-200
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• 2013

Purpose: The purpose of this study was to describe the essential structure of the lived experience of working mothers' parenting burden in Korea. Methods: Eight working mothers with young children were interviewed. The Colaizzi analysis of phenomenological research was applied. Results: Seven theme clusters were extracted: a life with constant conflict, sense of guilt, feeling anxious because of lack of information about education for their children, social stigma as a deficient mother, family relationship becoming distant, a life being exhausted, day to day struggle. Conclusion: These results provide an opportunity to have a better understanding of the experiences of working mothers related to parenting their young children. It would also serve as a medium for the formulation of appropriate nursing intervention relevant to burdens of parenthood.

• Journal of Pharmaceutical Investigation
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• v.39 no.2
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• pp.111-115
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• 2009

The pharmacokinetics of cyclosporin A (CsA) after single and multiple oral dosing of new CsA self-micro-emulsifying drug delivery system (SMEDDS) in dogs were estimated. A single dose study was performed following a two-way crossover design against six dogs with reference SMEDDS. For a multiple dose study, three dogs were allocated for each drug, and 100 mg of drug was administered daily for 6 days. Whole blood concentration of CsA was analyzed by radio-immunoassay. Both drug showed identical blood concentration profiles in both studies, and no statistical difference was detected in pharmacokinetic parameters. The relative bioavailabilities of test SMEDDS were 91.4% and 89.1%, respectively, in the single dose study and the last day of multiple dose study. Especially, multiple dose study proved the good relationship between C-0/C-2 and AUC for reference SMEDDS, which is an indispensable part of therapeutic drug monitoring. These results suggest newly formulated CsA SMEDDS possibly shows identical pharmacokinetics and pharmacodynamic behaviors in clinical trials.

• Proceedings of the KSRS Conference
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• 2004.10a
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• pp.115-118
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• 2004

Images with high resolution are desired and often required in many visual applications. When resolution can not be improved by replacing sensors, either because of cost or hardware physical limits, super resolution image reconstruction method is what can be resorted to. Super resolution image reconstruction method refers to image processing algorithms that produce high quality and high resolution images from a set of low quality and low resolution images. The method is proved to be useful in many practical cases where multiple frames of the same scene can be obtained, including satellite imaging, video surveillance, video enhancement and restoration, digital mosaicking, and medical imaging. The method can be either the frequency domain approach or the spatial domain approach. Much of the earlier works concentrated on the frequency domain formulation, but as more general degradation models were considered, later researches had been almost exclusively on spatial domain formulations. The method in spatial domains has three stages: i) motion estimate or image registration, ii) interpolation onto high resolution grid and iii) deblurring process. The super resolution grid construction in the second stage was discussed in this paper. We applied the Maximum A­Posteriori(MAP) reconstruction method that is one of the major methods in the super resolution grid construction. Based on this method, we reconstructed high resolution images from a set of low resolution images and compared the results with those from other known interpolation methods.

• Journal of muscle and joint health
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• v.27 no.2
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• pp.103-111
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• 2020

Purpose: This study aimed to investigate the relationship between general hospital nurses' work environment, resilience, and intention to remain, as well as to identify the factors associated with nurses' intention to remain. Methods: Study participants were nurses at a general hospital in Jeollabuk-do, South Korea. Data collection was undertaken from July 6th to 20th, 2017, through questionnaire responses from 257 nurses. Descriptive statistics were employed for data analysis, including: independent t-test, one way ANOVA, Pearson's correlation coefficient, and multiple regression analysis using SPSS/WIN 22.0. Results: Nurses' work environment, resilience, and intention to remain were found to have a statistically significant correlation. Intention to remain showed statistically significant positive correlations with the nurse's work environment (r=.72, p<.001), resilience (r=.50, p<.001). Factors found to influence intention to remain were work environment, resilience, job satisfaction, and health status. Conclusion: The study findings support the development of a specialized program to strengthen nurses' intention to remain. During the program's formulation, it is necessary to improve nurses' work environment and find ways to bolster the resilience of individual nurses.

• Korean Journal of Clinical Pharmacy
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• v.10 no.3
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• pp.130-139
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• 2000

This study is intended to set the criteria for the classification of prescription and non-prescription drugs, and classify hospital pharmacy formulations according to the criteria. 717 hospital pharmacy formulations were collected ken the Center for review and evaluation of health insurance, and national provincial offices. Hospital pharmacy formulations were evaluated based on the 'Guidelines on the Hospital Pharmacy Formulations (Notification No. 2000-46)'by the Ministry of Health and Welfare. Drug classification advisory committee was composed of twelve medical and pharmaceutical specialists, and suggested opinions on the drug classification. Among 717 formulations, 651 drugs $(90.8\%)$ satisfied the basic conditions for the hospital pharmacy formulations. 312 formulations $(43.5\%)$ were classified as drugs for the disinfection and tests. For the rest of them, 231 formulations were classified as prescription drugs whereas 108 drugs were as non-prescription drugs. 56 non-prescription drugs were included as hospital formulations, because there were no therapeutic alternatives. Iu sum 599 drugs $(83.5\%)$ were suggested as hospital pharmacy formulations. The study also recommends pharmaceutical companies to produce drugs of limited commercial value, and doctors to change their unique prescribing behavior in order to prevent the abuse of hospital pharmacy formulations.

• CELLMED
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• v.7 no.2
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• pp.9.1-9.6
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• 2017

Recurrent Acute Pancreatitis/ Chronic Pancreatitis (RAP/ CP) is generally marked by sudden onset of symptoms like severe abdominal pain, vomiting and weight loss that needs emergency hospitalization. Owing to irreversible and progressive nature of the disease and limitations of conventional treatment, many patients look for an alternative solution. Here, we report data of 250 well diagnosed cases of acute recurring/ chronic pancreatitis, enrolled in between January 1997 to August 2016, in our Ayurvedic clinical practice in Northern part of India. Ayurveda is well recognized as an independent medical system parallel to conventional medicines in India and a subject is free to opt for any system of medicine for the prevention and treatment of any ailment. The subjects were treated with a complex herbo-mineral formulation based on the principles of Rasa Shastra in Ayurveda that deals with the therapeutics of processed metals in the prevention and treatment of diseases. They were also prescribed a regulated balanced diet and lifestyle. Significant improvement has been noted in subjects who have completed the treatment.