• Journal of Nutrition and Health
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• 제55권4호
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• pp.450-461
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• 2022

Purpose: DNA damage and repair responses are induced by metabolic diseases and environmental stress. The balance of DNA repair response and the antioxidant system play a role in modulating the entire body's health. This study uses a high-fat and high-calorie (HFC) drink to examine the new roles of a plant-based multivitamin/mineral supplement with phytonutrients (PMP) for regulating the antioxidant system and cellular DNA repair signaling in the body resulting from metabolic stress. Methods: In a double-blind, randomized, parallel-arm, and placebo-controlled trial, healthy adults received a capsule containing either a PMP supplement (n = 12) or a placebo control (n = 12) for 8 weeks. Fasting blood samples were collected at 0, 1, and 3 hours after consuming a HFC drink (900 kcal). The blood samples were analyzed for the following oxidative stress makers: areas under the curve reactive oxygen species (ROS) levels, plasma malondialdehyde (MDA), erythrocytes MDA, urinary MDA, oxidized low-density lipoprotein, and the glutathione:oxidized glutathione ratio at the time points. We further examined the related protein levels of DNA repair signaling (pCHK1 (Serine 345), p-P53 (Serine 15), and 𝛄H2AX expression) in the plasma of subjects to evaluate the time-dependent effects of a HFC drink. Results: In a previous study, we showed that PMP supplementation for eight weeks reduces the ROS and endogenous DNA damage in human blood plasma. Results of the current study further show that PMP supplementation is significantly correlated with antioxidant defense. Compared to the placebo samples, the blood plasma obtained after PMP supplementation showed enhanced DNA damage response genes such as pCHK1(Serine 345) (a transducer of DNA response) and 𝛄H2AX (a hallmark of DNA damage) during the 8 weeks trial on metabolic challenges. Conclusion: Our results indicate that PMP supplementation for 8 weeks enhances the antioxidant system against oxidative stress and prevents DNA damage signaling in humans.

• Tribology and Lubricants
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• 제40권4호
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• pp.111-117
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• 2024

Due to global CO₂ emission reductions and fuel efficiency regulations, the trend toward transitioning from internal combustion engine vehicles to electric vehicles (EVs) has accelerated. Consequently, the problem of EV failures has become a focal point of active research. The parasitic capacitance generated during motor-shaft rotation induces voltage that deteriorates the raceway and ball surfaces of bearings, causing electrical damage in EVs. Despite numerous attempts to address this issue, most studies have been conducted under high viscosity lubricant and low load conditions. However, due to factors such as high-speed operation, rapid acceleration and deceleration, motor heating, and motor system-decelerator integration, current EV applications have shown diminished stability in lubrication films of motor bearings, thereby leveraging the investigation to address the risk of electrical damage. This study investigates the electrical damage to rolling bearing elements in EV motor drive systems. The experimental analysis focuses on the effects of electric currents and operational loads on bearing integrity. A test rig is designed to generate high-rate voltage specific to a motor system's parasitic capacitance, and bearing samples are exposed to these currents for specified durations. Component evaluation involves visual inspections and vibration measurements. In addition, a predictive model for electrical failure is developed based on accumulated data, which demonstrates the ability to predict the likelihood of electrical failure relative to the duration and intensity of current exposure. This in turn reduces uncertainties in practical applications regarding electrical erosion modes.

• Steel and Composite Structures
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• 제19권4호
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• pp.917-937
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• 2015

During a seismic event, a considerable amount of energy is input into a structure. The law of energy conservation imposes the restriction that energy must either be absorbed or dissipated by the structure. Recent earthquakes have shown that the use of concentric bracing system with their low ductility and low energy dissipation capacity, causes permanent damage to structures during intense earthquakes. Hence, engineers are looking at bracing system with higher ductility, such as chevron and eccentric braces. However, braced frame would not be easily repaired if serious damage has occured during a strong earthquake. In order to solve this problem, a new bracing system an off-centre bracing system with higher ductility and higher energy dissipation capacity, is considered. In this paper, some numerical studies have been performed using ANSYS software on a frame with off-centre bracing system with optimum eccentricity and circular element created, called OBS_C_O model. In addition, other steel frame with diagonal bracing system and the same circular element is created, called DBS_C model. Furthermore, linear and nonlinear behavior of these steel frames are compared in order to introduce a new way of optimum performance for these dissipating elements. The obtained results revealed that using a ductile element or circular dissipater for increasing the ductility of off-centre bracing system and centric bracing system is useful. Finally, higher ductility and more energy dissipation led to more appropriate behavior in the OBS_C_O model compared to DBS_C model.

• Journal of Microbiology and Biotechnology
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• 제11권3호
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• pp.524-528
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• 2001

The measurement of radiation response using simple and informative techniques would be of great value in studying the genetic risk following occupational, therapeutic, or accidental exposure to radiation. When patients receive radiation therapy, many suffer from side effects. Since each patient receives a different dose due to different physical conditions, it is important to measure the exact dose of radiation received by each patient to lessen the side effects. Even though several biological dosimetric systems have already been developed, there is no ideal system that can satisfy all the criteria for an idean dosimetric system, especially for low-dose radiation as used in radiation therapy. In this study, an SOS Chromotest of E. coli PQ37 was evaluated as a novel dosimeter for low-dose gamma-rays. E. coli PQ37 was originally developed to screen chemical mutagens using the SOS Chromotest-a colorimtric assay, based on the induction of ${\beta}$-galactosidase ue to DNA damage. The survival fraction of E. coli PQ37 decreased dose-dependently with an increasing dose of cobalt-60 gamma-rays. Also, a good linear correlation was found between the biological damage revealed by the ${\beta}$-galactosidase expression and the doses of gamma-rays. The expression of ${\beta}$-galactosidase activity that responded to low-dose radiation under 1 Gy was $Y=0.404+(0.089{\pm}0.3)D+(-0.018{\pm}0.16)D^2$ (Y, absorbance at 420 nm; D, Dose of irradiation) as calculated using Graph Pad In Plot and Excel. When a rabbit was fed with capsules containing an agar block embdded with E. coli PQ37 showed a linear response to the radiation doses. Accordingly, the results confirm that E. coli PQ37 can be used as a sensitive biological dosimeter fro cobalt-60 gamma-rays. To the best of our knowledge, this is the first time that a bacterium has been used as a biological dosimeter, especially for low-dose radiation.

• Proceedings of the Korea Concrete Institute Conference
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• 한국콘크리트학회 2008년도 추계 학술발표회 제20권2호
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• pp.241-244
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• 2008

The authors proposed a new rapid-screening method for more reasonably evaluating seismic capacities of medium and low-rise RC buildings controlled by both shear and flexure in Ref. [1]. The method proposed in Ref. [1] was based on relationships between required strengths of each failure system for ductility factors and damage degrees of overall system derived from the view-point of ductility factors. The proposed method was also verified using observed real damage data of low-rise RC buildings caused by past earthquakes. Results indicated that the methodology proposed in Ref. [1] compares well with real damages and is a useful strategy for rapidly identifying low-rise RC buildings having high potential seismic risk. In this study, in order to verify the applicability of the new methodology proposed in Ref. [1] to real RC building systems, seismic capacities of existing eleven low-rise RC buildings in Korea are evaluated based on the new method.

• Earthquakes and Structures
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• 제9권1호
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• pp.127-143
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• 2015

In conventional seismic design, structures are assumed to be fixed at the base. To reduce the impact of earthquake loading, while at the same time providing an economically feasible structure, minor damage is tolerated in the form of controlled plastic hinging at predefined locations in the structure. Uplift is traditionally not permitted because of concerns that it would lead to collapse. However, observations of damage to structures that have been through major earthquakes reveal that partial and temporary uplift of structures can be beneficial in many cases. Allowing a structure to move as a rigid body is in fact one way to limit activated seismic forces that could lead to severe inelastic deformations. To further reduce the induced seismic energy, slip-friction connectors could be installed to act both as hold-downs resisting overturning and as contributors to structural damping. This paper reviews recent research on the concept, with a focus on timber shear walls. A novel approach used to achieve the desired sliding threshold in the slip-friction connectors is described. The wall uplifts when this threshold is reached, thereby imparting ductility to the structure. To resist base shear an innovative shear key was developed. Recent research confirms that the proposed system of timber wall, shear key, and slip-friction connectors, are feasible as a ductile and low-damage structural solution. Additional numerical studies explore the interaction between vertical load and slip-friction connector strength, and how this influences both the energy dissipation and self-centring capabilities of the rocking structure.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• 제24권6호
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• pp.67-74
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• 2010

Most of domestic low-voltage consumers are supplied from the TN-C system of KEPCO, but their load installations have established according to the national statutory standard for electrical installations based on the TT system. In this work, to propose the proper system earthing arrangements of ensuring the protection of information-technology equipment against lightning surges, the protection performance of TT and TN systems against lightning surges was investigated. As a result, when lightning surge was injected to the neutral line of distribution system, the potential difference between the equipment earth terminal and neutral point of low-voltage mains in a TT system was significantly raised. The TT system is not advised due to the risk of damage to the sensitive computer equipment. Main equipotential bonding is an important requirement for protection of low-voltage installations against lightning surges. The TN system provides the best means to reduce the incoming lightning surges through the neutral line of low-voltage service systems. In addition, It is highly recommended to install the additional earthing at the service position of low-voltage consumers.

• The Transactions of the Korean Institute of Electrical Engineers P
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• 제58권1호
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• pp.90-94
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• 2009

The inundation of substation and ground power equipment breaks out every summer season in low-lying downtown and low-lying shore by localized heavy rain, typhoon and tidal wave. For diminishing flood damage of electrical equipment in the root, flood protection system which is used the basic frame of Pad transformer is developed using pneumatic pressure. This system is established on pressure generator equipment and sensor of flooded level operates at flooding occurrence and is maintained a shutting tightly structure. The system is able to protect indraft water in Pad Transformer and supply the electricity at emergency(flooding). And we tested safety for insulation resistance at flooding and applying an electrical current. We estimate that loss cost which is caused by with flooding and the power failure will be diminished if it is addition to advances the reliability evaluation by setting an example.

• International Journal of Aeronautical and Space Sciences
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• 제15권1호
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• pp.20-31
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• 2014

This paper deals with the development of a realistic shape optimization of damaged columns that are subjected to conservative and non-conservative forces, using the Genetic Algorithm (GA). The analysis is based on the design of the most optimized shape of the column under the constraint of constant weight, considering the Static, Vibrational, and Flutter characteristics. Under the action of conservative and non-conservative longitudinal forces, an elastic column loses its stability. A numerical analysis based on FEM has been performed on a uniform damaged column, to compute the fundamental buckling load, vibration frequency, and flutter load, under various end restraints. An optimization search based on the Genetic Algorithm is then executed, to find the optimal shape design of the column. The optimized column references the one having the highest buckling load, highest vibration frequency, and highest flutter load, among all the possible shapes of the column, for a given volume. A comparison is then made between the values obtained for the optimized damaged column, and those obtained for the optimized undamaged column. The comparison reveals that the incorporation of damage in the column alters its optimal shape to only a certain extent. Also, the critical load and frequency values for the optimized damaged column are comparatively low, compared with those obtained for the optimized undamaged column. However, these results hold true only for moderate-intensity damage cases. For high intensity damage, the optimal shape may not remain the same, and may vary, according to the severity of damage.

• Journal of Power Electronics
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• 제10권6호
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• pp.702-708
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• 2010

In this paper, a fault diagnosis algorithm for brushless DC (BLDC) motor drives is proposed to maintain control performance under switch open-damage. The proposed fault diagnosis algorithm consists of a simple algorithm using measured phase current information and it detects open-circuit faults based on the operating characteristic of BLDC motors. The proposed algorithm quickly recovers control performance due to its short detection time and its reconfiguration of the system topology. It can be embedded into existing BLDC drive software as a subroutine without additional sensors. The feasibility of the proposed fault diagnosis algorithm is proven by simulation and experimental results.