• 동의생리병리학회지
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• 제19권6호
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• pp.1599-1603
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• 2005

The study was designed to investigate the effects of Leonuri herba extract (LHE) on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and further to determine the mechanism of action of LHE. The results in normal rats were as follows, LHE significantly increased rCBF in a dose-dependent manner, and MABP did not change in a dose-dependent manner. This results were suggested that LHE significantly increased rCBF by dilating pial arterial diameter. The LHE-induced increase in rCBF was significantly inhibited by Pretreatment with indomethacin(1 mg/kg, i.p.), an inhibitor of cyclooxygenase, and was significantly inhibited by methylene blue($10{\mu}g/kg$, i.p.), an inhibitor of guanylate cyclase. The LHE-induced MABP did not change by pretreatment with indomethacin but was significantly inhibited by methylene blue. This results were suggested that the mechanism of LHE was mediated by cyclooxygenase.

• 동의생리병리학회지
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• 제20권6호
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• pp.1538-1542
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• 2006

The study was designed to investigate the effects of MokhwyangJoki-san Extract (MJSE) on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and further to determine the mechanism of MJSE. The results in normal rats were as follows ; MJSE significantly increased rCBF in a dose-dependent manner, and MABP did not change in a dose-dependent manner. This results were suggested that MJSE significantly increased rCBF by dilating pial arterial diameter. The MJSE-induced increase in rCBF was significantly inhibited by pretreatment with methylene blue (10 ${\mu}g/kg$, i.p.), an inhibitor of guanylate cyclase, and was not changed by indomethacin (1 ${\mu}g/kg$, i.p.), an inhibitro of cyclooxygenase. The MJSE-was not changed MABP was decreased by pretreatment with indomethacin but was not changed by methylene blue. This results were suggested that the mechanism of MJSE was mediated by guanylate cyclase.

• 한국임상수의학회지
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• 제16권2호
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• pp.253-256
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• 1999

The influence of essential oils from aboriginal softwoods as Pinus densiflora, Pinus koraiensis, Chamaecyparis obtusa and Chamaecyparis pisifera on the motor coordination, pulse, mean blood artery pressure and pain reducing test was investigated in mice and rats. The motor coordination of mouse was not induced by the inhalation of each oil. Furthermore, these oils did not alter the changes of the mean blood pressure and pulse rate. Chamaecyparis pisifera trand to reduce the mean blood pressure. The abdominal pain induced by acetic acid was reduced only by an essential oil from Pinus koraiensis in mouse.

• 대한본초학회지
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• 제24권3호
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• pp.139-146
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• 2009

Objectives : This study was conducted to investigate the effect of HTE001, a multi-herbal mixture consisting of 10 herbs, Cornus Frutus, Schizandrae Fructus, Rubi Fructus, Cnidi Fructus, Acanthopanacis senticosi Radix, Cinnamomi Cortex, Eucommiae Cortex, Allii Bulbus, Rehmanniae Radix and Ginseng Radix, on electrostimulation-induced penile erection in rats. Methods : Intracavernous pressure (ICP) and mean arterial blood pressure (MAP) were simultaneously monitored through electric stimulation of the cavernous nerve after the oral administration of HTE001 (30, 100, 300 mg/kg) in normal rats. Statistical analysis was performed on maximal intracavernous pressure (ICP), maximal intracavernous pressure/mean arterial blood pressure (ICP/MAP) ratio, and the area under the curve (AUC) of ICP/MAP ratio. Results : Oral administration of HTE001 300 mg/kg caused the ICP to increase in a frequency-dependent manner. And HTE001 300 mg/kg treatment group showed the highest value in the ICP/MAP ratio and the AUC value of the ICP/MAP ratio compared to the control group at 2 Hz, 6 Hz and 10 Hz, respectively without an effect on the mean arterial blood pressure under the same stimulation of the cavernous nerve. Conclusions : These results show that HTE001 improve penile erection and prolong the decay period in normal rats without affecting mean arterial blood pressure, and suggest that HTE001 could be a good therapeutic candidate to treat erectile dysfunction.

• Archives of Pharmacal Research
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• 제21권4호
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• pp.370-373
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• 1998

Ten substituted phenacyl derivatives of 4-hydroxypiperidine were synthesized and studied for their effects on the mean arterial blood pressure (MABP) in normotensive anaesthetized rats and smooth muscles contractions of isolated rabbit jejunum. Two derivatives caused fall in blood pressure at the dose of 10-20 mg/kg and one rise in blood pressure at the dose of 20 mg/kg. Two compounds exhibited biphasic response (hypotensive followed by hypertensive) and one gave triphasic response at 10 mg/kg dose. Rest of four derivatives were found devoid of any effect on mean arterial blood pressure up to the dose of 30 mg/kg. All the derivatives except two caused relaxant effect on the spontaneous contraction of rabbit jejunum at the dose range of 0.1 -2 mg/kg.

• 한국산학기술학회논문지
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• 제10권8호
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• pp.1926-1938
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• 2009

본 연구에서는 혈압 측정 시 생체 임피던스가 변화하는 현상을 이용하여 혈류량 변화를 검출하는 시스템을 구현하였다. 혈압의 측정은 오실로메트릭법을 적용하였으며, MAA 알고리즘을 이용하여 평균 동맥압을 산출한 후 평균 동맥압에 대한 여러 가지 특성비율을 설정하여 수축기 및 이완기 혈압을 추정하였다. 인체 임피던스 측정은 교류 정전류원과 락인-증폭기를 이용하였으며, 측정 부위에 인가되는 커프 압력에 의해 생체 임피던스 변화량을 이용하여 혈류량 변화를 측정하였다.

• 동의생리병리학회지
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• 제21권1호
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• pp.54-61
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• 2007

The study was designed to investigate the effects of Mixture of Yukgunja-tang and Bambusae Caulis in Liquamen (YTBCL) on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats, and further to determine the mechanism of action of YTBCL. The results in rats were as follows ; YTBCL 25 ${\mu}l$ significantly decreased rCBF and MABP compared with basal condition. YTBCL 100 ${\mu}l$ significantly increased rCBF compared with basal condition, but decreased MABP compared with basal condition. YTBCL 50 ${\mu}l$ significantly increased rCBF compared with basal condition, but MABP was somewhat decreased compared with basal condition. The VTBCL 50 ${\mu}l$-induced increase in rCBF was significantly inhibited by pretreatment with methylene blue (10 ${\mu}g$/kg, i.p.), an inhibitor of guanylate cyclase and indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase. The YTBCL 50 ${\mu}l$-induced decreased MABP significantly increased by pretreatment with methylene blue but was inhibited by indomethacin. This results were suggested that the mechanism of YTBCL was mediated Dy guanylate cyclase.

• 대한한방내과학회지
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• 제30권2호
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• pp.298-305
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• 2009

Objectives: The present study was carried out to investigate the effects of Yupoongyangyeong-tang(YYT) on changes of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats. In addition, the author also investigated action mechanisms of YYT on changes in rCBF and MABP. Methods and Results : In this study, treatment with YYT elevated rCBF in a dose-dependent manner, but MABP levels were elevated only in the 10 mg/ml treatment group. Pre-treatment with indomethacin. an inhibitor of cyclooxygenase, inhibited increase of rCBF effectively. Pre-treatment with methylene blue, an inhibitor of guanylate cyclase, inhibited increase of rCBF induced by YYT, too. In addition. pre-treatment with indomethacin also inhibited increase of MABP. However, pre-treatment with methylene blue did not affect MABP levels. Conclusion : These results suggest that YYT is useful to treat patients with diseases related to cerebral ischemia, because YYT can increase rCBF. In addition, the mechanisms are thought to be related to both cyclooxygenase and guanylate cyclase.

• 대한한의학방제학회지
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• 제10권1호
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• pp.93-103
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• 2002

This experimental studies were done to investigate the effects of Sambutang(SBT) and consitituent herbs on the regional cerebral blood flow(rCBF) and mean arterial blood pressure(BP) in rats. The results are as follows: SBT and consitituent herbs(SBT omitting Zingiberis Rhizoma Recens, Zingiberis Rhizoma Recens. Ginseng Radix and Aconiti iateralis preparata Radix) was increased rCBF significantly in a dose-dependent manner. SBT omitting Zingiberis Rhizoma Recens and Ginseng Radix were decreased significantly BP in rats. But, SBT, Aconiti iateralis preparata Radix and Zingiberis Rhizoma Recens were not affected BP in rats. According to the above findings. it is suggested that SBT causes a diverse response of rCBF, and specially the rCBF by increasing SBT is mediated action of Zingiberis Rhizoma Recens.

• 대한한방내과학회지
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• 제18권2호
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• pp.160-166
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• 1997

To evaluate the effect of acupuncture on the hypertension, the study was done by acupuncture on bilateral Inyong(ST9) with rats which are normal and acutely increased hypertensive. The results are as follows: 1. Under the normal condition, the acupuncture on bilateral Inyong caused a quick drop of mean arterial pressure(MAP), but heart rate(HR) was not changed significantly. 2. To increase the blood pressure, acutely epinephrine was administered and it caused a increase in both MAP and HR. With acupuncture, the MAP was decreased while HR did not show a significant change. In conclusion, the acupuncture was somewhat effective in lowering the mean arterial pressure in the rat.