• Journal of Pharmaceutical Investigation
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• 제40권1호
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• pp.33-38
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• 2010

Sibutramine is a serotonin-norepinephrine reuptake inhibitor indicated for the management of obesity in conjunction with a reduced calorie diet. The oral administration of sibutramine is followed by its dose-related side effects. In this study, sibutramine was formulated into drug in adhesive (DIA) patches in an attempt to overcome these problems. The effects of different formulation variables including pressure-sensitive adhesive (PSA), loading amount of drug, thickness of matrix and enhancer on the skin permeation of the drug were evaluated using excised hairless mouse skin. In the acrylic adhesive with carboxyl functional group, low release of sibutramine was observed due to the strong interaction between carboxyl group of adhesive and amine group of sibutramine. The acrylic adhesive without functional group provided good adhesion force and allowed high drug loading. Changing drug load as well as thickness of the matrix was found to alter permeation rate. $Crovol^{(R)}$ PK40 and $Crovol^{(R)}$ A40, were found to be effective enhancers for sibutramine. The optimized patch contained 20% sibutramine, and 5% $Crovol^{(R)}$ A40 as permeation enhancer, in $80\;{\mu}m$ thick Duro-$Tak^{(R)}$ 87-9301 matrix.

• 한방비만학회지
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• 제8권1호
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• pp.101-108
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• 2008

다낭성 난소 소견을 동반한 비만 여성 환자의 경지(經遲) 증상을 한약 처방과 침, 이침(耳針), 전기지방분해침,식이조절, 운동요법 등의 생활습관교정 등의 한방 비만 치료와 한약 처방, 침, 좌훈요법 등을 이용한 한방 조경(調經) 치료를 시행하여 유효한 결과를 얻었기에 보고하는 바이다.

• Journal of Animal Science and Technology
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• 제62권2호
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• pp.111-120
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• 2020

The definition of meat analog refers to the replacement of the main ingredient with other than meat. It also called a meat substitute, meat alternatives, fake or mock meat, and imitation meat. The increased importance of meat analog in the current trend is due to the health awareness among consumers in their diet and for a better future environment. The factors that lead to this shift is due to low fat and calorie foods intake, flexitarians, animal disease, natural resources depletion, and to reduce greenhouse gas emission. Currently, available marketed meat analog products are plant-based meat in which the quality (i.e., texture and taste) are similar to the conventional meat. The ingredients used are mainly soy proteins with novel ingredients added, such as mycoprotein and soy leghemoglobin. However, plant-based meat is sold primarily in Western countries. Asian countries also will become a potential market in the near future due to growing interest in this product. With the current advance technology, lab-grown meat with no livestock raising or known as cultured meat will be expected to boost the food market in the future. Also, insect-based products will be promising to be the next protein resource for human food. Nevertheless, other than acceptability, cost-effective, reliable production, and consistent quality towards those products, product safety is the top priority. Therefore, the regulatory frameworks need to be developed alongside.

• 한방비만학회지
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• 제5권1호
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• pp.21-29
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• 2005

Objectives : This study was carried out to evaluate the difference of body mass index(BMI) distribution and the difference of effect of weight reduction program among Sasang constitution. Methods : Sasang constitution was differentiated by QSCC II of 875 cases. Body composition was analysed by bioelectrical impedance analysis(Inbody 3.0, Biospace, Seoul, Korea) in before and after treatment to evaluate the effect among Sasang constitution. The weight reduction program including very low calorie diet, electrical acupuncture and herbal medicine was treated to all cases equally during 1 month. Results and Conclusions : The group of Taeum was more obese and less reducted in body fat mass and % body fat in tools of percent rates of the changes than other type of Sasang constitution. In conclusion, the group of Taeum is more easy to become obese and more difficult to treat obesity

• 한방비만학회지
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• 제1권1호
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• pp.33-42
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• 2001

Objectives: This study was to investigate the reductive effects of oriental medicine on the body fat and abdominal obesity, Methods: The subject were selected among the patients who were treated with 4weeks total program, visited our obesity clinic from October 1999 to August 2000, We practiced combined therapy such as herbal medicine, acupuncture therapy, moxibution therapy, negative therapy, auricular acupuncture, electrolipolysis, colon hydrotherapy, heat therapy, Chuna therapy, low-calorie diet teaching, exercise teaching, and correcting life style for 4 weeks. Results and Conclusion: 1. Body weight, RBW, and BMI were significantly reduced each by 5.4kg, 10.4% and $2.2kg/m^2$ (p<0.01). 2. % Body fat was significantly reduced by 3.3%. Fat mass was reduced by 4.0kg(17.0%) and soft lean mass was reduced by 1.5kg(3.7%), thus it was acknowledged that fat mass was significantly reduced compared to soft lean mass by oriental medicine treatment for obesity. 3. WHR was significantly reduced by 0.02. Waist circumference was reduced by 6cm(6.6%) and hip circumference was reduced by 4.5cm(4.6%), thus it was acknowledged that waist fat was significantly reduced compared to hip circumference by oriental medicine treatment for obesity.

• Journal of Nutrition and Health
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• 제26권5호
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• pp.639-650
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• 1993

The purpose of this study was to assess the nutrition education and training needs as a basis for program planning for day care providers. A sample of 239 day care teachers responded to a questionnare assessing demographic characteristics, nutrition education experiences, and measuring the level of basic knowledge of food & nutrition. Menu planning was added to the questionnarie for 158 day care center directors. The results of this study can be summarized as follows: 1) majority(92.5%) of day care teachers and 74.1% of day care directors were interested in receiving nutrition education and training programs. 2) The topics generating the greatest interest for day care teachers were good food habits, food preparation & meal planning and food sanitation. 3) As a result of measuring the level of basic nutrition knowledge, day care teachers possessed the moderate amount of knowledge about five basic food groups, cholesterol, protein containing food, fat, while they possessed the poor knowledge about vitamin and calorie. 4) Day care teachers and directors possessed a certain level of knowledge about what the good snacks are and how to teach the unbalanced diet oriented children, while they possessed a low level of knowledge about children's nutrition requirement.

• Journal of Obesity & Metabolic Syndrome
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• 제27권4호
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• pp.203-212
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• 2018

Dynamic energy balance can give clinicians important answers for why obesity is so resistant to control. When food intake is reduced for weight control, all components of energy expenditure change, including metabolic rate at rest (resting energy expenditure [REE]), metabolic rate of exercise, and adaptive thermogenesis. This means that a change in energy intake influences energy expenditure in a dynamic way. Mechanisms associated with reduction of total energy expenditure following weight loss are likely to be related to decreased body mass and enhanced metabolic efficiency. Reducing calorie intake results in a decrease in body weight, initially with a marked reduction in fat free mass and a decrease in REE, and this change is maintained for several years in a reduced state. Metabolic adaptation, which is not explained by changes in body composition, lasts for more than several years. These are powerful physiological adaptations that induce weight regain. To avoid a typically observed weight-loss and regain trajectory, realistic weight loss goals should be established and maintained for more than 1 year. Using a mathematical model can help clinicians formulate advice about diet control. It is important to emphasize steady efforts for several years to maintain reduced weight over efforts to lose weight. Because obesity is difficult to reverse, clinicians must prioritize obesity prevention. Obesity prevention strategies should have high feasibility, broad population reach, and relatively low cost, especially for young children who have the smallest energy gaps to change.

• 한국식품조리과학회지
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• 제21권1호
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• pp.64-74
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• 2005

To develop the diet for Korean type 2 diabetic patients, a consumer survey was conducted (N=35) and was analyzed statistically. The survey compared the results of a questionnaire, somatometry, and blood parameters before and 8 weeks after the experiment. It was divided into Diabetic diet enforcement group (DDE) vs. Non diabetic diet enforcement group (NDDE). There was no significant difference in body weight, body mass index (BMI), body fat, triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) of the subjects before and 8 weeks after the experiment. DDE's average fasting glucose (FBG) and post prandial 2 hours blood glucose (PP2) were significantly decreased before and after the experiment (p<0.05). NDDE's average FBG and PP2 showed no significant difference. In terms of Hemoglobin $A_lC\;(HbA_1C)$ content, DDE's had significantly decreased level both before and after the experiment (p<0.05), while there was no significant difference in the NDDE group. Cholesterol and High density lipoprotein cholesterol (HDL-C) were significantly different in DDE (p<0.05) both before and after the experiment. Whereas in the case of NDDE, there was no significant difference on the cholesterol and HDL-C, while DDE's showed a significant difference before and after the experiment. In terms of patients distribution depending on their treatment (p<0.05), NDDE had no significant difference before and after the experiment. For an item asking blood glucose control, DDE had significant difference before and after the experiment (p<0.01), while NDDE had no significant difference. For program satisfaction (p<0.05) and health (p<0.001), both the groups changed significantly after the experiment. But there was no significant difference in applying it to their real life after the experiment. Based on these results, DDE had the decreased blood glucose levels, $HbA_1C$, and cholesterol and increased HDL-C, with decreased rate of the patients taking oral hypoglycemic agents. In addition, many of the patients who participated in the experiment were found to be satisfied with the program, in terms of having less trouble in glucose control and exhibited improvement in health. Hence, based on the above results it was concluded that program was a very successful one for the treatment of diabetes.

• Journal of Nutrition and Health
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• 제41권1호
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• pp.54-64
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• 2008

본 연구에서는 중년여성을 대상으로 식행동 개선을 초점을 두어 6개월 간 교육을 실시하여 식사의 질, 체성분 및 혈액 성분 변화를 알아보았다. 프로그램 종료 후 대상자를 식행동 점수 변화 정도에 따라 식행동향상군과 식행동비향상군으로 나누어 비교해 본 결과, 식행동향상군의 체중, BMI, 복부지방률 그리고 내장지방의 감소율이 식행동비향상군보다 더 컸고, 식이섬유, 칼슘, 철분, 비타민 C의 섭취 변화율도 식행동향상군이 식행동비향상군보다 더 컸으며, 식행동향상군에서만 각 영양소의 INQ와 MAR이 유의적으로 증가하였다. 또한 식행동향상군의 중성지방의 감소율이 식행동비향상군의 감소율보다 더 컸다. 동일한 영양교육에 참여하였지만 대상자가 스스로 잘못된 식행동을 개선할 경우, 식이섭취 수준이 더 많이 개선되었을 뿐만 아니라 식사의 질도 향상되었고, 체중과 체지방의 감량하였으며, 혈중 지질 수준도 향상시키는 효과를 보였다 이상의 연구에서처럼 식행동이 향상됨에 따라 체중감량과 식사의 질 개선 그리고 혈중 지질 변화에 효과적임을 알 수 있었고, 장기적으로 만성질환을 예방 관리할 수 있을 것으로 생각된다. 따라서 추후에 이루어지는 비만관리 프로그램은 영양지식의 전달에 초점을 맞추기보다는 균형잡힌 영양소 섭취와 식행동 개선 및 향상을 유도하는 교육내용이 포함되어 있는 체계적인 프로그램을 장기간 시행하여 식행동 향상에 따른 효과를 살펴보는 것이 필요하다.

• 대한지역사회영양학회지
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• 제18권6호
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• pp.611-625
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• 2013

The purpose of this study was to investigate dietary behaviors and health-related lifestyles of adult visitors at a public health center in Gyeonggi urban area. A survey using questionnaire was conducted with 949 visitors at Seongnam public health centers from June to August, 2012. The data from 905 respondents were analyzed by gender, consisting of 322 males and 583 females, and age group, consisting of 243 low-age group (LA), 312 middle-age group (MA), 350 high-age group (HA), aged 20 to 30 years, 31 to 50 years, and 51 to 69 years, respectively. Average Body Mass Index was 23.0, which increased with age, and education level was high in LA. 59.0 percent of the subjects had various diseases, and the incidence of hypertension was the highest, followed by allergy, hyperlipidemia, diabetes mellitus, joint rheumatism. Incidence rates of chronic disease increased with age, which were lower than those from 2011 Korea National Health and Nutrition Examination Survey (KNHANES). Weekly drinking frequency rate and smoking rate decreased with age, and exercise performing rate was high at male and HA, which showed the same tendency as KNHANES. Female and HA showed more healthy dietary behaviors such as restricting salt, sugar, oily foods, foods containing food additives, calorie, caring for balanced diet, and referring to nutrition label. Subjects chose stress as the first factor, followed by diet, exercise, etc., among 13 suggested factors which strongly influence on human's life-span. In general, public health center visitors, especially female and HA, showed better dietary behaviors and health-related lifestyles compared with KNHANES.