• Journal of Radiation Protection and Research
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• 제27권2호
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• pp.81-87
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• 2002

The interaction of low density extremely low frequency magnetic field (ELF MF) in the frequency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) mutation induced by bleomycin and on the frequency of sister chromatid exchanges (SCEs) induced by 1,2,4-benzenetriol(BT) was demonstrated. CHO cells pretreated with bleomycin or 1,2,4-benzenetriol were exposed for 24hrs to a sinusoidal 0.8mT magnetic field at 60Hz. Frequency of HPRT mutation and SCEs were determined. ELF MF exposure led to a two-fold increase of the frequency of HPRT mutation induced by bleomycin. No increase of mutation frequency was observed by ELF MF alone ELF MF also increased the frequency of SCEs induced by BT while no Increase of SCE frequencies were observed by ELF MF alone. These results suggest that low density ELF MF field would art as an enhancer rather than as an initiator of mutagenic effects in CHO cell.

• Journal of Radiation Protection and Research
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• 제26권3호
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• pp.275-279
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• 2001

In uranium enrichment plants and nuclear fuel fabrication facilities, exact measurement of fissile isotope enrichment of uranium is required for material accounting in international safeguards inspection as well as process quality control. The purpose of this study was to develop a simple measurement system which can portably be used at nuclear fuel fabrication plants especially dealing with low enriched uranium. For this purpose, a small size CZT (CdZnTe) detector was used, and the detector performance in low uranium gamma/X -rays energy range was investigated by use of various enriched uranium oxide samples. New enrichment measurement technique and analysis method for low enriched uranium oxide, so-called, 'semi-peak ratio technique' was developed. The newly developed method was considered as an alternative technique for the low enrichment and would be useful to account nuclear material in safeguarding activity at nuclear fuel fabrication facility.

• Journal of electromagnetic engineering and science
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• 제14권2호
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• pp.74-78
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• 2014

This paper presents a modified TEM horn that improves radiation characteristics at a low frequency region. The proposed antenna consists of an asymmetric TEM (ATEM) horn and a loop structure with an elliptical shape. The bandwidth and gain at low frequency region can be enhanced by using the ATEM horn configuration and adding a loop structure with an elliptical shape to the ATEM horn. The bandwidth of the proposed antenna is from 2.14 to over 20 GHz, whereas that of the conventional TEM horn is from 2.7 to over 20 GHz, where the dimensions of both antennas are the same except for the thickness of the loop structure. The physical and electrical dimensions of the proposed antenna are $60mm{\times}62.5mm{\times}64mm$ ($width{\times}height{\times}length$) and $0.428{\lambda}_L{\times}0.445{\lambda}_L{\times}0.456{\lambda}_L$, where ${\lambda}_L$ corresponds to the lowest frequency of the bandwidth. The realized gain of the proposed antenna is improved by 0.802 dB on average at the low frequency region (2 to 8 GHz), where the maximum gain increase is 2.932 dB when compared to a conventional TEM horn.

• 설비공학논문집
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• 제28권9호
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• pp.350-354
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• 2016

Although fibrous insulations are generally used with resistive insulation type, metallic insulation is proper matter to satisfy low head-loss and equipment life when considering the specific condition, especially for Nuclear power plant. Common insulation is resistance insulation with a low thermal conductivity. but RMI is made of sheet plate with low emissivity and closed air space. Thermal radiation is blocked by stainless steel with low emissivity. Thermal conductivity and thermal convection are blocked by closed air space. This study shows the changes and effects of the heat loss according to shape and method of stacking sheet plates inserted into the insulation and analyzed the most optimized way for thermal insulation performance. The result shows that using sheet plate structure through raised and protruding shape processing was the appropriate model to optimize thermal performance. Additionally, insulating performance of RMI improved by placing the sheet plate in a high temperature region intensively.

• 한국방사선학회논문지
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• 제13권1호
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• pp.45-53
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• 2019

본 연구는 의료용 선형가속기 시설을 차폐하는 콘크리트에 대한 중성자 방사화 연구로써, 일반 콘크리트와 저 방사화 콘크리트를 비교 분석하였다. 실험 방법은 MCNPX (Ver. 2.5.0)와 FISPACT-2010를 사용하여 모의실험을 진행하여, 광자선과 중성자선에 대한 차폐능을 산정하고 중성자 방사화 평가를 진행하였다. 그 결과 차폐능은 일반 콘크리트에서 20~50 cm 효율적이였으며, 방사화 평가의 경우 저 방사화 콘크리트에서 방사능이 낮게 계산되었으나, 모두 자체처분허용 농도를 초과하지 않는 수준으로 산정되었다. 이를 종합적으로 분석한 결과 일반 콘크리트를 사용하는 것이 효율적인 것으로 판단된다.

• Radiation Oncology Journal
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• 제29권3호
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• pp.147-155
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• 2011

Purpose: This study was designed to determine the influencing factors and clinical course of pathologically proven cases of radiation-induced brain injury (RIBI). Materials and Methods: The pathologic records of twelve patients were reviewed; these patients underwent surgery following radiotherapy due to disease progression found by follow-up imaging. However, they were finally diagnosed with RIBI. All patients had been treated with 3-dimensional conventional fractionated radiotherapy and/or radiosurgery for primary or metastatic brain tumors with or without chemotherapy. The histological distribution was as follows: two falx meningioma, six glioblastoma multiform (GBM), two anaplastic oligodendroglioma, one low grade oligodendroglioma, and one small cell lung cancer with brain metastasis. Results: Radiation necrosis was noted in eight patients and the remaining four were diagnosed with radiation change. Gender (p = 0.061) and biologically equivalent dose $(BED)_3$ (p = 0.084) were the only marginally influencing factors of radiation necrosis. Median time to RIBI was 7.3 months (range, 0.5 to 61 months). Three prolonged survivors with GBM were observed. In the subgroup analysis of high grade gliomas, RIBI that developed <6 months after radiotherapy was associated with inferior overall survival rates compared to cases of RIBI that occurred ${\geq}6$ months (p = 0.085). Conclusion: Our study demonstrated that RIBI could occur in early periods after conventional fractionated brain radiotherapy within normal tolerable dose ranges. Studies with a larger number of patients are required to identify the strong influencing factors for RIBI development.

• 한국방사선학회논문지
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• 제14권6호
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• pp.725-731
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• 2020

구(sphere)형의 섬광체를 사용한 방사선 스펙트로스코피 검출기를 설계하였고, 여러 대의 검출기를 사용하여 방사선원의 위치를 추적하는 시스템을 개발하였다. 방사선원의 위치 추적은 방사선의 수는 거리의 역자승 법칙에 따라 감소하는 이론을 바탕으로 위치 추적 알고리듬을 설계하였으며, 여러 위치의 방사선원에서 발생된 방사선의 수를 측정하여 알고리듬을 통해 위치를 계산하였다. 방사선원에서 발생되는 방사선은 각 검출기에서 서로 다른 계수로 검출되며, 이러한 검출되는 계수의 차이는 거리의 역자승에 비례하여 달라진다. 설계한 방사선원 위치 추적 시스템의 성능을 검증 및 평가하기 위해 Geant4 Application for Tomographic Emission (GATE) 시뮬레이션을 실시하였으며, 서로 다른 위치에 놓이 방사선원에서 발생된 방사선을 각 검출기로 계수하였다. 측정된 방사선의 수는 방사선원 위치 추적 알고리듬을 통해 위치가 추적되었으며, 실제 방사선원의 위치와 알고리듬으로 계산된 위치와의 오차를 평가하였다. 실제 방사선원의 위치와 계산된 위치와의 오차는 평균 X축 0.11%, Y축 0.37%로 측정되었으며, 매우 정확하게 위치를 측정할 수 있음이 검증되었다.

• 대한디지털의료영상학회논문지
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• 제16권1호
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• pp.43-47
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• 2014

Sens of insecutity of the public and professionals about harmful effects of radiation is increasing in an accident at the Chernobyl and Fkushima nuclear power plant.Anxiety was amplified to lack of information about radiation majority of people. To target the middle and high school in the region of Daegu and Gyeongsangbuk-do, to investigate the radiation recognition of the next generation, it is intended to present a model of education for the safe use of radiation. The High School of the six metropolitan cities, city, town through the questionnaire and needs to be educational experience of radiation and use knowledge level of radiation, experience in daily life, understanding of man-made radiation and natural radiation, information channel on radiation, the radiation Distribute the total 800 parts of, to recover the 629 unit, was analyzed for 155 females 474 males. Many people 75.36% of the people, to 24.64% female subjects of this investigation, was constant, respectively from 13 to 18 years age. It is a large number and 30.37% of the respondents as "normal" level of knowledge of radiation, for the type of radiation, most knew. You have answer for risk experience of the medical radiation was higher, touching a lot of information via the broadcast medium in general, and the accuracy is low. I thought we wanted to be educated three or more twice a year, as an educator,about 71.37% and radiation-related understanding of knowledge and background in accordance with the diversification of information channels, the regional differences between urban and rural areas. But I considered the difference age (grade) for each is displayed, intended for junior high school students, the target surface and use the occurrence of radiation, high school students, the need for education about risk and application of radiation through this study.

• Radiation Oncology Journal
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• 제32권3호
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• pp.187-197
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• 2014

Purpose: We aimed to analyze the treatment outcome and long-term toxicity of 70 Gy hypofractionated intensity-modulated radiotherapy (IMRT) for localized prostate cancer using a customized rectal balloon. Materials and Methods: We reviewed medical records of 86 prostate cancer patients who received curative radiotherapy between January 2004 and December 2011 at our institution. Patients were designated as low (12.8%), intermediate (20.9%), or high risk (66.3%). Thirty patients received a total dose of 70 Gy in 28 fractions over 5 weeks via IMRT (the Hypo-IMRT group); 56 received 70.2 Gy in 39 fractions over 7 weeks via 3-dimensional conformal radiotherapy (the CF-3DRT group, which served as a reference for comparison). A customized rectal balloon was placed in Hypo-IMRT group throughout the entire radiotherapy course. Androgen deprivation therapy was administered to 47 patients (Hypo-IMRT group, 17; CF-3DRT group, 30). Late genitourinary (GU) and gastrointestinal (GI) toxicity were evaluated according to the Radiation Therapy Oncology Group criteria. Results: The median follow-up period was 74.4 months (range, 18.8 to 125.9 months). The 5-year actuarial biochemical relapse-free survival rates for low-, intermediate-, and high-risk patients were 100%, 100%, and 88.5%, respectively, for the Hypo-IMRT group and 80%, 77.8%, and 63.6%, respectively, for the CF-3DRT group (p < 0.046). No patient presented with acute or late GU toxicity ${\geq}$grade 3. Late grade 3 GI toxicity occurred in 2 patients (3.6%) in the CF-3DRT group and 1 patient (3.3%) in the Hypo-IMRT group. Conclusion: Hypo-IMRT with a customized rectal balloon resulted in excellent biochemical control rates with minimal toxicity in localized prostate cancer patients.

• Journal of Radiation Protection and Research
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• 제37권3호
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• pp.123-128
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• 2012

방사선 노출은 해마 기능이상으로 인한 인지장애와 기억력 감퇴가 나타난다. 본 연구에서는 마우스에 방사선 노출(감마선 0.5 또는 2 Gy) 후 passive avoidance 및 object recognition test를 적용한 행동이상, apoptosis 측정 및 신경발생 관찰지표로서 Kiel 67 (Ki-67) 및 doublecortin (DCX)에 대한 면역염색 방법을 적용하여 diethyldithiocarbamate(DDC)의 학습기억 장애 경감효과를 관찰하였다. DDC는 방사선 조사 30분 전에 1회(체중 kg당 1,000 mg) 복강 내 주사하였다. Passive avoidance 및 object recognition test 결과, 정상대조군에 비해 방사선 단독조사군(2 Gy)에서 유의성 있는 학습기억 장애를 나타냈으며, 방사선 조사 후 12시간에 치아이랑 부위의 apoptosis 발생세포의 수가 증가하였고, Ki-67 및 DCX 양성세포의 수는 현저히 감소하였다. 방사선 노출 전 DDC 처리군에서는 유의성 있는 행동장애 완화, apoptosis 발생 감소가 관찰되었고, 평균치를 기준으로 Ki-67 및 DCX 양성세포의 수도 약간 증가하였다. DDC는 성숙마우스에서 방사선에 의한 해마 신경세포발생 및 학습기억 장애 개선효과가 있는 것으로 사료된다.