• Asian-Australasian Journal of Animal Sciences
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• 제18권4호
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• pp.497-501
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• 2005

An experiment was conducted on crossbred male calves to study the effect of arsenic (As) on immunity status and certain hematological parameters. Ten crossbred male calves of 3-4 months of age were distributed into two equal groups. Group I was kept as control, whereas, group II was supplemented daily with 50 ppm As (as $As_sO_3$) up to 90 days, in the diet. Calves of both groups were fed as per ICAR standards and their requirements were fulfilled by feeding concentrate mixture and green oats. All calves were kept under similar managemental conditions. Blood samples were collected at fortnightly intervals to estimate various haematological parameters and superoxide dismutase (SOD) enzyme activity. Serum Ig and serum glutamic pyruvate transaminase (SGPT) were also measured. Cell-mediated immune responses of the calves were monitored at 0, 45 and 90 of experimental feeding, through lymphocyte proliferation. No change in blood total leukocyte counts (TLC), differential leukocyte counts (DLC), packed cell volume (PCV), haemoglobin (Hb) and SGPT was observed with As supplementation. A decrease in SOD activity was noticed in group II calves. Stimulation index (SI) for lymphocyte proliferation decreased from 1.14 to 0.79 in group II calves during 90 days experimental feeding, whereas, there was no change in SI values in group I indicating significant decrease in immune response of As supplemented calves. Blood As concentration increased in group II calves with the decrease in immune response. Short term supplementation of As to growing calves suggested suppressive effects on cell-mediated immunity. However, long term experiments are required to demonstrate clearly the efects of this toxic metal in calves.

• Asian-Australasian Journal of Animal Sciences
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• 제30권4호
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• pp.486-494
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• 2017

Objective: An experiment was conducted to determine the nutrient intake, digestibility, microbial protein synthesis, haemato-biochemical attributes, immune response and growth performance of Gaddi kids fed with oat fodder based basal diet supplemented with either tea seed or tea seed saponin (TSS) extract. Methods: Eighteen male kids, $7.03{\pm}0.16$ months of age and $19.72{\pm}0.64kg$ body weight, were distributed into three groups, $T_0$ (control), $T_1$, and $T_2$, consisting of 6 animals each in a completely randomized design. The kids were fed a basal diet consisting of concentrate mixture and oat fodder (50:50). Animals in group III ($T_2$) were supplemented with TSS at 0.4% of dry matter intake (DMI), and group II ($T_1$) were supplemented with tea seed at 2.6% of DMI to provide equivalent dose of TSS as in $T_2$. Two metabolism trials were conducted, 1st after 21 days and 2nd after 90 days of feeding to evaluate the short term and long term effects of supplementation. Results: The tea seed ($T_1$) or TSS ($T_2$) supplementation did not affect DMI as well as the digestibility of dry matter, organic matter, crude protein, neutral detergent fibre, and acid detergent fibre. Nutritive value of diet and plane of nutrition were also comparable for both the periods. However, the average daily gain and feed conversion ratio (FCR) were improved (p<0.05) for $T_1$ and $T_2$ as compared to $T_0$. The microbial protein supply was also higher (p<0.05) for $T_1$ and $T_2$ for both the periods. There was no effect of supplementation on most blood parameters. However, the triglyceride and low density lipoprotein cholesterol levels decreased (p<0.05) and high density lipoprotein-cholesterol level increased (p<0.05) in $T_2$ as compared with $T_0$ and $T_1$. Supplementation also did not affect the cell mediated and humoral immune response in goats. Conclusion: Tea seed at 2.6% of DMI and TSS at 0.4% DMI can be fed to Gaddi goats to improve growth rate, FCR and microbial protein synthesis.

• Nutrition Research and Practice
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• 제9권4호
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• pp.400-403
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• 2015

BACKGROUND/OBJECTIVES: By the year 2050, thirty-eight percent of the Korean population will be over the age of 65. Health care costs for Koreans over age 65 reached 15.4 trillion Korean won in 2011, accounting for a third of the total health care costs for the population. Chronic degenerative diseases, including coronary heart disease (CHD), drive long-term health care costs at an alarming annual rate. In the elderly population, loss of independence is one of the main reasons for this increase in health care costs. Korean heath policies place a high priority on the prevention of CHD because it is a major cause of morbidity and mortality. SUBJECTS/METHODS: This evidence-based study aims to the estimate potential health care cost savings resulting from the daily intake of omega-3 fatty acid supplementation. Potential cost savings associated with a reduced risk of CHD and the medical costs potentially avoided through risk reduction, including hospitalizations and physician services, were estimated using a Congressional Budget Office cost accounting methodology. RESULTS: The estimate of the seven-year (2005-2011) net savings in medical costs resulting from a reduction in the incidence of CHD among the elderly population through the daily use of omega-3 fatty acids was approximately 210 billion Korean won. Approximately 92,997 hospitalizations due to CHD could be avoided over the seven years. CONCLUSIONS: Our findings suggest that omega-3 supplementation in older individuals may yield substantial cost-savings by reducing the risk of CHD. It should be noted that additional health and cost benefits need to be revisited and re-evaluated as more is known about possible data sources or as new data become available.

• Journal of Nutrition and Health
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• 제12권2호
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• pp.99-105
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• 1979

This study was carried out using rats weighing $40{\sim}50\;g$ which were devided into seven groups with various diet compositions emphasizing fat levels of perilla seed oil for the period of 41/2 weeks. The levels of fat in the diet were 5%, 10%, 15% and animals were fed ad libitum. The results are as follows : 1) Yellow pjgmentation of both neck and tail was clearly observed in groups fed 10% and 15% level perilla seed oil without vitamin I supplementation (IV and VII). 2) The growth rate in groups fed 15% level perilla seed oil was reduced as compared to that in groups fed 5% or 10% level perilla seed oil. 3) The mean hematocrit values of 15% level perilla seed oil groups tended to be lower than those of control group, tut the differences were not significant. 4) The serum vitamin I concentration showed different value in various groups, the values of control group were significantly higher than those of perilla seed oil groups-15% level with or without vitamin E supplementation (VI and VII) and 10% level without vitamin E supplementation (IV). According to the results, 10% level-perilla seed oil in the diet can be considered safe if vitamin E is not omitted from the vitamin mixture ana the group fed 15% fat with P/S ratio of 1 appeared to be safe during the experimental period. Finally the long-term studios have to be persued in many aspects by using perilla seed oil in the experimental diet. Because rats are known t4 be quite resistant to the experimental diets, comparative studies using various animal species have to he conducted.

• Nutrition Research and Practice
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• 제15권4호
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• pp.431-443
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• 2021

BACKGROUND/OBJECTIVES: Nobiletin (NOB), a citrus flavonoid, is reported to have beneficial effects on cardiovascular and metabolic health. However, there is limited research investigating the effect of long-term supplementation with low-dose NOB on high-cholesterol diet (HCD)-induced hypercholesterolemia and non-obese nonalcoholic fatty liver disease (NAFLD). Therefore, we investigated the influence of NOB on hypercholesterolemia and NAFLD in HCD-fed mice. SUBJECTS/METHODS: C57BL/6J mice were fed a normal diet (ND) or HCD (35 kcal% fat, 1.25% cholesterol, 0.5% cholic acid) with or without NOB (0.02%) for 20 weeks. RESULTS: HCD feeding markedly reduced the final body weight compared to ND feeding, with no apparent energy intake differences. NOB supplementation suppressed HCD-induced weight loss without altering energy intake. Moreover, NOB significantly decreased the total cholesterol (TC) levels and the low-density lipoprotein (LDL)/very-LDL-cholesterol to TC ratio, and increased the high-density lipoprotein-cholesterol/TC ratio in plasma, compared to those for HCD feeding alone. The plasma levels of inflammatory and atherosclerosis markers (C-reactive protein, oxidized LDL, interleukin [IL]-1β, IL-6, and plasminogen activator inhibitor-1) were significantly lower, whereas those of anti-atherogenic adiponectin and paraoxonase were higher in the NOB-supplemented group than in the HCD control group. Furthermore, NOB significantly decreased liver weight, hepatic cholesterol and triglyceride contents, and lipid droplet accumulation by inhibiting messenger RNA expression of hepatic genes and activity levels of cholesterol synthesis-, esterification-, and fatty acid synthesis-associated enzymes, concomitantly enhancing fatty acid oxidation-related gene expression and enzyme activities. Dietary NOB supplementation may protect against hypercholesterolemia and NAFLD via regulation of hepatic lipid metabolism in HCD-fed mice; these effects are associated with the amelioration of inflammation and reductions in the levels of atherosclerosis-associated cardiovascular markers. CONCLUSIONS: The present study suggests that NOB may serve as a potential therapeutic agent for the treatment of HCD-induced hypercholesterolemia and NAFLD.

• 한국가금학회지
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• 제38권3호
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• pp.173-179
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• 2011

본 연구는 복합 생균제를 사료 공급을 통하여 갈색 산란계(Hy-Line Brown)에 산란 초기 21~40주, 산란 중기인 41~65주로 나누어 산란계의 생산성과 산란에 미치는 영향을 조사하였다. 복합 생균제를 생산하고 생균제를 구성하는 균주의 특성에 대하여 내산성(pH 2.5), 내담즙성(Oxgall 0.3%) 및 특정 병원균에 대한 항균력을 시험하였고, 산란 시기별로 분변 내 미생물의 변화를 조사하였다. 생균제는 4종의 복합생균으로 각각의 대두박 기질에 의한 고상식 발효물로서 원료에서 생산까지 9단계 과정을 거쳐 생산하였다. 복합 생균제를 구성하는 Bacillus subtilis, Lactobacillus plantarum, Enterococcus faecium에서 높은 내산성, 내담즙성, 항균력 등이 나타나는 것을 확인하였으며, Saccharomyces cerevisiae는 항균력이 낮은 것으로 나타났다. 산란 생산성은 급여 후 대조구에 비해 높은 산란율을 보였으나, 0.1% 급여구와 0.2% 급여구 사이의 유의차는 없었다(P>0.05). 난중에 있어서 산란 초기 21~40주는 대조구와 유의차를 보였으나, 0.1% 급여구와 0.2% 급여구간에는 유의차가 인정되지 않았다(P>0.05). 그러나 산란 중기에서 0.2% 급여구와 0.1% 급여구 사이에 유의차를 보였으며, 대조구와도 유의성 각각 인정되었다(P<0.05). 폐사율은 대조구와 비교하였을 때 0.2% 급여구에서 폐사율이 격감되는 유의차가 있었고(P<0.05) 산란 시기별로는 산란 초기에 0.2% 급여구가 폐사율 감소를 보였으나, 산란 중기에는 0.1% 급여구와의 유의차가 나타나지 않았다. 사료 섭취량은 산란 전기에는 유의성이 없었으나, 산란 후기의 0.2% 급여구에서 유의적인 증가가 인정되었다(P<0.05). 분변 미생물 조사에서 복합 생균제 급여 후 0.1% 급여구의 전기, 중기 모두 Lactobacillus가 유의적으로 증가되었으나, Coli form은 중기에 0.1%, 0.2% 급여구에서 각각 유의적으로 감소하는 경향을 나타내었다(P<0.05). 결론적으로 산란계 사료 내 복합 생균제의 첨가는 산란율과 난중의 향상과 분변 미생물의 정상적인 변화로 폐사율을 감소시키는 것으로 사료된다.

• Journal of Animal Science and Technology
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• 제62권1호
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• pp.31-42
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• 2020

The aim of this study was to investigate the effects of 3-nitrooxypropanol (NOP) on gas production, rumen fermentation, and animal performances depending on animal type using a meta-analysis approach. A database consisted of data from 14 studies, 18 experiments and 55 treatments. The supplementation of NOP linearly decreased methane (CH₄) emissions [g/kg dry matter intake (DMI)] regardless of animal type and length of experimental period (beef, p < 0.0001, R² = 0.797; dairy, p = 0.0003, R² = 0.916; and long term, p < 0.0001, R² = 0.910). The total volatile fatty acids (VFA) concentration and the proportion of acetate, based on beef cattle database, were significantly decreased with increasing NOP supplementation (p = 0.0015, R² = 0.804 and p = 0.0003, R² = 0.918), whereas other individual VFAs was increased. Based on the dairy database, increasing levels of NOP supplementation linearly decreased proportion of acetate (p = 0.0284, R² = 0.769) and increased that of valerate (p = 0.0340, R² = 0.522), regardless of significant change on other individual VFAs. In animal performances, the DMI, from beef cattle database, tended to decrease when the levels of NOP supplementation increased (p = 0.0574, R² = 0.170), whereas there was no significant change on DMI from dairy cattle database. The NOP supplementation tended to decrease milk yield (p = 0.0606, R² = 0.381) and increase milk fat and milk protein (p = 0.0861, R² = 0.321, p = 0.0838, R² = 0.322). NOP is a viable candidate as a feed additive because of its CH₄ mitigation effects, regardless of animal type and experiment period, without adverse effects on animal performances.

• 한국식품위생안전성학회지
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• 제7권2호
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• pp.123-135
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• 1992

This study was performed to investigate the term effect of fermented milk in drink on rats fed by cholesterol diet. 150 to 5-week-old male rates of Sprague-Dawley strain weer divided into six groups according to diet and content of fermented milk in drink. The first group served as normal control group fed by synthetic pellets of standard diet. The second , cholesterol control group, was treated with standard diet containing 1% of cholesterol and 500000IU/100g of vitamin D2. The other four groups. fermented milk groups, FM-25,FM-50 , FM 75 and FM-100 were treated with the cholesterol and vitamin D2 diet and supplied with 25%, 50%, 75%, 100% of fermented milk in drink , respectively. The animals were sacrificed for analysis in 3, 6, 9 and 12 months. Weight gain, diet intake , and drink consumption were significantly different among groups. Fermented milk reduced serum cholesterol to a significant effect (p<0.05) and significantly increased the ratio of high density lipprotein cholesterol to total cholesterol(p<0.05). Serum triglycerides were reduced to a smaller and less significant effect in fermented milk group. The aorta and liver of fermented milk showed slighter medial calcification and necrosis and milder fat degeneration than did the cholesterol control group. Supplementation of fermented milk may have a helpful effect on hypercholesteremia and atherosclerosis.

• Clinical and Experimental Pediatrics
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• 제59권12호
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• pp.466-470
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• 2016

Early, aggressive nutrition is an important contributing factor of long-term neurodevelopmental outcomes. To ensure optimal growth in premature infants, adequate protein intake and optimal protein/energy ratio should be emphasized rather than the overall energy intake. Minimal enteral nutrition should be initiated as soon as possible in the first days of life, and feeding advancement should be individualized according to the clinical course of the infant. During hospitalization, enteral nutrition with preterm formula and fortified human milk represent the best feeding practices for facilitating growth. After discharge, the enteral nutrition strategy should be individualized according to the infant's weight at discharge. Infants with suboptimal weight for their postconceptional age at discharge should receive supplementation with human milk fortifiers or nutrient-enriched feeding, and the enteral nutrition strategy should be reviewed and modified continuously to achieve the target growth parameters.