• 제목/요약/키워드: logarithmic form

검색결과 46건 처리시간 0.027초

레보프라이드 정(레보설피리드 25 mg)에 대한 레보피드 정의 생물학적 동등성 (Bioequivalence of Levopid Tablet to Levopride Tablet (Levosulpiride 25 mg))

  • 조혜영;강현아;문재동;이용복
    • Journal of Pharmaceutical Investigation
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    • 제32권2호
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    • pp.127-133
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    • 2002
  • Levosulpiride is the 1evo-enantiomer form of racemic sulpiride, a benzamide derivative selectively inhibiting dopaminergic $D_2$ receptors at the trigger zone both in the central nervous system and in the gastrointestinal tract. The purpose of the present study was to evaluate the bioequiva1ence of two levosulpiride tablets, Levopride (SK Pharmaceutical Co., Ltd.) and Levopid (Dae Won Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The levosulpiride release from the two levosulpiride tablets in vitro was tested using KP VII Apparatus II method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty eight normal male volunteers, $23.82{\pm}3.26$ years in age and $69.13{\pm}8.58$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 25 mg of levosulpiride was orally administered, blood was taken at predetermined time intervals and the concentrations of levosulpiride in serum were determined using HPLC method with fluorescence detector. The dissolution profiles of two levosulpiride tablets were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t\;and\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two tablets based on the Levopride were -1.17%, 1.20% and -1.09%, respectively. There were no sequence effects between two tablets in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) $(e.g.,\;log(0.93){\sim}log(1.07)\;and\;log(0.90){\sim}log(1.14)\;for\;AUC_t\;and\;C_{max}$, respectively). The 90% confidence interval using untransformed data was within ${\pm}20%$ $(e.g.,\;-19.47{\sim}16.20\;for\;T_{max})$. All parameters met the criteria of KFDA guideline for bioequivalence, indicating that Levopid tablet is bioequivalent to Levopride tablet.

시험 콘크리트 말뚝의 지지력 거동 (Carrying Capacity Behavior of Instrumented PC Piles)

  • 이영남;이종섭
    • 한국지반공학회지:지반
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    • 제14권5호
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    • pp.163-172
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    • 1998
  • 말뚝의 지지력 거동을 연구하기 위하여 말뚝 제작시 다수의 변형률계를 설치한 2본의 말뚝들에 대하여 항타시에 그리고 항타후 소정의 시간이 경과된 시점에 동재하시험과 정재하시험을 몇 차례 수행하였다. 콘관입저항값 그리고 표준관입저항값과 말뚝의 단위 주면마찰력과의 관계를 규명하기 위해 재하시험전에 시험지반에 대하여 론관입시험과 표준관입시험도 실시하였다. 지지력과 두부침하량 관계를 살펴보면, 0.055D(D: 직경)의 두부침하량에서 전체지지력이 극한에 도달하였고, 이 때에 주면마찰력은 극한간에 도달했으나, 선단지지력은 계속 증가하는 것으로 나타났다. 말뚝의 지지력은 항타후 시간이 경과함에 따라 자연대수함수로 증가하였으며, 지지력 성분중 주면마찰력 성분이 항타한 후 40일 경과한 시점에 초기값의 4.6배 정도로 현저하게 증가하였다. 지지력 거동에 대한 시간경과의 영향을 보면, 시험말뚝들은 초기항타시에는 선단지지말뚝으로 거동하다가 시간이 경과하면서 주면마찰 말뚝으로 거동이 변화되었음을 관찰할 수 있었다. 단위 주면마찰력은, 토질분류에 따라 다르지만, 콘관입저항칼(q.)과 표준관입저항값(N)과 일정한 관계를 갖는 것으로 나타났으며, 관계상수는 현재 국내에서 사용하고 있는 간보다 큰 것으로 나타났다.

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광학(光學) 및 전자현미경기술(電子顯微鏡技術)에 의(依)한 Mycoplasma pneumoniae의 분열(分裂)과 연속분화(連續分化)에 관(關)한 연구(硏究) (Replication and Sequential Development of Adherent Mycoplasma Pneumoniae Studied by Light and Electron Microscopies)

  • 김치경
    • Applied Microscopy
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    • 제12권2호
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    • pp.11-22
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    • 1982
  • Mycoplasma pneumoniae의 형태적(形態的) 분화과정(分化過程)을 광학(光學) 및 Carbon replication과 critical point drying 전자현미경 기술(技術)을 이용하여 관찰(觀察)하였다. 단세포(單細胞)로 부터 시작하는 전분화(全分化) 과정에서 이 세균(細菌)은 구형(球形)과 방추형(紡錘形)의 세포형태(細胞形態)로 특유(特有)한 분화(分化)를 하며 이 과정은 배양액(培養液)의 pH변화(變化)와 일치(一致)하여 진행(進行)되었다. 본(本) 연구(硏究) 결과(結果)로 부터 M. pneumoniae의 단세포(單細胞)에서 시작되는 새로운 생활회로(生活回路)를 다음과 같이 제기(提起)하였다. 단세포기(單細胞期)를 지나 제1분열기(第1分裂期)에는 구형세포(球形細胞)가 주로 대수증식기(對數增殖期)의 초기에 이분법(二分法)에 의하여 분열하고 그 후에 방추형 세포(細胞)가 분절법(分節法)에 의하여 분열하는 제2분열기(第2分裂期)가 뒤 따른다. 방추형(紡錘形)의 긴 세포(細胞)는 극성(極性)을 갖고 세포 한쪽 끝으로 부터 성장(成長)하여 수 많은 방추형세포에 의한 망상기(網狀期)가 된다. 이와 같은 생장회로(生長回路)는 좋은 생장(生長) 환경에서는 반복되지만 pH가 6.8 이하로 떨어지거나 다른 조건(條件)들이 나빠지면 세포표면(細胞表面)이 조악(粗惡)한 구형(球形)으로 변형(變形)되어 사멸기(死滅期)에 들어가 모든 세포(細胞)는 생명력(生命力)을 상실하게 된다.

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다양한 규모매개변수를 이용한 비정상성 Gumbel 모형의 비교 연구 (Comparison Study on the Various Forms of Scale Parameter for the Nonstationary Gumbel Model)

  • 장한진;김수영;허준행
    • 한국수자원학회논문집
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    • 제48권5호
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    • pp.331-343
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    • 2015
  • 비정상성 빈도해석을 위해 개발된 비정상성 확률분포 모형들은 대부분 매개변수에 시간항을 포함하는 형태로 정의된다. 이 중에서도 우리나라에 널리 사용되고 있는 Gumbel 모형에 대해 살펴보면, 비정상성 Gumbel 모형의 위치 및 규모매개변수는 시간에 대해 선형(linear) 및 지수(exponential) 함수의 관계를 보이는 형태로 가정한다. 규모매개변수의 지수함수의 형태는 음(-)의 값이 추정되는 것을 방지하기 위해 제안되어 널리 사용되고 있으나 이로 인해 확률수문량이 과다산정되는 문제가 발생하기도 한다. 본 연구에서는 이러한 문제를 해결하기 위해 비정상성 Gumbel 모형의 규모매개변수의 다양한 형태를 비교하고자 한다. 이를 위해 비정상성 Gumbel 모형의 규모매개변수를 지수함수, 선형, 로그 형태로 가정하여 비교하였다. 각 모형의 매개변수의 추정은 최우도법을 적용하였고 규모매개변수의 형태별 정확도 비교를 위해 모의실험을 수행하였으며, 실제 자료에 대한 적용으로 자료기간 30년 이상을 보유하면서 경향성을 가지는 강우량 자료들을 대상으로 비정상성 빈도해석을 수행하였다. 그 결과, 지수함수 형태를 가정한 규모매개변수를 가지는 비정상성 Gumbel 모형이 가장 작은 오차를 가지는 것으로 분석되었다.

여뀌과 이형경식물의 Dinorphism과 Bisexuality의 변화 (STUDIES ON THE DIMORPHISM AND TRANSITION OF BISEXUALITY OF HETEROSTYLOUS POLYGONACEAE)

  • Harn, Chang-Yawl
    • Journal of Plant Biology
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    • 제3권2호
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    • pp.6-18
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    • 1960
  • The present experiments were designed in order to clarify the differences between the long and short styled plants and the transgressive gradition in the degree of dimorphism among the three heterostylous species of the Polygonus, P. japonica, F. esculentum, and P. senticosa, based on investigations regarding the floral structure, ecological and physiological traits, the results of which are summarized as follows: (1) P. japonica, although it exhibits typical dimorphism, has undergone so high a differentiation between long and short styled that its long styled individuals behave as if they were female; and short styled individuals as if male. In long-styled individuals, filament, anther, and pollen grains show signs of degeneration, most of the pollen being abortive. On the other hand, in short styled individuals, the filament, anther, and pollen grains have attained remarkable development; the pollen grians are large and fertile. In short-plant the fertilized flowers readily drop off in every stage of their embryo development. This species has completely lost the self-fertile property, which is characteristic of the non-dimorphic Polygonum genus. Although this specsei typically exhibits the physiological characteristics of the non-dimorphic Polygonum genus. Although this specisei typically exhibits the physiological characteristics of dimorphism in controlled pollination, the short-styled individuals bear no seed in nature, thus misleading taxonomists to idenfity the short-styled plant as male. 2) The morphological feature of the flower organ of P. senticosa obviously indicates definite dimorphism. Physiologically, however, no differentiation towards dimorphism was observed, the species still retaining, both in long and short-individuals, the self-fertile property common to the Polygonum genus. Elaborate examinations revealed that regardless of the modes of pollination, both fertiization and seed setting flourish, no differentiation betwen legitimate and illegitimate unions being recognizable. This sort of physiological property has not been observed in the investigations of other heterostylous plants. It is assumed that this species is differentiated structurally into dimorphism, but not yet physiologically. In nature, however, this plant would have more opportunities to be cross-pollinated, i.e., legitimately combined, than self-pollinated because of the development of two forms of flowers. 3) In terms of heterostylism, the F. esculentum just occupies the intermediate position between P. japonica and P. senticosa structurally, ecologically, and physiologically. Doescription of some of the physiological behavior of the plant will suffice to demonstrate the above facts. While P. japonica has completely lost its self-fertile property, P. senticosa still retains it wolly. In F. esculentum 2-6% of self-fertility is the result in illegitimate combination. There occur occasionally hereditary self fertile individuals among some of the F. or 20 min. irradiation plot, when they reach any stage of the same bacterial population. In addition to this increase of total population in the plots with the more dose of UV light irradiation, it seems that the more dose of UV light irradiation is the more shortened the generation time of Azotobacter. Therefore, it is clear that variation of reproductive rate must be, mere or less, due to the genetic effects induced by UV light irradiation. On the other hand, the lag phase or logarithmic growth phase in nonirradiated culture is shortened prominently, and this must be due to the difference in bacterial number of the original inoculm. The generation time of Azotobacter is shortened by exogeneous treatment of nuclei acid derivatives, and the degree is greater in case of DNA derivatives than RNA dervatives. W.H. Price reported that the rate of ribose nucleic acid to protein in Staphylococcus muscae is proportional to the generation time: that is the faster the cell can form ribose nucleic acid, the more rapid its growth. This explains the shortening of generation time by exogeneous RNA derivatives in this work reasonably. On the other hand, it is well known that the desoxyribose nuclic acid content per cell is constant and independent of the generation time. A.D. Laren and W.N. Takahashi reported that the infectious RNA from TMV is 6 times as sensitive to inactivation by UV as it is in the form of intact virus, and that inactivation of infectious TMV involves onlu a local change on RNA chain. But, the effect of exogeneous DNA in this work suggests that irradiated living cell which cotain DNA bring about some change on DNA moleculs as well as RNA molecules. And if the mutagenic effects of UV take into consideration, it is very reasonable. Therefore, it is clear that the variation of the generation time by UV irradiation is, more or less, due to the genetic effects. Therefore, it seems that the shortness of the average lifewpan of Azotobacter by UV irradiation is resulted not only from the influence of the environmental conditions, but also from the variation of genetic factor of the individual.

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모자건강관리를 위한 위험요인별 감별평점분류기준 개발에 관한 연구 (A Study on the Risk Factors for Maternal and Child Health Care Program with Emphasis on Developing the Risk Score System)

  • 이광옥
    • 대한간호학회지
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    • 제13권1호
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    • pp.7-21
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    • 1983
  • For the flexible and rational distribution of limited existing health resources based on measurements of individual risk, the socalled Risk Approach is being proposed by the World Health Organization as a managerial tool in maternal and child health care program. This approach, in principle, puts us under the necessity of developing a technique by which we will be able to measure the degree of risk or to discriminate the future outcomes of pregnancy on the basis of prior information obtainable at prenatal care delivery settings. Numerous recent studies have focussed on the identification of relevant risk factors as the Prior infer mation and on defining the adverse outcomes of pregnancy to be dicriminated, and also have tried on how to develope scoring system of risk factors for the quantitative assessment of the factors as the determinant of pregnancy outcomes. Once the scoring system is established the technique of classifying the patients into with normal and with adverse outcomes will be easily de veloped. The scoring system should be developed to meet the following four basic requirements. 1) Easy to construct 2) Easy to use 3) To be theoretically sound 4) To be valid In searching for a feasible methodology which will meet these requirements, the author has attempted to apply the“Likelihood Method”, one of the well known principles in statistical analysis, to develop such scoring system according to the process as follows. Step 1. Classify the patients into four groups: Group $A_1$: With adverse outcomes on fetal (neonatal) side only. Group $A_2$: With adverse outcomes on maternal side only. Group $A_3$: With adverse outcome on both maternal and fetal (neonatal) sides. Group B: With normal outcomes. Step 2. Construct the marginal tabulation on the distribution of risk factors for each group. Step 3. For the calculation of risk score, take logarithmic transformation of relative proport-ions of the distribution and round them off to integers. Step 4. Test the validity of the score chart. h total of 2, 282 maternity records registered during the period of January 1, 1982-December 31, 1982 at Ewha Womans University Hospital were used for this study and the“Questionnaire for Maternity Record for Prenatal and Intrapartum High Risk Screening”developed by the Korean Institute for Population and Health was used to rearrange the information on the records into an easy analytic form. The findings of the study are summarized as follows. 1) The risk score chart constructed on the basis of“Likelihood Method”ispresented in Table 4 in the main text. 2) From the analysis of the risk score chart it was observed that a total of 24 risk factors could be identified as having significant predicting power for the discrimination of pregnancy outcomes into four groups as defined above. They are: (1) age (2) marital status (3) age at first pregnancy (4) medical insurance (5) number of pregnancies (6) history of Cesarean sections (7). number of living child (8) history of premature infants (9) history of over weighted new born (10) history of congenital anomalies (11) history of multiple pregnancies (12) history of abnormal presentation (13) history of obstetric abnormalities (14) past illness (15) hemoglobin level (16) blood pressure (17) heart status (18) general appearance (19) edema status (20) result of abdominal examination (21) cervix status (22) pelvis status (23) chief complaints (24) Reasons for examination 3) The validity of the score chart turned out to be as follows: a) Sensitivity: Group $A_1$: 0.75 Group $A_2$: 0.78 Group $A_3$: 0.92 All combined : 0.85 b) Specificity : 0.68 4) The diagnosabilities of the“score chart”for a set of hypothetical prevalence of adverse outcomes were calculated as follows (the sensitivity“for all combined”was used). Hypothetidal Prevalence : 5% 10% 20% 30% 40% 50% 60% Diagnosability : 12% 23% 40% 53% 64% 75% 80%.

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