• 한방비만학회지
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• 제15권1호
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• pp.9-23
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• 2015

Objectives: This study was investigated the improvement effects of Pakistani Ephedra herba-containing Gangji-hwan-1, 2, 3 (Di-fatty; DF-1, 2, 3), Chinese Ephedra herba-containing Gangjihwan-4 (DF-4) and combination of DF-1 and Gamisoche-hwan (GSH) on obesity in a high fat diet-fed obese mouse model. Methods: Eight-week-old C57BL/6N mice were divided into seven groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF-1, 2, 3, 4, and DF-1+GSH groups given a high fat diet with DF-1, 2, 3, 4 (40, 80, 160, 80 mg/kg), and DF-1+ GSH (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio (FER), blood lipid markers, liver histology, and fat weight and histology were examined. Results: Body weight gain was significantly decreased in DF and DF-1+GSH groups compared with control. The extent of decreases was eminent in DF-1+GSH group. FER and circulating concentration of leptin were decreased in DF and DF-1+GSH groups compared with control. Circulating concentrations of triglyceride, glucose and insulin were decreased in DF and DF-1+GSH groups compared with control. The size of adipocytes were decreased by DF and DF-1+GSH groups compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF and DF-1+GSH groups decreased the number of large adipocytes. Conclusions: In conclusion, these results suggest that DF and DF-1+GSH groups decrease FER, plasma leptin concentration, blood anti-obesity biomarkers and fat mass, improves body weight gain. In addition, these effects were more effective in DF-1+GSH combination group than in DF-1, 2, 3, 4 groups.

• 한국식품영양과학회지
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• 제44권1호
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• pp.57-65
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• 2015

본 연구에서는 초등학생들을 영아기 영양법에 따라 모유영양군, 인공영양군, 혼합영양군으로 분류하여 영아기 영양법에 따른 식습관과 영양 섭취 상태를 비교 분석함으로써 영아기 영양법이 이후의 식사법에 미치는 영향을 살펴보고자 하였으며, 그 결과는 다음과 같다. 전체 조사대상자의 평균 연령은 9.7세였으며, 신장, 체중, 체질량지수는 각각 139.0 cm, 34.6 kg, $17.8kg/m^2$로 영아기 영양법에 따른 군간 유의한 차이가 없었다. 영아기 영양방법에 대해 조사한 결과 초유를 섭취한 비율은 모유영양군 97.2%, 혼합영양군 92.7%로 인공영양군의 40.9%보다 유의하게 높았으며(P<0.001), 이유 시기 및 첫 이유 식품에서 세 군간 유의한 차이는 보이지 않았다. 또한 식습관 조사 결과 간식을 전혀 먹지 않는다는 비율은 모유영양군 10.0%, 인공영양군 9.4%로 혼합영양군의 3.8%보다 유의하게 높았으며(P<0.05), 식사 및 외식빈도 등은 군간 유의한 차이를 보이지 않았다. 총 식습관 점수와 에너지 및 영양소 섭취량은 영아기 영양법에 따른 군간 유의한 차이를 보이지 않았다. 이상의 연구 결과를 종합하여 볼 때 성장기 아동에서 영아기 영양법에 따라 간식섭취 빈도, 우유 유제품 및 채소 섭취 정도 등과 같은 식습관이 다른 것으로 나타났으며, 추후 영아기 영양법에 따른 성장, 건강, 식습관 및 식사섭취상태 등에 대한 장기적인 추적조사가 필요할 것으로 사료된다.

• Journal of Microbiology and Biotechnology
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• 제17권12호
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• pp.1970-1975
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• 2007

Squalene synthase plays an important role in the cholesterol biosynthetic pathway. Inhibiting this enzyme in hypercholesterolemia can lower not only plasma cholesterol but also plasma triglyceride levels. A squalene synthase inhibitor was screened from Prunus mume fruit, and then purified via sequential processes of ethanol extraction, HP-20 column chromatography, ethyl acetate extraction, silica gel column chromatography, and crystallization. The squalene synthase inhibitor was identified as chlorogenic acid with a molecular mass of 354 Da and a molecular formula of $C_{16}H_{18}O_9$ based on UV spectrophotometry, $^1H$ and $^{13}C$ NMRs, and mass spectrometry. Chlorogenic acid inhibited the squalene synthase of pig liver with an $IC_{50}$ level of 100 nM. Since chlorogenic acid was an effective inhibitor against the squalene synthase of an animal source, it may be a potential therapeutic agent for hypercholesterolemia.

• 한국항공우주학회지
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• 제43권12호
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• pp.1108-1115
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• 2015

본 연구에서는 마우스피스 방법을 이용하여 산소의 질량유량 측정과 헬륨의 체적유량 측정에 대한 관계식을 정리하였다. 마우스피스 방법은 상사된 실험식을 이용함으로써 시험비용을 절감할 수 있다. 마우스피스 방법에서는 기체헬륨을 측정하여 용이하게 액체산소의 누설량을 측정할 수 있다. 시제품의 누설량 측정에서 상온과 극저온 상태의 헬륨과 산소간의 누설량 관계를 이해하기 위해 실험을 수행하여 비교하였다. 헬륨의 누설 체적유량[$A.m{\ell}/s$]은 액체상태의 산소 누설의 질량유량[g/s]에 대비하여 174배였다. 실험식과 비교된 계산식은 미국 국립기술표준원의 자료를 이용하여 증명하였다.

• 대한교통학회지
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• 제19권3호
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• pp.61-73
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• 2001

본 연구는 부산의 도심에 위치한 대규모 교통유발시설 부설주차장의 적정규모 추정모형의 구축을 연구의 목적으로 하였다. 이를 위해 부설주차장 이용 차량의 평균 도착시간 간격과 평균 주차시간 간격을 이용한 대기행렬시뮬레이션인 GPSS모형을 사용하여 적정 주차장 규모를 산정한 후 연상면적과 적정주차면수의 관계를 용이하게 추출할 수 있는 회귀식을 이용하여 모형식을 구축하였다. 적정주차규모 모형을 구축한 결과 현재의 주차면 수는 적정주차면수에 비해 초과 공급되어 있어, 도심내의 주차장 과잉공급으로 인한 불필요한 승용차 이용을 방지하고, 토지이용의 효율성 제고를 위해서는 현 부설주차장의 설치기준에 대한 개선이 필요할 것으로 판단된다. 그러나 본 연구의 수행 과정에서 나타난 문제점은 대상시설의 선정에서 이용율이 현저히 떨어지고 있는 시설들을 포함시킴으로 인해 적정주차규모가 다소 적게 산정될 수 있다는 점이다. 또한 본 연구에서는 주차 이용행태만으로 적정주차규모를 산정했으나 주차장의 규모에 관한 연구는 토지이용과 교통여건, 상권 등이 종합적으로 고려된 연구가 되어야 할 것으로 판단된다.

• Nutrition Research and Practice
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• 제9권4호
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• pp.370-378
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• 2015

BACKGROUND/OBJECTIVES: Athletes generally desire changes in body composition in order to enhance their athletic performance. Often, athletes will practice chronic energy restrictions to attain body composition changes, altering their energy needs. Prediction of resting metabolic rates (RMR) is important in helping to determine an athlete's energy expenditure. This study compared measured RMR of athletic and non-athletic adolescents with predicted RMR from commonly used prediction equations to identify the most accurate equation applicable for adolescent athletes. SUBJECTS/METHODS: A total of 50 athletes (mean age of $16.6{\pm}1.0years$, 30 males and 20 females) and 50 non-athletes (mean age of $16.5{\pm}0.5years$, 30 males and 20 females) were enrolled in the study. The RMR of subjects was measured using indirect calorimetry. The accuracy of 11 RMR prediction equations was evaluated for bias, Pearson's correlation coefficient, and Bland-Altman analysis. RESULTS: Until more accurate prediction equations are developed, our findings recommend using the formulas by Cunningham (-29.8 kcal/day, limits of agreement -318.7 and +259.1 kcal/day) and Park (-0.842 kcal/day, limits of agreement -198.9 and +196.9 kcal/day) for prediction of RMR when studying male adolescent athletes. Among the new prediction formulas reviewed, the formula included in the fat-free mass as a variable [$RMR=730.4+15{\times}fat-free\;mass$] is paramount when examining athletes. CONCLUSIONS: The RMR prediction equation developed in this study is better in assessing the resting metabolic rate of Korean athletic adolescents.

• 동아시아식생활학회지
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• 제4권3호
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• pp.21-30
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• 1994

The relationship between bone mineral density and the environmental factors were investigated from the view point of preventing osteoporosis in Korean pubescent girls. The effects of calcium, nutrient intake, physical activity on total bone mineral density, lumbar spine and femoral bone mineral density and total bone mineral content were evaluated 33 healthy pubescent girls aged 14∼16y. A convenient method was used to assess nutritional and energy intake and calcium index was used together. Calcium intake in childhood was estimated by asking whether subjects usually drank milk as children. Eating habits data and history of menstruation were obtained by questionnaire and interview. Average energy expenditure was calculated. Bone mineral density and content were measured by dual energy x-ray absorptiometry using a Lunar DPX＋Scanner (Lunar, Madison, WI). The lumbar spine(L2∼L4) and three sites in the proximal femur (femoral neck, trochanteric region, and Ward's triangle)were measured. Height and weight were measured, and the body mass index(BMI) was derived from the formula : BMI=kg/㎡ Statistical analysis was performed by simple correlation using the SAS package. The mean calcium intake (736mg) was below the RDA of 800mg/d. Twelve percent of the total subjects did not drink milk at all because they did not like the taste. Skipping meals, low calcium intake and low energy intake were significantly correlated with the low BMD. Also the data indicate that girls who reported drinking milk with every meal during childhood had significantly higher bone densities than girls who reported drinking milk less frequently. The results suggest that milk consumption in childhood appears to be needed not only for growth and development, but possibly also to assure an optimal peak of bone mass and thus greater latitude for the maintenance or skeletal integrity in the face of bone losses. There was a highly significant correlation between the total BMD and overall level of physical activity. Body weight was a better predictor of total BMD than was and other factor. Simple mechanical loading may explain why body weight, but total BMC was positively relatd to height. Conclusively, increasing calcium intake and physical activity in the pubescent girls could influence BMD.

• 화약ㆍ발파
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• 제24권1호
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• pp.29-37
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• 2006

최근 국내 터널현장에서 기계식 장전장비를 활용한 벌크에멀전 (bulk emulsion) 폭약의 수요가 증가되면서 국내 암반 및 주변여건에 적합한 발파의 합리적인 설계기준이 요구되고 있다. 본 연구에서는 현재까지 국내에서 기계식 장전장비를 활용한 벌크에멀젼 폭약을 적용하여 시공한 사례 중 굴진효율 및 여굴량이 양호한 발파결과를 근거로 암반등급별 최적 비장약량과 영역별 적정 장약량을 검토하였다. 또한, 조건을 만족하는 발파결과를 분석하여 RMR 암반분류와 벌크에멀젼 폭약의 최적 비장약량과의 상관식 $({\Upsilon}= 0.669 + (0.0154{\times}RMR),\;r=0.81)$을 얻었고, 영역별로 천공장 변화에 따른 적정 장약량 범위를 산출하였다.

• Journal of Advanced Marine Engineering and Technology
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• 제6권2호
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• pp.69-91
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• 1982

The major factors which affect the crankshaft axial vibration are such items as the axial stiffness and mass of crankshaft, the thrust block stiffness, the propeller's entrained water and the exciting and damping forces of engine, propeller and shafting. Among above mentioned items, the axial stiffness and mass of crankshaft, thrust block stiffness and propeller's entrained water were treated in detail in part I, and so in this paper, the rest of above items will be studied. The exciting forces of crankshaft axial vibration are generated mainly from the gas explosion pressure of cylinder, the thrust fluctuation of propeller, and sometimes the torsional vibration of crankshaft induces the crankshaft axial vibration. As for the propeller thrust fluctuation, its harmonic components can be fairly exactly calculated from the experimental results of propeller in the towing tank, but as the calculation process is rather tedious and laborious, the empirical values are ordinarily used. On the other hand, the table of harmonic components of gas pressure has been already published by major slow speed diesel engine makers, but the axial thrust conversion factor of radial force is not unknown yet, and as its estimated value is unreliable, the axial vibration force of gas pressure is uncertain. As the calculation of damping force is very complicated and it includes some uncertain factors, the thoretically estimated amplitudes of axial vibration are much more incorrect in comparison with those of torsional vibrations. Authors have paid special attentions to deriving the theoretical calculation formula of axial conversion factor of radial force and damping force of crankshaft axial vibration and developed a computer program to calculate resonance amplitudes and additional stresses of crankshaft axial vibrations. Also, to check the reliability of the developed computer program, the axial vibrations of three ships' propulsion shaftings were analyzed and their results were compared with those of measured values and makers' results.

• 물과 미래
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• 제15권2호
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• pp.33-39
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• 1982

본 논문에서는 우리나라의 3개 단일목적댐(춘천, 청평, 화천)과 3개 다목점댐(소양, 안동, 대청)의 월 유하량 자료를 Thomas-Fiering 법과 조화함수법으로 50년간 모의발생하여 한계용량의 개념에 의하여 해석하였으며 조기별(월의 수) 단일목적 저수지와 다목적 저수지의 한계용량을 결정하였다. 그 결과 다음과 같은 Feller 형의 공식을 얻었다. (1) 단일목적 저수지 $R_n=2.8357 I\sqrt{n}$ (2) 다목적 저수지 $R_n=2.5145 I\sqrt{n}$ 그러므로 우리나라의 댐 지점에서의 월유하량은 Thomas-Fiering 법이 적합하며 Rippl의 누가곡선법에 의하지 않고 위의 공식에 의하여 주기별 한계용량을 쉽게 구할 수 있다.