• 셀메드
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• 제8권2호
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• pp.6.1-6.7
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• 2018

Myristica fragrans Houtt is commonly known as "nutmeg", it produces two spices: mace and nutmeg. Mace and nutmeg are strongly aromatic in nature and known as jowzabuwa and javetri/bisbasah respectively in the Unani system of medicine. M. fragrans was used as early as 700 BCE by Indian, however, ancient Greeks and Romans were not aware of it. Later Arab traders introduce M. fragrans into Europe followed by Portuguese and Dutch merchants. Mace is very useful medicine in the Unani system of medicine because of its therapeutic uses in salasal al-bawl (urinary incontinence), amrad-i-qalb (cardiac diseases), amrad-i-dimagh (central nervous system), zo'fe bah (sexual debility), amrad al-rahim (uterine diseases), and su-i-hazim (indigestion). The most important constituents of mace essential oil are ${\alpha}-pinene$, sabinene, myrcene, limonene, 1,8-cineole, terpinen-4-ol, myristicin, ${\gamma}-terpinene$, and safrole. The seed and mace extract of nutmeg contain quite high tannins, flavonoids, and terpenoids. Mace has pharmacological functions such as antibacterial and antifungal, anti-inflammatory, analgesic, antidiarrhea, antioxidant, chemoprotective, neuropharmacologic, and antidiabetic properties. To explore the correlation between the traditional uses and the same proven by recent researches, a comprehensive review is highlighted in this paper. Further, pharmacological activities which are not reported in classical texts are also discussed.

• Annals of Laboratory Medicine
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• 제38권6호
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• pp.538-544
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• 2018

Background: Serum copeptin has been demonstrated to be useful in early risk stratification and prognostication of patients with acute myocardial infarction (AMI). However, the prognostic value of copeptin after percutaneous coronary intervention (PCI) for clinical outcomes remains uncertain. We investigated the prognostic role of serum copeptin levels immediately after successful PCI as a prognostic marker for major adverse cardiac events (MACE; comprising death, repeat PCI, recurrent MI, or coronary artery bypass grafting) in patients with AMI. Methods: A retrospective study was performed in 149 patients with AMI who successfully received PCI. Serum copeptin levels were analyzed in blood samples collected immediately after PCI. The association between copeptin levels and MACE during the follow-up period was evaluated. Results: MACE occurred in 34 (22.8%) patients during a median follow-up of 30.1 months. MACE patients had higher copeptin levels than non-MACE patients did. Multiple logistic regression analysis showed that the increase in serum copeptin levels was associated with increased MACE incidence (odds ratio=1.6, P =0.005). Conclusions: A high level of serum copeptin measured immediately after PCI was associated with MACE in patients with AMI during long-term follow-up. Serum copeptin levels can serve as a prognostic marker in patients with AMI after successful PCI.

• Journal of Chest Surgery
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• 제55권6호
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• pp.442-451
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• 2022

Background: This meta-analysis was conducted to evaluate the effect of fractional flow reserve (FFR) on clinical outcomes after coronary artery bypass grafting (CABG). Methods: Five online databases were searched for studies that (1) enrolled patients who underwent isolated CABG or CABG with aortic valve replacement and (2) demonstrated the effect of an FFR-guided strategy on major adverse cardiac events (MACE) after surgery based on a randomized controlled trial or adjusted analysis. MACE included cardiac death, acute myocardial infarction (MI), and repeated revascularization. The primary outcomes were all MACE outcomes and a composite of all-cause death and MI, and the secondary outcomes were the individual MACE outcomes. Publication bias was assessed using a funnel plot and the Egger test. Results: Six articles (3 randomized and 3 non-randomized studies: n=1,027) were selected. MACE data were extracted from 4 studies. The pooled analyses showed that the risk of MACE was not significantly different between patients who underwent FFR-guided CABG and those who underwent angiography-guided CABG (hazard ratio [HR], 0.80; 95% CI, 0.57-1.12). However, the risk of the composite of death or MI was significantly lower in patients undergoing FFR-guided CABG (HR, 0.62; 95% CI, 0.41-0.94). The individual MACE outcomes were not significantly different between FFR-guided and angiography-guided CABG. Conclusion: FFR-guided CABG might be beneficial in terms of the composite outcome of death or MI compared with angiography-guided CABG although data are limited.

• 전자공학회논문지B
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• 제30B권4호
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• pp.44-55
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• 1993

In this paper, we proposed a new optical method for the efficient recognition of Korean characters. There are six filters in the proposed method which employed the concepts of amplitude-modulated phase-only filter(AMPOF) and spatial frequency modulation(SFM). Here, amplitude modulation is used to achieve improved correlation discrimination and SFM is to reduce the number of filters. We also used a simplified synthetic discriminant function(SDF) for distortion invariance of input image. In order to recognize the partial rotation invariant Korean characters, the proposed distortion invariant minimum average correlation energy (MACE) filter is synthesized SFM, partial rotation invariant filter (PRIF), AMPOF and MACE for partial rotation invariance in the frequency domain. The advantage of the proposed filters is to supress the sidelobes of cross correlation peak away from the autocorrelation peak and to produce sharp correlation peaks. We performed simulation and optical experiment for some of Korea characters using the proposed method. The results show that the proposed method has more improved discriminant ability and reduced processing time than the conventional methods.

• 한국광학회:학술대회논문집
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• 한국광학회 2007년도 동계학술발표회 논문집
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• pp.177-178
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• 2007

• 한국정보과학회 언어공학연구회:학술대회논문집(한글 및 한국어 정보처리)
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• 한국정보과학회언어공학연구회 1989년도 한글날기념 학술대회 발표논문집
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• pp.148-153
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• 1989

본 논문에서는 광 상관기 (optical correlator) 에 의한 한글문자 분리 인식의 한 방법을 제안하였다. 효율적인 분리 인식을 위해서 병렬 나무 (tree) 구조로부터 입력 신호를 두 방향으로 병렬 처리하여 각 방향으로 자음과 모음을 따로 분리시켜 2단계 만에 인식한 뒤 이들을 위치에 따라 조합하여 문자 분리 인식하도록 하며, 아울러 이러한 병렬 나무구조의 각 단계에서 필터 합성시 MACE (minimum average correlation energy) 개념을 이용하여 광 상 관평면상에서 부엽의 문제를 줄이고, 실제 광 시스템에서 생길 수 있는 왜곡을 학습표본에 포함하여 광 상관기 시스템에 의한 실질적인 한글 문자의 왜곡에 무관한 분리인식을 하도록 하였다.

• 대학교육
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• 통권8호
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• pp.44-46
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• 1984

• Korean Journal of Radiology
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• 제23권10호
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• pp.939-948
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• 2022

Objective: Evidence supports the efficacy of coronary computed tomography angiography (CCTA)-based risk scores in cardiovascular risk stratification of patients with suspected coronary artery disease (CAD). We aimed to compare two CCTA-based risk score algorithms, Leiden and Confirm scores, in patients with diabetes mellitus (DM) and suspected CAD. Materials and Methods: This single-center prospective cohort study consecutively included 1241 DM patients (54.1% male, 60.2 ± 10.4 years) referred for CCTA for suspected CAD in 2015-2017. Leiden and Confirm scores were calculated and stratified as < 5 (reference), 5-20, and > 20 for Leiden and < 14.3 (reference), 14.3-19.5, and > 19.5 for Confirm. Major adverse cardiovascular events (MACE) were defined as the composite outcomes of cardiovascular death, nonfatal myocardial infarction (MI), stroke, and unstable angina requiring hospitalization. The Cox model and Kaplan-Meier method were used to evaluate the effect size of the risk scores on MACE. The area under the curve (AUC) at the median follow-up time was also compared between score algorithms. Results: During a median follow-up of 31 months (interquartile range, 27.6-37.3 months), 131 of MACE were recorded, including 17 cardiovascular deaths, 28 nonfatal MIs, 64 unstable anginas requiring hospitalization, and 22 strokes. An incremental incidence of MACE was observed in both Leiden and Confirm scores, with an increase in the scores (log-rank p < 0.001). In the multivariable analysis, compared with Leiden score < 5, the hazard ratios for Leiden scores of 5-20 and > 20 were 2.37 (95% confidence interval [CI]: 1.53-3.69; p < 0.001) and 4.39 (95% CI: 2.40-8.01; p < 0.001), respectively, while the Confirm score did not demonstrate a statistically significant association with the risk of MACE. The Leiden score showed a greater AUC of 0.840 compared to 0.777 for the Confirm score (p < 0.001). Conclusion: CCTA-based risk score algorithms could be used as reliable cardiovascular risk predictors in patients with DM and suspected CAD, among which the Leiden score outperformed the Confirm score in predicting MACE.

• Korean Journal of Radiology
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• 제23권2호
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• pp.172-179
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• 2022

Objective: We aimed to evaluate the ostium of right coronary artery of anomalous origin from the left coronary sinus (AORL) with an interarterial course throughout the cardiac cycle on CT and analyze the clinical significance of the ostial findings. Materials and Methods: From January 2011 to December 2015, 68 patients (41 male, 57.3 ± 12.1 years) with AORL with an interarterial course and retrospective cardiac CT data were included. AORL was classified as high or low ostial location based on the pulmonary annulus in the diastolic and systolic phases on cardiac CT. In addition, the height, width, height/width ratio, area, and angle of the ostium were measured in both cardiac phases. After cardiac CT, patients were followed until December 31, 2020 for major adverse cardiac events (MACE). Clinical and CT characteristics associated with MACE were explored using Cox regression analysis. Results: During a median follow-up period of 2071 days (interquartile range, 1180.5-2747.3 days), 13 patients experienced MACE (19.1%, 13/68). Seven (10.3%, 7/68) had the ostial location change from high in the diastolic phase to low in the systolic phase. In the univariable analysis, younger age (hazard ratio [HR] = 0.918, p < 0.001), high ostial location (HR = 4.008, p = 0.036), larger height/width ratio (HR = 5.621, p = 0.049), and smaller ostial angle (HR = 0.846, p = 0.048) in the systolic phase were significant predictors of MACE. In multivariable cox regression analysis, younger age (adjusted HR = 0.917, p = 0.002) and high ostial location in the systolic phase (adjusted HR = 4.345, p = 0.026) were independent predictors of MACE. Conclusion: The ostial location of AORL with an interarterial course can change during the cardiac cycle, and high ostial location in the systolic phase was an independent predictor of MACE.

• 한국광학회지
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• 제14권4호
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• pp.383-391
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• 2003

개인의 신원정보 보호를 위하여 새로운 광 정보보호 시스템을 제안하였다. 개인 신원정보의 확인과 인증을 위하여 얼굴영상과 개인식별번호로 구성된 신원정보를 사용하였다. 영상 암호화는 4-f 광상관기의 입력과 푸리에영역에서 랜덤위상패턴을 사용하는 위상암호화 기술을 사용하였다. 그렇지만 암호화된 영상을 복원하는 과정에서 개인의 신원정보가 유출될 가능성이 있다. 이에 대처하기 위하여 신원확인 과정에서 영상을 복원하지 않고 암호화된 영상을 그대로 사용하였다. 암호화된 개인식별번호는 제안된 MMACE_p 필터를 사용하여 분류ㆍ인식하였고, 개인정보의 인증은 OWMF를 사용하여 얼굴영상의 상관치를 구하여 확인하였다. 제안된 MMACE_p 필터는 10개의 암호화된 숫자를 한꺼번에 인식할 수 있도록 4개의 MACE_p필터를 다중화하여 합성하였고, OWMF는 얼굴영상의 분리인식 능력과 SNR을 향상시킬 수 있도록 하였다. 컴퓨터 시뮤레이션을 통하여 제안된 정보보호기술이 개인신원정보 보호에 적용될 수 있음을 보였다.