• Journal of Yeungnam Medical Science
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• 제17권1호
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• pp.66-74
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• 2000

1991년 3월부터 1995년 3월까지 영남대학교 의과대학 부속병원 내과에서 입원해서 혈청학적, 방사선학적 및 조직학적으로 간세포함으로 진단받은 156명의 환자 중 진단당시부터 폐전이를 동반한 12명(7.7%)을 제외한 144명의 환자를 대상으로 최소한 5개월 이상을 추적관찰하여 폐전이를 동반한 경우와 동반하지 않은 경우로 나누어 나이, 성별, Child-Pugh 점수, 간경변증 동반유무, AFP치 및 간동맥 색전술여부 등을 조사하여 그 차이점을 비교 분석하여 다음과 같은 결과를 얻었다. 추적관찰 중 폐전이를 동반한 경우가 26례(18.0%)였는데 간동맥 색전술을 시행한 경우가 26례 중 24례(92.3%), 시행하지않은 경우가 26례 중 2례(7.7%)였다. 폐전이를 동반하지 않은 118례 가운데 간동맥 색전술을 시행한 경우가 78례, 시행하지 않은 경우가 40례였다. 따라서 간동맥 색전술 시행후 폐전이를 동반한 경우가 102례 중 24례(23.5%), 간동맥 색전술을 시행하지 않고 폐전이를 동반한 경우가 42례 중 2례(4.7%)로 나타나서 간동맥 색전술 이후 폐전이가 더 빈번함을 알 수 있었다(p<0.01). 그러나, 나이, 성별, Child-Pugh 접수, 간경변증 동반유무 및 AFP치는 차이를 보이지 않았다. 결론적으로 간세포암에서 간동맥 색전술 이후 폐전이가 보다 많이 동반됨을 알 수 있었고 이에 관련되는 근본적인 설명과 그외 관련인자들에 대한 보다 많은 연구가 필요할 것으로 사료된다.

• Korean Journal of Radiology
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• 제24권11호
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• pp.1142-1150
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• 2023

Objective: To evaluate ^99mtechnetium-three polyethylene glycol spacers-arginine-glycine-aspartic acid (^99mTc-3PRGD₂) single-photon emission computed tomography (SPECT)/computed tomography (CT) imaging for diagnosing lymph node metastasis of primary malignant lung neoplasms. Materials and Methods: We prospectively enrolled 26 patients with primary malignant lung tumors who underwent ^99mTc-3PRGD₂ SPECT/CT and ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET)/CT imaging. Both imaging methods were analyzed in qualitative (visual dichotomous and 5-point grades for lymph nodes and lung tumors, respectively) and semiquantitative (maximum tissue-to-background radioactive count) manners for the lymph nodes and lung tumors. The performance of the differentiation of lymph nodes with and without metastasis was determined at the per-lymph node station and per-patient levels using histopathological results as the reference standard. Results: Total 42 stations had metastatic lymph nodes and 136 stations had benign lymph nodes. The differences between metastatic and benign lymph nodes in the visual qualitative and semiquantitative analyses of ^99mTc-3PRGD₂ SPECT/CT and ¹⁸F-FDG PET/CT were statistically significant (all P < 0.001). The area under the receiver operating characteristic curve (AUC) in the semi-quantitative analysis of ^99mTc-3PRGD₂ SPECT/CT was 0.908 (95% confidence interval [CI], 0.851-0.966), and the sensitivity, specificity, positive predictive value, and negative predictive value were 0.86 (36/42), 0.88 (120/136), 0.69 (36/52), and 0.95 (120/126), respectively. Among the 26 patients (including two patients each with two lung tumors), 15 had pathologically confirmed lymph node metastasis. The difference between primary lung lesions in patients with and without lymph node metastasis was statistically significant only in the semi-quantitative analysis of ^99mTc-3PRGD₂ SPECT/CT (P = 0.007), with an AUC of 0.807 (95% CI, 0.641-0.974). Conclusion: ^99mTc-3PRGD₂ SPECT/CT imaging may notably perform in the direct diagnosis of lymph node metastasis of primary malignant lung tumors and indirectly predict the presence of lymph node metastasis through uptake in the primary lesions.

• Tuberculosis and Respiratory Diseases
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• 제71권2호
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• pp.139-143
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• 2011

Small bowel metastasis of pleomorphic carcinoma of the lung is very rare. A 58-year-old man was admitted to our hospital with abdominal palpable mass in the right upper quadrant area. He underwent right middle and lower lobectomy for early stage pleomorphic carcinoma of the lung approximately 3 months ago. USG-guided biopsy was performed for abdominal mass. Pathologic examination revealed a metastatic pleomorphic carcinoma from the lung. He received chemotherapy followed by radiation therapy but died due to septic shock caused by intestinal stenosis and adhesion. We report the first case of small bowel metastasis by pleomorphic carcinoma of the lung after curative surgery.

• Tuberculosis and Respiratory Diseases
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• 제63권3호
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• pp.283-288
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• 2007

원발성폐암의 위장관 전이, 특히 십이지장으로의 전이는 매우 드물며, 부검에서 발견되는 경우가 더 많다. 본 증례의 58세 남자는 왼쪽 등의 통증과 흉부 X-선 촬영에서 좌상엽에 종괴로 의뢰되어 경기관지폐생검 결과 폐선암을 진단 받았으며, 이후 소화불량과 상복부불편감을 호소하여 시행한 위내시경 결과 십이지장 팽대부의 점막 돌출을 발견하여 이에 대한 조직검사에서 폐선암의 십이지장 전이로 밝혀졌다.

• Tuberculosis and Respiratory Diseases
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• 제50권5호
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• pp.624-629
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• 2001

우안 시력 장애와 안구종괴를 주소로 내원한 환자에서 폐종괴가 관찰되어 경기관지 폐생검과 안구 적출술을 시행하여 폐선암의 우안구 전이를 진단한 1예를 경험하여 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제67권6호
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• pp.574-576
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• 2009

An intramedullary spinal cord metastasis (ISCM) rarely develops in systemic cancer but is indicative of a poor prognosis. A 56-year-old man was admitted due to weakness of the lower extremities. He had received radiotherapy 3 months prior for a brain metastasis that had developed 1 year after achieving a complete response from chemotherapy for extended stage small cell lung cancer. Although the brain lesion had improved partially, ISCM from the cervical to lumbar-sacral spinal cords, which was accompanied by a leptomeningeal dissemination, was diagnosed based on magnetic resonance imaging of the spine and cerebrospinal fluid cytology. Finally, he died of sudden cardiac arrest during treatment. This is the first case of ISCM involving the whole spinal segments. Physicians should be aware of the subsequent development of ISCM in lung cancer patients with a previously known brain metastasis who present with new neurological symptoms.

• 동의생리병리학회지
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• 제26권6호
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• pp.980-982
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• 2012

Metastasis to the pancreas from extra-pancreatic primary cancers are rare; they commonly present as a manifestation of widespread disease and rarely as an isolated mass of the pancreas. Examinations showed a pancreatic tumor infiltrating the pancreas tail portion and an endoscopic ultrasound guided percutaneous biopsy proved that the lesion was metastatic from the lung carcinoma. Most metastatic cases of the pancreas tend to be discovered in patients with widely disseminated malignant disease. In addition, patients with pancreatic metastasis are often asymptomatic, the metastatic lesions are found incidentally, and are misdiagnosed as primary pancreatic tumors. This report that patient undergoing chemotherapy for a small cell lung cancer, who 1 year and 3 months later, accidentally diagnosed of solitary pancreas metastasis and confirmed histology by needle biopsy using endoscopic ultrasound.

• Archives of Pharmacal Research
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• 제25권4호
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• pp.522-527
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• 2002

The antimetastatic effect of BCG-CWS, which was emulsified in an oil-in-water form with either Drakeol 6VR mineral oil (BCG-CWS/DK) or squalane (BCG-CWS/SQA), on lung metastasis produced by highly metastatic murine tumor cells, Colon26-M3.1 carcinoma cells and B16-BL6 melanoma cells, was investigated in syngeneic mice. An intravenous (i.v.) administration of BCG-CWS (100 mg/mouse) 1 day after tumor inoculation significantly inhibited tumor metastasis of both Colon26-M3.1 carcinoma and B16-BL6 melanoma cells in experimental lung metastasis models. No differences in the antitumor activity of the two oil-based formulations (BCG-CWS/DK and BCG-CWS/SQA) were obverved. However, BCG-CWS/SQA administered through subcutaneous (s.c.) route was shown to be effective only when it was consecutively injected (3 times) after tumor inoculation. An in vivo analysis for tumor-induced angiogenesis shwed that a single i.v. administration of BCG-CWS/SQA inhibited the number of tumor-induced blood vessels and suppressed tumor growth. Furthermore, the multiple administration of BCG-CWS/SQA given at on week intervals led to a significant reduction in spontaneous lung metastasis of B16-BL6 melanoma cells in a spontaneous metastasis model. These results suggest that BCG-CWS emulsified with squalane is a potent inhibitory agent of lung metastasis, and that the anti metastatic effect of BCG-CWS is related to the suppression of tumor growth and the inhibition of tumor-induced angiogenesis.

• Radiation Oncology Journal
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• 제31권4호
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• pp.267-272
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• 2013

Although significant advances in the treatment of intrahepatic lesions, it is reported that the prognosis for patients with hepatocellular carcinoma (HCC) who have extrahepatic metastasis remains poor. We report a patient with lung, liver, brain, bone and subcutaneous metastasis from HCC who has survived more than 7 years maintaining relatively good performance status as a result of repeated therapies. A 55-year-old male patient with HCC underwent right lobectomy of the liver and cholecystectomy in September 2006. He received wedge resection for lung metastasis twice (July 2009, January 2011) and Gamma Knife stereotactic radiosurgery for brain metastasis (April 2011). Over the last 3 years, he has developed metastasis in subcutaneous tissues, muscle, and bone with pain. He has undergone 7 courses of radiotherapies for subcutaneous tissues, muscle, and bone metastasis and been prescribed sorafenib and he is still capable of all self-care.

• Tuberculosis and Respiratory Diseases
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• 제66권1호
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• pp.52-57
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• 2009

전이성 위암은 발생 빈도가 매우 낮으며, 부검 연구를 통한 발생률은 0.2%에서 1.7%으로 알려져 있다. 전이성 위암과 원발성 위암은 육안으로 구별되지 않으며, 특히 병리학적으로 선암이 나온 경우 임상적 문제가 발생할 수 있다. 64세 남자 환자가 외부병원에서 객혈을 토혈로 오인하여 우연히 발견하게 된 위악성종양에 대해 위부분절 제술을 먼저 시행 받았다가, 이후에도 지속된 객혈로 폐암이 발견되어 다시 폐엽절제술을 시행 받은 후, 다시 재발한 폐암으로 본원을 방문하였다가 면역조직화학염색을 통해 최초의 위암이 폐암의 위 전이였음을 확인한 드문 예를 경험하여 이를 보고한다.