• Journal of Cerebrovascular and Endovascular Neurosurgery
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• v.25 no.2
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• pp.117-131
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• 2023

Intracranial dural arteriovenous fistulas (DAVF) are abnormal connections between intracranial arterial and venous systems within the dural layers. Intracranial DAVFs are rare but can occur wherever dural components exist. The pathogenesis of DAVFs is controversial. Venous hypertension is considered as a main cause of clinical symptoms which are subclassified into asymptomatic, benign and aggressive manifestations. To date, several classification schemes have been proposed to stratify the natural course and risks of DAVFs. Currently, endovascular therapy is the main treatment modality. Moreover, the use of radiosurgery and radiotherapy has been limited. Open surgery is also selectively performed as a main treatment modality for specific types of DAVFs and an adjunctive modality for the endovascular approach. Herein, we present a review of the general perspectives of intracranial DAVFs with an emphasis on the role of surgery.

• Journal of Pharmacopuncture
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• v.16 no.4
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• pp.14-21
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• 2013

Objectives: The objective of this study was to examine how an integrated approach to type 2 diabetes mellitus treatment could improve glycemic control and immune-potentiating activities adherent to oral hypoglycemic agents along with a botanical compound, among primary care patients. Methods: In this study, we used the self-control and the group-control methods. Candidates meeting the trial conditions were selected from among volunteers who had taken the test substance for 45 days. During the trial, all groups were on a controlled diet; neither were the original medications nor their dosages changed. Results: The results showed that the botanical compound (Glyco-Persica$^{(R)}$) significantly reduced the main clinical symptoms in diabetes type 2. In the treatment group, 36 of 52 patients (69.23%) and in the control group 10 of 52 patients (19.23%) showed reduced symptoms, and this difference was statistically significant (P < 0.05). The fasting blood sugar in the treatment group after treatment compared with that before treatment and with that in the control group after treatment was statistically different (P < 0.05). The post-prandial glucose in the treatment group after treatment was significantly different from that before treatment and from that in the control group after treatment (P < 0.05); the post-prandial blood sugar in the treatment group was reduced by 8.98%. Conclusions: The results revealed that the botanical compound (Glyco-Persica$^{(R)}$) has significant hypoglycemic properties which affect main clinical symptoms in diabetes type 2. Body weight, blood pressure, heart rate, routine blood, stool and urine tests showed no meaningful negative changes after the course of treatment. There was no significant adverse reaction during the trial.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.35 no.4
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• pp.1-30
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• 2022

Objectives : The purpose of this study was to explore the experience of patients with facial palsy symptoms treated with Korean medicine treatment(KMT) after western treatment. Methods : We conducted an individual in-depth interview with 10 participants who had experience in both western and KMT for facial palsy symptoms. This qualitative study adopted the grounded theory of Strauss and Corbin, and collected data was analyzed by using coding(open-axial-selective) that was performed to create paradigm model, which can explain this study's main theme. Results : The central phenomenon of this study was 'choosing Korean medicine treatment after western treatment preceded', and the core category was derived as 'selecting process of KMT after western medical treatment and improvement plan of Korean medicine treatment'. Conclusions : For patients with facial palsy, KMT was perceived as an essential treatment rather than an alternative, and recognized as the main treatment. Patients didn't settle for western treatment which was in progress, actively selected KMT and suggested the specific plan for improvement of KMT. Through this, we should be considered the direction of the KMT for facial palsy symptom which is the common disease of KMT.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.13 no.8
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• pp.704-710
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• 2000

Metal electrode materials for plasma display panel should have low electrical resistivity in order to maintain stable gas discharge and have fast response time. They should also hae good film uniformity adhesion and thermal stability. In this study Cr/Cu/Cr metal electrode structure is formed by DC magnetron sputtering. Cr and Cu films were deposited on ITO coated glasses with various DC power density and main pressures as the major parameters. After metal electrodes were formed a heat treatment was followed at 55$0^{\circ}C$ for 20 min in a vacuum furnace. The intrinsic stress of the sputtered Cr film passed a tensile stress maximum decreased and then became compressive with further increasing DC power density. Also with increasing the main pressure stress turned from compression to tension. After heat the treatment the electrical resistivity of the sputtered Cu film of 2${\mu}{\textrm}{m}$ in thickness prepared at 1 motor with the applied power density of 3.70 W/cm$^2$was 2.68 $\mu$$\Omega$.cm With increasing the main pressure the DC magnetron sputtered Cu film became more open structure. The heat treatment decreased the surface roughness of the sputtered Cr/Cu/Cr metal electrodes.

• Journal of Sasang Constitutional Medicine
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• v.32 no.1
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• pp.50-57
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• 2020

Objectives Allergic reaction to antibiotics is associated with increased use. And rate of Irritable Bowel Syndrome(IBS) is on the increase associated with stress, depression, anxiety, or previous intestinal problem. This case study reports significant improvement of patients with diarrhea accompanied by IBS who had suffered from allergic reaction to antibiotics after treatment with Sasang constitutional medicine. Methods This patient was diagnosed as Taeeumin type. Sasang constitutional medicine was taken by the patient, almost three times per day during treatment periods. We measured the degree of the main symptoms such as diarrhea, abdominal discomfort, insomnia, itching etc, using Visual Analogue Scale(VAS). Results The symptoms of diarrhea, abdominal discomfort, and insomnia were improved. VAS score was decreased from 4~5 to 0~1 for about two weeks. Conclusions This case shows that Sasang constitutional medicine treatment can contribute to improve main symptoms accompanied by IBS.

• Radiation Oncology Journal
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• v.38 no.1
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• pp.1-10
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• 2020

Radiotherapy (RT) has been used for decades as one of the main treatment modalities for cancer patients. The therapeutic effect of RT has been primarily ascribed to DNA damage leading to tumor cell death. Besides direct tumoricidal effect, RT affects antitumor responses through immune-mediated mechanism, which provides a rationale for combining RT and immunotherapy for cancer treatment. Thus far, for the combined treatment with RT, numerous studies have focused on the immune checkpoint inhibitors and have shown promising results. However, treatment resistance is still common, and one of the main resistance mechanisms is thought to be due to the immunosuppressive tumor microenvironment where myeloid-derived suppressor cells (MDSCs) play a crucial role. MDSCs are immature myeloid cells with a strong immunosuppressive activity. MDSC frequency is correlated with tumor progression, recurrence, negative clinical outcome, and reduced efficacy of immunotherapy. Therefore, increasing efforts to target MDSCs have been made to overcome the resistance in cancer treatments. In this review, we focus on the role of MDSCs in RT and highlight growing evidence for targeting MDSCs in combination with RT to improve cancer treatment.

• Archives of Pharmacal Research
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• v.27 no.2
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• pp.254-258
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• 2004

The purpose of this study was to investigate the pharmacokinetic alteration of diltiazem and its main metabolite, deacetyldiltiazem, after oral administration of diltiazem in rabbits with or with-out cimetidine co-administration. The area under the plasma concentration-time curve (AUC) of diltiazem was significantly elevated in rabbits pretreated with cimetidine, suggesting that the oral clearance, an index of intrinsic clearance, may be decreased by the cimetidine treatment. Consistent with the increased AUC by the treatment, peak plasma concentration ($C_{max}$) for diltiazem was also elevated. Apparent volume of distribution normalized by the bioavailability (($V_{d}$/F) of diltiazem increased sigrificantly in rabbits pretreated with cimetidine increased. Taken together with the fact that the first pass metabolism for diltiazem is the primary determinant for the oral bioavailability, these observations indicate that increases in the oral clearance and (($V_{d}$/F may be a manifestation of the decreased first pass metabolism. Consistent with the hypothesis, the AUC of deacetyldiltiazem was significantly decreased in rabbits with cimetidine treatment. Ratio of deacetyldiltiazem to total diltiazem in the plasma was significantly decreased in rabbits with cimetidine treatment. These observations suggested that the metabolism of diltiazem to deacetyldiltiazem was reduced by cimetidine treatment and that the dosage of diltiazem should be adjusted when the drug is co-administered chronically with cimetidine in a clinical setting.

• Journal of the korean academy of Pediatric Dentistry
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• v.25 no.1
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• pp.171-184
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• 1998

The purpose of the study was to observe the association between the main colors of school children's drawings of dental treatment situation and their dental anxiety. The subjects of study were 688 school children from 2nd to 4th grade. Caries experience was investigated by oral examination. Questionnaire survey was done regarding children's attitude toward the dentist and dental treatment and their experience of pain and fear during the dental treatment. Colors with high frequency of use were green, blue, yellow, orange, pink, purple, gray, brown, yellow ochre, red, white, and black in order. Boys used green and blue, and girls used yellow and orange, more than each other. As the grade increased, white, yellow, and blue increased and brown decreased. Colors with high dental anxiety level were black, brown, red, white, blue, orange, yellow and green, yellow ochre, gray, pink, and purple in order, and the upper four represented 10.5% of the subjects. Children with high decayed teeth rate had a tendency to use colors of high dental anxiety level. Black color had the most obvious association with the pain and fear of dental treatment.

• The Journal of Korean Medicine
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• v.44 no.3
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• pp.39-46
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• 2023

Objectives: This research aims to analyze the relationship between Daeseunggi-tang and sepsis in literature. Methods: The main treatment symptoms of Daeseunggi-tang presented in Sanghanron and GeumGweyoryak, the symptoms of Ju-hwang and Nae-ham which correspond to sepsis in Korean Medicine, the symptoms of sepsis presented in the related papers including international guideline and diagnosis criteria of spesis were compared and analyzed. Results: The main treatment symptoms of Daeseunggi-tang were very similar to the symptoms of sepsis, and were almost identical to the symptoms of Ju-hwang and Nae-ham (especially Hwa-ham, Gu-ham), which are the Korean medicine descriptions of sepsis. Conclusions: Based on the above research results, it seems to be possible to use Daeseunggi-tang for the treatment of sepsis.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.15 no.1
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• pp.14-22
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• 2019

The aim of this study was to determine the factors contributing to the barrier of dental treatment for special needs patients perceived by the main caregivers of the patients. A questionnaire was developed with three parts: patient-related factors, caregiver-related factors, and factors for treatment barriers. Patient- and caregiver-related factors were analyzed for correlations with the barrier factors. Fisher's exact test and Chi-square test were used at the level of 0.05. A total of 52 caregivers (mean age [SD]=50.2 [11.5] years) for the patients with intellectual and cognitive disabilities (mean age [SD]=38.9 [21.3]) responded to the questionnaires. Oral hygiene status, need for assistance in tooth brushing, and cooperation for tooth brushing were correlated with the level of treatment cooperation of the patients (p<0.05). The above three factors were also correlated with the treatment barrier despite patients presenting oral symptoms (p<0.05). Two thirds of the caregivers felt the treatment cost as severe or a considerable financial burden. For patients, insurance types and need for assistance in tooth brushing, and for caregivers, education levels and financial status were significant factors contributing to financial burden (p<0.05). There were background factors of the patients and their caregivers associated with access to dental treatment for special needs patients. Deficient cooperative skills and financial burdens were the main obstacles to treatment access. Tooth brushing skills and oral hygiene status can be proxy measures to cooperative ability for dental treatment.