• Korean Journal of Culture and Social Issue
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• v.22 no.1
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• pp.19-39
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• 2016

Though research has shown that public transportation drivers experience greater burnout than other drivers, the sources of their burnout and possible mediators remain largely unknown. In response, in this study we investigate the relationships among sensation seeking, Type A driving behavior, and meaning of work to elucidate the burnout experienced by bus drivers in Gyeonggi-do, South Korea. To collect data regarding these relationships, 188 bus drivers answered a questionnaire involving the sensation seeking scale, burnout scale, and meaning of work scale. Results showed that Type A driving behavior mediated the relationship between sensation seeking and burnout, while meaning of work moderated the mediated model. These findings demonstrate that sensation-seeking bus drivers tend to experience greater burnout given their tendency to exhibit Type A driving behavior, and this relationship depends on perceived meaning of work. This study therefore contributes meaningful information and outlines significant implications in understanding drivers' burnout.

• BMB Reports
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• v.56 no.6
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• pp.359-364
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• 2023

KAI1/CD82, a membrane tetraspanin protein, can prevent various cancers and retinal disorders through its anti-angiogenic and anti-metastatic capacity. However, little is known about its anti-inflammatory effect and molecular mechanism. Therefore, the present study aimed to inLPSvestigate effect of a recombinant protein of the large extracellular domain of human KAI1 (Gly 111-Leu 228, rhKAI1) on lipopolysaccharides (LPS)-stimulated RAW264.7 macrophage-like cells and mouse bone marrow-derived macrophages (BMDM) and to identify its underlying mechanism. Our data showed that rhKAI1 suppressed expression levels of classically macrophages (M1) phenotype-related surface markers F4/80+CD86+ in LPS-stimulated BMDM and RAW264.7 cells. In addition, LPS markedly increased mRNA expression and release levels of pro-inflammatory cytokines and mediators such as interleukin (IL)-1β, IL-6, tumor necrosis factor-α, cyclooxygenase-2, nitric oxide and prostaglandin E2, whereas these increases were substantially down-regulated by rhKAI1. Furthermore, LPS strongly increased expression of NF-κB p65 in the nuclei and phosphorylation of ERK, JNK, and p38 MAPK. However, nuclear translocation of NF-κB p65 and phosphorylation of JNK were greatly reversed in the presence of rhKAI1. Especially, rhKAI1 markedly suppressed expression of toll-like receptor (TLR4) and prevented binding of LPS with TLR4 through molecular docking predict analysis. Importantly, Glu 214 of rhKAI1 residue strongly interacted with Lys 360 of TLR4 residue, with a binding distance of 2.9 Å. Taken together, these findings suggest that rhKAI1 has an anti-inflammatory effect on LPS-polarized macrophages by interacting with TLR4 and down-regulating the JNK/NF-κB signaling pathway.

• Journal of Nutrition and Health
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• v.56 no.3
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• pp.231-246
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• 2023

Purpose: The aim of this study was to investigate the anti-osteoarthritic effect of the ethanol extract of Boswellia serrata gum resin (FJH-UBS) enriched with keto-β-boswellic acid and 3-O-acetyl-11-keto-β-boswellic acid compared to the conventional Boswellia serrata extract by adding the process of removing oil with hexane, in the monosodium iodoacetate (MIA)-induced osteoarthritis rat model. Methods: Sprague-Dawley (SD) rats were orally administered 0, 40, or 80 mg of FJH-UBS/kg body weight (BW)/day for 5 weeks and injected with MIA intra-articularly into right knee joints on day 15 to induce osteoarthritis. Changes in the knee joint microarchitecture, cartilage degradation, the expression of inflammatory mediators, cytokines, and matrix metalloproteinases (MMPs) in serum and synovia were observed. Results: Oral administration of FJH-UBS (80 mg/kg BW/day) reduced MIA-induced knee swelling and cartilage degradation and increased the expression of type II collagen and aggrecan in articular cartilage. Furthermore, FJH-UBS administration reduced MIA-induced increases in the serum levels of prostaglandin E2, leukotriene B4, interleukin (IL)-1β, IL-6, and MMP-13, and MIA-induced increases in the mRNA expressions of inducible nitric oxide synthase, cyclooxygenase-2, 5-lipoxygenase, IL-1β, IL-6, TNF-α, MMP-2, MMP-9, and MMP-13 in the synovia of knee joints. Conclusion: These results indicate that FJH-UBS exerts its anti-osteoarthritic effects by suppressing the expressions of inflammatory cytokines and MMPs and, thus, cartilage degradation. Furthermore, they suggest that FJH-UBS has potential use as a functional food that improves joint and cartilage health.

• Korean Journal of Social Welfare Studies
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• v.41 no.3
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• pp.29-56
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• 2010

One of the most popular keywords in 21th century is "Information Society". Information Society improves the overall quality of human life, but increases the negative aspects such as internet addiction and digital divide. The purpose of this study is to understand the vicious cycle between socio-economic disparities and digital divide. This study analyzed the effects of poverty on school maladjustment and academic achievement and mediation effects by using parental monitoring and internet use types as mediators. Data were obtained from the Korea Youth Panel Survey(KYPS). Structural equation modeling was employed for statistical analyses. The result showed that poverty reduced parental monitoring and information-oriented type of internet use. Youth who used less information-oriented type showed more school maladjustment and less academic achievement. However, the relationship between poverty and entertainment-oriented type was non-significant. Thus, parental monitoring and the internet use types were one of the main pathways which can affect school maladjustment and academic achievement among youth in poverty. There was the possible vicious cycle between poverty and digital divide. Based on this study, we strongly suggest improvement of the media competence to solve the problem of digital divide among youth in poverty.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.9 no.6
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• pp.443-450
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• 2019

Vicia amoena has traditionally been used to treat disease of rheumatism, arthralgia, muscular paralysis, abscess and eczema, and it has anti-inflammatory properties. However, validity of the anti-inflammatory activity has not been scientifically in vestige acted so far. Therefore, the aim of this study was to investigate the anti-inflammatory potential of V. amoena using the ethanolic extract. To evaluate the anti-inflammatory effects, we examined the inflammatory mediators such as nitric oxide (NO) and prostaglandin E₂ (PGE₂) on RAW264.7 cells. Our results indicated that ethanolic extract of V. amoena significantly inhibited the LPS-induced NO and PGE₂ production in RAW264.7 cells. The ethanolic extract of V. amoena has inhibited the PGE₂ production by 88.0±0.8 % at the concentration of 40㎍/ml. This results showed that ethanol extract of V. amoena is expected to be a good candidate for development into source of inflammation inhibitor

• Korean Journal of Culture and Social Issue
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• v.19 no.3
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• pp.319-341
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• 2013

This study investigated the mediating effects of social support and coping on the relation between traumatic event type, posttraumatic growth and wisdom by the data from 247 adults by using path analysis. Besides, the difference of the level of posttraumatic growth and related variables between traumatic event type groups. At first, The results of the MANCOVA, person-related traumatic event group were higher than the non-personal traumatic event group in negative coping and trauma stress level, and lower in social support, positive coping, posttraumatic growth and wisdom. The path analysis results shows that traumatic event type was related to wisdom by mediate factors. Traumatic event type affected wisdom through social support, positive coping, posttraumatic growth. The significant mediators were social support, positive coping, posttraumatic growth. Negative coping was not a significant mediator between event type and posttraumatic growth. The results show that non-personal traumatic event group are tends to have high level of social support, positive coping, posttraumatic growth, and wisdom. In the end, we described that the implication and the limitation of this study and suggestions for following studies.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2020.12a
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• pp.81-81
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• 2020

Pneumonia is infection of air sacs in lungs by bacteria, viruses, fungi and abnormal atmosphere condition. That causes to inflammation and fills up with pus and fulid in air sacs. The symptoms of pneumonia are heavy cough, fever, shortness and rapid respiration and sputum with blood. Also, that remains sequela after the recovery. Thymus quinquecostatus (TQ) has a strong antibacterial effect. That has been used a natural medicine for bronchitis, asthma and nervous inflammation. In this study evaluated anti-inflammatory effects of TQ on IFN (interferon)-γ/TNF (tumor necrosis factor)-α (20 ng/ml) stimulation. MRC-5 cells were seeded at 1 × 10⁵ cells/well in a 24-well plate and stabilized overnight at 37℃. The cells were treated with various concentrations of TQ extracts (DW, 30, 50, 70, 95% EtOH, 0.1~100 mg/ml) for 4h, Subsequently IFN-γ/TNF-α (20 ng/ml) was added to each well and incubated over 12h. the production of inflammatory cytokines were measured by Enzyme-linked immunosorbentassay(ELISA) method. The absorbance was measured at 450 nm using microplate reader. The treatment with TQ extract at dose of 0.1 to 100 mg/ml did not show cytotoxicity in MRC-5 cells (showed cytotoxicity at 95% EtOH 100 mg/ml). The results demonstrated that stimulation of TNF-α/IFN-γ significantly increased the production of inflammatory mediators in the MRC-5 cells compared with unstimulated cells. By contrast, treatment with TQ extreats doses of 0.001 to 10 mM significantly suppressed the production of IL-6 and IL-8. Especially. The higher percent of ethyl alcohol extracts suppressed the production of inflammatory cytokines. This results are considered that essential oil of TQ is extracted according to ethyl alcohol percent. Therefore, TQ has potential to mitigate pulmonary disease that can be used a medicine for pneumonia

• Journal of Venture Innovation
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• v.6 no.3
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• pp.73-93
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• 2023

This study provides a prospect for the fast growing the smartwatch market by investigating the relationship between the satisfaction and the continuous use intention of Apple watch users, as well as the factors influencing their satisfaction. Based on the TAM, this study uses system quality, information quality, and self-efficacy as independent variables, perceived usefulness, perceived ease of use, and satisfaction as mediators, and continuous use intention as the dependent variable. We analyze the data of 256 individuals who completed an online survey with SPSS 26.0 and AMOS 26.0 software. This study conducts several tests and analyses to empirically evaluate the data including reliability analysis, factor analysis, feasibility analysis, path analysis, hypothesis verification, and mediation analysis. Our results investigate which factors may influence consumers' intention to continuously using Apple Watch devices in the future. In summary, satisfaction has a positive effect on the intention to continuously use smartwatchs. Perceived usefulness and perceived ease of use have a positive effect on satisfaction. Among the three factors (system quality, information quality, and self-efficacy), only self-efficacy has no significant impact on perceived usefulness but had a positive effect on perceived ease of use. In addition, system quality and information quality positively affect perceived usefulness, perceived ease of use, satisfaction, and continuous intention to use an Apple Watch. Taking the Apple Watch as the subject of our research topic, this study provides theoretical value by exploring the impact of user's satisfaction with their smartwatch on their continuous usage intention. This study further explains the influence of system quality, information quality, and self-efficacy on user satisfaction. Additionally, this research offers valuable insight to practitioners by confirming that information quality, system quality, and self-efficacy are important features for enhancing satisfactory user experiences which in turn may increase users' intention to continued using smartwatches.

• Journal of Venture Innovation
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• v.6 no.1
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• pp.17-34
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• 2023

This study tried to find a way to increase major satisfaction to overcome the difficulties of college due to the recent decrease in the number of educated population. In particular, problem-solving ability and digital literacy, which are essential in the era of the 4th industrial revolution, were set as influencing factors and mediators and tried to verify them. Therefore, in order to find out the effect of problem-solving ability on major satisfaction and the mediating effect of digital literacy, a study was conducted targeting junior college secretarial majors. A total of 193 questionnaires were analyzed, and regression analysis was performed to verify the hypothesis, and bootstrapping was performed using the SPSS PROCESS macro model 4 to verify the significance of the mediating effect. The results of the study are as follows. First, it was found that problem-solving ability had a positive(+) effect on major satisfaction. Second, problem-solving ability was found to have a positive(+) effect on all four sub-factors of digital literacy. Third, as a result of analyzing the mediating effect of digital literacy in the relationship between problem-solving ability and major satisfaction, among the four sub-factors of digital literacy, information literacy, critical understanding, and information analysis ability completely mediated between problem-solving ability and major satisfaction. has been shown to be effective. On the other hand, the ability to comply with norms was found to have no mediating effect. In this study, it was verified that problem-solving ability affects major satisfaction, and it was found that it is necessary to make various efforts to cultivate problem-solving ability. In addition, based on these research results, suggestions for preparing practical measures to increase major satisfaction were suggested.

• Journal of the Korean Applied Science and Technology
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• v.40 no.5
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• pp.988-1000
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• 2023

Hesperetin(HT) is a potent antioxidant flavonoid aglycone derived from hesperidin(HD). The antioxidant, anti-inflammatory, and antimicrobial activities of HT and its cyclodextrin(CD) inclusion complexes were compared in vitro. HT was prepared by enzymatic hydrolysis of HD, and HT/CD complexes were prepared using 𝛽-cyclodextrin(𝛽-CD) and hydroxypropyl-𝛽-cyclodextrin(HP-𝛽-CD) by solvent co-evaporation method. The solubility of the HT/HP-𝛽-CD inclusion complex increased 93.5-fold compared to HT, and the solubility of HT/𝛽-CD increased 22.5-fold. The HT/HP-𝛽-CD inclusion complex showed a similar effect as HT on radical scavenging activity in antioxidant assays, whereas the HT/𝛽-CD inclusion complex showed slightly lower activity than HT. Cytotoxicity was low in the following order; HT/HP-𝛽-CD, HT/𝛽-CD, and HT in murine macrophage RAW264.7 cells. Treatment with HT and HT/CD inclusion complexes reduced the levels of inflammatory mediators such as nitric oxide(NO), tumor necrosis factor-𝛼(TNF-𝛼) and interleukin-6(IL-6) in the cells. HT and HT/HP-𝛽-CD inclusion complex were more effective than HT/𝛽-CD inclusion complex at relatively low concentrations. Inhibitory effects were tested on skin-pathogenic bacteria, Staphylococcus aureus and Pseudomonas aeruginosa, and they showed an antimicrobial effect on S. aureus in the order of HT = HT/HP-𝛽-CD > HT/𝛽-CD, but they did not show any significant inhibitory effect on P. aeruginosa. In conclusion, HT, the aglycone form of HD, and its CD inclusion complexes showed various biological activities. HT/HP-𝛽-CD inclusion complex, which is the highly soluble form of HT, showed relatively higher activity compared to HT/𝛽-CD inclusion complex.