• Journal of Preventive Medicine and Public Health
• /
• v.42 no.1
• /
• pp.1-4
• /
• 2009

Objectives : Isolated cleft lip with or without cleft palate(CL/P) is among the most common human birth defects, with a prevalence of approximately 1 in 700 live births. The B-Cell Leukemia/lymphoma 3(BCL3) gene has been suggested as a candidate gene for CL/P based on association and linkage studies in some populations. This study tests for an association between markers in BCL3 and isolated, non-syndromic CL/P using a case-parent trio design, while considering parent-of-origin effects. Methods : Forty case-parent trios were genotyped for two single nucleotide polymorphisms(SNPs) in the BCL3 gene. We performed a transmission disequilibrium test(TDT) on individual SNPs, and the FAMHAP package was used to estimate haplotype frequencies and to test for excess transmission of multi-SNP haplotypes. Results : The odds ratio for transmission of the minor allele, OR(transmission), was significant for SNP rs8100239(OR=3.50, p=0.004) and rs2965169(OR=2.08, p=0.027) when parent-of-origin was not considered. Parentspecific TDT revealed that SNP rs8100239 showed excess maternal transmission. Analysis of haplotypes of rs2965169 and rs8100239 also suggested excess maternal transmission. Conclusions : BCL3 appears to influence risk of CL/P through a parent-of-origin effect with excess maternal transmission.

• Journal of the Korean Home Economics Association
• /
• v.42 no.7
• /
• pp.119-129
• /
• 2004

The main purpose of this study was to examine the effects of maternal materialism and parenting on materialism in adolescents. Moreover, the relative significance of maternal materialism and parenting materialism in adolescents was also explored. The study subjects were 199 (98 male, 101 female) high school students in Seoul and their mothers. The following are the major findings. 1) Maternal materialism was not related with male adolescents' materialism but was with female adolescents'. 2) Maternal support, and open communication were negatively related with female adolescents' materialism while maternal control, and permissiveness were positively related. On the other hand, only maternal control was positively related with male adolescents' materialism. 3) Stepwise regression analysis revealed that maternal support, followed by maternal materialism, was the most important variable affecting female adolescents'. However, for male adolescents, maternal control was the only one variable affecting their materialism.

• Korean Journal of Child Studies
• /
• v.20 no.1
• /
• pp.147-164
• /
• 1999

The purpose of this study was to investigate (1) intergenerational transmission from mother's internal working model of relationships formed in her childhood and infant's attachment patterns and (2) the associations among maternal working models, maternal sensitivity, and infant attachment patterns. The subjects were twenty 12- to 20-month-old infants and their mothers. The Adult Attachment Interview (1996) was used to assess mother's internal work model of relationships. Interviews were audio-recorded and transcribed verbatim. Each dyad was videotaped in the modified Ainsworth Strange Situation(1978) and filmed for 3 minutes in the Questionaire Situation of Smith and Pederson (1988). Mothers were classified as autonomous(F), dismissing(Ds), preoccupied(E), or unresolved/disorganized(Ud). Infants were classified as secure(B), insecure-avoidant(A), or insecure-resistant(C). Exact A/B/C/D and Ds/F/E/Ud agreement was observed in 55% of the dyads. Maternal sensitivity was related to infant attachment patterns but not to maternal working models.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• v.32 no.1
• /
• pp.28-34
• /
• 2021

Objectives: This study aimed to examine the effect of maternal adverse childhood experiences (ACEs) on the attention-deficit/hyperactivity disorder (ADHD) symptoms in the offspring and to examine the mediating role of antepartum health risk on the intergenerational transmission of maternal ACEs. Methods: The participants consisted of 461 mother-child dyads. Mothers completed the ACEs questionnaire and Diagnostic Predictive Scales. Multivariate logistic regression analysis was used to estimate the risk of ADHD symptoms in the offspring of mothers with ACEs and the mediating effect of antepartum health risks by path analysis. Results: In all, 35.4% (n=163) had at least one maternal ACE, and 11.1% (n=51) had three or more. Compared to the non-ADHD symptom group, the group of offspring with ADHD symptoms showed a significant association with maternal ACE score (p<0.001) and antepartum health risks (p<0.001). Multivariate analysis further showed a significant association between the sum of maternal ACEs [odds ratio (OR)=1.264, 95% confidence interval (CI)= 1.060-1.516, p=0.009], antepartum health risks (OR=1.236, 95% CI=1.036-1.475, p=0.019), and ADHD symptoms in the offspring. In the mediation model in which the mother's ACE score affected the offspring's ADHD symptoms, partial mediation through antepartum health risks was found to be significant (B=0.041, 95% CI=0.011-0.124). Conclusion: Maternal ACEs are significantly related to the incidence of ADHD symptoms in the offspring and antepartum health risks exert an indirect effect. These findings suggest that maternal ACEs have a negative impact on the offspring's brain development through intergenerational transmission, resulting in neurodevelopmental disorders such as ADHD.

• Journal of The Korean Society of Grassland and Forage Science
• /
• v.32 no.4
• /
• pp.325-334
• /
• 2012

It has been known that endophyte (Neotyphodium coenophialum) is beneficial to tall fescue (Schedonorus phoenix Scop.) because the mutualistic endophyte is able to confers tolerance against abiotic and biotic stresses to tall fescue. However, this fungal endophyte produces toxic alkaloid resulting in negative effects on animal performance. Recently, Non-toxic endophyte have been developed and inserted into tall fescue to avoid detrimental effect on animal but remaining positive influence on tall fescue. In order to keep this beneficial impact, it is essential to have endophyte infected tall fescue through vertical transmission from maternal plants to seeds. Little research has been carried out on endophyte transmission. To get basic information related to endophyte transmission, experiment was conducted to examine the effect of plant genotype on endophyte transmission under water stresses. Overall endophyte concentration in seeds was higher than that in panicles and endophyte concentration in seeds and panicles relied on plant. This study revealed that drought is not a critical component to control the endophyte transmission from maternal plants to seeds. Plant genotype is an important factor controlling the endophyte transmission from plant to seed.

• Korean Journal of Child Studies
• /
• v.27 no.6
• /
• pp.69-79
• /
• 2006

This study investigated intergenerational transmission from mother's attachment representation to infant's attachment pattern and the associations between maternal attachment representation and their childhood experiences. Subjects were forty 12- to 15-month-old infants and their mothers. The Adult Attachment Interview (Main & Goldwyn, 1984) was used to assess mother's attachment representation. The Strange Situation (Ainsworth, 1978) was used to classify infant's attachment relationship. Mothers were classified as autonomous (F), dismissing (Ds), preoccupied (E), or unresolved/disorganized (Ud). Infants were classified as secure (B), insecure-avoidant (A), insecure-resistant (C), or insecure-disorganized (D). Exact A/B/C/D and Ds/F/E/Ud agreement was observed in 30 of 40 dyads(75%). Maternal childhood experiences were related to maternal attachment representation.

• Genes and Genomics
• /
• v.40 no.12
• /
• pp.1339-1349
• /
• 2018

Cerebral palsy (CP) is a non-progressive neurological disease, of which susceptibility is linked to genetic and environmental risk factors. More and more studies have shown that CP might be caused by multiple genetic factors, similar to other neurodevelopmental disorders. Due to the high genetic heterogeneity of CP, we focused on investigating related molecular pathways. Ten children with CP were collected for whole-exome sequencing by next-generation sequencing (NGS) technology. Customized processes were used to identify potential pathogenic pathways and variants. Three pathways (axon guidance, transmission across chemical synapses, protein-protein interactions at synapses) with twenty-three genes were identified to be highly correlated with CP. This study showed that the three pathways associated with CP might be the molecular mechanism of pathogenesis. These findings could provide useful clues for developing pathway-based pharmacotherapies. Further studies are required to confirm potential roles for these pathways in the pathogenesis of CP.

• Korean Journal of Child Studies
• /
• v.35 no.2
• /
• pp.117-136
• /
• 2014

This study examined the effects of maternal grandmothers' positive parenting behavior, mothers' emotion regulation, and positive parenting behavior on children's emotion regulation. A total of 348 mothers of fourth and fifth graders responded to questionnaires, which included items related to their mothers' positive parenting behavior, their own emotion regulation and positive parenting behavior, and their children's emotion regulation. The data were analyzed by means of correlations and Structural Equation Modeling (SEM). First, maternal grandmothers' positive parenting behavior significantly affected mothers' emotion regulation, but mothers' emotion regulation did not directly affect their children's emotion regulation. Second, maternal grandmothers' positive parenting behavior had an effect on mothers' positive parenting behavior, which led to a high level of their children's emotion regulation. Lastly, maternal grandmothers' positive parenting behavior indirectly influenced children's emotion regulation through mothers' emotion regulation and positive parenting behavior. This study emphasizes the intergenerational transmission of positive parenting, as well as a crucial influence of mothers' positive parenting behavior on children's emotion regulation.

• Korean Journal of Child Studies
• /
• v.38 no.1
• /
• pp.233-249
• /
• 2017

Objective: This study examined the effects of maternal grandmothers' positive parenting behavior and mothers' self-differentiation and positive parenting behavior on self-concept in late childhood. Methods: A total of 341 $5^{th}$- and $6^{th}$- grade elementary school children and their mothers participated in the study. Children were surveyed regarding perceptions of their mothers' positive parenting behavior and their own self-concept. Mothers responded to questionnaires regarding both positive parenting behavior of their mothers and their own self-differentiation. The data were analyzed using SEM. Results: Maternal grandmothers' positive parenting behavior had an indirect effect through mothers' self-differentiation and positive parenting behavior on children's self-concept. Mothers who perceived positive parenting behavior in their mothers in their childhood showed positive parenting behavior (as perceived by their children), and those children reported a higher level of self-concept. Mothers who perceived their mother's parenting behavior in their childhood more positively reported a higher level of self-differentiation, and those mothers showed more positive parenting behavior (as perceived by their children), which led to more positive self-concept in children. Conclusion: The findings specify the pathways from maternal grandmothers' positive parenting behavior to children's self-concept through mothers' self-differentiation and positive parenting behavior in an aspect of the intergenerational transmission of parenting. The findings also emphasize the importance of mothers' positive parenting behavior for positive self-concept in late childhood.

• Parasites, Hosts and Diseases
• /
• v.37 no.3
• /
• pp.149-156
• /
• 1999

Pneumocystis carinii is pulmonary pathogen of immunocompromised humans or other mammals. Its infection results from activation of organism involves in latent infection or form new infection through the air. Almost all children are known to be infected within 2 to 4 years of birth, though prenatal transplacental transmission has not yet been demonstrated. In this study we observed experimental P.carinii infection in neonatal rats, thus investigating the possibility of transplacental vertical transmission by Diff-Quik staining of the lung impression smears and in-sity hybridization for lung sections. The postive rate of P.carinii infection in immunosuppressed maternal rats was 100%, but that in normal maternal rats was 0%. Cystic forms of P.carinii were observed in three of six 1-week old neonatal rats born of heavily infected mothers, but none of them was positive by in-situ hybridization. Five weeks after birth, cystic forms were detected in four neonatal rats. In the lobes of the lungs, no predilection site of P.carinii was recognized. Counts of cystic forms on smears and the reactivity of in-situ hbridization in the lungs of neonatal rats 0 were signficantly lower than in maternal rats. The present findings suggest that P.carinii is rarely transmitted through the placenta and proliferates less successfully in the lungs of neonatal rats than in mothers.