• 제목/요약/키워드: lymphatic system

검색결과 104건 처리시간 0.025초

The Magnetic Mobility of Biomolecule Sanals of the Lymphatic Primo Vascular System

  • Noh, Young-Il;Hong, Ye-Ji;Shin, Jun-Young;Rhee, Jin-Kyu;Lee, Sang-Suk
    • Journal of Magnetics
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    • 제18권2호
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    • pp.188-191
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    • 2013
  • The magnetic properties for sanal's mobility inside of the lymphatic primo vascular system, the so-called Kyungrak (or meridian) system, are investigated under a low static magnetic field with the anatomy technology and optical microscope. One sanal with a size of 1 ${\mu}m$ under microscope selected and separated from the primo vessels of the primo vascular system are observed in rabbits' lymphatic vessels around abdominal aorta and placed in PBS solution with petridish. The moving displacement of sanal versus the measuring time of 20 Oe below a magnetic field of 80 Oe is stronger in dominanting dependence according to the x-direction than y-direction.

Assessment of Meningeal Lymphatics in the Parasagittal Dural Space: A Prospective Feasibility Study Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

  • Bio Joo;Mina Park;Sung Jun Ahn;Sang Hyun Suh
    • Korean Journal of Radiology
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    • 제24권5호
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    • pp.444-453
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    • 2023
  • Objective: Meningeal lymphatic vessels are predominantly located in the parasagittal dural space (PSD); these vessels drain interstitial fluids out of the brain and contribute to the glymphatic system. We aimed to investigate the ability of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in assessing the dynamic changes in the meningeal lymphatic vessels in PSD. Materials and Methods: Eighteen participants (26-71 years; male:female, 10:8), without neurological or psychiatric diseases, were prospectively enrolled and underwent DCE-MRI. Three regions of interests (ROIs) were placed on the PSD, superior sagittal sinus (SSS), and cortical vein. Early and delayed enhancement patterns and six kinetic curve-derived parameters were obtained and compared between the three ROIs. Moreover, the participants were grouped into the young (< 65 years; n = 9) or older (≥ 65 years; n = 9) groups. Enhancement patterns and kinetic curve-derived parameters in the PSD were compared between the two groups. Results: The PSD showed different enhancement patterns than the SSS and cortical veins (P < 0.001 and P < 0.001, respectively) in the early and delayed phases. The PSD showed slow early enhancement and a delayed wash-out pattern. The six kinetic curve-derived parameters of PSD was significantly different than that of the SSS and cortical vein. The PSD washout rate of older participants was significantly lower (median, 0.09; interquartile range [IQR], 0.01-0.15) than that of younger participants (median, 0.32; IQR, 0.07-0.45) (P = 0.040). Conclusion: This study shows that the dynamic changes of meningeal lymphatic vessels in PSD can be assessed with DCE-MRI, and the results are different from those of the venous structures. Our finding that delayed wash-out was more pronounced in the PSD of older participants suggests that aging may disturb the meningeal lymphatic drainage.

The Effect of Manual Lymph Drainage on the Changes of Autonomic Nervous System and Pain in Stressed Hospital Office Employees

  • Ko, Min-Gyun
    • 한국컴퓨터정보학회논문지
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    • 제25권11호
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    • pp.263-268
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    • 2020
  • 본 연구는 도수림프배출법이 스트레스가 있는 의료기관 사무직 종사자들에 대한 자율신경계와 통증에 미치는 효과를 알아보고자 하였다. 총 30명의 스트레스가 많은 의료기관 사무직 여성들이 자발적으로 연구에 참여하였다. 대상자들은 도수림프배출군과 휴식군으로 무작위 분류하였다. 각 군에 20분간 중재를 실시하였다. 도수림프배출군 내에서 교감신경, 부교감신경, 통증에서 유의한 차이가 나타났고(p<.05), 두 군간의 비교에서는 교감신경, 부교감신경, 통증에서 유의한 차이가 나타났다(p<.05). 그러므로, 도수림프배출법은 스트레스가 있는 의료기관 사무직 종사들의 스트레스와 통증을 감소시키는데 큰 도움이 될 것이다.

자궁경부암 환자에서의 Lymphoscintigraphy 소견 (Iliopelvic Lymphoscintigraphic Findings in Carcinoma of Uterine Cervix)

  • 임상무;홍성운;박상윤;이제호;이의돈;이경희;박기복;최창운
    • 대한핵의학회지
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    • 제24권2호
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    • pp.286-292
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    • 1990
  • Iliopelvic lymphoscintigraphy was performed to visualize the changes of the lymphatic system using Technetium-99m antimony sulfide colloid in carcinoma of uterine cervix. There were no differences between various indices and clinical stages, but comparison with computed tomographic and postoperative findings, there was meaningful difference in index of decrease and increase, respectively. And lymphoscintigraphy showed by pass way of lymphatic channel in 42 cases (16%) and this suggested the presence of normal shunts of lymphatic channels. Iliopelvic lymphoscintigraphy may be useful for evaluation of lymphatic system in carcinoma of uterine cervix, expecially for screening method.

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스킨-림프-칩 상에서 LymphanaxTM 의 림프 형성 촉진능 (LymphanaxTM Enhances Lymphangiogenesis in an Artificial Human Skin Model, Skin-lymph-on-a-chip)

  • 박필준;김민섭;최시은;김현수;정석
    • 대한화장품학회지
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    • 제50권2호
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    • pp.119-129
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    • 2024
  • 인체 피부 림프계는 간질액을 배출하고 면역 시스템을 활성화하는 중요한 역할을 한다. 자외선과 자연적인 노화와 같은 환경 요인들은 종종 이러한 림프관의 구조적 변화를 일으키며, 이로 인해 피부 기능 장애를 발생시키기도 한다. 그러나 이러한 연구를 위한 동물 실험 대체 방안이 없기 때문에 여전히 연구를 진행하기엔 적합하지 않은 제한 사항들이 존재한다. 인체 피부 림프계를 더 잘 이해하고 림프관 형성에 관련된 분자 및 생리학적 변화를 조사하기 위해, 생체 모방 미세유체 플랫폼인 'skin-lymph-on-a-chip'을 제작하여, 새로운 체외 인체 피부 림프 모델을 개발하였다. 간단히 말해, 이 플랫폼은 체외에서 분화된 일차 정상 인간 표피 각질형성세포(NHEKs)와 피부 림프 내피세포(HDLECs)를 공동 배양하는 것을 의미한다. 약 500 시간 동안 자연 발효를 통해 확보하고 집약된 인삼 뿌리 추출물인 LymphanaxTM의 림프관 형성 효과를 평가하기 위해 해당 시스템에 적용하였고, 분자 수준 요인들의 변화는 딥러닝 기반 알고리즘을 사용하여 분석하였다. 결론적으로, LymphanaxTM는 skin-lymph-on-a-chip에서 건강한 림프관 형성을 촉진하였고, 그 성분들이 칩내에서 분화된 NHEKs를 거의 침투하지 않는 결과를 통해, HDELCs에 간접적으로 영향을 미쳤음을 확인하였다. 전반적으로, 이 연구는 기존과 차별화된 체외 인체 피부 림프모델 시스템의 확보와 더불어 이를 통한 LymphanaxTM의 림프 활성화 효과에 대한 새로운 관점을 제공한다.

Photoacoustic lymphangiography before and after lymphaticovenular anastomosis

  • Oh, Anna;Kajita, Hiroki;Matoba, Eri;Okabe, Keisuke;Sakuma, Hisashi;Imanishi, Nobuaki;Takatsume, Yoshifumi;Kono, Hikaru;Asao, Yasufumi;Yagi, Takayuki;Aiso, Sadakazu;Kishi, Kazuo
    • Archives of Plastic Surgery
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    • 제48권3호
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    • pp.323-328
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    • 2021
  • Background Lymphaticovenular anastomosis (LVA) is a minimally invasive surgical procedure used to treat lymphedema. Volumetric measurements and quality-of-life assessments are often performed to assess the effectiveness of LVA, but there is no method that provides information regarding postoperative morphological changes in lymphatic vessels and veins after LVA. Photoacoustic lymphangiography (PAL) is an optical imaging technique that visualizes the distribution of light-absorbing molecules, such as hemoglobin or indocyanine green (ICG), and provides three-dimensional images of superficial lymphatic vessels and the venous system simultaneously. In this study, we performed PAL in lymphedema patients before and after LVA and compared the images to evaluate the effect of LVA. Methods PAL was performed using the PAI-05 system in three patients (one man, two women) with lymphedema, including one primary case and two secondary cases, before LVA. ICG fluorescence lymphography was performed in all cases before PAL. Follow-up PAL was performed between 5 days and 5 months after LVA. Results PAL enabled the simultaneous visualization of clear lymphatic vessels that could not be accurately seen with ICG fluorescence lymphography and veins. We were also able to observe and analyze morphological changes such as the width and the number of lymphatic vessels and veins during the follow-up PAL after LVA. Conclusions By comparing preoperative and postoperative PAL images, it was possible to analyze the morphological changes in lymphatic vessels and veins that occurred after LVA. Our study suggests that PAL would be useful when assessing the effect of LVA surgery.

복부 림프절의 명명법 및 림프 배액 패턴 (Nomenclature and Lymphatic Drainage Patterns of Abdominal Lymph Nodes)

  • 조현석;안지현
    • 대한영상의학회지
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    • 제83권6호
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    • pp.1240-1258
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    • 2022
  • 림프계는 염증 및 악성 세포의 확산 경로를 제공한다. 종양이 확산되는 림프절의 위치와 림프 배액 경로를 인지하는 것은 종양의 병기 결정, 치료 방법 선택 및 환자의 예후 예측에 중요하다. 복강 내 악성 종양에서 림프절 전이는 흔하기 때문에 림프절 전이를 발견하고 질병의 확산 방식을 이해하는 것은 영상의학과 의사에게 필수적이다. 이 임상화보에서는 도식적인 그림들과 림프절을 색으로 표시한 CT 영상을 사용하여, 상부 및 하부 위장관, 간, 담낭, 담관 및 췌장의 림프절 위치와 이름, 그리고 림프 배수 경로에 관해 기술하였다. 또한 각 장기에서 발생하는 악성 종양의 국소 림프절의 종류에 대해 기술하고 몇몇 증례의 영상을 제시하였다.

동정맥루의 복합성 혈류학 소견이 그 관리에 미치는 영향 (Impact of Complex Hemodynamics to the Management of ArterioVenous(AV) Fistula)

  • 이병붕
    • 대한기계학회:학술대회논문집
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    • 대한기계학회 2002년도 학술대회지
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    • pp.9-10
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    • 2002
  • Human circulatory system between heart and tissue is not directly connected in normal condition but mandatory to go through the capillary system in order to fulfill its physiologic aim to deliver oxygen and nutrients, etc. to the tissue and retrieve used blood together with waste products from the tissue properly. When abnormal connection between arterial and venous system (AV fistula), these two circulatory systems respond differently to the hemodynamic impact of this abnormal connection between high pressure (artery) and low pressure (vein) system. Depending upon the location and/or degree (e.g. size and flow) of fistulous condition, each circulatory system exerts different compensatory hemodynamic response to this newly developed abnormal inter-relationship between two systems in order to minimize its hemodynamic impact to own system of different hemodynamic characteristics. Pump action of the heart can assist the failing arterial system directly to maintain arterial circulation against newly established low peripheral resistance by the AV fistula during the compensation period, while it affects venous system in negative way with increased venous loading. However, the negative impact of increased heart action to the venous system is partly compensated by the lymphatic system which is the third circulatory system to assist venous system independently with different hemodynamics. The lymphatic system with own unique Iymphodynamics based on peristaltic circulation from low resistance to high resistance condition, also increases its circulation to assist the compensation of overloaded venous system. Once these compensation mechanisms should fail to fight to newly established hemodynamic condition due to this abnormal AV connection, each system start to show different physiologic ${\underline{de}compensation}$ including heart and lymphatic system. The vicious cycle of decompensation between arterial and vein, two circulatory system affecting each other by mutually negative way steadily progresses to show series of hemodynamic change throughout entire circulation system altogether including heart. Clinical outcome of AV fistula from the compensated status to decompensated status is closely affected by various biological and mechanical factors to make the hemodynmic status more complicated. Proper understanding of these crucial biomechanical factors iii particular on hemodyanmic point of view is mandatory for the advanced assessment of biomechanical impact of AV fistula, since this new advanced concept of AY fistula based on blomechanical information will be able to improve clinical control of the complicated AV fistula, either congenital or acquired.

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우측 후하악부에 발생한 낭포성 활액종의 치험례 (CYSTIC HYGROMA ON RETROMANDIBULAR AREA - A CASE REPORT -)

  • 이승훈;최소영;김진욱;변기정;김진수
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • 제35권4호
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    • pp.261-265
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    • 2009
  • Cystic hygroma, a cystic subtype of lymphangioma, is relatively rare tumor of lymphatic origin. The lesion is a benign, painless, soft, compressible malformation of the lymphatic system. They can arise anywhere along the lymphatic system, however they are usually located in the head and neck regions and in most cases appear by the age of 2 years. The cases in the adult is rarely occurred and a few cases are described in the literature. Surgical excision remains the treatment of choice. But complete extirpation of these lesion is often impossible, because the tumor tends to spread along vital structures. Therefore recurrence rates are accordingly high. This is a case report about 19 year old male patient with cystic hygro a on right retromandibular area. We obtained the successful, functional and esthetic result by surgical excision of the mass. Therefore, we report the case with a review of literatures.

폐림프관종증 1예 (Pulmonary Lymphangiomatosis)

  • 조용선;유지홍;손상용;조황래;김수중;한민수;강홍모
    • Tuberculosis and Respiratory Diseases
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    • 제47권4호
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    • pp.533-537
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    • 1999
  • 저자들은 수년동안 반복적으로 유미흉이 재발하였던 31세 여자환자에서 환자의 연령, 임상 양상 등을 고려하여 볼 때 LAM이 의심되었으나, 흉부전산화단층 촬영상 흉막비후와 흉막하 소엽간중격의 비대 소견을 보이고, 낭성병변은 보이지 않으며, 조직검사상 폐실질의 림프혈관들의 확장성 변화를 동반한 증식을 관찰하였으나 평활근의 증식은 동반되지 않았으며 면역조직화학 염색 검사상 HMB-45와 에스트로젠수용체검사에서 음성을 보여 폐림프관종증으로 진단된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

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