DOI QR코드

DOI QR Code

A patient who has survived for a long period with repeated radiotherapies for multifocal extrahepatic metastases from hepatocellular carcinoma

  • Jo, Sunmi (Department of Radiation Oncology, Inje University Haeundae Paik Hospital) ;
  • Shim, Hye Kyung (Department of Nuclear Medicine, Inje University Haeundae Paik Hospital)
  • Received : 2013.10.21
  • Accepted : 2013.12.13
  • Published : 2013.12.31

Abstract

Although significant advances in the treatment of intrahepatic lesions, it is reported that the prognosis for patients with hepatocellular carcinoma (HCC) who have extrahepatic metastasis remains poor. We report a patient with lung, liver, brain, bone and subcutaneous metastasis from HCC who has survived more than 7 years maintaining relatively good performance status as a result of repeated therapies. A 55-year-old male patient with HCC underwent right lobectomy of the liver and cholecystectomy in September 2006. He received wedge resection for lung metastasis twice (July 2009, January 2011) and Gamma Knife stereotactic radiosurgery for brain metastasis (April 2011). Over the last 3 years, he has developed metastasis in subcutaneous tissues, muscle, and bone with pain. He has undergone 7 courses of radiotherapies for subcutaneous tissues, muscle, and bone metastasis and been prescribed sorafenib and he is still capable of all self-care.

Keywords

References

  1. Jung KW, Won YJ, Kong HJ, Oh CM, Seo HG, Lee JS. Cancer statistics in Korea: incidence, mortality, survival and prevalence in 2010. Cancer Res Treat 2013;45:1-14. https://doi.org/10.4143/crt.2013.45.1.1
  2. Taura N, Hamasaki K, Nakao K, et al. The impact of newer treatment modalities on survival in patients with hepatocellular carcinoma. Clin Gastroenterol Hepatol 2006;4:1177-83. https://doi.org/10.1016/j.cgh.2006.06.008
  3. Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 2009;27:1485-91. https://doi.org/10.1200/JCO.2008.20.7753
  4. Katyal S, Oliver JH 3rd, Peterson MS, Ferris JV, Carr BS, Baron RL. Extrahepatic metastases of hepatocellular carcinoma. Radiology 2000;216:698-703. https://doi.org/10.1148/radiology.216.3.r00se24698
  5. Uka K, Aikata H, Takaki S, et al. Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma. World J GastroenteroI 2007;13:414-20. https://doi.org/10.3748/wjg.v13.i3.414
  6. Uchino K, Tateishi R, Shiina S, et al. Hepatocellular carcinoma with extrahepatic metastasis: clinical features and prognostic factors. Cancer 2011;117:4475-83. https://doi.org/10.1002/cncr.25960
  7. Natsuizaka M, Omura T, Akaike T. et al. Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol 2005;20:1781-7. https://doi.org/10.1111/j.1440-1746.2005.03919.x
  8. Zachau L, Zeckey C, Schlue J, et al. Haematogenous abdominal wall metastasis of differentiated, alpha-fetoprotein-negative hepatocellular carcinoma after previous antiandrogen therapy within a site of lipoma manifestation since childhood. World J Surg OncoI2012;10:98. https://doi.org/10.1186/1477-7819-10-98
  9. Huang YJ, Tung WC, Hsu HC, Wang CY, Huang EY, Fang FM. Radiation therapy to non-iatrogenic subcutaneous metastasis in hepatocellular carcinoma: results of a case series. Br J Radiol 2008;81:143-50. https://doi.org/10.1259/bjr/81811976
  10. Jung SM, Jang JW, You CR, et al. Role of intrahepatic tumor control in the prognosis of patients with hepatocellular carcinoma and extrahepatic metastases. J Gastroenterol Hepatol 2012;27:684-9. https://doi.org/10.1111/j.1440-1746.2011.06917.x
  11. Seong J, Koom WS, Park HC. Radiotherapy for painful bone metastases from hepatocellular carcinoma. Liver Int 2005;25: 261-5. https://doi.org/10.1111/j.1478-3231.2005.01094.x
  12. Kim HY, Park JW, Nam BH, et al. Survival of patients with advanced hepatocellular carcinoma: sorafenib versus other treatme nts. J Gastroenterol Hepatol 2011;26:1612-8. https://doi.org/10.1111/j.1440-1746.2011.06751.x
  13. Niibe Y, Kenjo M, Kazumoto T, et al. Multi-institutional study of radiation therapy for isolated para-aortic lymph node recurrence in uterine cervical carcinoma : 84 subjects of a population of more than 5,000. Int J Radiat Oncol Biol Phys 2006;66:1366-9. https://doi.org/10.1016/j.ijrobp.2006.07.1384
  14. Niibe Y, Kuranami M, Matsunaga K, et al. Value of high-dose radiation therapy for isolated osseous metastasis in breast cancer in terms of oligo-recurrence. Anticancer Res 2008; 28(6B):3929-31.
  15. Punglia RS, Morrow M, Winer EP, Harris JR. Local therapy and survival in breast cancer. N Engl J Med 2007;356:2399-405. https://doi.org/10.1056/NEJMra065241
  16. Niibe Y, Hayakawa K. Oligometastases and oligo-recurrence: the new era of cancer therapy. Jpn J Clin Oncol 2010;40:107-11. https://doi.org/10.1093/jjco/hyp167
  17. Koukourakis MI, Papadopoulou A, Kyrgias G. Long-term survival of a patient with multiple abdominal metastasis from endometrial carcinoma treated with multi-portal conformal re-irradiation and chemotherapy. Hematol Oncol Stem Cell Ther 2011;4:45-7. https://doi.org/10.5144/1658-3876.2011.45
  18. Yun HG. A case report of a gastric cancer patient with a good quality of life after radiotherapies to 17 metastases for 4 years. J Korean Soc Ther Radiol Oncol 2011;29:127-33. https://doi.org/10.3857/jkstro.2011.29.2.127

Cited by

  1. The effect and mechanism of bufalin on regulating hepatocellular carcinoma cell invasion and metastasis via Wnt/β-catenin signaling pathway vol.48, pp.1, 2013, https://doi.org/10.3892/ijo.2015.3250
  2. Extrahepatic metastasis of hepatocellular carcinoma to the paravertebral muscle: A case report vol.9, pp.22, 2013, https://doi.org/10.4254/wjh.v9.i22.973
  3. The Influence of Paracetamol on the Penetration of Sorafenib and Sorafenib N-Oxide Through the Blood–Brain Barrier in Rats vol.45, pp.6, 2013, https://doi.org/10.1007/s13318-020-00639-z
  4. A Case of Hepatocellular Carcinoma with Recurrence of Skeletal Muscle Metastasis to the Right Lower Leg 9 Years after Hepatectomy vol.54, pp.1, 2013, https://doi.org/10.5833/jjgs.2019.0162