• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6803-6806
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• 2013

Background: Interferon regulatory factor 6 (IRF6) is a transcription factor with distinct and conserved DNA and protein binding domains. Mutations within the protein binding domain have been significantly observed in subjects with orofacial cleft relative to healthy controls. In addition, recent studies have identified loss of expression of IRF6 due to promoter hypermethylation in cutaneous squamous cell carcinomas. Since mutational events occurring within the conserved domains are likely to affect the function of a protein, we investigated whether regions within the IRF6 gene that encodes for the conserved protein binding domain carried mutations in oral squamous cell carcinoma (OSCC). Materials and Methods: Total chromosomal DNA extracted from 32 post surgical OSCC tissue samples were amplified using intronic primers flanking the exon 7 of IRF6 gene, which encodes for the major region of protein binding domain. The PCR amplicons from all the samples were subsequently resolved in a 1.2% agarose gel, purified and subjected to direct sequencing to screen for mutations. Results: Sequencing analysis resulted in the identification of a mutation within exon 7 of IRF6 that occurred in heterozygous condition in 9% (3/32) of OSCC samples. The wild type codon TTC at position 252 coding for phenylalanine was found to be mutated to TAC that coded for tyrosine (F252Y). Conclusions: The present study identified for the first time a novel mutation within the conserved protein binding domain of IRF6 gene in tissue samples of subjects with OSCC.

• Journal of Medicine and Life Science
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• 제20권1호
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• pp.43-47
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• 2023

Streptococcus suis (S. suis) is an emerging zoonotic pathogen that causes bacterial meningitis in humans. S. suis is an encapsulated gram-positive facultative anaerobic bacterium and is an important pathogen in pigs. This infectious disease usually manifests in humans as meningitis, endocarditis, septicemia, and arthritis. Most cases originate in Southeast Asia, and human S. suis infections are often reported in countries with a high density of pigs. Meningitis is a common clinical manifestation of S. suis infection. Moreover, hearing loss is a common complication that can be bilateral, profound, and/or permanent. This report presents two cases of bacterial meningitis and hearing loss caused by S. suis in patients without a history of direct exposure to pigs in an intensive pork industry region.

• 대한한방내과학회지
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• 제25권4호
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• pp.200-206
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• 2004

Anterior inferior cerebellar artery(AICA) is a branch of the basilar artery which supplies the bloods for ventrolateral cerebellum and the lateral tegmentum of the lower two-thirds of pons. AICA occlusion can cause such symptoms as acute-onset unilateral deafness, vertigo, facial weakness and ataxia. A case of sudden hearing loss, facial palsy and vertigo caused by AICA territory infarction recently presented itself. Korean Oriental and Western medical therapy were applied in combination. Facial palsy and vertigo improved, but hearing loss did not improve. This case is reported with a brief overview of related literatures.

• Journal of Digestive Cancer Research
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• 제4권2호
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• pp.113-121
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• 2016

Background: We evaluated technique of hepatic resections using suprahilar-extrafascial dissection of Glissonean pedicle with vascular stapling device for pedicle transection with intent to minimize operative time and blood loss. Methods: We analyzed the clinical records of 326 patients who underwent anatomic liver resection by suprahilar-extrafascial pedicle isolation with vascular stapling division technique. Results: The minor liver resections were associated with significantly shorter surgery duration (105.1±21.1 vs. 225.6±75.6) and transection time (40.1±14.5 vs. 96.3±55.2) than major hepatectomies (p<0.0001 for all). The mean blood loss was 350.8±100.5 mL in minor resection and 485.4±250.2 mL in major resection (p=0.001). The mean blood transfusion requirement was 400.8±109.5 mL for minor resections and 550.9±100.0 mL for major hepatectomy (p=0.072). There was no significant difference in morbidity and mortality between groups (p=0.980; p=0.945). Major as well as minor liver resection were oncology superior with no significant difference in the 5-year overall survival rates. Conclusion: Suprahilar-extrafascial dissection of Glissonean pedicle represents an effective and safe technique of liver resection. Presented approach allows early and easy ischemic delineation of appropriate liver territory to be removed with selective inflow vascular control. It is not time consuming and it is very useful in re-resection, as well as oncological reasonable.

• Journal of Korean Neurosurgical Society
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• 제55권5호
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• pp.296-299
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• 2014

We report a rare case of pronator teres syndrome in a young female patient. She reported that her right hand grip had weakened and development of tingling sensation in the first-third fingers two months previous. Thenar muscle atrophy was prominent, and hypoesthesia was also examined on median nerve territory. The pronation test and Tinel sign on the proximal forearm were positive. Severe pinch grip power weakness and production of a weak "OK" sign were also noted. Routine electromyography and nerve conduction velocity showed incomplete median neuropathy above the elbow level with severe axonal loss. Surgical treatment was performed because spontaneous recovery was not seen one month later.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 추계학술대회 논문집 전력기술부문
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• pp.291-293
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• 2003

Energy markets of the Northeast Asia countries and in particular South Korea are perspective enough from the standpoint of export of energy resources from Russia. South Korea Power System has been rapidly growing. However, recently it has been confronted with difficulties in regard to constructing new Power Stations and especially Hydro Power Plants. Therefore it is mutually beneficial to build electric tie to South Korea in order to use highly effective Power of Northeast Asia. In this paper, we describe the maximum available transmission power through interconnected line without loss of stability in power system. For this simulation, the AC transmission system is assumed appropriate for this preliminary study. The transmission system will pass through territory of North Korea and connect to 765 kV Network near Seoul with long distance.

• 환경정책연구
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• 제11권4호
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• pp.3-37
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• 2012

우리나라의 국토 및 환경 분야를 다루는 다양한 국가계획에서 생물다양성 보전 및 보호지역 주요 이슈가 어떻게 다뤄지고 있는지를 고찰하고 시사점을 도출하고자 하였다. 생물다양성협약의 "생물다양성 2011~2020 전략목표"와 "보호지역 결정문" 내용을 토대로 주요 이슈를 선정한 후, 주요 이슈별로 우리나라 국토 및 환경 관련 주요 중장기 국가계획 7개의 내용을 정리 분석하였다. 생물다양성 2011~2020 전략목표 5와 관련하여 녹지총량제, 습지총량제 등 거의 모든 국가계획에서 다양한 제도 도입과 활용을 다루고 있으며, 보호지역 확대와 관련된 전략목표 11(2020년까지 육상 육수 생태계 17%, 연안 해양 생태계 10%)의 경우 우리나라는 국토면적 대비 보호지역 15%(2015년), 연안 해양보호구역 13%(2015년, 2020년)로 목표를 제시하고 있다. 보호지역 결정문의 주요 권고사항인 국가별 보호지역 실행프로그램(PoWPA)의 장기 이행계획 수립 개정에 대한 내용은 언급되지 않고 있으나, 관심이 필요한 10가지 보호지역 이슈에 대해서는 각종 국가계획에서 다양하게 다뤄지고 있는 것으로 나타났다. 하지만, 그 내용의 충분성 및 국가 계획별 상호 연계성 등에 있어서는 개선의 여지가 많음을 보여주고 있었다. 특히 "보호지역 관리효과성평가"의 경우 당사국에 2015년까지 국가 보호지역의 60%까지 수행하고 그 결과를 보고하도록 권고하고 있으나, 각종 국가계획에서 이에 대한 직접적 기술은 없는 것으로 나타났다. 고찰내용을 토대로 한 제안사항은 (1) "국토종합계획"에서 자연환경 보전이 국가경쟁력의 주요 요소임을 인지하고 생물다양성 및 보호지역 이슈에 대한 내용 강화, (2) 관련 국가계획들간의 상호 연계성 강화를 통한 효과적인 국가 보호지역 목표 성취를 위해 국가 환경 분야의 최상위 국가계획에서 범부처 차원의 "국가 보호지역시스템 계획" 수립, (3) 국가차원의 "보호지역실행프로그램 중장기 이행계획" 수립, (4) 각종 국가계획에 "생물다양성 전략목표"와 관련된 성과목표 설정과 보호지역결정문에서 권고하고 있는 주요 이슈들 중 관리효과성평가 등 미흡한 분야에 대한 내용 강화이다.

• 대한한의학회지
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• 제30권1호
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• pp.64-75
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• 2009

Objective: This study was designed to investigate the effect of Samultang (SMT) under hippocampus cells ischemia both in vitro and in vivo. Methods: In the in vitro study, HT22 cells, predominantly detected in the cytoplasm, which coincides with the location of the mitochondria, were used as indicators. In the in vivo study, permanent middle cerebral artery occlusion (MCAO) was induced on rats. SMT was given orally 2 h before induction of permanent focal brain ischemic injury. Result: In the in vitro study, SMT had protective effects in glutamate-induced cytotoxicity, which was revealed as apoptosis characterized by chromatic condensation and the loss of mitochondrial membrane potential in HT22 cells. In the in vivo study, TTC (2,3,5-triphenyltetrazolium chloride) staining showed a marked ischemic injury in blood supply territory of the middle cerebral artery (MCA) such as the cerebral cortex and striatum. However, treatment with SMT significantly reduced infarcted volume. SMT increased marked survival of HT22 cells against glutamate-induced cytotoxicity in MTT assay. Conclusion: These results suggest that water extract of SMT provides neuroprotection against ischemic or oxidative injury by inhibition of apoptotic cell death.

• Journal of Korean Neurosurgical Society
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• 제59권4호
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• pp.400-404
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• 2016

We report a case of acute ischemic stroke involving both the anterior and posterior circulation associated with a persistent primitive trigeminal artery (PPTA), treated by endovascular revascularization for acute basilar artery (BA) occlusion via the PPTA. An otherwise healthy 67-year-old man experienced sudden loss of consciousness and quadriplegia. Magnetic resonance imaging showed an extensive acute infarction in the right cerebral hemisphere, and magnetic resonance angiography showed occlusion of the right middle cerebral artery (MCA) and BA. Because the volume of infarction in the territory of the right MCA was extensive, we judged the use of intravenous tissue plasminogen activator to be contraindicated. Cerebral angiography revealed hypoplasia of both vertebral arteries and the presence of a PPTA from the right internal carotid artery. A microcatheter was introduced into the BA via the PPTA and revascularization was successfully performed using a Merci Retriever with adjuvant low-dose intraarterial urokinase. After treatment, his consciousness level and right motor weakness improved. Although persistent carotid-vertebrobasilar anastomoses such as a PPTA are relatively rare vascular anomalies, if the persistent primitive artery is present, it can be an access route for mechanical thrombectomy for acute ischemic stroke.

• 신재생에너지
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• 제16권2호
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• pp.20-27
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• 2020

According to "The Renewable Energy 3020 Implementation Plan", offshore wind power accounts for 12 GW of the total new capacity of 48.7 GW. Like the south-west 2.5 GW offshore wind farm case, government-led development has had difficulty in securing the residents' acceptability. This study contributes to the study of local acceptance by analyzing the perceptions of Maldo residents. To this end, in-depth interviews were conducted with the head of a village and fishing village chief, and the entire contents of the interview were revised and analyzed. The cognitive structure of the stakeholders could be confirmed using semantic network analysis, which analyzes the network structure among words. Based on the analysis results, focusing on the identity frames related to the compensation process from previous national projects, gain vs. loss frames act as the dominant frame in terms of profits from offshore wind turbines. To invigorate offshore wind farms, the policy implications as follows. First, a negotiation organization should be organized to deal with strategic opposition by fishes. Second, installing offshore wind farms on a public water body will result in demands for compensation from various actors, and a licensed fishing territory as an offshore wind farm installation site should be considered.