Previous studies about effect of respiratory motion on diagnostic imaging and radiation therapy have been performed by monitoring external motions but these can not reflect internal organ motion well. The aim of this study was to develope the artificial pulmonary nodule able to perform non-invasive implantation to dogs in the thorax and to evaluate applicability of the model to respiratory motion studies on PET image acquisition and radiation delivery by phantom studies. Artificial pulmonary nodule was developed on the basis of 8 Fr disposable gastric feeding tube. Four anesthetized dogs underwent implantation of the models via trachea and implanted locations of the models were confirmed by fluoroscopic images. Artificial pulmonary nodule models for PET injected $^{18}F$-FDG and mounted on the respiratory motion phantom. PET images of those acquired under static, 10-rpm- and 15-rpm-longitudinal round motion status. Artificial pulmonary nodule models for radiation delivery inserted glass dosemeter and mounted on the respiratory motion phantom. Radiation delivery was performed at 1 Gy under static, 10-rpm- and 15-rpm-longitudinal round motion status. Fluoroscpic images showed that all models implanted in the proximal caudal bronchiole and location of models changed as respiratory cycle. Artificial pulmonary nodule model showed motion artifact as respiratory motion on PET images. SNR of respiratory gated images was 7.21. which was decreased when compared with that of reference images 10.15. However, counts of respiratory images on profiles showed similar pattern with those of reference images when compared with those of static images, and it is assured that reconstruction of images using by respiratory gating improved image quality. Delivery dose to glass dosemeter inserted in the models were same under static and 10-rpm-longitudinal motion status with 0.91 Gy, but dose delivered under 15-rpm-longitudinal motion status was decreased with 0.90 Gy. Mild decrease of delivered radiation dose confirmed by electrometer. The model implanted in the proximal caudal bronchiole with high feasibility and reflected pulmonary internal motion on fluoroscopic images. Motion artifact could show on PET images and respiratory motion resulted in mild blurring during radiation delivery. So, the artificial pulmonary nodule model will be useful tools for study about evaluation of motion on diagnostic imaging and radiation therapy using laboratory animals.
The purpose of this study is to explore latent classes of longitudinal medical expenses of older people and to analyze its predictors and its effects on subjective health. Among participants of the Korean Health Panel, the sample of this study includes 1,119 people who is 65-year-old or older and reported their medical expenses for nine consecutive years. The analyses were conducted in three steps. First, Growth Mixture Model (GMM) was applied to find distinct subgroups showing similar patterns in medical expenses. The results showed four groups which were classified as high medical expenditure maintenance group, medical expenditure increase group, low medical expenditure maintenance group, and medical expenditure reduction group. Second, the multinominal logistic regression found that the presence of spouse, economic participation, the number of chronic diseases, and the type of health insurance were significant predictors of latent classes in medical expenses. In particular, the greater the number of chronic diseases, the higher the likelihood of belonging to the high medical expenditure maintenance group. In addition, medical benefit recipients are more likely to belong to the low medical cost maintenance and medical cost reduction groups. Third, multiple regression analysis revealed that the older people in the groups with low or reducing expenses reported better subjective health than people with higher expenses. This study has its meanings in exploring the heterogeneity in longitudinal medical expenses among older people and its predictors and its associations with health outcome. The results of this research provide background information in establishing public health policy for older people.
Lee Eun-Hyun;Park Hee Boong;Kim Myung Wook;Kang Sunghee;Lee Hye-Jin;Lee Won-Hee;Chun Mison
Radiation Oncology Journal
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v.20
no.4
/
pp.359-366
/
2002
Purpose : The purpose of the present study was to analyze and evaluate prior studies published in Korea on the cancer-related quality of life, in order to make recommendations for further research. Materials and Methods : A total of 31 studies were selected from three different databases. The selected studies were analyzed according to 11 criteria, such as site of cancer, domain, independent variable, research design, self/proxy rating, single/battery instrument, translation/back translation, reliability, validity, scoring, and findings. Results : Of the 31 studies, approximately half of them were conducted using a mixed cancer group of patients. Many of the studies asserted that the concept of quality of life had a multidimensional attribute. Approximately 30% were longitudinal design studies giving information about the changes in quality of life. In all studies, except one, patients directly rated their level of quality of life. With respect to the questionnaires used for measuring the quality of life, most studies did not consider whether or not their reliability and validity had been established. In addition, when using questionnaires developed in other languages, no studies employed a translation/ back-translation technique. All studies used sum or total scoring methods when calculating the level of quality of life. The types of variables tested for their influence on qualify of life were quite limited. Conclusion : It is recommended that longitudinal design studies be peformed, using methods of data collection whose validity and reliability has been confirmed, and that studies be conducted to identify new variables having an influence on the quality of life.
The purpose of this study is to examine the social gerontology studies in the Journal of the Korean Gerontological Society during 1980-2008 in terms of research topics, research methods, and theoretical trends. A total of 161 studies were analyzed; 27 studies in 1980's, 52 studies in 1990's, and 82 studies in 2000's. The major findings were as follows. First, the research topics were classified into five categories; 1) social change and social system (34 studies), 2) actual socio-condition (62 studies), 3) social problem and deviation (34 studies), 4) social culture (25 studies), and 5) gerontology study and gerontological theory (6 studies), and the major research trends and research results were examined. Second, in research methods, most of studies in 1980's were literature reviews and studies tended to be gradually expanded to quantitative research, but there were only eight quantitative researches. In statistical methods applied to the quantitative researches, thirty-six percent of the researches used basic statistical techniques, sixty-four percent advanced statistical techniques, and the basic ones were gradually replaced by the advanced ones. Third, most of the studies examined the social facts through relevant documents and statistics, or introduced the theories. So, only 12 studies (7.5%) were based on theories. Finally, the studies on various sociological research topics, qualitative studies, longitudinal studies, studies based on theories, and international cooperative studies, inter-disciplinary or multi-disciplinary studies were suggested for the future.
Kim, Dongil;lee, hye eun;Keum, ChangMin;Park, Altteuri;Oh, Jiwon
(The) Korean Journal of Educational Psychology
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v.32
no.1
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pp.99-130
/
2018
The purpose of this study was to examine the longitudinal relationship between resilience and social support of school violence exposure types including school bullying, victimization, and dual experience. The study used data obtained from the third year (2012) of the Seoul Education Longitudinal Study of 1,137 elementary school students in grade 6 who reported experiencing school violence. The results of the autoregressive cross-lagged model are as follows. First, as a result of measuring the self-regression coefficients of resilience and social support of the youth exposed to school violence at 3 time points (2012, 2014, and 2016), it was found for all types of violence that resilience and social support at the previous time point showed a signigicant positive effect on the same variable at the next time point. Second, in the case of the cross-lagged effects of resilience and social support, the effect of previous social support on resilience at the next time point was statistically significant for the victimization group, but not for the bullying or dual experience groups. Third, considering the opposite path from resilience to social support, resilience at the previous time point had a significant influence on the social support at the next time point for both the bullying and victimization groups. This result is new and can be complementary to the cross-sectional studies so far using a longitudinal view. The results of this study suggest that the bullying and victimized students who are relatively more resilient are less likely to perceive social support than those who are not resilient. Finally, we discuss the longitudinal relationship between resilience and social support, the limitations of this study, and implications for future research.
This study explored the influence of failure experience of Korean pharmaceutical industries on the innovative activities of corporations from the perspectives of R&D and knowledge search. Previous studies have defined the cause of the failure or studied the reasons for the decline. However, studies analyzing the influence of failure on the innovative activities of corporations are rare. This study set a research period of 10 years for the Korean pharmaceutical industry to conduct a longitudinal analysis of the influence of the influence of failure on innovation activities and the influence of innovation activities on radical innovation. A summary of the research results is as follows. Firstly, failure of corporations induce exploratory innovation activities, and the extent differs greatly from the size of financial slack resource. Secondly, experiences of corporations' failure were not significant from the perspective of knowledge search. Thirdly, the interaction between the corporation's exploratory innovation activities and knowledge search had a positive (+) relationship with radical innovation performance. This study is significant in that it suggested empirical evidence by verifying the positive influence of failure to learning and innovation unlike previous researches viewing failure negatively, and suggested the direction of future studies based on these research results.
This paper studies the relation between canonical/variegated babble (CB/VB) and early speech in an infant acquiring Mandarin Chinese from 9 to 17 months. The infant was audio-and video-taped in her home almost every week. The data analyzed here come from 1,621 utterances extracted from 23 sessions ranging from 30 minutes to one hour, from age 00:09;07 to 01:05;27. The data was digitized, and segments from 23 sessions were transcribed in narrow IPA and coded for analysis. Babble was coded from age 00:09;07 to 01:00;00, and words were coded from 01:00;00 to 01:05;27, proto-words appeared at 11 months, and some babble was still present after 01:10;00. 3821 segments were counted in CB/VB utterances, plus the segments found in 899 word tokens. The data transcription was completed and checked by the author and was rechecked by two other researchers who majored in Chinese phonetics in order to ensure the reliability, we reached an agreement of 95.65%. Mandarin Chinese is phonetically very rich in consonants, especially affricates: it has aspirated and unaspirated stops in labial, alveolar, and velar places of articulation; affricates and fricatives in alveolar, retroflex, and palatal places; /f/; labial, alveolar, and velar nasals; a lateral;[h]; and labiovelar and palatal glides. In the child's pre-speech phonetic repertoire, 7 different consonants and 10 vowels were transcribed at 00:09;07. By 00:10;16, the number of phones was more than doubled (17 consonants, 25 vowels), but the rate of increase slowed after 11 months of age. The phones from babbling remained active throughout the child's early and subsequent speech. The rank order of the occurrence of the major class types for both CB and early speech was: stops, approximants, nasals, affricates, fricatives and lateral. As expected, unaspirated stops outnumbered aspirated stops, and front stops and nasals were more frequent than back sounds in both types of utterances. The fact that affricates outnumbered fricatives in the child's late babble indicates the pre-speech influence of the ambient language. The analysis of the data also showed that: 1) the phonetic characteristics of CB/VB and early meaningful speech are extremely similar. The similarities of CB/VB and speech prove that the two are deeply related; 2) The infant has demonstrated similar preferences for certain types of sounds in the two stages; 3) The infant's babbling was patterned at segmental level, and this regularity was similarly evident in the early speech of children. The three types being coronal plus front vowel; labial plus central and dorsal plus back vowel exhibited much overlap in the phonetic forms of CB/ VB and early speech. So the child's CB/ VB at this stage already shared the basic architecture, composition and representation of early speech. The evidence of similarity between CB/VB and early speech leaves no doubt that phones present in CB/VB are indeed precursors to early speech.
The present study aimed to examine the moderating effects of marital satisfaction (MS) on the association between the number of chronic disease (CD) and depressive symptoms (DS) among ol der men and women. The 6th wave of the Korean Longitudinal Study of Ageing was utilized and the sample was married men (N=585) and women (N=460) aged 65 and over. Multiple regression analysis using SPSS WIN 25.0 and Process Macro was used to test moderating effects of MS. Control variables were age, education, household income, parent-child relationship satisfaction, self-rated health, cognitive function, current smoking status and CD of spouse. Resul ts from elderly men showed the moderating effect of MS was significant. Specifically, those with more CD were more likely to report higher level of DS in the low MS group. However, the effect of CD on DS was not significant in the high MS group. Results from elderly women showed the moderating effect of MS was not significant. This study showed the moderating effect of MS on the association between CD and DS differed by gender in later life. It suggests practical intervention to utilize the resources of spouses is in need to promote mentally healthy aging even though having chronically ill in later life.
This study aimed to investigate the association between social support and the change of depressive symptoms and its difference by gender among Korean Baby Boomer. We used the Korean Longitudinal Study of Aging (KLoSA) 5th (in 2014) and 6th waves (in 2016). Samples were Korean Baby Boomer (born 1955 to 1963) who have spouse and children(N = 1,210). Dependent variable was depressive symptoms and independent variables were four social support variables (spousal relationship satisfaction, parent-child relationship satisfaction, frequency of social contact, and number of participation groups). Interaction variables between social support and gender were also included in the model. Hierarchical regression analysis with the lagged dependent variable was performed. Results showed that the higher the satisfaction of spousal relationship and the satisfaction of parent-child relationship, the less the depressive symptoms increased. All interaction variables were not significant. These findings mean that the support from the spouse and the child is helpful in lowering depressive symptoms, and the associations between social support and depressive symptoms are not different by gender among Baby Boomer. It implies that interventions for enhancing family relationships, especially spousal relationship and parent-child relationship, may be useful to reduce depressive symptoms among Korean Baby Boomer.
Seonghyeon Kwon;Yesung Lee;Eunhye Seo;Daehoon Kim;Jaehong Lee;Youshik Jeong;Jihoon Kim;Jinsook Jeong;Woncheol Lee
Annals of Occupational and Environmental Medicine
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v.35
/
pp.41.1-41.11
/
2023
Background: Shift work has been reported to have several harmful effects on the human body. However, a small number of studies have evaluated the association between shift work and adverse effects on the thyroid. In our longitudinal study, we examined the causal association between shift work and the risk of hypothyroidism. Methods: A Kangbuk Samsung Cohort Study was conducted on 112,648 men without thyroid disease at baseline who were followed up at least once between 2012 and 2019. Shift work status and shift schedule types were categorized using standardized questionnaires. Hypothyroidism was defined using the reference ranges of serum thyroid-stimulating hormones and free thyroxine levels. Hazard ratios (HRs) and 95% confidence intervals (CIs) for incident hypothyroidism were estimated using Cox proportional hazards regression analyses with the daytime work group as the reference. Results: During the 501,237 person-years of follow-up, there were 6,306 incident cases of hypothyroidism (incidence density, 1.26 per 100 person-years). The multivariable-adjusted HR of incident hypothyroidism for the shift work total group that included all shifts compared with the daytime work group was 1.27 (95% CI: 1.15-1.40). For the fixed evening, fixed night, rotating shift, and other shift workers, the multivariable-adjusted HRs (95% CI) were 1.11 (0.76-1.61), 2.18 (1.20-3.93), 1.39 (1.23-1.56), and 1.00 (0.82-1.22), respectively. In subgroup analyses by age, the association between shift work and hypothyroidism was more pronounced in younger participants (< 40 years; HR: 1.31; 95% CI: 1.16-1.47). Conclusions: Our large-scale cohort study showed an association between shift work and the incidence of hypothyroidism, especially in younger workers with night shifts.
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