• Journal of Korean Society of Industrial and Systems Engineering
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• v.19 no.39
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• pp.63-73
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• 1996

With the success of flexible manufacturing systems (FMSs), flexible assembly systems (FASs) have been developed to automate factories further. As in a cellular FMS, a cellular FAS is considered as the most flexible and feasible assembly system configuration Because of the differences between manufacturing and assembly operation, the logic of cell formation and cell layout between a FMS and a FAS is not the same. Since the time for assembly operation is usually relatively short, the transfer time is thus very crucial for the performance of assembly systems. Therefore in assembly systems it is important to reduce the transfer time by sequencing operations efficiently and arranging machines like the sequences. The network-type layout is not only feasible for the machine arrangement based on operation sequences, but it has also layout flexibility. Therefore it is a reasonable layout configuration for cellular FASs. This paper presents a method for the cell layout based on the network-type layout in a cellular FAS design.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2004.04a
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• pp.518-523
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• 2004

PLGA was suggested. Under various conditions, their diameters and porosity as well as mechanical strength were evaluated. In addition to those, cell(chondrocyte) proliferation and formation of extracelluar matrices were also investigated along with the conventional membrane type PLGA scaffolds for the potential use in tissue engineering. As conclusions, this type of scaffold showed a potential of application to tissue engineering in view of mechanical stability as well as cellular responses.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1995.11a
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• pp.167-170
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• 1995

LiCoO$_2$is a electrode material of Li ion Cell which is expected as the cell with a very high electric charge density. The recent study is mainly to focused on a high power secondary cell. If very thin Li ion Cell can be made in the scale of IC substrate it can be a electric souse in IC chip , micro machine or very thin electrical display etc. LiCoO$_2$thin film can be made by CVD, Laser ablation, E-Beam, ton Beam process, sputtering etc. But to make the material with a high quality for a cell is difficult as the electrode in cell have the fitable ratio in components and a lattice structure of bulk etc. In this study, LiCoO$_2$is made by R.F magnetron sputtering with the variance of substrate temperature and oxygen partial pressure etc. In the substrate temperature of 600$^{\circ}C$ and the oxygen rate of 10%, we can acquire the good thin film LiCoO$_2$compared wish a bulk material.

• Journal of the Korean Operations Research and Management Science Society
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• v.23 no.4
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• pp.63-73
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• 1998

With the success of flexible manufacturing systems(FMSs), flexible assembly systems(FASs) have been developed to automatic factories further. As in a cellular FMS, a celluar FAS is considered as the most flexible and feasible assembly systems configuration. This paper presents a method for the integrated layout design in cellular FASs. Unlike the traditional paper, this paper deals with the formation of cells and the layout of cells for jobs with operation times on different machines. The procedure in this paper consists of two distinct phases. The first phase presents machine arrangement in a double rows flowline. cell formation not to allow intercellular movements, and integrated layout design in cellular FASs considering the characteristics of FAS, layout, and production factors This phase uses older optimal algorithm. The second phase proposes to balance the system with an objective of reducing the degree of workload deviation in the cells. Simulated annealing method is used to balance the system. This phase also shows the integrated layout design in cellular FASs with the cost less than total cost of the first phase.

• Journal of Sensor Science and Technology
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• v.23 no.3
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• pp.170-172
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• 2014

$CO_2$ sensor was used only one solid electrolyte in many cases. To improve the sensing characteristics of $CO_2$ sensors, solid electrolyte $CO_2$ sensor has been developed by bi-electrolyte type sensor using Na-Beta-alumina and YSZ. However, in many further studies, bi-electrolyte type sensor was made by pellet pressed by press machine and additional treatment for formation of interface. In the aspect of mass production, using thick film and additional treatment is not suitable. In this study, $CO_2$ sensor was fabricated by bi-electrolyte structure which was made by an NBA paste layer deposited on YSZ pellet and fired at $1650^{\circ}C$ for 2 hour. The formation of stable interface between YSZ and NBA were confirmed by SEM image. When the type IV electrochemical cell arrangement represented by $CO_2,O_2,Pt{\mid}Li_2CO_3-CaCO_3{\parallel}NBA{\parallel}YSZ{\mid}O_2,Pt$ is used to measure the $CO_2$ concentration in air. This sensor EMF should depend only on the concentration of $CO_2$ by logarithmic. Also, sensor shows $P_{CO_2}$ and EMF relationship like nerstian reaction at a temperature of $450^{\circ}C$.

• Journal of Korean Institute of Industrial Engineers
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• v.26 no.1
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• pp.1-8
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• 2000

We extended a minimum spanning tree algorithm (Cho et al., 1997) by characterizing the mutually independent cells with maximizing the grouping efficiency referring to few propositions developed by Shu, 1990 in cellular manufacturing system. Each row of the machine-part incidence matrix is regarded as a node in a graph, and a distance function is defined for every pair of nodes. It shows that there are K mutually independent cells in the cellular manufacturing system if only if there are K-1 arcs of length 1 in the minimum spanning tree of the graph, and gives an effective policy for sub-cell formation from larger cells.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1995.04a
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• pp.958-961
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• 1995

MODROC 기법이 대표적인 일반화된 기계-셀 형성 기법은 부품 생산비용, 부품가공시간, 공정순서, 로트 크기 등을 고려하여, 기계-셀을 형성함에 있어, 보다 현실적인 접근을 추구한 것이다. 그러나, 수리적 문제 해결의 한계로 인해 현실 접근성이 제한되며, 신경망을 이용한 기존의 기법들 역시 수리적 제한환경을 설정한 것이어서 현실적인 응용가능성이 떨어지고 있다. 본 논문에서는 공정순서와 공장배치를 고려하여 기계-셀의 효율적인 형성을 꾀하였다. 신경망 모델인 자기조직화 형성기법을 응용하였으며, 공장 작업영역과 기계-셀의 위치가 주어짐에 따라 공정순서를 고려하여 물류의 이동을 최소화하는 기계-셀의 형성 방법을 꾀하였다. 본 기계-셀 형성 방법은 기존의 방식에 비해 짧은 시간에 기계-셀을 형성할 수 있으며, 그에 따른 부품군의 형성은 공정을 고려하여 총 물류량을 감소시키는 방향으로 결정되는 장점을 갖고 있다. 또한, 다변화되는 환경에 대한 적응성과 예외적 요소(exceptional element)에 대한 셀 형성 및 처리가 매우 유연하게 나타내어 진다. 본 연구에서는 공정 간에 기계의 중복이 있는 경우의 기계-셀 형성 문제에 대해 제한된 기법을 적용하였다.

• Genomics & Informatics
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• v.14 no.2
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• pp.53-61
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• 2016

Toxoplasma gondii is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. It causes encephalitis, uveitis, chorioretinitis, and congenital infection. T. gondii invades the host cell by forming a moving junction (MJ) complex. This complex formation is initiated by intermolecular interactions between the two secretory parasitic proteins-namely, apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2) and is critically essential for the host invasion process. By this study, we propose two potential leads, NSC95522 and NSC179676 that can efficiently target the AMA1 hydrophobic cleft, which is a hotspot for targeting MJ complex formation. The proposed leads are the result of an exhaustive conformational search-based virtual screen with multilevel precision scoring of the docking affinities. These two compounds surpassed all the precision levels of docking and also the stringent post docking and cumulative molecular dynamics evaluations. Moreover, the backbone flexibility of hotspot residues in the hydrophobic cleft, which has been previously reported to be essential for accommodative binding of RON2 to AMA1, was also highly perturbed by these compounds. Furthermore, binding free energy calculations of these two compounds also revealed a significant affinity to AMA1. Machine learning approaches also predicted these two compounds to possess more relevant activities. Hence, these two leads, NSC95522 and NSC179676, may prove to be potential inhibitors targeting AMA1-RON2 complex formation towards combating toxoplasmosis.

• Archives of Plastic Surgery
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• v.38 no.4
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• pp.438-444
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• 2011

Purpose: Adipose-derived stromal cells (ASCs) are readily harvested from lipoaspirated tissue or subcutaneous adipose tissue fragments. The stromal vascular fraction (SVF) is a heterogeneous set of cell populations that surround and support adipose tissue, which includes the stromal cells, ASCs, that have the ability to differentiate into cells of several lineages and contains cells from the microvasculature. The mechanisms that drive the ASCs into the osteoblast lineage are still not clear, but the process has been more extensively studied in bone marrow stromal cells. The purpose of this study was to investigate the osteogenic capacity of adipose derived SVF cells and evaluate bone formation following implantation of SVF cells into the bone defect of human phalanx. Methods: Case 1 a 43-year-old male was wounded while using a press machine. After first operation, segmental bone defects of the left 3rd and 4th middle phalanx occurred. At first we injected the SVF cells combined with demineralized bone matrix (DBM) to defected 4th middle phalangeal bone lesion. We used P (L/DL)LA [Poly (70L-lactide-co-30DL-lactide) Co Polymer P (L/DL)LA] as a scaffold. Next, we implanted the SVF cells combined with DBM to repair left 3rd middle phalangeal bone defect in sequence. Case 2 was a 25-year-old man with crushing hand injury. Three months after the previous surgery, we implanted the SVF cells combined with DBM to restore right 3rd middle phalangeal bone defect by syringe injection. Radiographic images were taken at follow-up hospital visits and evaluated radiographically by means of computerized analysis of digital images. Results: The phalangeal bone defect was treated with autologous SVF cells isolated and applied in a single operative procedure in combination with DBM. The SVF cells were supported in place with mechanical fixation with a resorbable macroporous sheets acting as a soft tissue barrier. The radiographic appearance of the defect revealed a restoration to average bone density and stable position of pharyngeal bone. Densitometric evaluations for digital X-ray revealed improved bone densities in two cases with pharyngeal bone defects, that is, 65.2% for 4th finger of the case 1, 60.5% for 3rd finger of the case 1 and 60.1% for the case 2. Conclusion: This study demonstrated that adipose derived stromal vascular fraction cells have osteogenic potential in two clinical case studies. Thus, these reports show that cells from the SVF cells have potential in many areas of clinical cell therapy and regenerative medicine, albeit a lot of work is yet to be done.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.65 no.1
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• pp.63-71
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• 2020

The purpose of this study was to analyze the growth characteristics of perilla according to the materials of the seedbed for the development of seedling plug technology suitable for the mechanical transplantation of perilla. Perilla (Perilla frutescens var. japonica Hara) cultivars Deulsaem and Sodam were used in this experiment. The composition ratios of 170 products from 16 companies published in the 'Korean Association of Seedbed Media' homepage were compared according to usage and type, and 11 products that corresponded to the average were selected. The seedbed was classified according to the seedbed for paddy rice as light-weight, semi-weight, and weight, and based on the seedbed for horticulture, as light-weight and ultra-light. The seedlings were placed in 72-cell (semi-automatic), 128-cell (automatic) and 220-cell (automatic) plug trays. We selected 2 light-weight seedbeds of paddy rice and 2 light-weight seedbeds of horticultural products with the highest plant growth. We analyzed plant height and mat formation of the perilla roots. Results showed that the perilla height and mat formation were the best in light-weight seedbeds of paddy rice (product R1). Therefore, light-weight seedbeds of rice (product R1) were suitable for perilla plant transplantation. The estimated major components were vermiculite 41.0%, cocopeat 31.0%, peat moss 5.7%, and red-yellow soil 20.0%. The mechanical transplantation of perilla significantly boosts plant growth and reduces sowing and thinning efforts. However, continuous evaluation of newly introduced, commercial seedbeds is needed.