• BMB Reports
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• 제48권1호
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• pp.48-53
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• 2015

Oxidized LDL (oxLDL) performs critical roles in atherosclerosis by inducing macrophage foam cell formation and promoting inflammation. There have been reports showing that oxLDL modulates macrophage cytoskeletal functions for oxLDL uptake and trapping, however, the precise mechanism has not been clearly elucidated. Our study examined the effect of oxLDL on non-muscle myosin heavy chain IIA (MHC-IIA) in macrophages. We demonstrated that oxLDL induces phosphorylation of MHC-IIA (Ser1917) in peritoneal macrophages from wild-type mice and THP-1, a human monocytic cell line, but not in macrophages deficient for CD36, a scavenger receptor for oxLDL. Protein kinase C (PKC) inhibitor-treated macrophages did not undergo the oxLDL-induced MHC-IIA phosphorylation. Our immunoprecipitation revealed that oxLDL increased physical association between PKC and MHC-IIA, supporting the role of PKC in this process. We conclude that oxLDL via CD36 induces PKC-mediated MHC-IIA (Ser1917) phosphorylation and this may affect oxLDL-induced functions of macrophages involved in atherosclerosis.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2002년도 제1차워크샵
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• pp.63-63
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• 2002

RNA pseudoknots are not only important structural elements for forming the tertiary structure, but also responsible for several functions of RNA molecules such as frameshifting, read-through, and the initiation of translation. There exists no automatic method for drawing RNA pseudoknot structures, and thus representing RNA pseudoknots currently relies on significant amount of manual work. In this talk, I will introduce the first algorithm for automatically generating a drawing of RNA pseudoknot structures. Two basic criteria were adopted when designing the algorithm: (1) Overlapping of structural elements should be minimized to increase the readability of the drawing, and (2) The whole RNA structure as well as the pseudoknots themselves should be recognized quickly and clearly. The algorithm has been implemented in a JAVA program, which can be executed on any computing systems. Experimental results show that this program generates a clear and compact drawing of RNA pseudoknots and allows a biologist to gain insights into RNA pseudoknot structures. The program can also be used as useful aids in designing biochemical experiments to elucidate more precise mechanism of RNA functions associated with pseudoknots.

• Toxicological Research
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• 제29권2호
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• pp.81-86
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• 2013

Toxicoproteomics integrates the proteomic knowledge into toxicology by enabling protein quantification in biofluids and tissues, thus taking toxicological research to the next level. Post-translational modification (PTM) alters the three-dimensional (3D) structure of proteins by covalently binding small molecules to them and therefore represents a major protein function diversification mechanism. Because of the crucial roles PTM plays in biological systems, the identification of novel PTMs and study of the role of PTMs are gaining much attention in proteomics research. Of the 300 known PTMs, protein acylation, including lysine formylation, acetylation, propionylation, butyrylation, malonylation, succinylation, and crotonylation, regulates the crucial functions of many eukaryotic proteins involved in cellular metabolism, cell cycle, aging, growth, angiogenesis, and cancer. Here, I reviewed recent studies regarding novel types of lysine acylation, their biological functions, and their applicationsin toxicoproteomics research.

• Journal of Communications and Networks
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• 제12권4호
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• pp.375-381
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• 2010

A flooding attack, such as DoS or Worm, can be easily created or even downloaded from the Internet, thus, it is one of the main threats to servers on the Internet. This paper presents an online real-time network response system, which can determine whether a LAN is suffering from a flooding attack within a very short time unit. The detection engine of the system is based on the incremental mining of fuzzy association rules from network packets, in which membership functions of fuzzy variables are optimized by a genetic algorithm. The incremental mining approach makes the system suitable for detecting, and thus, responding to an attack in real-time. This system is evaluated by 47 flooding attacks, only one of which is missed, with no false positives occurring. The proposed online system belongs to anomaly detection, not misuse detection. Moreover, a mechanism for dynamic firewall updating is embedded in the proposed system for the function of eliminating suspicious connections when necessary.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2002년도 ICCAS
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• pp.77.6-77
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• 2002

This paper describes a motored wheelchair that is suitable for disabled persons. A distinguish feature of our wheelchair is that a closed link mechanism is introduced. This link module changes conventional motored wheelchairs to computer controlled ones. It means that using intelligent functions of the computer, conventional motored wheelchairs can be navigated like an intelligent robot. Three examples of intelligent navigation functions are demonstrated. The first one is a motored wheelchair controlled by the head movement of the operator. The second one is a motored wheelchair with the image processing. Last one is a motored wheelchair with the remote sensing function.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1997년도 추계학술대회 논문집
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• pp.591-595
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• 1997

In analysis of piping vibration of petrochemical plant, the forcing functions mainly depend upon the equipment working mechanism and vibration resources in the piping systems. In general, harmonic function is used for the system with rotary equipments. Mechanical driving frequencies, wave functions, and response spectrum are used for reciprocating compressors, surge vibration of long transfer piping, and seismic/wind vibration, respectively. In this study, for the spray injection case inside the pipe, forcing function was modeled, in which two different fluids are distributed uniformly. To confirm the results, the scheme used for the forcing function was applied for real piping system. The vibration mode of the real system was consistent with the 4th mode obtained by simulation using the forcing function formulated in this study.

• 한국문헌정보학회지
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• 제23권
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• pp.1-31
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• 1992

The present study aims at a systematic access to EC information. EC information is the outcome of the complex organizations, the continuous changes in functions and the subsequent changes in policies. An attempt for an effective approach to the information requires the examination of the organizational structures and changes, the processes involved in formulating and implmenting the information policies, and the infrastucture for information. Information activities of the major organizations of EC have been examined with a special reference to the Commission of European Communities. The Commission is the EC institution from which the majority of the EC's documentation originates. The information functions of the Commission have been studied in such categories as information production and distribution, authorizing services, and information services to the public.

• 셀메드
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• 제2권2호
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• pp.14.1-14.7
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• 2012

Cordycepin, a nucleoside derivative, was extracted from $Cordyceps$ $sinensis$, and then proved to be a bioactive compound present in traditional Chinese medicine Cordyceps. Early investigations revealed cordycepin possessed anti-microbial activity mainly by inhibiting nucleic acid synthesis. Although cordycepin is not used as antibacterial agents in clinic, its other pharmacological effects and possible mechanisms have gradually been deeply studied. This review serves to summarize the research progress of cordycepin.

• Molecules and Cells
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• 제39권3호
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• pp.169-178
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• 2016

Although $N{\alpha}$-terminal acetylation (Nt-acetylation) is a pervasive protein modification in eukaryotes, its general functions in a majority of proteins are poorly understood. In 2010, it was discovered that Nt-acetylation creates a specific protein degradation signal that is targeted by a new class of the N-end rule proteolytic system, called the Ac/N-end rule pathway. Here, we review recent advances in our understanding of the mechanism and biological functions of the Ac/N-end rule pathway, and its crosstalk with the Arg/N-end rule pathway (the classical N-end rule pathway).

• 전자공학회논문지A
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• 제30A권12호
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• pp.1-9
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• 1993

In this paper, to realize the network management function in automated manufacturing network Mini-MAP, the network management requirements are analyzed and the network management system is implemented on the basis of this analysis. The implemented management system which has both local management and remote management mechanism is considered as a single domain on the Mini-MAP network. Here, the remote management functions consist of network status, monitoring and remote operations and the local management functions have parameter display and network self testing. The MAP network controller is designed according to the MAP version 3.0 specifications and IEEE 802 standards. the operations of network management system are certified througth the test environments which consists of the implemented network adaptor and softwares for Mini-MAP.