• 대한기관윤리심의기구협의회지
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• 제1권2호
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• pp.30-42
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• 2019

In pharmaceutical clinical trials as human material research, the collection, use, storage and provision of human materials must be in accordance with the criteria stipulated in 「Bioethics and Safety Act」, except in the case that some criteria about it is in the law related to clinical trials such as 「Pharmaceutical Affairs Act」 and 「Enforcement Rule on Safety of Drugs, etc.」 so these take precedence over. Under 「Bioethics and Safety Act」, the core aspect of the legal standard for obtaining informed consent is the use of statutory form . The use of statutory form ensure that both those who obtain informed consent and those who give it can know the contents contained this form as well as recognize its importance. Thus, the person who has the right to informed consent can sign the statutory form after correct understanding of the contents. In reality, however, some researchers and IRB members determine that only the main informed consent form is to be used because most of contents on statutory from are included in the main informed consent form. Some other researchers and IRB members judge that the use of statutory form is not needed if human materials may only be used for laboratory testing and the rest will not be stored and provided for future use. Most of these determination and judgement is based on the interpretation of the Korea National Institute for Bioethics Policy(hereafter, KoNIBP) on IRB Information Portal Site. But, it is questionable whether the KoNIBP's interpretation is legally valid and the KoNIBP is the legal entity having authority to interpret existing statute. In some cased not only using the main informed consent form including enough information about the collection, use, storage and provision of human materials but also collecting necessary minimum human materials, and discarding the rest, unusing the statutory form may not cause the problem to respect and protect the research participant's rights. Therefore, the provision stipulating the criteria about the use of statutory form as the legal standard of obtaining informed consent that applies all human material research without exception should review to revise. At least, straighten out the confusion surrounding whether or not the statutory form is to be used, before the revision of related provision, considering the logical opinions of some researchers and IRB Members, the Ministry of Health and Welfare as the legal entity having authority to interpret existing statute should represent its opinion about permission of the acceptable exceptions.

• 한국유가공학회:학술대회논문집
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• 한국유가공기술과학회 2004년도 제58회 춘계유가공심포지움 - 세계 우유의 날 기념 국제 심포지움
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• pp.21-39
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• 2004

Fermented milks have been recognized as healthy foods since ancient times, but those using intestinal bacteria such as Bifidobacterium and lactic acid bacteria (LAB) are even more valuable from the standpoint of view of maintaining health. They have also now come to be recognized as important in the field of preventive medicine. Although advances in the medical sciences in the last 50 years have significantly increased the human lift span, an unfortunate fact is that many of us are now living long enough to experience chronic disorders such as coronary heart disease, hypertension, osteoporosis, diabetes and cancer. In recent years there has been renewed interest in health promotion and disease prevention by incorporating probiotic bacteria into foods to counteract harmful bacteria in the intestinal tract. Therefore, there are now a wide variety of commercial products containing prospective probiotics that claim health-promoting effects, such reductions in large botvel carcinogens and mutagens, antitumor properties, cholesterol-lowering effects, increased lactose digestion, relief from con-stipation, stimulation of immunocomponent cells and enhancement of phagocytosis. Two well-known representative probiotic is LAB and Bifidobaclerium. Traditional probiotic dairy strains of LAB which have been designated as GRAS (Generally Recognized As Safe) bacteria have a long history of safe use and most strains are considered comestible microorganisms with no pathogenic potential. Accordingly, there is considerable interest in extending the range of foods containing probiotic organisms from dairy foods to infant formulas, baby foods, and pharmaceuticals. In addition, the ingestion of probiotics, prebiotics, and symbiotic as wll as combinations of pro- and prebiotics has recently aroused renewed interest as enhancing the beneficial relationship between the host and intestinal microflora in both healthy and diseased indivisuals. Non-communicable chronic diseases such as cancer, cerebral hemorrhage, is chemic heart disease, and diabetes mellitus has recently been recognized as adult diseases in Japan as well as other countries. and are considered to be inevitably associated with aging. These diseases occur as a result of individual life styles. The Japanes Government. Ministry of Health, Labor and Welfare has proposed substituting the term 'adult diseases' with 'lifestyle-related diseases'. It has emphasized the importance of prevention rather than treatment. since the well-known increase in the elderly population in Japan is predicted to result in a variety of socioeconomic problems. n this lecture on the Present status of fermented milk products in Japan, I will report a strategy for the development of fermented milk products in Japan from the standpoint of view of research in Japan on LAB and Bifidobacteria. They could play an important role in preserving human health by controlling intestinal microflora capable of producing toxic effects on the host.

• Journal of Nutrition and Health
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• 제55권3호
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• pp.390-405
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• 2022

충북지역 65세 이상 노인들의 조리실습을 병행한 영양교육의 효과를 연구한 결과에서 위생, 식습관, 영양지식, 만족도 모든 항목에서 1, 2차연구에 지속적으로 참여한 지역 (괴산, 보은, 진천)이 위생, 식습관, 영양지식, 만족도 점수 모두 유의적 (p < 0.001)으로 높은 것으로 나타났다. 고령사회에서 65세 이상 인구가 20%이상인 초고령 사회로 빠르게 진입하고 있는 우리나라 농촌지역에서는 고령층의 식생활 향상을 통한 건강증진 및 질병예방을 위한 효과적인 영양교육이 필수적이라 사료된다.

• 대한물리치료과학회지
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• 제5권1호
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• pp.549-556
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• 1998

To survey the recognition of Community Based Rehabilitation(CBR) by Public Health Center(PHC) Physical Therapists in Seoul Province. This study analysed general characteristic of Physical Therapists and cognition, participation, education, problems and requirements for CBR. The subjects of this study were 31 therapists who work at PHC in Seoul Province and Seoul City Childerns Municipal Hospital. Data was collected for 18 days from April 13 to 31, 1998 and results computed from 25 responses. First, Female therapists outnumber males. The age category 30 to 35 old represented 44.0% of the total number studied. 48.0% of therapists had worked more than 7 years and therapists usually 84.0% worked from 3 to 4 years at the PHC. Junior colleage graduates were 72.0%, and respondents with family responsibility were 52.0%. Second, Recently pain control and therapeutic exercises has become the major requirement of patients at PHC(56.0%). If the offered expanded services, a rehabilitation programe at PHC(36.0%) was highly. When asked about a working guide book, nobody had one. Third, 64.0% of therapists were aware of the present level of CBR, 28.0% of them had gotten an information from newspaper and mass media. Fourth, For CBR, 72.0% had positive ideas in which they could participate. 56.0% wished to compose a team of various rehabilitation specialists. 52.0% wished for the meeting day to be flexible and 64.0% desired to meet once or twice a week. Fifth, Almost all(92.0%) desired more educational opportunity about CBR. Example, once or twice a year(48.0%) and training period of 4 to 7 day(44.0%). They wanted to learn theory and parctice together(88.0%) and 48.0% wanted national mutirehabilitation center as a educational managing organization. Sixth, The most important requirement for accomplishing CBR by Physical Therapists was job security and adequate number of therapists(48.0%). Required number of physical therapists in the PHC was 3(52.0%). The cooperative agency should be the distict govement(32.0%) and community welfare center of the disabled persons(32.0%). Factors inhibiting the execution of CBR were lack of physical therapists(56.0%), and equipments for pain control and for therapeutic exercises(68.0%).

• 보건행정학회지
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• 제24권1호
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• pp.56-70
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• 2014

Background: Korea shows rapid population aging and increase in healthcare service use and expenditure. Also, this would be accelerated because of the baby boomers who will be 65 years old and more in 2020. Chronic disease is another reason that increases the use of healthcare service and expenditure of the middle- and old-aged households. Catastrophic health expenditure (CHE) is the index which can indicate the households' burden of health spending. Despite the importance, there are few studies on CHE of middle- and old-aged households and especially no panel study yet. This is the reason that this study is carried out. Methods: This study used 3-year data from the Korea Welfare Panel Study conducted from 2009 to 2011. We defined CHE if a household's health expenditure is equal or greater than the threshold value if income remaining after subsistence needs has been met. We used 4 different threshold values which are 10%, 20%, 30%, and 40%. In order to look at the households which experienced CHE, we conducted panel logit analysis after correspondence analysis and conditional transition probability analysis. Results: This study showed three notable results. First, there has been a difference among age groups, which implies that the older people are, the more easily they can experience CHE. Second, the households with no private insurance are shown to have a higher CHE occurrence rate. Lastly, there has been a significant difference among the kinds of chronic diseases. The households which have cancer, cerebrovascular disease, and heart disease have a higher CHE occurrence rate. However, the households with diabetes have no significant effects to CHE occurrence. Also, hypertension has a negative effect to the occurrence. Conclusion: With the results, it can be implied that elderly people with chronic disease are more needed in medical coverage and healthcare. Also, private insurance can play its role in protecting households from CHE. Therefore, it needs to conduct studies on CHE especially about different age groups, private insurance, and chronic disease.

• 인간행동과 음악연구
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• 제13권1호
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• pp.19-40
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• 2016

본 연구의 목적은 보건복지부에 의해 지정된 54개 호스피스 완화의료 기관에서 시행되고 있는 음악치료에 대한 수치 기반의 현황 자료를 제공하는 것이다. 54개 기관의 코디네이터에게 E-mail로 설문지를 발송하여 총 47개 기관(87%)의 음악치료사와 코디네이터로부터 E-mail과 우편으로 회신을 받았다. 조사기간은 2014년 10월 30일부터 12월 5일까지였으며, 음악치료사 대상 설문지는 근무조건/처우, 음악치료 환경, 진행 및 개인역량 등 총 65문항으로 구성하였다. 코디네이터 대상 설문지는 각 기관의 음악치료 시행 여부 및 코디네이터의 관점에서 바라 본 음악치료의 현황과 개인정보 등 총 28문항으로 구성하였다. 설문에 응답한 47개 기관 중 음악치료 시행 기관은 22개 기관(46.8%)이었으며, 음악치료사 28명 가운데, 음악치료를 전공한 음악치료사는 19명(67.9%)인 것으로 파악되었다. 세션 준비, 수행, 평가와 관련해 음악치료를 진행하기에 적합한 환경이 갖추어져 있는지를 묻는 문항에 대해 음악치료사(M = 3.43, SD = 0.96)와 코디네이터(M = 2.73, SD = 0.77)의 응답 간에 유의한 차이가 있는 것으로 나타났다(p < .05). 국내 호스피스 완화의료에서의 음악치료는 현재 시행 기관이 많지 않고 환경이 열악하지만, 음악치료에 대한 인식 결과를 볼 때 향후 호스피스 완화의료에서 보다 중요한 역할을 할 것으로 예상된다. 본 연구의 결과는 한국 호스피스 완화의료 기관에서의 음악치료 현황에 대한 최초의 정량적, 통계적 기초자료로서 의의가 있다.

• 융합정보논문지
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• 제11권7호
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• pp.181-188
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• 2021

본 연구는 중소병원들이 지속적으로 안정성과 효과성을 유지할 수 있는 전략방안의 검토를 위하여 전문병원에 대한 기대수준 대비 이용 후 지각 만족도와 기대요소 간의 관계를 살펴보았다. 연구방법은 20세 이상의 부산 및 경남 거주자를 대상으로 구조화된 설문지를 이용하여, 카이제곱 검정, 로지스틱 회귀분석을 실시하였다. 연구결과, 첫째, 응답자의 68.0%가 특성화를 표방하는 병원을 전문병원으로 인식하였고, 보건복지부 지정병원이라 인식한 응답자는 21.3%로 확인되었다. 둘째, 주관적으로 인식하는 전문병원 이용 경험이 있는 경우에는 대부분의 이용자들이 기대수준 대비 지각하는 만족도가 충족되었으며, 이용했던 병원을 계속 이용 할 의사가 있는 것으로 확인되었다. 셋째, 기대수준 대비 이용 후 지각 만족도에는 치료에 대한 안전성과 치료의 질적 수준이 유의하게 영향을 미치는 인과관계가 있음을 확인하였다. 이 결과는 의료소비자들의 지각 만족도 향상과 감정적 애착 관리를 통한 장기적이고 지속적인 효과를 위한 전략 수립에 유용한 정보로 활용될 수 있을 것으로 사료된다.

• 한국임상수의학회지
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• 제30권6호
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• pp.459-463
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• 2013

본 연구는 Lactobacillus plantarum (L. plantarum)과 Bacillus subtilis (B. subtilis)의 합제 (LB)를 이유자돈에 경구 투여하여, 면역반응, 설사발생 그리고 분변 중 균수변화 등에 미치는 효과를 평가하기 위해 수행하였다. 28일령의 이유자돈 100두를 대상으로 군 당 20두씩 5개 군 (NC, 항생제와 LB 무투여; PC, 0.03% chlortetracycline 투여; LB 1, LB 0.5 kg/ton feed; LB 2, LB 1.0 kg/ton feed; LB 3, LB 2.0 kg/ton feed)으로 나누어, 4주 동안 LB를 투여하면서, 1주일 간격으로 분변지수를 산출하여 군별로 기록하였으며, 투여 종료 후, 혈액 및 분변을 채취하여, 혈액시료로부터 IgG와 IFN-${\gamma}$를 분석하였고, 분변시료로부터 lactic acid bacteria (LAB)와 Enterobacteriaceae (ENT)의 수를 확인하였다. LB 투약 2주째부터, LB 2와 LB 3의 설사지수는 NC에 비해 통계적으로 유의성 있게 감소하였으며 (P<0.05), IgG와 IFN-${\gamma}$의 농도도 NC에 비해 통계적으로 유의성 있게 증가하였다(P<0.05). 또한, LB 2와 LB 3의 LAB와 ENT 수는 NC과 PC에 비해 통계적으로 유의성 있게 변화하는 결과를 나타내었다(P<0.05). 이상의 결과로부터, LB는 강력한 항생제 대체제로서 자돈 설사예방에 사용될 수 있을 것으로 사료된다.

• 가정과삶의질연구
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• 제27권1호
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• pp.73-88
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• 2009

The purpose of this study was to investigate the influence of the factors such as self-esteem, social supports, socio-economic status of parents, degree of disability in child, stress coping, religion, and sports.exercise on the qualities of lives in mothers with disabled children. Data were collect from 45 institutions(schools from kindergarten to senior-high, special education institutes, and social welfare institutions) by self-report questionnaire, and the subjects of the study were 386 mothers in Seoul whose children were attending the schools or institutions. Findings according to socio-demographic variables are as follows: 1. Mothers with disabled children in this study thought their quality of life as average degree. 2. The younger the mothers and children, the higher the quality of life was. 3. The higher the educational level and monthly income, the higher the quality of life was. 4. There was no statistically significant difference between the existence and nonexistence of spouse, and between the existence and nonexistence of religion as well. Findings analyzed by multiple regression are as follows: 1. Among 7 independent variables 'self-esteem'(${\beta}$=.49, p<.001), 'social supports'(${\beta}$=.15, p<.01), and 'socio-economic status'(${\beta}$=.11, p<.05) were found to be statistically significant in quality of life in mothers, while the rests were found not significant. 2. 'Self-esteem' was found to be the most influencing variable, meaning that the psychological factor such as self-esteem is more important than environmental factors in qualities of lives in mothers. 3. The total amount of explanation of the model was Adjusted R square=.301, so that it can be said about 30% can be explained among total variance of the qualities of lives in mothers with disabled children. Conclusions and recommendations based on the results above are: First, it is strongly recommended to conduct programs promoting self-esteem in mothers with disabled children, and to include 'self-esteem' hereafter in the studies related to qualities of lives in mothers with disabled children. Second, comprehensive and practical countermeasures should to be formulated to back up expenses for education and medical care, purchasing relative tools and equipments, plus helping to find jobs.

• Journal of Periodontal and Implant Science
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• 제31권3호
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• pp.565-571
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• 2001

The purpose of this study is to determine if a relationship exists among osteoporosis, alveolar bone density and periodontal disease in postmenopausal osteoporotic women and postmenopausal healthy women. Twenty-two women were evaluated for this study. They were attending the postmenopausal clinic, Seoul National University Hospital and generally healthy except osteoporosis. They had experienced menopause not less than one year when we began to examine them. Bone densities of lumbar area(L2-L4) was determined by DEXA(LUNAR-expert Co,. U.S.A). We diagnosed osteoporosis when T-score was below -2.5 and healthy state when T-score was over -1. Osteoporotic(10 female), not hormone-treated group and healthy control group(12 female) were asked for their age, menopausal age, menopausal period and the number of remaining teeth and examined clinically for plaque index(PI), gingival index(GI), clinical attachment loss(CAL) on their 6 Ramfjord index teeth. Intraoral radiographs were taken in maxillary anterior zone. All films were equally exposed and developed. Each films was digitized and analysed using image processing software, Scion image. Alveolar bone regions of interest were selected and Intensity of each pixel was quantized in the array ranging from 0(white) to 255(black). The two groups were comparable with respect age, menopausal age, menopausal period and number of remaining teeth. The osteoporotic women had significantly lower alveolar bone density than controls in maxilla. But no significant difference was found with respect clinical attachment loss, plaque index and gingival index. Supported by the Ministry of Public Health and Welfare, Korea (HMP-00-CH-10-0009).