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http://dx.doi.org/10.7314/APJCP.2012.13.6.2437

Metastasis-associated Factors Facilitating the Progression of Colorectal Cancer  

Zhang, Yao-Yao (Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University)
Chen, Bin (Department of Oncology, General Hospital of Guangzhou Military Command of PLA)
Ding, Yan-Qing (Department of Pathology, School of Basic Medical Sciences, Southern Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.6, 2012 , pp. 2437-2444 More about this Journal
Abstract
Tumor metastasis remains the principal cause of treatment failure and poor prognosis in patients with colorectal cancer. It is a multistage process which includes proteolysis, motility and migration of cells, proliferation in a new site, and neoangiogenesis. A crucial step in the process of intra- and extra-vasation is the activation of proteolytic enzymes capable of degrading the extracellular matrix (ECM). In this stage, urokinase plasminogen activator receptor (uPAR) and matrix metalloproteinases (MMPs) are necessary. Micrometastases need the presence of growth factor and vascular growth factor so that they can form macrometastasis. In addition, cell adhesion molecules (CAMs) and guanine nucleotide exchange factors (GEFs) play important roles in the progression of colorectal cancer and metastatic migration. Further elucidation of the mechanisms of how these molecules contribute will aid in the identification of diagnostic and prognostic markers as well as therapeutic targets for patients with colorectal metastasis.
Keywords
Adhesion molecules; proteolysis; angiogenesis; growth factor; metastasis; colorectal cancer;
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