• Clinical and Experimental Pediatrics
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• v.53 no.2
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• pp.136-145
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• 2010

Natural killer T (NKT) cell is a special type of T lymphocytes that has both receptor of natural killer (NK) cell (NK1.1, CD161c) and T cell (TCR) and express a conserved or invariant T cell receptor called $V{\alpha}14J{\alpha}18$ in mice or Va24 in humans. Invariant NKT (iNKT) cell recognizes lipid antigen presented by CD1d molecules. Marine-sponge-derived glycolipid, ${\alpha}-galactosylceremide$ (${\alpha}-GalCer$), binds CD1d at the cell surface of antigen-presenting cells and is presented to iNKT cells. Within hours, iNKT cells become activated and start to secrete Interleukin-4 and $interferon-{\gamma}$. NKT cell prevents autoimmune diseases, such as type 1 diabetes, experimental allergic encephalomyelitis, systemic lupus erythematous, inflammatory colitis, and Graves' thyroiditis, by activation with ${\alpha}-GalCer$. In addition, NKT cell is associated with infectious diseases by mycobacteria, leshmania, and virus. Moreover NKT cell is associated with asthma, especially CD4+ iNKT cells. In this review, I will discuss the characteristics of NKT cell and the association with inflammatory diseases, especially asthma.

• Natural Product Sciences
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• v.21 no.4
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• pp.293-296
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• 2015

A new L-isoascorbic acid derivative epi-leptosphaerin (1) and two known compounds leptosphaerin (2), and verongamine (3) were isolated from sponges of the orders Verongida and Thorectidae. Compounds 1 and 2 are most likely of sponge-associated fungal origin. In the present study, isolated compounds were investigated for their inhibition of soluble epoxide hydrolase (sEH), which is considered a promising target for the management of pain, inflammation, and comorbidities associated with diabetes. Compound 3, verongamine, displayed weak inhibitory activity against sEH with an $IC_{50}$ value $51.5{\pm}1.0{\mu}M$.

• Animal Systematics, Evolution and Diversity
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• v.25 no.2
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• pp.141-144
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• 2009

A new marine sponge in the family Ancorinidae, Penares hongdoensis n. sp. was collected from Hongdo Island, Korea by SCUBA diving in 2004. P. hongdoensis n. sp. is closely related to P. cortius de Laubenfels, 1930 in their spicules. However, they differ in kind and size of spicules and growth form. The dichotriaene rhabds of new species are larger than that of P. cortius. And the new species has oxyaster, but P. cortius has oxyspheraster. Although the growth forms of both species are irregular massive, this new species shows conspicuous long projection toward upper part.

• Journal of Microbiology
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• v.39 no.4
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• pp.254-264
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• 2001

Sponges are host organisms for various symbiotic microorganisms such as archaea, bacteria, cyano-bacteria and microalgae. Sponges are also sources of a wide variety of useful natural products like cyto-toxins. antifouling agents, antibiotics, and anti-inflammatory and antiviral compounds, Symbiotic microorganisms is sponges can be sources of various natural products, because metabolites previously ascribed to sponges have recently been demonstrated to be biosynthesized by symbionts. If a symbiotic microorganisms from which some natural products are derived can be cultured, the microorganism could be used in a mass production of the bioactive comopounds. We summarize recent research on iso-lation and cultivation of sponge-symbiotic microorganisms and the symbiotic relationship.

• Fisheries and Aquatic Sciences
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• v.9 no.4
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• pp.175-178
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• 2006

An acidic ent-cyclic peroxide was isolated from a sponge, Plakotis sp., and showed activity against leishmaniasis and pathogenic fungi. To improve the activity of this compound, we coupled the acidic ent-cyclic at the C1 position of ircinol A. Compound 3 exhibited significant activity against Leishmania mexican a and fungi with $IC_{50}$ values of 0.7 and $0.3-34{\mu}g/mL$, respectively. The yield of compound 3 was 98%.

• YAKHAK HOEJI
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• v.45 no.6
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• pp.575-581
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• 2001

The galactolipid M-5, which showed anti-inflammatory activity is glycoglycerolipid isolated from the Okinawa marine sponge Phyllospongia foliascens. Glycolipids have been synthesized by various methods, especially it were generally known that synthetic method of M-5 analogue and synthetic method of various glycolipids by glycosidation after synthesis of glycerolipid part. The others, it was not suggested that synthetic method via glycosylglycerol obtained by degradation from diglycoside. This study was carried out to investigate the synthesis of galactosylglycerol from melibiose as M-5 intermediate. Synthesis of galactosylglycerol was accomplished by selective protection of hydroxy group of sugar and diol cleavage by Pb(OAc)$_4$. As a result, galactosylglycerol was synthesized by 8 steps pathway and their structures were elucidated by analysis instrument.

• Animal cells and systems
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• v.8 no.4
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• pp.247-250
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• 2004

A taxonomic study on marine sponges was conducted by SCUBA diving at Gageodo Island, Korea from August 1999 to July 2001. Among them, Haliclona (Gellius) coreana n. sp. turned out to be new to science. This new species seems to be close to H. (G.) arcoferus Vosmaer, 1885, based on the type of spicules. However, it is different in size of toxa and growth form. Toxa of the new species is half in length compared to H. (G.) arcoferus. The growth form is jar shaped in this new species, but flat in H. (G.) arcoferus.

• Animal Systematics, Evolution and Diversity
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• v.34 no.2
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• pp.79-91
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• 2018

Three new genera and species of siphonostomatoid copepods are described as associates of sponges from shallow water of Samar Island in the Philippines: Samarus filipes n. gen., n. sp., Paurocheres dentatus n. gen., n. sp., and Platymyzon umbonatum n. gen., n. sp. A new family Samarusidae is proposed to accommodate Samarus n. gen. which has rudimentary legs 1-5 represented only by filiform setae. Paurocheres n. gen. is characterized by 2-segmented endopod of leg 4 and reduced setation of legs, and Platymyzon n. gen. by missing of mandibular gnathobase.

• Animal Systematics, Evolution and Diversity
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• v.37 no.4
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• pp.335-339
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• 2021

In 2020, during a survey of cnidarian fauna around Chuja-do locating in the northern part of Jeju-do, Korea, several hydroids were collected from the subtidal zone by SCUBA diving. Through taxonomic examination, one unrecorded species, Hydrodendron stechowi Hirohito, 1995, was found in Korea. It was newly added to the list of Korean hydrozoan fauna. This species was discovered for the first time since its first report as a new species in Japan. Their vivid orange-colored colonies were attached to the sponge on rocky substrate between depths of 15 and 20 m. Thus, a total of five species belonging to genus Hydrodendron, including the species reported in this study, have been reported in Korean waters so far.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.26 no.4
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• pp.305-311
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• 1993

Marine organisms were investigated to identify the marine actinomycetes that produced noble bioactive compounds. Microorganism counts range from $2.1{\times}10^3\;to\;1.2{\times}10\;CFU/g$ of marine organisms. Actinomycetes constituted 0.01 to $0.5\%$ of culturable microbial community. We identified the marine actinomycetes that produced novel bioactive compounds. During the course of screening for bioactives from the marine microorganisms, we found that the strain in sponge had antimicrobial activities. From the morphological, cultural and various physiological characteristics, this strain was identified for Actinomycetes No. 101. The optimal compositions of culture medium for Actinomycetes No. 101 were starch 30g/l as carbon source, casamino acid 10g/l as nitrogen source. The optimal pH of medium and fermentation temperature were $6.5{\sim}7.0$ and $30^{\circ}C$, respectively. Fermentation has been conducted in the marine broth at $30^{\circ}C$ for 72 hour. The yield of fermentation got about 3g as dry weight(per liter of broth). The distribution of antimicrobial activity of Actinomycetes No. 101 was screened by paper disc. The extract of cultured cell and broth inhibited the growth of Staphylococcus aureus and Bacillus subtilis, but the inhibition action was week against yeast and mold.