• Title/Summary/Keyword: long-term cost

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Single Dose Topical Application of Clotrimazole for the Treatment of Otomycosis: Is This Enough?

  • Dundar, Riza;Iynen, Ismail
    • Korean Journal of Audiology
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    • v.23 no.1
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    • pp.15-19
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    • 2019
  • Background and Objectives: To determine the efficacy of filling the external auditory meatus with 1% clotrimazole at a single visit for the treatment of otomycosis. Subjects and Methods: This prospective study included 40 patients who were referred to our clinic with complaints of ear itching, pain, and fullness, and were diagnosed with unilateral otomycosis. After cleaning the mycotic hyphae from the external auditory meatus, the ear canal was filled with 1% clotrimazole, using an intravenous catheter and syringe. The patients received follow-up examinations on post-treatment days 7, 15, and 45. Results: The follow-up otomicroscopic examinations revealed that 95% of the ear canals were entirely clean and that all symptoms had resolved. The post-treatment scores of pain, aural fullness and itching were significantly lower than the pre-treatment scores (p<0.01). Conclusions: Filling the external auditory meatus with 1% clotrimazole at a single visit is an easy, efficient, and cost-effective treatment for otomycosis. Additionally, high patient compliance makes this treatment superior to long-term topical therapy.

Research on the influence of we-chat applet on improving user experience

  • Liu, Zi-Yang;Liao, Kai;Wang, Jun-Lin
    • Proceedings of the Korean Society of Computer Information Conference
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    • 2020.07a
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    • pp.613-615
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    • 2020
  • As a service application developed for users, we-chat applets can be used without downloading and installation, which realizes the immediate response between offline enterprises and users, and more importantly, it provides users with a convenient platform to find products and improve the cost-effective channel for customers. Therefore, it is beneficial to improve the user experience in the future by studying how to use wechat applets Realize the long-term market competitiveness of enterprises.

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Single Dose Topical Application of Clotrimazole for the Treatment of Otomycosis: Is This Enough?

  • Dundar, Riza;Iynen, Ismail
    • Journal of Audiology & Otology
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    • v.23 no.1
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    • pp.15-19
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    • 2019
  • Background and Objectives: To determine the efficacy of filling the external auditory meatus with 1% clotrimazole at a single visit for the treatment of otomycosis. Subjects and Methods: This prospective study included 40 patients who were referred to our clinic with complaints of ear itching, pain, and fullness, and were diagnosed with unilateral otomycosis. After cleaning the mycotic hyphae from the external auditory meatus, the ear canal was filled with 1% clotrimazole, using an intravenous catheter and syringe. The patients received follow-up examinations on post-treatment days 7, 15, and 45. Results: The follow-up otomicroscopic examinations revealed that 95% of the ear canals were entirely clean and that all symptoms had resolved. The post-treatment scores of pain, aural fullness and itching were significantly lower than the pre-treatment scores (p<0.01). Conclusions: Filling the external auditory meatus with 1% clotrimazole at a single visit is an easy, efficient, and cost-effective treatment for otomycosis. Additionally, high patient compliance makes this treatment superior to long-term topical therapy.

MicroRNA-Gene Association Prediction Method using Deep Learning Models

  • Seung-Won Yoon;In-Woo Hwang;Kyu-Chul Lee
    • Journal of information and communication convergence engineering
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    • v.21 no.4
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    • pp.294-299
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    • 2023
  • Micro ribonucleic acids (miRNAs) can regulate the protein expression levels of genes in the human body and have recently been reported to be closely related to the cause of disease. Determining the genes related to miRNAs will aid in understanding the mechanisms underlying complex miRNAs. However, the identification of miRNA-related genes through wet experiments (in vivo, traditional methods are time- and cost-consuming). To overcome these problems, recent studies have investigated the prediction of miRNA relevance using deep learning models. This study presents a method for predicting the relationships between miRNAs and genes. First, we reconstruct a negative dataset using the proposed method. We then extracted the feature using an autoencoder, after which the feature vector was concatenated with the original data. Thereafter, the concatenated data were used to train a long short-term memory model. Our model exhibited an area under the curve of 0.9609, outperforming previously reported models trained using the same dataset.

Analysis of Budget Trends related to Creation of Urban Park in Seoul - Focusing on Budgetary Document - (서울시 도시공원조성예산 변동 추세 - 예산서를 중심으로 -)

  • Ko, Ha-jung
    • Journal of the Korean Institute of Landscape Architecture
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    • v.48 no.3
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    • pp.1-11
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    • 2020
  • Urban parks are important spaces of ecological and socio-cultural value to citizens who lead busy lives in increasingly complex and densely populated megalopolises. However, creating and maintaining city parks takes the will of the authorities to put it into practice and provide the attendant financial resources. That explains why we are focused on the budget aspects for the Seoul Metropolitan City in relation to creating park spaces. Our findings were as follows: 1) The overall city budget has steadily increased, but the budget allocated to Green Seoul Bureau and new park development has decreased since 2011. 2) As for elected officials, the budget grew during the time of the first, third, and fourth mayors as the creation of parks was considered to be a major priority, but after the sixth popularly elected mayor, the budget was sharply cut. 3) About 10% of the budget was allocated to the parks managed by the self-governing districts, compared to the ones under the direct management of the city. Furthermore, the analysis of the average annual budget for each park and how long (in terms of year) the budget for each park is invested showed that it was classified into three different types of category. Local governments adhere to the principle that their budget must be compiled and expended for a single year, which makes it hard to establish and push ahead with a long-term plan. However, as parks and green areas should not be approached from a short-term perspective for performance but from a long-term perspective, securing the consistent amount of budget is essential. This study has significance in that it attempted to analyze the budget issues related to parks, which has not been studied in depth so far, but the subject in this paper was limited to the budget for Green Seoul Bureau. Therefore, further research is needed because the parks managed by the self-governing districts were not considered.

Metal Oxide Thin Film Transistor with Porous Silver Nanowire Top Gate Electrode for Label-Free Bio-Relevant Molecules Detection

  • Yu, Tae-Hui;Kim, Jeong-Hyeok;Sang, Byeong-In;Choe, Won-Guk;Hwang, Do-Gyeong
    • Proceedings of the Korean Vacuum Society Conference
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    • 2016.02a
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    • pp.268-268
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    • 2016
  • Chemical sensors have attracted much attention due to their various applications such as agriculture product, cosmetic and pharmaceutical components and clinical control. A conventional chemical and biological sensor is consists of fluorescent dye, optical light sources, and photodetector to quantify the extent of concentration. Such complicated system leads to rising cost and slow response time. Until now, the most contemporary thin film transistors (TFTs) are used in the field of flat panel display technology for switching device. Some papers have reported that an interesting alternative to flat panel display technology is chemical sensor technology. Recent advances in chemical detection study for using TFTs, benefits from overwhelming progress made in organic thin film transistors (OTFTs) electronic, have been studied alternative to current optical detection system. However numerous problems still remain especially the long-term stability and lack of reliability. On the other hand, the utilization of metal oxide transistor technology in chemical sensors is substantially promising owing to many advantages such as outstanding electrical performance, flexible device, and transparency. The top-gate structure transistor indicated long-term atmosphere stability and reliability because insulator layer is deposited on the top of semiconductor layer, as an effective mechanical and chemical protection. We report on the fabrication of InGaZnO TFTs with silver nanowire as the top gate electrode for the aim of chemical materials detection by monitoring change of electrical properties. We demonstrated that the improved sensitivity characteristics are related to the employment of a unique combination of nano materials. The silver nanowire top-gate InGaZnO TFTs used in this study features the following advantages: i) high sensitivity, ii) long-term stability in atmosphere and buffer solution iii) no necessary additional electrode and iv) simple fabrication process by spray.

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Formal Estimation Method for Optimal Budget Appropriation of Highway Construction Projects under Long-term Continuation Contracts (장기계속계약제도 하에서 고속도로공사 최적공사비 산출방안 정립에 관한 연구)

  • Koo, Bon-Sang;Yu, Jung-Ho;Park, Jong-Ho
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.35 no.6
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    • pp.1405-1412
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    • 2015
  • In Korea, public infrastructure projects employ "long term continuation (LTC) contracts," which require budgets to be reevaluated and re-appropriated annually throughout the multi-year life of the project. However, such contracts also make it susceptible to frequently changing government policies, in which budgets required for existing projects are allocated to new projects and thus does not provide a consistent stream of capital to multi-year projects. Each year, the KEC needs to attain government funds for construction of its multiple highway construction sites. Because it is difficult to know the amount that may be actually appropriated to KEC in a given year, it is in turn difficult to anticipate and provide sufficient funds necessary for construction to run smoothly and continuously. The lack of a good logic for appropriation has resulted in projects having a skewed distribution of capital. To get better budget appropriations from the central government, the KEC first needs a systemized approach that rationalizes the annual construction capital optimally required for its individual sites. The goal of this research was to devise a way that allows the KEC to determine and calculate the optimal construction costs that would be required for its individual construction sites on an annual basis. Both the optimal progress rate and the essential work types were assessed through a workshop with 24 professionals (KEC employees and contractors) who had extensive experience in KEC projects and also were currently working in these projects.

Portfolio Analysis on the New Power Generation Sources of the Sixth Basic Plan for Long Term Electricity Demand and Supply (포트폴리오 이론을 활용한 제6차 전력수급기본계획의 신규전원구성 비교 연구)

  • Kim, Juhan;Kim, Jinsoo
    • Environmental and Resource Economics Review
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    • v.23 no.4
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    • pp.583-615
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    • 2014
  • Including the rolling black out in 2011, Korea has suffered from rapid increase of electricity consumption and demand forecasting failure for last five years. In addition, because of the Fukushima disaster, high fuel prices, and introduction of new generation sources such as renewables, the uncertainty on a power supply strategy increases. Consequently, a stable power supply becomes the new agenda and a revisino of strategy for new power generation sources is needed. In the light of this, we appraises the sixth basic plan for long term electricity demand and supply considering the changes of foreign and domestic conditions. We also simulate a strategy for the new power generation sources using a portfolio analysis method. As results, a diversity of power generation sources will increase and the share of renewable power generation will be surged on the assumptions of a cost reduction of renewable power sources and an increase of fuel costs. Particularly, on the range of a risk level(standard deviation) from 0.06 and 0.09, the efficient frontier has the most various power sources. Besides, the existing power plan is not efficient so that an improvement is needed. Lastly, the development of an electricity storage system and energy management system is necessary to make a stable and efficient power supply condition.

The Long-term Durability Evaluation of PC Box for Near-surface Transit System manufactured by Microwave Heat curing (마이크로웨이브 발열양생에 의해 제작된 저심도 철도시스템용 PC BOX의 장기내구성 평가)

  • Koh, Tae-Hoon;Yoo, Han-Ju
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.4
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    • pp.766-771
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    • 2016
  • This study examined the long-term durability of PC boxes, which was manufactured by low-carbon eco-friendly concrete using an alternative binder to cement and alternative fine aggregate to sand and microwave heat curing system to reduce the construction cost of a near-surface transit system. Based on the test results, the initial compressive strength of microwave heat cured concrete was higher than that of the steam cured concrete, but those were similar in the long-term age. In addition, there was no significant difference between the two curing conditions in the chemical resistance and the freeze-thawing resistance, and the chloride ion penetration level of the concrete cured by two methods was very low. Therefore, low-carbon eco-friendly concrete and microwave heat curing technology are expected to contribute to the economic construction of a near-surface transit system, and reduce carbon dioxide emissions and environmental impact.

Application of Simplified Curing Unit for the Extension of Storage Life and Improvement of Physicochemical Quality of Sweet Potatoes during Long-term Storage (간이 큐어링 설비를 이용한 큐어링 처리가 장기간 저장 중 고구마의 품질 개선에 미치는 영향)

  • Song, Jeong-Hwa;Kim, Sung-Kyeom;Chun, Chang-Hoo
    • Journal of Bio-Environment Control
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    • v.20 no.4
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    • pp.304-310
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    • 2011
  • To evaluate the effect of curing treatment using a newly developed simplified curing unit (SCU) on the physicochemical quality of stored sweet potatoes was investigated for six months. The SCU consisting of a heater, an air circulation fan, exhaust fans, and a humidifying duct was installed in a cold storage room where the harvested sweet potatoes were stacked. During the six days of curing treatment, air temperature and relative humidity in the storage room were set at $32^{\circ}C$ and 90%, respectively. Physical and chemical properties of sweet potatoes were measured at 1-month intervals from the first day of storage. McKinney index showing the incidence and severity of decay was 0.83% in the curing treatment, while that of untreated control was 5.08% over the same storing period. Firmness, soluble solids content, and dry matter content in the cured sweet potatoes were greater than those of untreated control. Moreover, the changes of skin color in uncured potatoes occurred rapidly than cured one which showed delay of skin discoloration during the long-term storage. Results suggest that the SCU treatment improves the physicochemical quality of stored sweet potatoes and extends their storability. Therefore, the SCU can be effectively used for curing treatment of sweet potatoes with a relatively low cost.