• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.12
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• pp.87-96
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• 2020

To use a hydraulic structure effectively, the velocity of a river should be known in detail. In reality, velocity measurements are not conducted sufficiently because of their high cost. The formulae to yield the flux and velocity of the river are commonly called the Manning and Chezy formulae, which are empirical equations applied to uniform flow. This study is based on Chiu (1987)'s paper using entropy theory to solve the limits of the existing velocity formula and distribution and suggests the velocity and distance formula derived from information entropy. The data of a channel having records of a spot's velocity was used to verify the derived formula's utility and showed R2 values of distance and velocity of 0.9993 and 0.8051~0.9483, respectively. The travel distance and velocity of a moving spot following the streamflow were calculated using some flow information, which solves the difficulty in frequent flood measurements when it is needed. This can be used to make a longitudinal section of a river composed of a horizontal distance and elevation. Moreover, GIS makes it possible to obtain accurate information, such as the characteristics of a river. The connection with flow information and GIS model can be used as alarming and expecting flood systems.

• BMB Reports
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• v.55 no.9
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• pp.465-471
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• 2022

Understanding and monitoring virus-mediated infections has gained importance since the global outbreak of the coronavirus disease 2019 (COVID-19) pandemic. Studies of high-throughput omics-based immune profiling of COVID-19 patients can help manage the current pandemic and future virus-mediated pandemics. Although COVID-19 is being studied since past 2 years, detailed mechanisms of the initial induction of dynamic immune responses or the molecular mechanisms that characterize disease progression remains unclear. This study involved comprehensively collected biospecimens and longitudinal multi-omics data of 300 COVID-19 patients and 120 healthy controls, including whole genome sequencing (WGS), single-cell RNA sequencing combined with T cell receptor (TCR) and B cell receptor (BCR) sequencing (scRNA(+scTCR/BCR)-seq), bulk BCR and TCR sequencing (bulk TCR/BCR-seq), and cytokine profiling. Clinical data were also collected from hospitalized COVID-19 patients, and HLA typing, laboratory characteristics, and COVID-19 viral genome sequencing were performed during the initial diagnosis. The entire set of biospecimens and multi-omics data generated in this project can be accessed by researchers from the National Biobank of Korea with prior approval. This distribution of large-scale multi-omics data of COVID-19 patients can facilitate the understanding of biological crosstalk involved in COVID-19 infection and contribute to the development of potential methodologies for its diagnosis and treatment.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.1B
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• pp.35-45
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• 2009

In this study, a laboratory experiment has been performed on a S-curved channel with two curved sections. In the experiments, effects of 3-D velocity structures on mixing characteristics of tracer material were investigated. As a result, it was clearly noticed that the primary flow travels taking the shortest course of the meandering channel and has a very ununiform distribution at the bends. The secondary cell which was developing at the first bend disappears at the crossover, and then, at the next bend, secondary cell is re-developing in the opposite direction. The experimental results show that mixing of tracer is significantly affected by the combined action of ununiform primary flow and secondary cell. The ununiform primary flow separates the tracer cloud in the longitudinal direction, and the secondary cell further separates the retarding tracer cloud mainly in the transverse direction. As a result, these complex flow structures cause separation and spreading of tracer cloud both in the longitudinal and in the transverse directions. The measured dimensionless transverse dispersion coefficients calculated using 2-D routing procedure ranges 0.012-0.875, and is generally proportional to width to depth ratio (W/h). The predicted values calculated by the theoretical equation overestimate slightly the measured transverse dispersion coefficients.

• Applied Microscopy
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• v.40 no.4
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• pp.261-266
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• 2010

ATP is the energy source synthesized at the electron transferase that consist of complex I, II, III, IV and V in mitochondrial cristae. The complex V functions as ATPase which composed of sub-complex $F_0$ and $F_1$. Porin or VDAC (voltagedependent anion-selective channel), is a family of small pore-forming proteins of the mitochondrial outer membrane, and play important roles in the regulated flux of anion, proton and metabolites between the cytosolic and mitochondrial compartments. The channel allows the diffusion of negatively charged solutes such as succinate, malate, and ATP in the fully open state, but of positively charged ions in subconducting state. In this study, in order to investigate the relationship of the function and localization between porin and ATPase we observed the distribution of porin and ATPase in the mitochondria of the bovine heart. Monoclonal antibodies against porin and ATPase ${\beta}$-subunit were used to detect porin and ATPase using light microscope with immunohistochemistry and immunofluorescence, and using electron microscope with immunogold-labeling. ATPase were stained in longitudinal section region in cardiac muscle, porin were stained in longitudinal section region in cardiac muscle. We viewed more specific pattern of localization and distribution of these proteins using immunofluorescence method. There were some region which were labeled with porin or ATPase respectively, and others which were labeled both proteins in cardiac muscle. The electron microscope results showed that immunogold labeled porin were labeled locally at mitochondrial outer membrane and ATPase were labeled evenly at mitochondrial cristae. But ATPase was not labeled at mitochondria cristae. These results confirmed the subcellular localizations of porin and ATPase in mitochondrial outer membrane and cristae. Also, we assumed that ATP synthesis always does not activation in all mitochondria exist in the bovine cardiac muscle.

• Journal of the Korean Society for Marine Environment & Energy
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• v.10 no.4
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• pp.187-192
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• 2007

Impact on cylindrical surface caused by plunging breaking waves is investigated experimentally. The breaking waves are generated in a wave flume by decreasing the wave maker frequencies linearly and focusing the generated wave components at one specific location. The breaking wave packets are based on constant wave steepness spectrum. Three inclination angles of cylinder are applied to examine the effect of contact angle between cylinder and front surface of breaking waves. Also, the effect of cylinder diameter on pressure distribution and its peak value is investigated by adopting three cylinders with different diameters. The longitudinal location of cylinder is slightly moved in eight different points to find out a probable maximum value of impact pressure. The pressures and total force on cylinder surface are measured by piezo-electric pressure sensors and 3-components load cell with 30kHz sampling rate. The variation of peak impact pressures and forces is analyzed in terms of cylinder diameter, inclination angle and location. Also, the pressure distribution on cylindrical surface is examined. The cylinder location and surface position are more important parameters that govern the magnitude and shape of peak pressures, while the cylinder diameter and inclined angle are relatively insignificant. In a certain conditions, the impact phenomenon becomes very unstable which results in a large variation of measured valves in repeated runs.

• Journal of the Korean Recycled Construction Resources Institute
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• v.8 no.4
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• pp.571-580
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• 2020

In this study, an experimental study on storage media for thermal energy storage system was conducted. For thermal energy storage medium, concrete has excellent thermal and mechanical properties and also has various advantages due to its low cost. In addition, the ultra-high strength concrete reinforced by steel fibers exhibits excellent durability against exposure to high temperatures due to its high toughness and high strength characteristics. Moreover, the high thermal conductivity of steel fibers has an advantageous effect on heat storage and heat dissipation. Therefore, to investigate the temperature distribution characteristics of ultra-high-strength concrete, concrete blocks were fabricated and a heating test was performed by applying high-temperature thermal cycles. The heat transfer pipe was buried in the center of the concrete block for heat transfer by heat fluid flow. In order to explore the temperature distribution characteristics according to different shapes of the heat transfer pipe, a round pipe and a longitudinal fin pipe were used. The temperature distribution at the differnent thermal cycles were analyzed, and the thermal energy and the cumulated thermal energy over time were calculated and analyzed for comparison based on test results.

• Journal of the Earthquake Engineering Society of Korea
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• v.10 no.6 s.52
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• pp.133-135
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• 2006

We propose and fabricate a novel fiber optic sensor for the detection of abnormal structural signals from various constructions. It's advantages are highly sensitive. small in dimension and electro-magnetic immune. Since this sensor was simply constructed with a single-mode fiber at infra-red wavelength and a laser-diode with the wavelength of 625 nm, the modes in the end of the optical fiber were not show as Gaussian distributed. So, we used the change of the mode distribution to get the sensor output by the external abnormal effect of structures. We investigated the resonance by performing the bending test of an aluminum beam attached with the fiber sensor. In the test, we could obtained a feasible signal to sense the abnormal condition of structures.

• Proceedings of the KSR Conference
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• 2011.05a
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• pp.680-689
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• 2011

A dynamic analysis procedure is developed to provide a comprehensive estimation of the dynamic response spectrum for locomotive's wheels running over a Pre-Stressed Concrete (PSC) box girder bridge on the Korea high speed railway. The wheel force spectrum with the bridge behavior are analyzed as the dynamic procedure for various running speeds (50~450km/h). The high-speed railway locomotive (KTX) is used as 38-degree of freedom system. Three displacements(vertical, lateral, and longitudinal) and three rotational components (pitching, rolling, and yawing). For one car-body and two bogies as well as five movements except pitching rotation components for four wheel axes forces are considered in the 38-degree of freedom model. Three dimensional frame element is used to model of the PSC box girder bridges, simply supported span length of 40m. The irregulation of rail-way is derived using the exponential spectrum density function under assumption of twelve level tracks conditions based on the normal probability procedure. The dynamic responses of bridge passing through the railway locomotive with high-speed analyzed by Newmark-${\beta}$ method and Runge-Kutta method are compared and contrasted considering the developed models of bridge, track and locomotive comprehensively. The dynamic analyses of wheel forces by Runge-Kutta method which are able to analyze the forces with high frequency running on the bridge and ground rail-way are conducted. Additionally, wheel forces spectrum and three rotational components of vehicle body for three typical running speeds is also presented.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.39 no.7
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• pp.707-712
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• 2015

During the welding process, welding distortion is caused by the non-uniformity of the temperature distribution in the weldment. Welding distortion is redistributed because the residual stress and rigidity change according to the removal of the welded structure. In shipbuilding in particular, this phenomenon may be observed during the cutting process of lugs that are attached to blocks for transfer. The redistribution of welding distortion also causes problems, such as damage to the cutting tool. The aim of this study is to experimentally analyze the redistribution of welding distortion because of the partial removal of the welded structure. In the experiments conducted in this study, fillet welding and cutting were performed, and longitudinal bending and angular distortion in the welded structures were then investigated and analyzed.

• Structural Engineering and Mechanics
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• v.63 no.6
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• pp.713-723
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• 2017

As a new type of ballastless track, longitudinal continuous slab track (CST) has been widely used in China. It can partly isolate the interaction between the ballastless track and the bridge and thus the rail expansion device would be unnecessary. Compared with the traditional track, CST is composed of multi layers of continuous structures and various connecting components. In order to investigate the performance of CST on a long-span bridge, the spatial finite element model considering each layer of the CST structure, connecting components, bridge, and subgrade is established and verified according to the theory of beam-rail interaction. The nonlinear resistance of materials between multilayer track structures is measured by experiments, while the temperature gradients of the bridge and CST are based on the long-term measured data. This study compares the force distribution rules of ballasted track and CST as respectively applied to a long span bridge. The effects of different damage conditions on CST structures are also discussed. The results show that the additional rail stress is small and the CST structure has a high safety factor under the measured temperature load. The rail expansion device can be cancelled when CST is adopted on the long span bridge. Beam end rotation caused by temperature gradient and vertical load will have a significant effect on the rail stress of CST. The additional flexure stress should be considered with the additional expansion stress simultaneously when the rail stress of CST requires to be checked. Both the maximum sliding friction coefficient of sliding layer and cracking condition of concrete plate should be considered to decide the arrangement of connecting components and the ultimate expansion span of the bridge when adopting CST.