• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2437-2444
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• 2012

Tumor metastasis remains the principal cause of treatment failure and poor prognosis in patients with colorectal cancer. It is a multistage process which includes proteolysis, motility and migration of cells, proliferation in a new site, and neoangiogenesis. A crucial step in the process of intra- and extra-vasation is the activation of proteolytic enzymes capable of degrading the extracellular matrix (ECM). In this stage, urokinase plasminogen activator receptor (uPAR) and matrix metalloproteinases (MMPs) are necessary. Micrometastases need the presence of growth factor and vascular growth factor so that they can form macrometastasis. In addition, cell adhesion molecules (CAMs) and guanine nucleotide exchange factors (GEFs) play important roles in the progression of colorectal cancer and metastatic migration. Further elucidation of the mechanisms of how these molecules contribute will aid in the identification of diagnostic and prognostic markers as well as therapeutic targets for patients with colorectal metastasis.

• Journal of International Society for Simulation Surgery
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• 제4권1호
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• pp.17-20
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• 2017

Purpose Interactive 3D visualization system through remote data transmission over heterogeneous network is growing due to the improvement of internet based real time streaming technology. Materials and Methods The current internet's IP layer has several weaknesses against IP spoofing or IP sniffing type of network attacks since it was developed for reliable packet exchange. In order to compensate the security issues with normal IP layer, we designed a remote medical visualization system, based on Virtual Private Network. Results Particularly in hospital, if there are many surgeons that need to receive the streaming information, too much load on the gateway can results in deficit of processing power and cause the delay. Conclusion End to end security through the network method would be required.

• 대한의용생체공학회:의공학회지
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• 제26권6호
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• pp.407-412
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• 2005

Convenience is one of the most important factors in medical image segmentation. Convenience is defined by compiling opinions from radiologists, and can be described as controllable maximum automation on the condition of producing only accurate results. The components of convenience are inclusive automation and inclusive modification. Inclusive modification consists of verify-and-confirm, undo-redo, exchange of segmentation methods, and intelligent modification tools. Inclusive automation is composed of automatic selection of a method, automatic selection of a confident segment, and automated chores. The convenient segmentation tool has been developed to segment X-ray images for orthopedic surgery, and has received an excellent evaluation from radiologists.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2016년도 제53차 동계학술대회논문집 24권1호
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• pp.335-336
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• 2016

본 논문에서는 다중 의료장비의 신호를 전송할 수 있는 MDEC과 연동성이 있는 CMS를 개발한다. 주요장비는 환자 감시를 위한 M20과 진단용 심전계 장비인 E40이 대상이 된다. 본 도구는 MDEC의 실효성을 입증하고 환자의 상태를 중앙 집중식으로 모니터링하기 위한 목적으로 개발한다. 먼저, CMS의 기능 구성을 정의하고 MDEC과의 연동성을 위한 프로토콜 정의를 통하여 실제 모니터링 도구를 개발하였다. 향후, 개발된 도구는 CMCIS(Central Monitoring and Cardiology Information System) 기반의 통합 시스템에 적용할 계획이다.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.418.2-418.2
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• 2002

With the Sunshine policy. exchange of goods and cultures inter Koreas is broaden and expectancy of reunification is getting higher. Especially. medical supplies and medicines is one of the biggest parts in the exchanges. So. need for preparing new medical administration system for reunification is needed. We are going to compare inter Koreas drug administration system in medical services. (omitted)

• 인터넷정보학회논문지
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• 제15권3호
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• pp.21-30
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• 2014

고혈압은 전 세계의 심혈관 및 뇌혈관 질환의 중요한 사망 원인으로서 지속적인 혈압관리가 필요하다. 본 연구에서는 급성장하고 있는 모바일 헬스케어 환경에서 지속적으로 혈압 관리를 받을 수 있는 생체정보 교환 서비스 모델로서 HL7 FHIR을 선택하였다. 개발한 HL7 FHIR 프레임워크는 매니저(스마트폰)과 에이전트(혈압계) 간에 블루투스 헬스기기 프로파일과 통하여 IEEE 11073-10407 PHD 프로토콜로 통신하여 혈압정보를 획득한다. 테스트 결과 고혈압 환자의 혈압 모니터링, 측정기록관리, 문서 생성, 측정정보전송을 성공적으로 수행하였다. 실제 임상환경에서는 TCP/IP 프로토콜을 통해 측정정보를 전송할 수 있으므로 모바일 헬스케어에서 지속적인 연구와 활성화가 기대된다.

• 대한임상독성학회지
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• 제14권2호
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• pp.144-150
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• 2016

Purpose: Glyphosate is a widely used non-selective herbicide. Previous studies have shown that glyphosate has genotoxicity, and that even low-doses of glyphosate can cause DNA damage. Melatonin is a hormone produced and secreted by the pineal gland that is known to be a potent anti-carcinogen, anti-oxidant, and genetic protector. This study was conducted to investigate the genoprotective effect of melatonin against glyphosate in human blood lymphocytes. Methods: Human peripheral blood was obtained from 15 young, healthy volunteers and cultured under four different toxicologic conditions. The four groups consisted of a control group, glyphosate only group (300 ng/mL), glyphosate with low level of melatonin group ($50{\mu}M$), and glyphosate with high level of melatonin group ($200{\mu}M$). The mean Sister Chromatid Exchange (SCE) frequency of each group was then analyzed. Results: Glyphosate exposed groups had a higher mean SCE frequency ($10.33{\pm}2.50$) than the control group ($6.78{\pm}2.31$, p<0.001). Interestingly, the group that received a low-level of melatonin had a lower mean SCE frequency ($8.67{\pm}2.58$) than the glyphosate-only group, while the group that received a high level of melatonin had a much lower mean SCE frequency ($8.06{\pm}2.50$) than the glyphosate-only group. There was statistical significance. Conclusion: Melatonin exerted a potent gene protective effect against the genotoxicity of glyphosate on human blood lymphocytes in a dose-dependent fashion.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제4권7호
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• pp.277-282
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• 2015

건강정보의 교환, 통합, 공유, 검색의 표준을 개발하는 Health Level Seven(HL7)에서 발표된 표준들은 글로벌한 의료정보 서비스에 성공적으로 사용되고 있다. 그러나 V2.x Message와 V3 Clinical Document Architecture(CDA)는 습득하고 개발하는 데 많은 시간이 소요되는 문제점이 있다. 개선된 Fast Healthcare Interoperability Resources(FHIR)를 사용함으로써 이러한 문제점을 해결할 수 있는 방법인지 모색한다. 개인건강기록이 사회적인 관심을 끌고 있고, 스마트폰 보급률이 급격히 증가하는 점을 반영하여 스마트폰으로 접속 가능한 개인건강기록 프로파일링 시스템을 개발한다. Furore에서 개발한 FHIR Profile editor tools을 통해 profile의 생성, 변경의 개선점을 찾아본다. 이와 같은 시스템을 구축하기 위해서 Electronic Medical Record(EMR) 시스템과 Personal Healthcare Record(PHR) 시스템 간의 정보교류를 FHIR Open API로 구성한다. PHR 프로파일링 시스템에서는 이들 트랜잭션을 RESTful 서비스로 제공한다. 본 연구에서는 FHIR를 통해 PHR 프로파일링 시스템 개발의 효율성을 검증한다.

• Clinical and Experimental Pediatrics
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• 제60권4호
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• pp.106-111
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• 2017

Purpose: This study aimed to determine the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among infants with neonatal indirect hyperbilirubinemia (NIH); compare G6PD-deficient and G6PD-normal patients regarding hyperbilirubinemia and need for exchange transfusions (ET); and assess risk factors for ET and kernicterus. Methods: This is a case-control retrospective study. Medical records of NIH patients admitted to the Pediatric Department, Salmaniya Medical Complex, Bahrain, between January 2007 and June 2010 were reviewed. Data on sex, age at presentation, hospitalization duration, need for ET, hemoglobin (Hb) level, reticulocyte count, direct Coombs test, serum total and indirect bilirubin levels, thyroid function, blood and urine cultures, G6PD status, and blood groups were collected and compared between the G6PD-deficent and G6PD-normal patients. Results: Of 1,159 NIH patients admitted, 1,129 were included, of whom 646 (57%) were male. Among 1,046 patients tested, 442 (42%) were G6PD deficient, 49 (4%) needed ET, and 11 (1%) had suspected Kernicterus. The G6PD-deficient patients were mainly male (P<0.0001), and had lower Hb levels (P<0.0001) and higher maximum bilirubin levels (P=0.001). More G6PD-deficient patients needed ET (P<0.0001). G6PD deficiency (P=0.006), lower Hb level (P=0.002), lower hematocrit count (P=0.02), higher bilirubin level (P<0.0001), higher maximal bilirubin level (P<0.0001), and positive blood culture result (P<0.0001) were significant risk factors for ET. Maximal bilirubin level was a significant risk factor for kernicterus (P=0.021) and independently related to ET (P=0.03). Conclusion: G6PD deficiency is an important risk factor for severe NIH. In G6PD-deficent neonates, management of NIH should be hastened to avoid irreversible neurological complications.

• 융합신호처리학회논문지
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• 제10권3호
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• pp.181-185
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• 2009

Recently, much attention to a self-organizing mobile ad-hoc network is escalating along with progressive deployment of wireless networks in our everyday life. Being readily deployable, the MANET (mobile ad hoc network) can find its applications to emergency medical service, customized calling service, group-based communications, and military purposes. In this paper we investigate a time slot exchange problem found in the time slot based MAC, that is designed for IEEE 802.11b interfaces composing a MANET. The paper provides a method to maintain the quality of voice call by providing a new time slot when the channel assigned for that time slot gets noisy with interferences induced from other nodes, which belong to the same and/or other subgroups. In order to assess the performance of the proposed algorithm, a set of simulations using the OPNET modeler has been performed assuming that the IEEE 802.11b interfaces are operating under a modified MAC, which is a time slot based reservation MAC implemented in the PCF part of the superframe. In a real-time voice call service over a MANET of a size 500 ${\times}$ 500 meter squares with the number of nodes up to 100, the simulation results are collected and analyzed with respect to the packet loss rate and packet delay. The results show us that the proposed time slot exchange protocol improves the quality of voice call over that of plain DCF.