• Journal of the Korean Home Economics Association
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• v.50 no.4
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• pp.103-113
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• 2012

In the U.S. where Direct-to-Consumer Advertising (DTCA) of prescription medications is permitted, spending on DTCA has been accelerating. As a result, it has been an issue of intense public policy attention regarding whether DTCA is beneficial to the public by promoting a healthy lifestyle. Most of the literature concerning DTCA focuses on its impact on demand and empirical evidence regarding its impact on health-related behavior is scant. This study uses a database of DTCAs for high blood cholesterol, hypertension, diabetes, and overweight treatment medications that have appeared in nationally circulated U.S. consumer magazines during 2000 to 2004 and the Simmons National Consumer Survey in order to compute the level of individual advertising exposure and examines whether those who are exposed to DTCA are more likely to engage in regular exercise and diet control. The study finds evidence that for those with chronic conditions, greater exposure to DTCA leads to less exercise but more diet control. By therapeutic class level, exposure to DTCA leads to less exercise for those with hypertension and who are overweight, whereas those with high blood cholesterol are more likely to engage in regular exercise. Looking into differential responses by socioeconomic status, those with less education are more likely to engage in exercise after being exposed to DTCA. The results imply that the effects of DTCA vary by therapeutic class. In order to enhance the benefits of DTCA, it is important to closely monitor the messages in DTCA and require it to include messages that promote lifestyle change should it be a part of the treatment.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.14
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• pp.6033-6038
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• 2015

Background: Experience of lung cancer includes negative impacts on both physical and psychological health. Pain is one of the negative experiences of lung cancer. Cognitive behavioral therapy techniques are often recommended as treatments for lung cancer pain. The objective of this review was to synthesize the evidence on the effectiveness of cognitive behavioral therapy techniques in treating lung cancer pain. This review considered studies that included lung cancer patients who were required to 1) be at least 18 years old; 2) speak and read English or Thai; 3) have a life expectancy of at least two months; 4) experience daily cancer pain requiring an opioid medication; 5) have a positive response to opioid medication; 6) have "average or usual" pain between 4 and 7 on a scale of 0-10 for the day before the clinic visit or for a typical day; and 7) able to participate in a pain evaluation and treatment program. This review considered studies to examine interventions for use in treatment of pain in lung cancer patients, including: biofeedback, cognitive/attentional distraction, imagery, hypnosis, and meditation. Any randomized controlled trials (RCTs) that examined cognitive behavioral therapy techniques for pain specifically in lung cancer patients were included. In the absence of RCTs, quasi-experimental designs were reviewed for possible conclusion in a narrative summary. Outcome measures were pain intensity before and after cognitive behavioural therapy techniques. The search strategy aimed to find both published and unpublished literature. A three-step search was utilised by using identified keywords and text term. An initial limited search of MEDLINE and CINAHL was undertaken followed by analysis of the text words contained in the title and abstract, and of the index terms used to describe the article. A second search using all the identified keywords and index terms was then undertaken across all included databases. Thirdly, the reference list of all identified reports and articles were searched for additional studies. Searches were conducted during January 1991- March 2014 limited to English and Thai languages with no date restriction. Materials and Methods: All studies that met the inclusion criteria were assessed for methodological quality by three reviewers using a standardized critical appraisal tool from the Joanna Briggs Institute (JBI). Three reviewers extracted data independently, using a standardized data extraction tool from the Joanna Briggs Institute (JBI). Ideally for quantitative data meta-analysis was to be conducted where all results were subject to double data entry. Odds ratios (for categorical data) and weighted mean differences (for continuous data) and their 95% confidence intervals were to be calculated for analysis and heterogeneity was to be assessed using the standard Chi-square. Where statistical pooling was not possible the finding were be presented in narrative form. Results: There were no studies located that met the inclusion requirements of this review. There were also no text and opinion pieces that were specific to cognitive behavioral therapy techniques pain and lung cancer patients.Conclusions: There is currently no evidence available to determine the effectiveness of cognitive behavioural therapy techniques for pain in lung cancer patients.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.3
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• pp.901-907
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• 2012

Objective: Cumulative evidence suggests that MLH1, the key component in the mismatch pathway, plays an important role in human cancers. Two potential functional polymorphisms (-93G>A and I219V) of MLH1 have been implicated in cancer risk. The aim of this meta-analysis was to summarize the evidence for associations. Methods: Eligible studies were identified by searching the electronic literature PubMed, ScienceDirect and Embase databases for relevant reports and bibliographies. Studies were included if of case-control design investigating MLH1 polymorphisms (-93G>A and I219V) and cancer risk with sufficient raw data for analysis. Odds ratios (OR) and 95% confidence intervals (95% CI) were used to evaluate the strength of associations. Results: Our meta-analysis from 33 published case-control studies showed the variant A allele of -93G>A polymorphism to be associated with increased risk in all genetic models (AA vs. GG: OR = 1.22, 95% CI: 1.03-1.44), especially among non-Asians (AA vs. GG: OR = 1.28, 95% CI: 1.04-1.58). For the I219V polymorphism, however, there was no main effect associated with overall cancer risk in any genetic model. Conclusions: The meta-analysis suggested that the MLH1 -93G>A polymorphism may be a biomarker of cancer susceptibility. Large sample association studies and assessment of gene-to-gene as well as gene-to-environment interactions are required to confirm these findings.

• The Journal of the Korea Contents Association
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• v.10 no.3
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• pp.204-214
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• 2010

This research was intended to provide a basic data on the study of utilization of assistive technology to improve vocational ability for people with intellectual disabilities. As this study was literature review, it was analyzed the qualitative level, methodology contents, and general characteristic of a study, related assistive technology application for improvement of vocational ability in people with intellectual disabilities. The results of this study were as follows; Firstly, experimental environments mostly consisted of separated experimental conditions and design employed multiple probe design; Secondly, all of studies were involved in the standard of selection of subjects, but the proportions of study describing the contents related to subjects was low. The proportions of study describing the behavior-control and exterior-variable control method was low; Thirdly, most study evaluated independent variable and presented fidelity of treatment but, the presentation of social validity was proved to be insufficient. In order to effective application of assistive technology in vocational rehabilitation, it is need a evidence that the application of assistive technology is evidence-based practice in vocational rehabilitation. We also need a supplementation between methodology contents and qualitative level of study in more study.

• Journal of Korean Society for Atmospheric Environment
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• v.23 no.5
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• pp.563-574
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• 2007

There seems to be a consensus among most people that visibility impairment is the most obvious indicator of air pollution. While considerable evidence on the association between air pollution and health outcomes including death and disease have been established, based on industrial complex areas or huge urban cities, time-series, case-crossover and cohort studies, scarce literature exists on the direct evidence for the association between visibility and adverse health outcomes. Our study is assessed the effect of air pollution measured by visibility impairment on respiratory mortality over a period of six years. Relative risks in respiratory deaths were estimated by a Poisson regression model of daily deaths between $1999{\sim}2004$. Daily counts of respiratory deaths as dependent variable was modelled with daily 24-hr mean visibility measurements (kilometers) as independent variable by means of Poisson regression. This model is controlled for confounding factors such as day of weeks, weather variables, seasonal variables and $PM_{10}$. The results in this study is observed the statistically significant association between an inverse health effect and visibility during the study period for respiratory mortality (percentage change in the relative risk for all aged -0.57%, 95% Cl, $-1.01%{\sim}-0.12%$; for $0{\sim}15$ aged -7.12%, 95% Cl, $-13.29%{\sim}-0.51%$; for 65+ aged -0.43%, 95% Cl, $-0.93%{\sim}-0.06%$ per 1 km increased in visibility). The effect size was much reduced during warm season. Visibility impairment resulting from air pollution is strongly associated with respiratory mortality, especially for children may be spent at outdoor. Our result provides a quick and useful indicator for eliciting the contribution of air pollution to the excess risk of respiratory mortality in Seoul, Korea.

• The Korean Journal of Cytopathology
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• v.18 no.1
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• pp.1-12
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• 2007

Approximately 70% of cervical cancers are caused by HPV types 16/18 and thus the implementation of vaccination programmes with vaccines against HPV types 16/18 will have a major impact on the incidence of cervical cancer worldwide. However, this reduction will not be seen until several decades after full implementation of such vaccination programmes since the vaccines must be given to young adolescents before exposure to the virus and women who are already sexually active are not likely to be protected. Both GSK and Merck insist that even vaccinated women must continue to participate in regular cervical screening by the most sensitive method available since the vaccine can only give protection against up to 70% of cervical cancers. It is unlikely that the current vaccines will be modified to include additional high risk HPV types in the foreseeable future. While HPV testing is highly sensitive, it is not recommended for women under 30 years of age nor for vaccinated women. Additionally, HPV testing has poor specificity. The Digene Hybrid Capture 2 test is licensed for use only in conjunction with a cytology test, not as a stand-alone test, and the high risk panel has recognised cross reactivity with low risk HPV types. None of the other HPV test methods currently commercially available are FDA approved and all must be internally validated before use. This makes comparison of test results between laboratories difficult. The most sensitive and specific screening test currently available for women of all ages is the Cytyc ThinPrep System consisting of the ThinPrep Pap Test (TPPT) and the ThinPrep Imaging System (Imager). The TPPT was the first LBC system approved by the US FDA in 1996 and there are about 4,000 processors in use worldwide. The Imager was FDA approved in 2003 and over 350 systems are in routine use, mainly in the US. 40% of TPPT in the US are processed on Imager. There is clear evidence in peer reviewed literature that the Imager increases laboratory productivity by 100% and growing evidence that Imager detects more high grade SIL than the conventional smear or manual evaluation of TPPT. This aspect is particularly important since the number of cytological abnormalities will decrease as vaccination programmes are implemented. Cytotechnologists will see fewer and fewer abnormal smears and their skills will be put at risk. By doubling throughput, Imager will allow cytotechnologists to maintain their skills.

• The Journal of the Korea Contents Association
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• v.21 no.9
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• pp.446-457
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• 2021

The aim of this study was to grasp the seriousness of depression problems in medical students by examining the research trends among them and to present desirable direction of the future study. A selective search has been conducted for literature published in Nurimedia (DBPIA), Korean studies Information Service System (KISS), Research Information Sharing Service (RISS), National Assembly Library (NANET) and National Digital Science Library (NDSL) databases. 18 papers have been selected for the final analysis. The results showed that studies on depression problems were published in very small proportion which researchers with diverse majors including psychiatry participated. Second, most of depression assessment tools usually measured depression only while some did various psychological symptoms. Third, independent t test was the most frequent analytic method. Last but not least, there was no research dealing with intervention about depression in medical students. To sum up, though numerous researchers with diverse specialties participated in the depression study and analyzed the data using various analyses and variables, there is a lack of intervention for depression of the medical students. Therefore, it is necessary to emphasize the necessity of practical intervention based on the evidence-based practice.

• Annals of Geriatric Medicine and Research
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• v.22 no.4
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• pp.167-175
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• 2018

Sarcopenia, a common clinical syndrome in older adults, is defined as decreased muscle mass, strength, and physical performance. Since sarcopenia is associated with the incidence of functional decline, falls, and even mortality in older adults, researchers and health care providers have been keen to accumulate clinical evidence to advocate the screening and prevention of sarcopenia progression in older adults. The factors that may accelerate the loss of muscle mass and function include chronic diseases, inactivity, and deficiency in appropriate nutritional support. Among these, nutritional support is considered an initial step to delay the progression of muscle wasting and improve physical performance in community-dwelling older adults. However, a nationwide study suggested that most Korean older adults do not consume sufficient dietary protein to maintain their muscle mass. Furthermore, considering age-associated anabolic resistance to dietary protein, higher protein intake should be emphasized in older adults than in younger people. To develop a dietary protein recommendation for older adults in Korea, we reviewed the relevant literature, including interventional studies from Korea. From these, we recommend that older adults consume at least 1.2 g of protein per kg of body weight per day (g/kg/day) to delay the progression of muscle wasting. The amount we recommend (1.2 g/kg/day) is 31.4% higher than the previously suggested recommended daily allowance (i.e., 0.91 g/kg/day) for the general population of Korea. Also, evidence to date suggests that the combination of exercise and nutritional support may enhance the beneficial effects of protein intake in older adults in Korea. We found that the current studies are insufficient to build population-based guidelines for older adults, and we call for further researches in Korea.

• The Journal of Korean society of community based occupational therapy
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• v.8 no.3
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• pp.77-89
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• 2018

Objective : The purpose of this study was to analyze occupational therapy intervention on the community mobility for stroke patients, and to provide evidence of intervention in the clinical fields. Methods : A systematic review was executed according to the PRISMA checklist. The accessed database was PubMed, EMBASE, Cochrane Library (CENTRAL), ProQuest Dissertations & thesis (PQDT), RISS, and KoreaMed. We included the articles published from 2005 to September 2018. RoBANS checklist was used to evaluate the quality of the articles. Included articles, totally eight, were categorized according to the type of intervention. Results : The study design of the literature was varied from two-group randomized trial, quasi-experimental study, case-control trial, one group pre-post comparison study, and cross-sectional study. In the evidence level, 6 articles were included in level II (75%). The percentage of low risk of bias in each article ranged from 52.5%~87.5%. Four studies (50%) provided intervention based on virtual reality or virtual environment. The three (37.5%) provided intervention based on the protocol, and the other (12.5%) did wheelchair training. All studies reported significant effects of the intervention. Conclusion : This systematic review provided evidences to use proper intervention in the clinical fields. Various type of studies should be conducted to prove the effect of occupational therapy intervention for community mobility.

• Acta Via Serica
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• v.3 no.2
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• pp.49-72
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• 2018

The extensive maritime trade network between the Harappan and Mesopotamian civilizations as early as the $3^{rd}$ millennium BCE is a testimony to the long maritime trade history of India. From the dawn of the historical epoch, the maritime trade network of India expanded extensively. The findings of a large number of coins, pottery, amphorae and other materials from Italy and various other European countries, west Asia, China, Korea, Africa, the Arabian Peninsula, Sri Lanka, Southeast Asia and Far-East countries in India, particularly in the coastal regions, are a testimony to the dynamic maritime trade of India with other countries in the early period. Similarly, pottery, sculptures, inscriptions and other materials of Indian origin are also found in those countries. The depiction of different types of ships on the coins, paintings, sculptures, seals and sealing, exhibit the variety of vessels used for navigation and other purposes in the early period. The over 7500 km-long coastline of India is well known for its seaports located at river mouths or outlets to the sea. The Periplus Maris Erythraei, Ptolemy, and Indian literary sources mention many seaports on the western coast of India. Interestingly, archaeological investigations in many of these port towns have yielded material evidence exhibiting their dominant role in transoceanic trade and commerce with many countries in the early period. This paper discusses in detail all the major ancient seaports on the western coast of India and their maritime trade activities. At the outset, the paper briefly deals with the Harappan's maritime network, their seaports and the type of ships of that period. Following this, the maritime trade network of India during the historical period with various countries in the east and west, the traces of Indian influence and materials abroad and foreign materials found in India, the products exported from India, the trade winds and navigational devices and the depiction of ships on the coins, paintings, and sculptures of the period are discussed in detail. After briefly highlighting the coastline of India and its favourable nature for safe anchorage of ships and the strategic position of the seaports of western India, an extensive account of the major ancient seaports of western India like Barygaza, Ashtacampra, Gundigar, Kammoni, Khambhat, Bardaxema, Suparaka, Calliena, Semylla, Sanjan, Naura, Tyndis, Muziris, Nelcynda and other seaports, and their maritime trade activities are given based on archaeological excavations and explorations, literature, epigraphy, foreign accounts, and numismatic evidence.