• 제목/요약/키워드: liquid absorption

검색결과 534건 처리시간 0.029초

난용성 항진균제 이트라코나졸의 액상제제화에 의한 생체이용율 개선 (Enhanced Bioavailability of Itraconazole in Liquid Preparation)

  • 황우신;권광일;방규호
    • 약학회지
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    • 제44권6호
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    • pp.528-533
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    • 2000
  • This study was to develop an effective itraconazole liquid preparation which exhibits an enhanced bioavailability. The solubility of itraconazole was increased (72-fold) in itraconazole liquid preparation as compared with itraconazole powder. The dissolution rate of itraconazole was higher for itraconazole liquid preparation filled into a hard gelatin capsule with 90% release within 20 min as compared to 55% for $Sporanox^{\circledR}$capsules. The oral absorption of itraconazole liquid preparation and $Sporanox^{\circledR}$tablets were studied in the rat. The area under the concentration-time curve $(AUC_{0-24hr})$ of itraconazole liquid preparation ($90.25\;{\pm}\;8.36\;{\mu}g{\cdot}hr/ml$) increased by 6.2 times compared to that of Sporanox tablets ($14.58\;{\pm}\;1.26\;{\mu}g{\cdot}hr/ml$) after oral administration of itraconazole 15 mg/rat each. $C_{max}$ also increased to $6.87\;{\pm}\;1.15\;{\mu}g/ml$ after administration of liquid preparation $1.58\;{\pm}\;0.16\;{\mu}g/ml$ of $Sporanox^{\circledR}$tablets. These results indicate that in vivo bioavailability of itraconazole liquid preparation was significantly enhanced as compared with $Sporanox^{\circledR}$tablets.

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CLSI M40-A2 기준에 따른 수송배지의 흡수 및 배출, 생존 효율, 회수율 평가 (Evaluation of Absorption and Release, Survival Efficiency and Recovery Rate of Transport Medium according to the CLSI M40-A2 Standard)

  • 하성일;석현수;신정섭;허웅;박강균;박연준
    • 대한임상검사과학회지
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    • 제51권2호
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    • pp.164-170
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    • 2019
  • 5종류의 수송배지를 흡수 및 배출 능력, 생존 효율, 회수율을 CLSI (Clinical and Laboratory Standards Institute) M40-A2의 Swab elution method (Quantitative) 기준으로 평가하였다. 액체배지가 반유동 배지보다 3가지 평가에서 대부분 우수한 결과값을 보여주었다. Flocked swab이 standard swab 형태보다 균의 흡수 및 배출의 능력 또한 우수하였다. 생존 효율에 대한 평가 결과는 액체배지(S4)가 가장 우수한 결과값을 보였다. 성장이 좋지 않은 S. pneumoniae는 액체배지(S4, S5)에서 생존효율과 회수율이 높았다. 균 회수율 평가 결과는 S. pyogenes는 모든 배지에서 CLSI 기준에 적합하였다. S. pneumoniae는 반유동 배지(S2, S3)에서 부적합하였고, 나머지 배지는 모두 기준에 적합하였다. H. influenzae는 반유동 배지(S1, S3)에서 부적합하였고, 반유동 배지(S2), 액체배지(S4, S5)에서 기준에 적합하였다. 호흡기 질환을 유발하는 S. pneumonia, H. influenzae의 생존 능력은 대부분의 배지에서 좋지 않았다. P. aeruginosa는 실온에서 과성장이 관찰되었다. 액체배지와 flocked swab의 조합이 3가지 평가 방법에서 가장 뛰어난 결과를 평가를 통해 확인하였다.

아세틸화 활엽수재의 치수변화 특성 (Dimensional Change of Acetylated Hardwood)

  • 한규성
    • 한국가구학회지
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    • 제11권2호
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    • pp.79-84
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    • 2000
  • It is well-known fact that dimensional stability of wood is greatly enhanced by acetylation of wood. This dimensional stability results from bulking of the reacted acetate within the cell wall, which reduces further swelling when the modified woods come into contact with water or water vapor. The purpose of this research was to determine the water absorption and dimensional stability of the acetylated solid wood in liquid water and in humidity tests. Beech and red oak were acetylated. Moisture and water absorption of acetylated wood were quite dependent on weight percent gain(WPG). Antiswelling efficiency(ASE) was quite dependent on WPG, but was not dependent on species.

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Improve the Gamma variation by monitoring the angle of the polarizer absorption axis

  • Wu, Chun-Wei;Huang, Chiu-Jung;Hu, Cheng-Chung;Cheng, Yao-Li
    • 한국정보디스플레이학회:학술대회논문집
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    • 한국정보디스플레이학회 2007년도 7th International Meeting on Information Display 제7권1호
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    • pp.293-296
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    • 2007
  • Gamma curve is one of the most important optical performance characteristics of a liquid crystal display. we present investigations on the relationship between gamma and polarizer. The gamma curve is affected by the angle of the polarizer absorption axis. When the crossed angle between the two polarizers turns larger, gamma values will decrease. The gamma variation caused from each polarizer variation could be improved by monitoring and controlling the axial direction of the polarizers.

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Comparison of absorption based on the location of seam of cloth diaper

  • Lee, Heeran;Lee, Hyojeong;Lee, Yejin
    • 패션비즈니스
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    • 제20권6호
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    • pp.94-110
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    • 2016
  • A necessity for infants, diapers are not only used over long durations, but are also in direct contact to the infants' skin, making the choice of diaper to be of utmost importance. Current interest in cloth diapers is rapidly increasing because of issues concerning the baby's health, green environment, and economy. However, previous researches on cloth diapers are limited to simply investigating the form and material of commercial cloth diapers. There are few in-depth researches for the optimal cloth diaper development. This is therefore a fundamental research for the development of optimized cloth diapers, and analyzes the difference in absorption depending on the placement of seam line (liner, darts, and I pattern), the locations of liquid spraying (1 cm and 8 cm ahead of the center), and the amount of liquid capacity (10 and 20 ml). Currently, the development of diaper patterns considers the crotch shape of the infants and the skin length deformation. As a result, in the case of the I-pattern, the horizontal seam line prevents water from spreading to the front and back, thus reducing the absorbed area. This result was more clearly visible when water was sprayed at the center. The effect of the seam line became more obvious when there was more water (20 ml); also, when water was sprayed at the center, more leakage was observed. Using the results of this research, implementation of horizontal seam is expected to prevent the upward spread of urine.

산업부산물의 Ca 성분 용출 특성 및 액상탄산화 반응을 이용한 침강성 탄산칼슘 제조에 관한 실험적 연구 (An experimental study on preparation of precipitated calcium carbonate using Ca component dissolution characteristics and liquid carbonation by the Industrial byproducts)

  • 임윤희;이주열;신재란;최창식;홍범의;강호종;박병현
    • 한국응용과학기술학회지
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    • 제32권1호
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    • pp.116-126
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    • 2015
  • 본 연구에서는 이산화탄소 고정화에 있어 이산화탄소 전환을 위해 MEA를 이용한 습식화학흡수법의 셔틀메카니즘을 도입하였다. 또한 알칼리 무기물질을 다량 함유한 산업부산물을 습식탄산화법을 이용해 처리하고자 하였다. 즉, 산업부산물의 화학적 처리를 통해 칼슘이온을 용출하였다. 산성물질을 이용한 용출상징수를 ICP로 분석한 결과, 칼슘이온이 최대 17,900 ppm(1.79%)을 확보하였다. 또한 MEA를 이용한 습식 흡수공정을 통해 상온, 상압조건의 이산화탄소 분위기에서 94%의 전환률을 얻었다. 슬러지의 액상탄산화를 통해 슬러지 mg 당 0.175 mg의 이산화탄소를 고정하였으며, 최종생성물의 XRD 분석결과 일반적인 탄산칼슘의 결정구조인 calcite 형상을 확인하였다.

물분해 수소제조를 위한 SI cycle에서의 EMIm[$EtSO_4$]를 이용한 $SO_2/O_2$ 분리공정 ($SO_2/O_2$ Separation Process with EMIm[$EtSO_4$] in SI Cycle for the Hydrogen Production by Water Splitting)

  • 이기용;김홍곤;정광덕;김창수
    • 한국수소및신에너지학회논문집
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    • 제22권1호
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    • pp.13-20
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    • 2011
  • $SO_2$ has been absorbed and separated selectively by an ionic liquid from $SO_2/O_2$ mixture decomposed from sulfuric acid during the thermochemical SI cycle for the water splitting. In order to design and operate high pressure $SO_2/O_2$ separation system, the solubility of $SO_2$ in [EMIm]$EtSO_4$ (1-ethyl-3-methylimidazolium ethylsulfate) has been measured by Magnetic Suspension Balance at high pressure and temperature. Based on the measured solubility, a pressurized separation system was set up and operated. 194 L/h of $SO_2$($SO_2:O_2$=0.65:1) has been separated with 99.85% of $O_2$ at the vent of absorption tower, which is 22.7% of the theoretically ideal capacity of the system. This discrepancy results from the reduced contact between the gaseous $SO_2$ and the ionic liquid. Increased $SO_2$ supply, scale-up of the absorption column, and a faster ionic liquid circulation speed were suggested to improve the separation capacity.

리튬브로마이드 수용액 유하액막의 흡수과정에 대한 근사 해법 : 증기 유동의 영향 (Approximate solutions on the absorption process of an aqueous LiBr falling film : effects of vapor flow)

  • 김병주;이찬우
    • 설비공학논문집
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    • 제9권2호
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    • pp.144-152
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    • 1997
  • Film absorption involves simultaneous heat and mass transfer in the vapor-liquid system. In the present work, the absorption process of water vapor by an aqueous soluton of LiBr flowing inside of the vertical tube was investigated. The continuity, momentum, energy and diffusion equations for the solution film and vapor were formulated in integral forms and solved numerically. The model could predict the film thickness, the pressure gradient, and the heat and mass transfer rate. Particularly the effects of vapor flow conditions on the absorption process were investigated in terms of the vapor Reynolds number. As the vapor Reynolds number increased, the shear stress at the vapor-solution interface also increased. Consequently solution film became thinner at higher vapor flowrate under the co-currentflow condition. Thinner film was capable of higher heat transfer to the wall and leaded to higher absorption rate of the water vapor into the solution film.

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Non-absorbable Gas Effects on Heat and Mass Transfer in Falling Film Absorption

  • Kim, Byongjoo;Lee, Chunkyu
    • Journal of Mechanical Science and Technology
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    • 제17권4호
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    • pp.581-589
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    • 2003
  • Film absorption involves simultaneous heat and mass transfer in the gas-liquid system. While the non-absorbable gas does not participate directly In the absorption process. its pretence does affect the overall heat and mass transfer. An experimental study was performed to investigate the heat and mass transfer characteristics of LiBr-H$_2$O solution flow ing over 6-row horizontal tubes with the water vapor absorption in the pretence of non-absorbable gases. The volumetric concentration of non-absorbable gas, air, was varied from 0.17 to 10.0%. The combined effects of the solution flow rate and its concentration on the heat and mass transfer coefficients were also examined. The presence of 2% volumetric concentration of air resulted in a 25% reduction in the Nusselt number and 41% reduction in the Sherwood number Optimum film Reynolds number was found to exist at which the heat and mass transfer reach their maximum value independent of air contents. Reduced Nusselt and Sherwood numbers. defined as the ratio of Nusselt and Sherwood numbers at given non-absorbable gas content to that with pure water vapor, were correlated to account for the reduction in the heat and mass transfer due to non-absorbable gases in a falling film absorption process.

접촉각이 유하액막 특성에 미치는 영향에 관한 실험적 연구 (An Experimental Study on the Effects of Contact Angle on a Falling Liquid Film)

  • 김경희;강병하;이대영
    • 설비공학논문집
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    • 제18권11호
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    • pp.867-873
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    • 2006
  • Vertical falling liquid film is extensively used in heat and mass transfer processes of many applications, such as evaporative coolers, cooling towers, and absorption chillers. In such cases, it is required that the falling film spreads widely in the surface forming thin liquid film to enlarge contact surface. An addition of surface active agent to a falling liquid film or hydrophilic surface treatment affects the fluid physical properties of the film. Surfactant addition not only decreases contact angle between the liquid and solid surface but also changes the surface from hydrophobicity to hydrophilicity. In this study, the effects of contact angle on falling film characteristics over a vertical surface have been investigated experimentally. The contact angle is varied either by an addition of surfactant to the liquid or by hydrophilic surface treatment. It is found that the wetted area is increased and film thickness is decreased by the hydrophilic treatment as compared with those of other surfaces. With this hydrophilic treatment, the falling liquid film spreads out widely in the surface. As surfactant concentration is increased, wetted area is also increased and the film thickness is substantially decreased.