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http://dx.doi.org/10.5657/fas.2006.9.4.175

Coupling of ent-Cyclic Peroxide and Ircinol A, Two Biologically Active Natural Marine Products  

Lim, Chi-Won (Biotechnology Research Center, National Fisheries R&D Institute)
Kim, Yeun-Kye (Biotechnology Research Center, National Fisheries R&D Institute)
Jang, Mi-Soon (Biotechnology Research Center, National Fisheries R&D Institute)
Park, Jin-Il (Biotechnology Research Center, National Fisheries R&D Institute)
Park, Hee-Yeun (Biotechnology Research Center, National Fisheries R&D Institute)
Publication Information
Fisheries and Aquatic Sciences / v.9, no.4, 2006 , pp. 175-178 More about this Journal
Abstract
An acidic ent-cyclic peroxide was isolated from a sponge, Plakotis sp., and showed activity against leishmaniasis and pathogenic fungi. To improve the activity of this compound, we coupled the acidic ent-cyclic at the C1 position of ircinol A. Compound 3 exhibited significant activity against Leishmania mexican a and fungi with $IC_{50}$ values of 0.7 and $0.3-34{\mu}g/mL$, respectively. The yield of compound 3 was 98%.
Keywords
ent-cyclic peroxide; Ircinol A; Leishmania; Coupling;
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Times Cited By KSCI : 2  (Citation Analysis)
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