• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2429-2435
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• 2012

Methyl isocyanate may have a role in cancer etiology, although the link is unclear. There is evidence in the literature that it can induce cancer in animals but the carcinogenic potency is weak. Pheochromocytoma of adrenal medulla and acinar cell tumors of pancreas have been observed in methyl isocyanate exposed animals. Conversely, emerging data from population-based epidemiological studies are contradictory since there is no evidence of such cancers in methyl isocyanate exposed humans. Recently, we reported a high prevalence of breast and lung cancers in such a population in Bhopal. In vitro findings appearing in the latest scientific literature suggest that genomic instability is caused by methyl isocyanate analogs in lung, colon, kidney, ovary epithelial cells, and that hepatocytes may undergo oncogenic transformation, have obvious implications. The conflicting information prompted us to present this update over the last three decades on methyl isocyanate-induced cancers after an extensive literature search using PubMed. While the pertinent literature remains limited, with a scarcity of strong laboratory analyses and field-epidemiological investigations, our succinct review of animal and human epidemiological data including in vitro evidences, should hopefully provide more insight to researchers, toxicologists, and public health professionals concerned with validation of the carcinogenicity of methyl isocyanate in humans.

• The Journal of Korean Medicine
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• v.38 no.1
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• pp.46-55
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• 2017

Objectives: The aim of this study is reviewing the literature to extract the key parameter, study design, perspective, cost-effectiveness index and find the calibration parameter for the clinical study with economical evaluation protocol on facial palsy. Methods: Literature search is performed using PUBMED for literature published from January 2000 to December 2016. We included randomized controlled trials(RCTs) and modelling study with economic assessment in which human participated. Results: As a result of literature search, the 198 articles were found. After reviewing the title, abstract and full text, the 5 articles were selected. Selected articles are classified into 4 RCT studies dealing with quality of life and 1 CEA(cost-effectiveness analysis) study. Conclusions: We found reliable key parameters, calibration parameters and elements of economical assessment study, which might be necessary factors for developing research protocol of clinical trial with economic evaluation about facial palsy patients.

• Journal of Korean Library and Information Science Society
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• v.39 no.4
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• pp.215-235
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• 2008

The purpose of this study aims to provide possible suggestions for the improvement of the literature classification number system as the search and browsing device on the library homepage. After analyzing and evaluating literature classification number system as the search and browsing device on the homepage of library adopting DDC, suggestions for the improvement were proposed. For the purpose of maximizing the effectiveness of literature classification number system as the browsing device, DDC third summary(the thousand section) which is suited to domestic circumstances was prepared.

• Journal of Korean Library and Information Science Society
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• v.46 no.4
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• pp.139-159
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• 2015

With advancement of information technology and accumulation of digital resources, the demand on collaboration among libraries, museums and repositories are increasing. The purpose of this study is to propose Korean literature houses as an example of larchiveum. This study explored data management, exhibits and programs of Korean literature house.

• Hwankyungkyoyuk
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• v.18 no.2 s.27
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• pp.44-54
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• 2005

The emphasis in environmental education for children should be on awareness, appreciation, and sensory experiences. By offering children opportunities to experience the elements of nature that surround them, teachers elevate children's comfort level and familiarity with the natural world. But many children have little contact with nature, because of urban living, hurried schedules, TV's attraction, and the low value most schools place on outdoor activities. So, teachers have to expand the real out-of-door experiences into the classroom by sharing and making accessible books focusing on nature and the natural environment. Namely, quality children's literature is an excellent vehicle for extending a particular experience or introducing new ones. Building on outdoor experiences through stories encourages children to explore more deeply what they have observed and experienced-concepts are reinforced, new knowledge gained, vicarious experiences provided. There are three-fold classification of environmentalism, especially environmental ethics, and three-aspects of the history in children's literature. The analytical results of this study are as follow. The environmental ideology in elementary Korean textbooks varies from 'egocentrism-didacticism' to 'ecocentrism-fantasy'. This finding has implication for selecting children's books and teaching environmental contents in elementary school. Therefore teachers and parents need to get ready to receive ecocriticism.

• Herbal Formula Science
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• v.17 no.1
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• pp.17-28
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• 2009

Objectives : The result is the followings after investingating composition, dosage and usage of Yukmijihwang-Hwan(六味地黃丸) in literature by country and Era. Methods : Investigated Classics of Oriental Medicine that Yukmijihwang-Hwan is first described. Results : Found 42 literatures searching Yukmijihwang-Hwan in Classics of Oriental Medicine. Literature that Yukmijihwang-Hwan is recorded by first was Yinhaijingwei(銀海精微), but capacity has not recorded. Yukmijihwang-Hwan Medicinal Decoction that eat(Yukmijihwang-Tang: 5 times) as pill than eat(Yukmijihwang-Hwan: 37 times) was more. Literature that composition of Yukmijihwang-Hwan is recorded by Rehmannia glutinosa(熟地黃) is 8 Ryang(兩), Poria cocos(白茯苓) is 3 Ryang, Paeonia suffruticosa(牧丹皮) is 3 Ryang, Alisma Canaliculatum (澤瀉) 3 Ryang, Cornus officinalis(山茱萸) 4 Ryang, Dioscorea batatus(山藥) 4 Ryang was most. Conclusions : Yukmijihwang-Hwan wat difference in composition and capacity that Chinese and Korean Classics of Oriental Medicine. After Dongeuibogam of the Korea is published, composition and capacity are connected until today.

• Journal of the Korea Society of Computer and Information
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• v.22 no.3
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• pp.131-138
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• 2017

New drug development is time-consuming and costly. Hence, it is necessary to repurpose old drugs for finding new indication. We suggest the way that repurposing old drug using massive literature data and biological network. We supposed a disease-drug relationship can be available if signal pathways of the relationship include significant genes identified in literature data. This research is composed of three steps-identifying significant gene using co-occurrence in literature; analyzing the shortest path on biological network; and scoring a relationship with comparison between the significant genes and the shortest paths. Based on literatures, we identify significant genes based on the co-occurrence frequency between a gene and disease. With the network that include weight as possibility of interaction between genes, we use shortest paths on the network as signal pathways. We perform comparing genes that identified as significant gene and included on signal pathways, calculating the scores and then identifying the candidate drugs. With this processes, we show the drugs having new possibility of drug repurposing and the use of our method as the new method of drug repurposing.

• Annual Conference on Human and Language Technology
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• 2001.10d
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• pp.334-340
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• 2001

본고는 올해 처음 시도하는 세종계획 관용표현 전자사전 구축에 관한 글이다. 본 전자사전이 완성되면 관용표현의 총체적 정보(형태, 통사, 의미, 화용 정보)를 수록하는 최초의 업적이 될 뿐만 아니라 실제 언어 자료에서 흔히 볼 수 있는 관습적 표현까지 모두 포괄하는 4만 표제어의 대규모 사전이 될 것이다. 본 사전에서는 관용표현의 형태 통사적 구성과 그 분포적 속성뿐 아니라, 관용표현이 가지는 논항의 존재 유무, 구조, 조사 통합 양상, 그리고 고정명사에 대한 수식어 제약, 어휘적 통사적 변형 양상, 선어말어미 제약, 어말어미 제약, 문장 유형 제약 등이 수록된다. 또한 각 논항의 의미역과 선택제약에 관한 정보, 그 외 다양한 의미 화용 정보 어원 표기 정보 등도 담기게 된다. 본고에서는 그러한 정보의 표기 양식을 하나하나 명시적으로 설명할 것이다.

• Journal of the Korean Home Economics Association
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• v.46 no.9
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• pp.71-85
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• 2008

This study examined the effects of a picture book literature education program in order to assess preschool children's recognition of and attitude towards picture books. The subjects were 56 five-year-old children, 30 of whom allocated to the experimental group and 26 to the control group. The literature education program lasted for 14 weeks. The control group children participated on the national early childhood education curriculum. Children were interviewed about their concepts, preferences, and attitudes towards picture books. The results indicated that compared to control group, children who participated in this program developed enhanced and richer concepts of picture books, displayed specific preferences, and put forward clearer reasons for their preference. ANCOVA result showed significant overall differences between the two groups. Children who participated in the ptrgram displayed more voluntary and active reading and applied the contents of the picture books to their real life situations.

• Journal of Korean Medical classics
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• v.26 no.1
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• pp.85-98
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• 2013

Objectives : Final assessment of realized on forecasting studies of the literature sector on traditional Korean medicine (2000-2010) revealed results as follows. Methods : We investigated the related peer-reviewed papers and research project reports through Oriental Medicine Advanced Searching Integrated System(OASIS) of Korea Institute of Oriental Medicine(KIOM) and several publishers. Results : Of total five projects, two were realized and three were partially done. The projects 'It wil be standardized by establishing the concept of traditional Korean medical terms' and 'CDs containing traditional medicine books from China, Japan and Korea wiil be released' were decided to be realized. In addition to those, the projects 'Systematic database will be build up for TKM books', 'translation and annotation versions on TKM old books will be completed', and 'A wide range of literature related to traditional medicine of each Asian countries' were concluded to be partially realized. Five projects on predicting TKM in the year 2006-2007 analyzed in 1996 were evaluated as realized or partially realized. Likewise, the five predictions should be reviewed whether it will be necessary in the future after assessment on their realization. Conclusion : Furthermore, it should be studies if the new projects are needed for the future in addition to the existing challenges.