• 한국임상수의학회지
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• 제35권4호
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• pp.126-129
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• 2018

This study was performed to describe the outcome of pars plana retinopexy with perfluoro-n-octane (PFO)-silicone oil (SiO) exchange in dogs with rhegmatogenous retinal detachment in Seoul National University Veterinary Medical Teaching Hospital (SNU VMTH) from 2014 to 2017. Nine eyes of 8 dogs were included in this study. Medical records including signalment, history, duration from onset of blindness to surgical intervention, pre-operative findings, duration from surgery to regaining vision, and post-operative complications were evaluated. No eyes were visual before surgery. Duration from onset of blindness to surgical intervention was 2-30 days (median 8 days); duration from surgery to regain vision was 1-14 days (median 6 days); follow-up time was 15-1088 days (median 69 days). Post-operative complications were divided as temporary vs permanent conditions. Temporary complications were corneal ulcer, uveitis, retinal haemorrhage, glaucoma, subconjunctival leakage of SiO, and vitreal haemorrhage. Permanent complications were anterior chamber migration of SiO, retinal degeneration, corneal degeneration, re-detachment, and cataract. Six of 9 eyes regained functional vision, five of which remained visual throughout the follow-up time while the other one lost vision after 3 months because of uveitic glaucoma. In conclusion, pars plana retinopexy with PFO-SiO exchange provided fair outcome in 66.7% cases described in this study.

• 전자공학회논문지
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• 제50권12호
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• pp.292-305
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• 2013

EPCglobal에서는 국제 표준인 EPCglobal Network를 기반으로 RFID와 WSN 기술을 효율적으로 통합 및 연동할 수 있는 EPC 센서 네트워크를 제안하였으나 센서 데이터를 처리하는데 있어 반드시 EPC가 있어야 하며 센서 데이터만을 위한 관리 기능은 제공하지 못하는 문제점이 있다. 의료 환경에서 가장 중요한 것은 기존의 의료정보시스템과의 의료정보 전송 표준을 통한 연계 및 연동이 무엇보다 중요한다. 본 논문에서는 EPC 센서 네트워크의 문제점 및 의료 환경에서 사용할 수 있는 USN 관리 시스템을 제안한다. 제안하는 시스템은 의료 환경에 적합한 SIP-HL7 기반의 USN 관리 시스템으로, RFID와 WSN 데이터를 SIP(Session Initiation Protocol) 기반으로 전송할 수 있는 시스템을 제안한다. 또한 기존 병원정보시스템과 연동하여 정보를 교환함은 물론 의료정보를 공유하고 전송하기 위한 HL7 기반의 SIP 인터페이스를 설계 및 구현한다.

• 대한한의학원전학회지
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• 제22권3호
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• pp.271-289
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• 2009

This thesis intend to help the eastern medical doctor to understand body condition from interpretation of perspirations(汗出) in daily time cycle. The conclusion is followed. 1. In most Eastern Medical classic and clinic literatures, the time of fever and perspirations are described as a result of disease's position at human body. Following this description, in daytime the perspirations must come from the Gi phase and night time the perspirations must come from the blood phase. Because in daytime the skin pores are opening and the defensive Gi is going out to the superficial portion of the body. In night time the skin pores are shutting and the defensive Gi is going in to the five solid organs. So a sweat in daytime comes out from the Gi phase and superficial portion of the body. And in night time comes out from the blood phase and five solid organs. But in recent real clinic cases, in daytime, there are so many perspirations from the five solid organs. Comparatively, the perspirations from the superficial portion of body are very little. And in same daytime perspirations, when the heat pathogens mixed with moist, the symptom revelation time delay to the afternoon. Therefore it can be concluded that the time of perspirations are combination of disease's Gi or blood phase and characteristics of pathogens. The position of disease at human body cannot simply judge the symptom revelation time. 2. The exchange of climate following time cycle of a day effect to the condition of human body. At same time it activates or not activates the pathogens in human body. So we can consider the kinds and characteristics of pathogens by distinguishing the symptom revelation time. In general differentiation of syndromes[辨證] pathogen's kinds and location are generally judged. By understanding the characteristics of pathogen, doctor can devise more correct and delicate prescription.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.201-205
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• 1997

With the recent advance of Web and its associated technologies, information sharing on distribute computing environments has gained a great amount of attention from many researchers in many application areas, such as medicine, engineering, and business. One basic requirement of distributed medical consultation systems is that geographically dispersed, disparate participants are allowed to exchange information readily with each other. Such software also needs to be supported on a broad range of computer platforms to increase the software's accessibility. In this paper, the development of world-wide-web based medical consultation system or radiology imaging is addressed to provide the platform independence and great accessibility. The system supports sharing of 3-dimensional objects. We use VRML (Virtual Reality Modeling Language), which is the de-facto standard in 3-D modeling on the Web. 3-D objects are reconstructed from CT or MRI volume data using a VRML format, which can be viewed and manipulated easily in Web-browsers with a VRML plug-in. A Marching cubes method is used in the transformation of scanned volume data set to polygonal surfaces of VRML. A decimation algorithm is adopted to reduce the number of meshes in the resulting VRML file. 3-D volume data are often very large-sized, and hence loading the data on PC level computers requires a significant reduction of the size of the data, while minimizing the loss of the original shape information. This is also important to decrease network delays. A prototype system has been implemented (http://netopia.snu.ac.kr/-cyber/). and several sessions of experiments are carried out.

• 대한의용생체공학회:의공학회지
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• 제44권4호
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• pp.225-241
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• 2023

The study empirically analyzed the differences in industry distribution and innovation activity performance in the metropolitan and non-metropolitan areas of Korea's bio companies, which are highlighted as future growth engines. The main innovation activities of the bio industry, which are focused on science and technology and expressed with high uncertainty, were analyzed, centering on human resources, technology cooperation, and investment promotion. As a result of the analysis, the biomedical industry in the metropolitan area was found to have a high proportion, and bio foods, bio-based chemicals, and energy industries in the non-metropolitan area, respectively. Moreover, the innovation activity performances differed between the two regions. In particular, the notable characteristics included human resources, investment promotion, and technical cooperation with medical institutions in the metropolitan area with a high proportion of biomedical industries, and technology personnel exchange and cooperation with private research institutions in the non-metropolitan area, which has a high proportion of bio foods, bio-based chemicals, and energy industries. This study is significant in that it is the first study to compare and analyze the performance of innovative activities based on the distribution of industries in the bio-industry, focusing on human resources, technology cooperation, and investment promotion. In addition, after investigating the distribution status and competitiveness of the domestic bio-industry by region, it will analyze the status and characteristics of the domestic bio-industry and present policy implications to implement relevant promotion policy more efficiently.

• 예술인문사회 융합 멀티미디어 논문지
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• 제6권6호
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• pp.103-110
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• 2016

최근 의료데이터의 유출사고가 빈번히 발생하여 환자의 프라이버시 침해 및 의료기관의 피해가 날로 증가하고 있다. 정부에서는 개인정보보호법등과 같은 법규를 제정하여 이러한 피해사례 예방하고 있다. 이중 의료기관 및 의료데이타에 대한 가이드라인은 보건복지부에서 발표한 '국내 의료기관 개인정보보호 가이드라인' 정도만 발표되어 있다. 환자개인의 민감정보를 포함한 의료데이타를 타의료기관 또는 제3의 연구기관등에 전달이 필요한 경우가 발생한다. 전달하고자 하는 의료 이미지 데이터를 일반적인 이미지파일 (JPG, JPEG, TIFF)의 포맷으로 자료의 교환이 이루어지고 있다. 이와같이 일반적인 이미지 포맷의 파일은 아무런 보호조치가 되어 있지 않아 외부로 유출시에는 파일내에 포함된 환자의 주요 식별정보가 노출되는 위험성이 존재한다. 본 연구에서는 이미지 파일에 대한 광학문자판독기술(OCR)을 적용하고 민감정보가 포함된 이미지파일에 암호화된 모자이크기술을 이용한 마스킹 기법을 도입하여 이러한 위험성을 해결하기 위한 이미지 비식별화 방안을 제시한다.

• 대한영상의학회지
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• 제79권5호
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• pp.254-258
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• 2018

목적: 보건의료정보화를 위한 진료정보교류 기반 구축 및 활성화 과제의 일부인 의료영상정보교류의 효용성을 높이기 위한 영상 품질 기준 연구에서 유방 자기공명영상검사의 적절한 프로토콜을 정립한다. 대상과 방법: 문헌 및 참고자료를 통한 국내외 유방 자기공명영상검사의 권고 프로토콜과 판독문 형식을 조사하고, 책임연구자가 설문지를 작성한 후, 국내 9명의 유방영상의학 전문가를 섭외하여 패널을 구성하였다. 전문가 패널은 총 3차례의 델파이 합의를 진행하여 유방자기공명영상 프로토콜의 합의안을 도출하였다. 결과: 합의된 유방자기공명영상 권고 프로토콜은 1.5 테슬라 이상의 기기로 유방 전용 코일을 사용하여 복와위 자세에서 영상을 획득하며, T2 강조영상과 조영 전 T1 강조영상을 포함한다. 조영증강영상은 적어도 2차례 이상 획득하며, 60~120초 사이 영상과 4분 이후 영상을 포함한다. 또한 조영증강 T1 강조영상의 절편 두께는 3 mm 이하, 측면 해상력은 120초 이하, 공간 내 평면 해상도는 $1.5mm^2$ 이하여야 한다. 결론: 국내 유방영상전문가 집단의 3차례에 걸친 델파이 합의를 통하여 효율적인 유방 자기공명영상검사의 검사 프로토콜 권고안을 정립하였다.

• BMB Reports
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• 제40권5호
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• pp.731-739
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• 2007

The purpose of this study was to develop paclitaxel-loaded poly(lactide-co-glycolide) (PLGA) nanoparticles coated with cationic SM5-1 single-chain antibody (scFv) containing a polylysine (SMFv-polylys). SM5-1 scFv (SMFv) is derived from SM5-1 monoclonal antibody, which binds to a 230 kDa membrane protein specifically expressed on melanoma, hepatocellular carcinoma and breast cancer cells. SMFv-polylys was expressed in Escherichia coli and purified by cation-exchange chromatography. Purified SMFv-polylys was fixed to paclitaxel-loaded PLGA nanoparticles to form paclitaxel-loaded PLGA nanoparticles coated with SMFv-polylys (Ptx-NP-S). Ptx-NP-S was shown to retain the specific antigen-binding affinity of SMFv-polylys to SM5-1 binding protein-positive Ch-hep-3 cells. Finally, the cytotoxicity of Ptx-NP-S was evaluated by a non-radioactive cell proliferation assay. It was demonstrated that Ptx-NP-S had significantly enhanced in vitro cytotoxicity against Ch-hep-3 cells as compared with non-targeted paclitaxel-loaded PLGA nanoparticles. In conclusion, our results suggest that cationic SMFv-polylys has been successfully generated and may be used as targeted ligand for preparing cancer-targeted nanoparticles.

• 대한한의학원전학회지
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• 제3권
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• pp.444-500
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• 1989

I have felt seriously a desire to study and analyse the medicine of the period of the Three Kingdoms when I thought and studied the ancient medical history. Therefore in Chapter II I inquired into the background of Politico-social and the currency of thought. In the Chapter III inquired into the system of Medical politics in the period of the Three Kingdoms. In the Chapter IV inquired into the general view of the period of the Three Kingdoms. In the Chapter V inquired into the writings of Medicine and Doctors. From this study, I reached at following-conclusions. 1. The Three Kingdoms are politically opposed to each other, but socialo culturaly cooperated, connected each other to import the technique and thought which developed in China, so generally their system and life pattern are alike. 2. On the system of medical politcics Goguryeo(高句麗) had the system of court phisician, Baek jeo(百濟) had medical doctor and collector in the Ministry of Drug which took charge of teaching and medical treatment and specially had spellchanting doctor who treat epidermic and psychological diease untreated with herb and acupuncture, Shilla(新羅) had the system of Yak chun which was charge of teaching and treatment, and had the Chimbang(針房) which assist doctor in the system of Yagchun(藥典制度). 3. The medical interchange with China made the Three Kingdoms to import the medical books. So the theory of medicine was systematized and the art of treatment developed. In the aspect of Herb the Three Kingdoms and China actively exchange their own district product. 4. The medicine of Three Kingdoms accommodated Yin Yang Ohang theory(陰陽五行說), the theory of body compose with four element(四大 : 地水火風) and the theory of life cultivation and breathing(導引養生說) with Therefore in many aspect of oriental medicine basic theory and treatment would improved. 5. The epidermic diease occurred in period of Three Kingdoms, is represented Yeok(疫), that is after all Ohn Diease(溫病), and epidermic diease, is relfected by earthquake, heavy rain, terrible droughty and eclipse of sun. The treatment of this diease did not developed in that time, we presume that there are many persons killed. 6. As the record of five starr(五星), comet(彗星) and eclipse of sun was showed, the astronomy of oriental medicine in the Three Kingdoms was high level and it became the mothers womb of Korean astronomy. 7. The medicine of the Three Kingdoms, concreted with Chinese medicine and their own ancient one, was reflect on Japanese medicine to improve the medical theory and treatment. 8. The Three Kingdoms peculiarly published Korea Nosabang(高麗老師方) Baekjyeo Shinjipbang(百濟新集方), so this independent medicine reflected on the development of natural hurb(鄕約) of the period of Korea(高麗).

• 대한예방한의학회지
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• 제9권2호
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• pp.77-91
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• 2005

The purpose of this study is to examine the recognition of the student of oriental medical school on cooperative system between Oriental and Western medicine and to provide basic information for the development of oriental medicine. In order to look at the level of recognition on cooperative system between Oriental and Western medicine, from September 1st to 15th of 2005, this study had been conducted through personal interview and questionnaires to 600 students who were attending the Department of Oriental Medicine (in both prep and regular courses) in D University, located in the City of Daegu. The data has been analyzed using statistic program, the SPSS WIN 12.0. Statistical analysis tools used for this study were frequency analysis, cross-over analysis and the t-test. The results are as follows; The students of oriental medical school had relatively high level of recognition on the basic concept, interests, necessity and potential for cooperative system between Oriental and Western medicine. However, they had negative understandings on the issue of unification of the two medical systems and it's possibility in the future. The students were optimistic about possible merits of cooperative system between Oriental and Western medicine, especially in the field of rehabilitation. On the reasons for lack of development of cooperative system between Oriental and Western medicine, the students listed prejudices existing on both sides firstly, followed by their contrasting approach on human illness, lack of legal and institutional support system, the indifferences of doctors and indifferences of oriental medical doctors. In addition, students understood that the dualism existing in our current medical system is aggravating mutual distrust between the two sides, causing the confusion of patients on the choice of medical facilities, and raising their medical bills. Therefore, in order to vitalize collaboration between Oriental and Western medicine in new health care environment, the following measures should be needed decreasing the prejudices between the two medical spheres with open mind improving educational programs in Western and Oriental medical schools; promoting joint academic research or exchange programs between the schools, and increasing government effort to minimize legal and institutional restrictions cooperative system between Oriental and Western medicine.