• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.217-217
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• 1994

Calcium entry blockers, capable of inhibiting transmembrane influx of extracellular calcium through specific calcium channels, are useful drugs in the treatment of angina pectoris, hypertension, cardiac arrythmia, and various cardiovascular disorders. Compounds having isoquinoline structures have recently been reported to possess calcium antagonistic action. Therefore, in the present study, we have attempted to synthesize some isoquinoline and related compound.; in order to search for potentially effective chemicals acting on cardiovascular system, and evaluated their pharmacological properties focusing on calcium antagonistic actions. Almost all of the compounds so far synthesized, had inhibitory action against phenylephrine or high potassium-induced contraction in vascular smooth muscle with different degrees of potencies depending on their structures, However, some of tetrahydroisoquinoline analogs showed directly inhibit calcium current in isolated rabbit cardiac myocytes examined by patch clamp techniques. The pharmacological properties of these compounds need more intensive investigation as to whether these chemicals may have developed as a new cardiovascular active drugs. Therefore, we are now under investigation of the mechanism of action of these compounds.

• Journal of Preventive Medicine and Public Health
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• v.32 no.2
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• pp.183-190
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• 1999

Objectives: The purpose of this study is to analyse factors related to the health promotion behavior or the basis of theory of reasoned action(TRA). Methods: 509 residents in the city of Kyunggi-do were selected through multistage random sampling. A structured questionnaire was developed or the basis of Triandis model and collected by interviewing. Results: Expectation toward act and social normative influence and age showed significant relationship to health promotion behavior, Also, facilitating factors, affective attitude, education level are indirectly related to health promotion behavior. Conclusions: The result suggest that TRA is useful in understanding the mechanism of health promotion behavior.

• YAKHAK HOEJI
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• v.25 no.1
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• pp.15-25
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• 1981

This study was attempted to investigate the action of debrisoquine, a sympathetic blocking agent presently employed in treating hypertension, on renal function and to elucidate the mechanism of its action. Debrisoquine, given intravenously, elicited increased urine flow, osmolar and free water clearances, along with marked increases in excretion of both sodium and potassium. Glomerular filtration rate also increased, but renal plasma flow tended to decrease, so that the filtration fraction tended to increase. Rates of reabsorption of sodium and potassium in renal tubules were also significantly diminished. The diuresis induced by debrisoquine was completely blocked by treatment with phentolamine and reserpine, and also markedly inhibited by acute renal denervation. Debrisoquine, when injected directly into a renal artery, produced antidiuretic effect and a reduction in urinary excretion of sodium and potassium, along with diminished renal plasma flow and increased filtration fraction. The above observations indicate that debrisoquine, when given intravenously, induces diuresis in the dog as a result of both diminished tubular reabsorption of electrolytes and of renal hemodynamic changes, which seem to be related to its inhibitory action of catecholamine-release from the sympathetic nerve endings.

• Korean Journal of Pharmacognosy
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• v.19 no.4
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• pp.256-261
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• 1988

The present studies were investigated to find out the uterus contractive components and action mechanism of contractive components. We observed that the contractive components of Dianthi Herba were extracted with methanol and dissolved in butanol. The butanol extracts of Dianthi Herba increased uterus contractility, and fraction 2 obtained from butanol extract was more powerful than other fractions. This action was not blocked by atropine, papaverine, prazosin, propranolol, chlorpheniramine, methysergide and diltiazem in vitro.

• Journal of the Korea Construction Safety Engineering Association
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• s.52
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• pp.48-57
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• 2011

A major purpose of management or occupational safety is a significant decrease in safety accidents. With this view, the establishment of occupational safety culture and the building of occupational communication network stand out as being more important than the past. This study has analysed the positive effects of occupational safety communication on safety consciousness and action of the employees in workplace. And it is confirmed that the occupational safety communication in workplace is the essential mechanism, through which the workers internalize safety consciousness and act safely. The safety consciousness and action of the employees are formed in safety culture, which is not only legal regulations, but a daily communication network in workplace. In these sense, the building of the occupational safety communication network is decisive for the establishment of safety culture. For these reasons, this study makes the proposition that a firm promotion of occupational communication network is necessary, which connects the safety culture and a effective safety management in workplace.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.11a
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• pp.485-488
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• 2004

Steel encased composite columns have been used for buildings and piers of bridges. Since column section for pier is relatively larger than that of building columns, economical steel ratio need to be investigated for the required performance. Composite action between concrete and embedded steel sections can be obtained by bonding and friction. However, the behavior. of the column depends on the load introduction mechanism. Compression can be applied to concrete section, steel section and composite section. In this paper, experiments on shear strength of the steel encased composite column were performed to study the effect of confinement by transverse reinforcements, mechanical interlock by holes, and shear connectors. Shear strength obtained from the tests showed considerably higher than the design value. Confinement, mechanical interlock and stud connectors increased the shear strength and these values can be used effectively to obtain composite action of SRC columns.

• Microbiology and Biotechnology Letters
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• v.23 no.4
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• pp.416-424
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• 1995

Mechanism of the cyclodextrin (CD) production reaction by cyclodextrin glucanotransferase (CGTase) using swollen extrusion starch as substrate was investigated emphasizing the structural features of starch granule. The degree of gelatinization was identified to be the most representative structural characteristic of swollen starch. The most suitable degree of gelatinization of swollen starch for CD production was around 63.52%. The structural transformation of starch granule during enzyme reaction was also followed by measuring the changes of the degree of gelatinization, microcrystallinity, and accessible and inaccessible portion to CGTase action of residual swollen starch. The adsorption phenomenon of CGTase to swollen starch was also examined under various conditions. The inhibition mechanism of CGTase by various CDs was identified to be competitive, most severely by a-CD. The mechanism elucidated will be used for development of a kinetic model describes CD production reaction in heterogeneous enzyme reaction system utilizing swollen extrusion starch.

• Journal of Institute of Control, Robotics and Systems
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• v.18 no.2
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• pp.81-86
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• 2012

Reconnaissance robots can reduce the danger of hazardous places by providing information before human personnel take action. For the usage, robot platform should be small and light. However, this fact leads to a scaling issue with terrain that landscape poses a huge obstacle for the vehicle. The problem can be solved by the inspiration of nature. This paper presents design of the locomotive mechanism inspired by Pill bugs. The mechanism was designed by the principles of a pill bug's locomotion and experiments were conducted to validate the mechanism.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.1495-1499
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• 2003

There is some equipment that helps user to exercise and to walk. But almost all equipments require some physical strength of their muscles. So we developed a system that could assist walking action of the people with lower-limb disability. The system called as walking stand adopted the balancing mechanism which assures the stable walking, and the 4 link-based mechanism that had 2 degrees of freedom on each leg. The walking stand uses four motors and has two sets of the special link-structure to simulate the human walking mechanism. With our system, even serious disabled with lower-limb disability may enjoy walking rehabilitation. And by adjusting the power, it can be used as the walking assistant mechanism instead of conventional wheelchairs. Experiments showed that our walking stand is applicable to the rehabilitation and also to the mobile device in our daily life for those people who do not have enough physical ability to walk by themselves.

• The Journal of Korean Medicine
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• v.41 no.4
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• pp.88-99
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• 2020

Objectives: The purpose of this study is to investigate the mechanism of acupuncture for treating chemotherapy-induced peripheral neuropathy. Methods: Based on domestic and international papers reported until October 2020, experimental papers on "chemotherapy induced peripheral neuropathy", "mechanism", and "acupuncture" were set up to identify the mechanisms of chemotherapy induced peripheral neuropathy. A total of seven papers were selected and searched: one pilot paper for people and six experimental papers for rats. Results: In the pilot paper studied by Bao, T., the effect of EA was demonstrated but no significant results were produced for the mechanism. Moon et al. derived the association between EA and plasma 𝛽-endorphin in rat experimental studies on oxalilatin-induced cold hypersensitivity. Meng et al. found relevance to 𝜇, 𝛿, and 𝛿 opioid through EA stimulation in paclitaxel-induced peripheral neuropathy. Lee et al. studied the relationship between EA and muscarin and 5-HT in rat experiments on oxaliplatin-induced coldness, associated with 5-HT and EA, especially with 5-HT3 receptors. Choi et al. revealed the association of adrenaline and opioid acting on 𝛼2- and 𝛽 adrenaline receptors with EA in rat experiments on paclitaxel-induced neuralgia. In rat experiments on oxaliplatin-induced neuralgia reported by Lee, 𝛽-endorphin and encephalin were studied to be mediated by EA. Zhang, T. et al. revealed in the paclitaxel induced rat experiment that EA activates 5-HT. Conclusion: It is inferred that peripheral neuropathy caused by anticancer drugs can be reduced by activating the action of 5-HT, 𝛽-endorphin, and encephalin through the descending inhibitory pathways. cell differentiation, herbal medicine, Pongamia, stem cells