• Radiation Oncology Journal
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• 제7권1호
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• pp.29-36
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• 1989

1979년부터 1985년까지 서울대학교병원 치료방사선과에서 비인강암으로 확진되어 방사선치료를 시행한 총 환자는 110명이었다. 이중 진단시 원격전이된 5명과, 근치 방사선량을 받지 못한 16명을 제외한 89명의 치료성적을 분석하였다. 생존 환자의 최소 추적기간은 36개월이었다. 전체 환자의 $43\%$가 T4병변, $72\%$가 제 4병기이었으며, 편평상피암이 $40\%$, 미분화암이 $47\%$이었고 임파상피암은 $5\%$이었다. T1, T2의 초기병변과 경부 임피절 전이는 6,500cGy의 선량으로 대부분이 근치되었다. 추적기간 중 재발된 환자는 42명, $(47\%)$으로, 이중 16명 $(38\%)$은 국소재발, 24명 $(57\%)$은 원격전이를 일으켰다. 국소재발된 예중 9명에게 재치료를 시행하여 이중 2명에서 장기 생존이 관찰되고 있다. 전체 환자의 5년 생존율 $42\%$, 무병생존율은 $38\%$이었다. T-병기와 조직학적 아형은 생존율에 무관하나, N-병기는 생존율에 유의한 상관관계가 있음이 증명되었다.

• Radiation Oncology Journal
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• 제29권4호
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• pp.260-268
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• 2011

Purpose: To evaluate the treatment outcome and prognostic factor after postoperative radiotherapy in retroperitoneal sarcoma. Materials and Methods: Forty patients were treated with surgical resection and postoperative radiotherapy for retroperitoneal sarcoma from August 1990 to August 2008. Treatment volume was judged by the location of initial tumor and surgical field, and 45-50 Gy of radiation was basically delivered and additional dose was considered to the high-risk area. Results: The median follow-up period was 41.4 months (range, 3.9 to 140.6 months). The 5-year overall survival (OS) was 51.8% and disease free survival was 31.5%. The 5-year locoregional recurrence free survival was 61.9% and distant metastasis free survival was 50.6%. In univariate analysis, histologic type (p = 0.006) was the strongest prognostic factor for the OS and histologic grade (p = 0.044) or resection margin (p = 0.032) had also effect on the OS. Histologic type (p = 0.004) was unique significant prognostic factor for the actuarial local control. Conclusion: Retroperitoneal sarcoma still remains as a poor prognostic disease despite the combined modality treatment including surgery and postoperative radiotherapy. Selective dose-escalation of radiotherapy or combination of effective chemotherapeutic agent must be considered to improve the treatment result especially for the histopathologic type showing poor prognosls.

• Radiation Oncology Journal
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• 제34권3호
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• pp.223-229
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• 2016

Purpose: This study is to investigate the effect of captopril when combined with irradiation. Materials and Methods: 4T1 (mouse mammary carcinoma) cells were injected in the right hind leg of Balb/c mice. Mice were randomized to four groups; control (group 1), captopril-treated (group 2), irradiated (group 3), irradiated and captopril-treated concurrently (group 4). Captopril was administered by intraperitoneal injection (10 mg/kg) daily and irradiation was delivered on the tumor-bearing leg for 15 Gy in 3 fractions. Surface markers of splenic neutrophils (G-MDSCs) and intratumoral neutrophils (tumor-associated neutrophils [TANs]) were assessed using flow cytometry and expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 alpha ($HIF-1{\alpha}$) of tumor was evaluated by immunohistochemical (IHC) staining. Results: The mean tumor volumes (${\pm}$standard error) at the 15th day after randomization were $1,382.0({\pm}201.2)mm^3$ (group 1), $559.9({\pm}67.8)mm^3$ (group 3), and $370.5({\pm}48.1)mm^3$ (group 4), respectively. For G-MDSCs, irradiation reversed decreased expression of CD101 from tumor-bearing mice, and additional increase of CD101 expression was induced by captopril administration. Similar tendency was observed in TANs. The expression of tumor-necrosis factor-associated molecules, CD120 and CD137, are increased by irradiation in both G-MDSCs and TANs. Further increment was observed by captopril except CD120 in TANs. For IHC staining, VEGF and $HIF-1{\alpha}$ positivity in tumor cells were decreased when treated with captopril. Conclusion: Captopril is suggested to have additional effect when combined to irradiation in a murine tumor model by modulation of MDSCs and angiogenesis.

• 대한전자공학회논문지SP
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• 제42권2호
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• pp.101-112
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• 2005

사람이 두 눈을 통하여 3차원 공간을 지각하는 것과 같이 두 대의 카메라로부터 얻어진 스테레오 영상을 이용하여 3차원 정보를 얻을 수 있다. 스테레오 영상은 많은 데이터량을 가지기 때문에 최근 수년간 디지털 비디오 압축 기술의 발전과 함께 스테레오 영상을 효율적으로 압축하기 위한 기술이 개발되고 있다. 스테레오 영상을 압축하고 3차원 정보를 추출하는데 이용되는 양안차 추정은 일반적으로 두 스테레오 영상의 화소 간의 밝기 차이를 이용한다. 하지만 두 카메라의 초점거리, 방향, 상대적 위치, 조리개에 의해 입사되는 빛의 양 등의 미세한 차이에도 스테레오 영상 간의 밝기차가 발생한다. 밝기차가 있는 스테레오 영상은 부정확한 양안차 벡터와 이에 따른 낮은 압축 효율과 같은 문제점을 발생시킬 수 있다. 따라서 이런 스테레오 영상 간의 밝기차를 사전에 보상한 후 압축함으로써 압축의 효율을 높이고, 또한 재생 시 두 눈을 통하여 들어오는 서로 다른 시각 정보로 인한 눈과 두뇌의 피로를 덜어 줄 수 있다. 본 논문에서는 간단하면서도 효율적인 전처리 방법으로 전역 밝기 보상과 국부지역 밝기 보상 및 계층적 밝기 보상을 제안한다 실험결과는 제안된 보상 방법이 효율적으로 스테레오 영상을 압축하는 것을 보여준다.

• 대한지리학회지
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• 제49권6호
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• pp.935-948
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• 2014

고혈압과 같은 만성 질환의 관리는 국가보건정책에서 중요한 사업이다. 본 연구는 지역사회 특성이 고혈압의 유병률에 어떻게 영향을 주는지를 분석하였다. 분석을 위해 237개 시군구 소지역의 건강상태 및 건강 행태를 포함한 다년간의 자료를 수집하였다. 지표는 2009~2011년 질병관리본부의 지역사회건강조사와 국민건강보험공단 등의 자료를 사용하였다. 지역간 변이 분석을 위해 지리적 가중회귀분석과 의사결정나무 모형을 이용하였다. 연구결과 다년간 자료를 이용하는 것이 단년간 자료를 이용하는 것보다 더 적합도가 높았는데 이것은 대부분의 변수에서 연도별 유의한 차이가 있었기 때문이다. 또 고혈압 유병률은 당뇨병 및 비만 유병률과 양의 관련성이 있었으며 인구밀도와는 음의 상관관계를 보였다. 특히 이러한 요인들의 지역적 변이는 지리적 가중회귀분석 결과에서 더욱 뚜렷하였다. 이상의 결과를 바탕으로 분석한 의사결정나무 모형에서는 고혈압 유병률에 영향을 미치는 중요한 변수가 지역별로 매우 상이하다는 것을 확인할 수 있었다. 지역주민의 건강상태, 건강행태, 사회경제적 요인의 지역간 차이를 규명하는 것은 고혈압 유병률을 감소시키기 위한 지역별 맞춤형 보건정책을 수립하는데 매우 중요하다. 본 연구의 결과는 만성질환 관리를 위한 맞춤형 지역보건정책을 수립하는데 기초자료를 제공할 수 있다는 데 의의가 있다.

• Journal of Periodontal and Implant Science
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• 제27권4호
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• pp.883-908
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• 1997

Bone remodeling is characterized by the coupling of osteoclast-mediated bone resorption and osteoblast-mediated bone formation. The process is tightly regualted at the local level by an incompletely known netwotk of peptide and non-peptide fators. Nitric oxide(NO), synthesized by nitric oxide synthetase(NOS) from L-arginine, is becoming recognized as an important bioregualtory molecule in a variety of tissue, but little is known about its possible role in periodontal tissue. The purpose of this study is to investigate the expression of nitric oxide synthetase(NOS) in inflamed gingiva and the effects of cytokine on the expression of NOS protein. The expression of NOS in gingival tissue was evaluated by immunohistochemical staining for $NOS_1$, $NOS_2$, $NOS_3$. The effect of cytokine on the expression of NOS in human periodontal ligament cells and osteoblast-like HOS cells by western blot analysis. Further, we studied that NO functions in periodontal ligament cells as a regulatory molecule. PDL cells incubated with NOS inhibitor and donor. The protein expression, type I collagen & non-collagenous protein, nitrate production and cell proliferation were evaluated The results were as follows. 1. $NOS_1$, $NOS_2$, $NOS_3$ was rarely distributed in healthy gingiva, but stronger stained in gingival epithelium, endothelial cells, and mononuclear cells of inflammed gingiva. 2. The cytokine stimulated $NOS_1$, and $NOS_3$ protein were not inducing or inhibitory effect to compared with control in PDL and HOS cells. 3.Incubation of cells with combination of $TNF-{\alpha}$, $IFN-{\gamma}$, LPS result in a time dependant increase in $NOS_2$ expression, reaching a maximal level after 24 hours of stimulation. 4. The osteonectin protein inhibitory effect of NMA, inhibitor of NOS, was reversed by Larginine in dose dependant manner. 5. NMA decreased cell poliferation and nitrate production, but the inhibitory efffect of NMA was also prevented by the NO donor, sodium nitropruiside. These results suggest that exogenously synthesized NO was playing a stimulating effect on cell proliferation or on non-collagenous protein expression. Therefore NO have an important role in mediation of localized bone destruction associated inflammatory bone disease such as periodontitis.

• 한국산림과학회지
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• 제96권3호
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• pp.295-299
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• 2007

밤 주산지별로 최적 재배품종을 선발하기 위하여 현재 재배되고 있는 주요 품종 및 국립산림과학원에서 육성된 신품종, 그리고 민간에서 육성된 지방품종을 대상으로 밤나무혹벌 (Dryocosmus kuriphilus)에 대한 내충성을 검정하였다. 2004년~2006년 3년간 밤나무혹벌 피해를 조사한 결과 중부지방의 공주와 충주 검정림에서는 모든 품종에서 밤나무혹벌의 피해가 전혀 나타나지 않았으나 남부지방의 광양, 산청 및 합천 검정림에서는 대부분의 품종에서 밤나무혹벌 피해를 관찰할 수 있었다. 지역별로는 합천지역이 밤나무혹벌 피해가 가장 심각함을 알 수 있었으며, 품종별로는 국립산림과학원에서 육성된 광은, 산대, 은산, 이대 품종이 저항성이 가장 높았고, 반면에 단택, 이평, 창방감율, 평기, 광덕, 세일, 신이평, 유마변이 품종은 20% 이상의 높은 피해율을 보여 상대적으로 밤나무혹벌에 대한 저항성이 낮은 것으로 판단되었다. 조사부위별로 결과지보다는 소약지에서 피해율이 월등히 높은 것으로 나타났다. 밤나무혹별 피해가 심한 광양, 산청 및 합천에서 주요 재배품종을 대상으로 년차별 밤나무혹벌 피해율의 변동을 조사한 결과 2005년을 기점으로 2006년에는 피해율이 현저히 감소함을 관찰할 수 있었는데, 이는 밤나무혹벌의 천적인 기생벌류의 밀도변동 등 생물학적 요인에 크게 영향을 받은 것으로 판단되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.9009-9013
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• 2014

Background: The aim of this study was to explore the efficacy and adverse reactions of CT-guided radioactive 125I-seed implantation treatment combined with chemotherapy for platinum-resistant recurrent ovarian carcinoma. Materials and Methods: From September 2010 to December 2012, 23 patients with platinum-resistant recurrent ovarian carcinoma were enrolled. All the patients refused, could not bear, or were not suitable for surgery. They all had no more than 3 lesions, which were detected and could also be measured by CT. All were clarified as single-lesion or multiple-lesion groups. A total of 41 lesions underwent implantation of from 8 to 106 125I seeds (median=43). Multi-plane implanting was adopted and 125I-seeds of (0.4-0.7)mCi were placed at intervals of (0.5-1.0) cm. After implantation treatment, all patients underwent 4 cycles of chemotherapy with gemcitabine $800mg/m^2$ (days 1, 8 and 15). Results: The outcome was evaluated with CT 3 weeks and every 3 months after implantation treatment. After 6 months, the volume of 32 out of 41 lesions (78.0%) was reduced at least 30%, within which 9 lesions completely disappeared(22.0%). Complete response was observed in 7 cases (30.4%), with a partial response in 4 cases (17.4%), 4 cases stable(17.4%)and 8 cases showing progression (34.8%). The total clinical remission rate was 47.8% (11/23). The clinical remission rate was 77.8% (7/9) in the single-lesion group and 28.6% (4/14) in the multiple-lesion group with a significant difference between the two(P=0.036). The common side effects observed were mild gastrointestinal reactions. Conclusions: 125I-seed implantation combined with chemotherapy applies an effective way in the treatment of platinum-resistant recurrent ovarian epithelial carcinoma with the advantages of high local control rates, good short-term effects, little trauma and less side effects.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6227-6232
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• 2014

Background: Oral squamous cell carcinoma (OSCC) remains as one of the most difficult malignancies to control because of its high propensity for local invasion and cervical lymph node dissemination. The aim of present study was to evaluate the efficacy of novel pH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in terms of their potential to change the VEGF-C expression profile in a rat OSCC model. Materials and Methods: 120 male rats were divided into 8 groups of 15 animals administrated with 4-nitroquinoline-1-oxide to induce OSCCs. Newly formulated doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) and free doxorubicin were IV and orally administered. Results: Results indicated that both oral and IV forms of DOX-MTX-nanoparticle complexes caused significant decrease in the mRNA level of VEGF-C compared to untreated cancerous rats (p<0.05). Surprisingly, the VEGF-C mRNA was not affected by free DOX in both IV and oral modalities (p>0.05). Furthermore, in DOX-MTX NP treated group, less tumors characterized with advanced stage and VEGF-C mRNA level paralleled with improved clinical outcome (p<0.05). In addition, compared to untreated healthy rats, the VEGF-C expression was not affected in healthy groups that were treated with IV and oral dosages of nanodrug (p>0.05). Conclusions: VEGF-C is one of the main prognosticators for lymph node metastasis in OSCC. Down-regulation of this lymph-angiogenesis promoting factor is a new feature acquired in group treated with dual action DOX-MTX-NPs. Beside the synergic apoptotic properties of concomitant use of DOX and MTX on OSCC, DOX-MTX NPs possessed anti-angiogenesis properties which was related to the improved clinical outcome in treated rats. Taking together, we conclude that our multifunctional doxorubicin-methotrexate complex exerts specific potent apoptotic and anti-angiogenesis properties that could ameliorate the clinical outcome presumably via down-regulating dissemination factor-VEGF-C expression in a rat OSCC model.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5155-5160
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• 2014

Aim: To investigate the efficacy and safety of lobaplatin-transcatheter arterial chemoembolization (TACE) combined with radioactive $^{125}I$ seed implantation in treatment of primary hepatocellular carcinoma (HCC). Methods: 75 patients with primary HCC were enrolled in the study, among them 43 receiving lobaplatin-TACE (TACE group) and 32 lobaplatin-TACE combined with $^{125}I$ seed implantation (TACE+$^{125}I$ group). After treatment, the local remission rates and postoperative complications of two groups were compared using the Pearson Chi-square test. Overall survival in the two groups was calculated using Kaplan-Meier survival curves and the differences were tested using Log-rank test. Results: There were 7 cases of complete response (CR), 13 of partial response (PR), 6 of stable disease (SD) and 17 of progressive disease (PD) in the TACE group, with 13 cases of CR, 9 of PR, 5 of SD and 5 of PD in the TACE+$^{125}I$ group. The disease control rates of TACE and TACE+$^{125}I$ group were 60.5% (26/43) and 84.4% (27/32), respectively, with a significant difference between them (P < 0.05). The survival rates at 6, 12 and 18 months in the TACE group were 100.0%, 81.8% and 50.0%, respectively, and those in TACE+$^{125}I$ group were 100.0%, 93.8% and 65.6%. The mean survival times in the TACE and TACE+$^{125}I$ groups were 19.5 and 22.9 months, respectively. There was a significant difference in the overall survival rate between two groups (P < 0.05). No serious complications were encountered in either group. Conclusion: Lobaplatin-TACE combined with $^{125}I$ seed implantation is favorable and safe for treatment of primary HCC.